刘超副教授

发布者:张欧扬发布时间:2023-03-01浏览次数:7527


Liu Chao|刘超博士、副教授、博士生导师


邮箱: liuchao66888@xmu.edu.cn

福建省厦门市厦门大学翔安校区药学院


教育及工作经历:

2022-至今. 厦门大学药学院    副教授


2020-2022  厦门大学, 公共卫生学院分子影像暨转化医学研究中心    博士后  合作导师: 刘刚 教授


2016-2020  厦门大学, 公共卫生学院分子影像暨转化医学研究中心    博士   导师: 刘刚 教授


2013-2016  北京工业大学, 生命科学与生物工程学院    硕士    导师: 曾毅 院士


2009-2013  河南师范大学, 生命科学学院    学士


研究方向:

致力于肿瘤免疫治疗及个性化疫苗体系设计、制备及功能评价,基于仿生学的功能化靶向递送系统构建,及基于表观遗传学的工程病毒载体改造。研究内容主要包括:


  • 新型功能化抗肿瘤/病毒疫苗设计;

  • 免疫共刺激信号递送平台;

  • T细胞免疫耐受诱导与逆转及肿瘤微环境调控。

科研成果:

设计制备了基于抗原递呈细胞衍生的功能化疫苗用于肿瘤及病毒免疫治疗,系统地研究了抗原递呈及免疫识别之间的相关性及其规律,探索了分子影像探针对疫苗载体的标记技术方法,建立了比较系统的肿瘤疫苗免疫学评价体系。发表SCI论文40余篇,其中以第一或通讯作者(含共同)在国际高水平期刊Nature NanotechnologyAdvanced MaterialsAngewandte ChemieACS Nano等上发表论文17篇,论文篇均影响因子超过13,并已向科技公司转让相关重要发明专利数项,受邀担任Military Medical ResearchIF=21.1)与Exploration杂志青年编委。

厦门大学“南强青年拔尖人才”,主持国家自然科学基金面上项目一项,省市级科学基金三项。

代表论著:

 (*: corresponding author; #: equal contribution)

 (1)Chao Liu#, Xue Liu#, Xinchu Xiang, Xin Pang, Siyuan Chen, Yunming Zhang, En Ren, Lili Zhang, Xuan Liu, Peng Lv, Xiaoyong Wang, Wenxin Luo, Ningshao Xia, Xiaoyuan Chen*, Gang Liu*. A Nanovaccine for Antigen Self-presentation and Immunosuppression Reversal as a Personalized Cancer Immunotherapy Strategy.Nature Nanotechnology, 2022, 17, 531-540.IF=38.3

News&Views: Yahya Mohammadzadeh, Michele De Palma*. Boosting dendritic cell nanovaccines.Nature Nanotechnology, 2022, 17, 442-444.

(2) Xue Liu#, Chao Liu#, Zizheng Zheng#, Siyuan Chen, Xin Pang, Xinchu Xiang, Jixian Tang, En Ren, Yuanzhi Chen, Min You, Xiaoyong Wang, Xiaoyuan Chen, Wenxin Luo*, Gang Liu*, Ningshao Xia*. Vesicular Antibodies: A bioactive multifunctional combination platform for targeted therapeutic delivery and cancer immunotherapy,Advanced Materials. 2019, 31(17), 201808294.IF=29.4

(3) Xiaoyu An#, Wei Xiang#, Xue Liu#, Shuo Li, Zhijian Xu, Pan He, Ri-Li Ge, Feng Tang*, Zhe Cheng*, Chao Liu*, Gang Liu*. A Bioengineered Nanovesicles Vaccine Boosts T-B cell Interaction for Immunotherapy of Echinococcus multilocularis.Angewandte Chemie International Edition. 2024, e202319489.IF=16.6

(4) Shuyu Xu, Xiaoxiao Shi, En Ren, Jianzhong Zhang, Xing Gao, Dan Mu, Chao Liu*, and Gang Liu*. Genetically engineered nanohyaluronidase vesicles: a smart sonotheranostic platform for enhancing cargo penetration of solid tumors.Advanced Functional Materials. 2022, 32(22):202112989.IF=19.0

(5) Xiaoxiao Shi, Yang Zhang, Shuyu Xu, Shuang Bai, Xue Liu, Yonghe Jiang, Chao Liu*, and Gang Liu *. Unimolecule-based Size-charge Switchable Nanomedicine for Deep Cancer Sono-immunotherapy.Nano Today. 2022, 43, 101417.IF=17.4

(6) Jingyi Liu#, Chao Liu#, Jinfeng Zhang#, Yunming Zhang, Keyin Liu, Ju-Xian Song, Sravan Gopalkrishnashetty Sreenivasmurthy, Ziying Wang, Yesi Shi, Chengchao Chu, Yang ZhangCai, sheng Wu, Xianhua Deng, Xingyang Liu, Jing Song, Rongqiang Zhuang, Shuqiong Huang, Pengfei Zhang, Min Li*, Lei Wen*, Yun wu Zhang, Gang Liu*. A self-assembled α-synuclein nanoscavenger for parkinson’s disease.ACS Nano. 2020, 14(2): 1533-1549.IF=17.1

(7) En Ren#, Chao Liu#, Peng Lv, Junqing Wang*, Gang Liu*. Genetically Engineered Cellular Membrane Vesicles as Tailorable Shells for Therapeutics.Advanced Science. 2021, 8(21): 202100460.IF=15.1

(8) Xue Liu#, Chao Liu#, Gang Liu, Wenxin Luo*, and Ningshao Xia. COVID-19: Progress in diagnostics, therapy and vaccination.Theranostics. 2020, 10(17):7821-7835.IF=12.4

(9) Jianzhong Zhang#, Xue Liu#, Yutian Xia, Shuyu Xu, Xuan Liu, Haiqing Xiao, Xiaoyong Wang, Chao Liu*, Gang Liu*. Genetically engineered nano-melittin vesicles for multimodal synergetic cancer therapy.Bioengineering & Translational Medicine. 2023, e10482.IF=7.4

(10) Yesi Shi#, Gan Lin#, Huili Zheng#, Dan Mu, Hu Chen, Zhixiang Lu, Pan He, Yang Zhang, Chao Liu*, Zhongning Lin*, Gang Liu* Biomimetic Nanoparticles Blocking Autophagy for Enhanced Chemotherapy and Metastasis Inhibition via Reversing Focal Adhesion Disassembly.Journal of Nanobiotechnology. 2021, 19(1):447.IF=10.2

(11) Xiaoqing Chen#, Xue Liu#, Yichao Jiang, Ningshao Xia, Chao Liu* and Wenxin Luo*. Abnormally primed CD8 T cells: The Achilles’ heel of CHB.Frontiers in Immunology. 2023,14, 1106700.IF=7.3

(12)Qianwen Mu#, Haolan Deng#, Xiaoyu An, Gang Liu, Chao Liu*. Designing Nanodiscs as Versatile Platforms for On-Demand Therapy. Nanoscale. 2024, 16, 2220-2234.IF=6.7

(13)Shuo Li, Xue Liu, Gang Liu*, Chao Liu*. Biomimetic nanotechnology for SARS-CoV-2 treatment. Viruses. 2023, 15(3):596.IF=4.7

(14) Xiaoyu An, Yun Zeng, Chao Liu*, Gang Liu*. Cellular-Membrane-Derived Vesicles for Cancer Immunotherapy. Pharmaceutics. 2024, 16(1): 22.IF=5.4

(15) Shuaiying Wu#, Chao Liu#, Shuang Bai, Zhixiang Lu*, Gang Liu *. Broadening the Horizons of RNA Delivery Strategies in Cancer Therapy.Bioengineering. 2022, 9(10): 576.IF=4.6

(16) Chao Liu, Haiyan Gao, Peng Lv, Jingyi Liu, Gang Liu*. Extracellular vesicles as an efficient nanoplatform for the delivery of therapeutics.Human Vaccines & Immunotherapeutics. 2017, 13(11), 2678-2687.IF=4.8

(17) Wei Xiang#, Xue Liu#, Lili Zhang, Chao Liu*, Gang Liu*. Cell membrane-encapsulated nanoparticles for vaccines and immunotherapy.Particuology. 2022, 64, 35-42.IF=3.5

专利:

  1. 刘刚;刘超;一种普适性的抗原自递呈肿瘤疫苗及其制备方法,2021-5-7ZL202010070724.9

  2. 刘刚;吕鹏;刘旋;陈笑梅;刘超;牟雅琳;一种可静脉注射的溶瘤病毒制剂及其制备方法,2020-9-1ZL201811026737.5

  3. 刘刚;刘超;张莉莉 ;一种水包油型碘化油纳米乳佐剂的制备方法及其应用, 2024-3-1, 202111220206.1

  4. 刘刚;徐晓;马红娟;赵振文;陈虎;何攀;刘超;楚成超;李东 ;工程化放射性聚合物微球及其制备方法和用途, 2023-7-7,中国, ZL202210736748.2

  5. 刘刚;代奇轩;王琳;陈虎;高兴;张洪瑞;楚成超;陆治香;刘超;放射性金属核素标记的金属有机纳米材料、制备及应用, 2023-10-24,中国, ZL202210889374.8

  6. Gang Liu; Xiao Xu; Hongjuan Ma; Zhenwen Zhao; Hu Chen; Pan He; Chao Liu; Chengchao Chu; Dong Li; Engineered Radioactive Polymeric Microsphere, and Preparation and Application Thereof, 2024-1-9,美国, US11865196B2


本实验室诚招博士后,博士及硕士研究生(长期有效)。