Zhixiang Lu 陆治香 副教授、博士生导师
福建省高层次人才C类
邮箱：zhixiangl@xmu.edu.cn
福建省厦门市厦门大学翔安校区药学院249室
教育及工作经历：
2023/04-至今，厦门大学，药学院，副教授
2020/01 - 2023/02，厦门大学，公共卫生学院分子影像暨转化医学研究中心，博士后，合作导师：刘刚教授
2014/09 - 2019/12，云南大学，化学科学与工程学院·药学院，博士，导师：张洪彬教授/郑立炎教授
2010/09 - 2014/06，云南大学，化学科学与工程学院·药学院，本科
研究兴趣为新型功能药物设计、微环境响应探针和递送载体，研究方向主要包括
1、设计多功能新型有机金属活性药物，揭示其抗肿瘤分子机制;
2、构建靶向、智能的特异成像探针，为疾病诊断提供有效途径;
3、研究微环境响应药物和基因递送载体，提高药物的靶向性、安全性、疗效等。
科研成果：
以第一或通讯作者（含共同）在国际高水平期刊Advanced Materials、Advanced Functional Materials, Small, Nano-Micro Letters, ACS nano等上发表论文20余篇，作为项目主持人主持厦门大学“南强青年拔尖人才B类”、国家自然科学基金等，以项目骨干身份参与国家重点研发计划。
代表性论文:
1. Shuang Bai, Hu Chen, Shiying Fu, Chao Liu, Xing Gao, Shuo Li, Yulun Chen, Yulu Lan, Yutian Xia, Qixuan Dai, Pan He, Yang Zhang, Qingliang Zhao, Jingsong Mao*, Zhixiang Lu*, Gang Liu*, Bioinspired Tumor Calcification-Guided Early Diagnosis and Eradication of Hepatocellular Carcinoma. Advanced Materials. 2024, 2310818.
2. Lijuan Yang, Yibo An, Dazhuang Xu, Fan Dai, Shillong Shao, Zhixiang Lu,* and Gang Liu*，Comprehensive Overview of Controlled Fabrication of Multifunctional Fluorescent Carbon Quantum Dots and Exploring Applications, Small 2024, 2309293.
3. Yibo An, Dazhuang Xu, Xiaofei Wen , Chuan Chen *, Gang Liu *, Zhixiang Lu *，Internal light sources-mediated PDT nanoplatforms: hope for the resolution of traditional penetration problem，Advanced Healthcare Materials, 2023, 2301326.
4. Dazhuang Xu, Jianlin Ge, Yibo An, Shuang Bai, Ziying Wang, Shuaiying Wu, Qixuan Dai, Zhixiang Lu*, and Gang Liu*, Molecular Engineering of NIR-II/IIb Emitting AIEgen for Multimodal Imaging-Guided Photo-Immunotherapy, Small, 2023, 23008.
5. Shuaiying Wu a, #, Jianzhong Zhang a, #, Jie pan a, Shuang Bai a, Ziying Wang b, Yulun Chen c, Dazhuang Xu a, Yibo An a, Chao Liu a, Chengchao Chu c, Qixuan Dai a, Zhixiang Lua, *, Gang Liu a, b, *, Integrated nanorods-mediated PD-L1 downregulation in combination with oxidative-stress immunogene therapy against cancer. Advanced Healthcare Materials, 2023: 2300110.
6. Shuaiying Wu a, Chao Liu a, Shuang Bai a, Zhixiang Lua, *, Gang Liu a, b, *, Broadening the horizons of RNA delivery strategies in cancer therapy. Bioengineering, 2022, 9, 576.
7. Zhixiang Lua, #, Shuang Bai a, #, Yonghe Jiang b, Shuaiying Wu a, Dazhuang Xu a, Jianzhong Zhang a, Xuqi Peng a, Hongrui Zhang a, Yesi Shi a, *, Gang Liu a, b, *，Amplifying Dendritic Cell Activation by Bioinspired Nanometal Organic Frameworks for Synergistic Sonoimmunotherapy, Small, 2022, 2203952.
8. Zhixiang Lu#, Shuang Bai #, Yonghe Jiang, Shuaiying Wu, Dazhuang Xu ,Yulun Chen, Yulu Lan，Yibo An, Jingsong Mao, Xuan Liu *, Gang Liu *, Porphyrin-based Covalent organic framework for imaging-guided combinatorial immune-sonodynamic therapy. Advanced Functional Materials, 2022, 2207749.
9. Shuang Bai #, Yulu Lan #, Shiying Fu, Jintao Pan, Zhixiang Lu *, Gang Liu *，Connecting Calcium-Based Nanomaterials and Cancer: from Diagnosis to Therapy. Nano-micro letter, 2022, 14(1),145.
10. Shuang Bai #, Zhixiang Lu#, Yonghe Jiang, Xiaoxiao Shi, Yesi Shi, Gan Lin, Chao Liu, Yang Zhang*, Gang Liu*, Nanotransferrin-based programmable catalysis mediates triple oxidative stress to boost immunogenic cell death for anti-tumor immunity. ACS nano, 2022, 16, 1, 997–1012.
11. Zhixiang Lu#, Shuang Bai #, Yesi Shi, Dazhuang Xu, Chengchao Chu *, Gang Liu *, Artificial nanocages-based 3D framework platforms: from construction design to biological applications. Chemical Engineering Journal, 2021, 426, 131891.
12. Zhixiang Lu, Mingjiang Wu, Shuang Wu, Shaoxiong Yang, Yuan Li, Xiaolan Liu, Liyan Zheng *, Qiue Cao * and Zhongtao Ding, Modulating the optical properties of the AIE fluophor confined within UiO-66's nanochannels for chemical sensing. Nanoscale, 2016, 8(40): 17489-17495.
13. Zhixiang Lu, Shaoxiong Yang, Xiaolan Liu, Yu Qin, Shuhan Lu, Yanxiong Liu, Ruidun Zhao, Liyan Zheng*, Hongbin Zhang *, Facile synthesis and separation of E /Z isomers of aromatic-substituted tetraphenylethylene for investigating their fluorescent properties via single crystal analysis. Journal of Materials Chemistry C, 2019, 7(14): 4155-4163.
14. Zhixiang Lu, Yanxiong Liu, Xiaolan Liu, Shuhan Lu, Yuan Li, Shaoxiong Yang, Yu Qin, Liyan Zheng *, Hongbin Zhang *, A hollow microshuttle-shaped capsule covalent organic framework for protein adsorption, Journal of Materials Chemistry B, 2019, 7(9): 1469-1474.
15. Zhixiang Lu, Yi Cheng, Wenwen Fan, Shaoxiong Yang, Xiaolan Liu, Yu Qin, Ruidun Zhao, Liyan Zheng * and Hongbin Zhang *, A stable silver metallacage with solvatochromic and mechanochromic behaviors for white LED fabrication. Chemical Communications, 2019, 55, 8474-8477.
16. Zhixiang Lu, Shuhan Lu, Yi Cheng, Yu Qin, Shaoxiong Yang, Xiaolan Liu, Wenwen Fan, Liyan Zheng *, Hongbin Zhang *, Synthesis of isoniazid-substituted tetraphenylethylene stereoisomers with dramatic differences on aggregate morphologies, optical and mechanocharomic properties. Journal of Photochemistry & Photobiology A: Chemistry, 2020, 392: 112357-112368.
17. Zhixiang Lu, Yunming Liu, Shuhan Lu, Yuan Li, Xiaolan Liu, Yu Qin and Liyan Zheng *, A highly selective TPE-based AIE fluorescent probe is developed for the detection of Ag+. RSC advances, 2018, 8(35): 19701-19706.
18. Yonggang Shi#, Zhixiang Lu#, Liyan Zheng *, Qiu-E Cao *，Silver-Driven Coordination Self-Assembly of Tetraphenylethene Stereoisomer: Construct Charming Topologies and Their Mechanochromic Behaviors. Inorganic Chemistry,2020, 59, 6508-6517.
19. Yonghe Jiang #, Yang Zhang #, Zhixiang Lu#, Xiaoyong Wang, Shuang Bai, Yulun Chen, Jinsong Mao *, Gang Liu *, Liquid Embolic Agents for Interventional Embolization. ChemPhysMater,2022, 1, 39–50.
20. 吴帅莹，蒋永和，陆治香*，刘刚*, 液体硅橡胶功能改性及其医学应用研究进展。中国材料进展。接收。
21. 许大壮, 潘金韬, 陆治香*, 刘刚*，近红外二区有机荧光纳米探针构建及手术导航研究进展。生命科学仪器，2021,19 (01), 4-11。
欢迎优秀硕士、博士研究生及博士后加入实验室（长期有效）。
