PI: 严小胜博士、副教授、博士生导师
厦门大学“南强青年拔尖B类人才”
个人简介：
严小胜博士，主要致力于超分子化学、手性化学和药物化学学科的交叉研究。目前，已在Nat. Commun., Adv. Mater., Angew. Chem. Int. Ed., J. Am. Chem. Soc., ACS Appl. Mater. Interfaces, Nanoscale, Chem. Commun., J. Org. Chem.等国际权威期刊上发表论文30余篇。主持国家自然科学基金青年基金项目、福建省自然科学基金面上项目、厦门大学校长基金和企业科技合作项目，参与国家自然科学基金重大研究计划集成项目、化学部专项项目、重点国际合作项目、重大研究计划培育项目和高等学校学科“生命物质跨膜转运学科创新引智基地”项目。谱学分析与仪器教育部重点实验室成员。获教育部自然科学奖二等奖（第三完成人）。2021年12月加入厦门大学药学院，研究工作主要围绕拟肽和环肽，以高效合成、分子识别、仿生组装、跨膜转运和手性效应等研究为基础，发展抗癌、抗菌等应用研究，助力肽类药物研发。
工作经历：
2021.12-至今 厦门大学药学院，副教授
2020.08-2021.11 厦门大学化学化工学院，科研助理（合作导师：江云宝教授）
2016.07-2020.07 厦门大学生命科学学院/化学化工学院，博士后（合作导师：韩家淮院士/江云宝教授）
教育背景：
2010.09-2016.06 厦门大学，博士，专业：分析化学（指导老师：江云宝教授）
2006.09-2010.06 华中农业大学，学士，专业：应用化学
代表性论文：
1. Xiaosheng Yan, Jinlian Cao, Huan Luo, Zhao Li, Zexing Cao, Yirong Mo, and Yunbao Jiang*. Heterochiral coupling to bilateral β-turn structured azapeptides bearing two remote chiral centers. Nat. Commun.2024, 15, 9271.
2. Kexin Lin, Peimin Weng, Yuanwei Qi, Jinkui Teng, Zhikun Lei, and Xiaosheng Yan*. Evolution of Peptidomimetics-Based Chiral Assemblies of β-Sheet, α-Helix, and Double Helix Involving Chalcogen Bonds. ACS Appl. Mater. Interfaces2024, DOI: 10.1021/acsami.4c10568.(Cover art)
3. Xiaosheng Yan,* PeiminWeng, Jinlian Cao, Kexin Lin, Yuanwei Qi, Xin Wu and Yun-Bao Jiang*. Simultaneous formation of helical and sheet-like assemblies from short azapeptides enables spontaneous resolution. Nanoscale2024, 16, 19221.
4. Jinlian Cao, Peimin Weng, Yuanwei Qi, Kexin Lin and Xiaosheng Yan*. Noncovalent interaction network of chalcogen, halogen and hydrogen bonds for supramolecular β-sheet organization. Chem. Commun.2024, 60, 1484−1487.
5. Xiaosheng Yan, Kunshan Zou, Jinlian Cao, Xiaorui Li, Zhixing Zhao, Zhao Li, Anan Wu, Wanzhen Liang, Yirong Mo, and Yunbao Jiang*. Single-handed supramolecular double helix of homochiral bis(N-amidothiourea) supported by double crossed C−I···S halogen bonds. Nat. Commun.2019, 10, 3610. (Editors’ highlights)
6. Xiaosheng Yan, Qian Wang, Xuanxuan Chen, and Yun-Bao Jiang*. Supramolecular Chiral Aggregates Exhibiting Nonlinear CD–ee Dependence. Adv. Mater.2020, 32, 1905667.
7. Xiang Lin, Bohan Kou, Jinlian Cao, Peimin Weng, Xiaosheng Yan,* Zhao Li,* and Yun-Bao Jiang*. Spontaneous Resolution of Helical Building Blocks through the Formation of Homochiral Helices in Two Dimensions. Angew. Chem. Int. Ed.2022, 61, e202205914.
8. Peimin Weng, Xiaosheng Yan,* Jinlian Cao, Zhao Li and Yun-Bao Jiang*. Intramolecular chalcogen bonding to tune the molecular conformation of helical building blocks for a supramolecular helix. Chem. Commun.2022, 58, 6461−6464.
9. Qingqing Fang, Yan Xu, Xiaosheng Yan,* Tao Jiang,* and Yunbao Jiang*. Synthetic approaches to metal-coordination-directed macrocyclic complexes. Front. Chem.2022, 10, 1078432.
10. Zhixing Zhao, Bailing Tang, Xiaosheng Yan,* Xin Wu,* Zhao Li, Philip A. Gale,* and Yun-Bao Jiang*. Crown ether-thiourea conjugates as ion transporters. Front. Chem. Sci. Eng.2022, 16, 81−91.
11. Xiaosheng Yan,* Peimin Weng, Di Shi and Yun-Bao Jiang*. Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions. Chem. Commun.2021, 57, 12562−12574. (Inside cover)
12. Xiaosheng Yan,† Jinlian Cao,† Yanhan Zhang, Peimin Weng, Daiyu Miao, Zhixing Zhao, Zhao Li and Yun-Bao Jiang*. Solvophobic interaction promoted supramolecular helical assembly of building blocks of weak intermolecular halogen bonding. Chem. Commun.2021, 57, 1802−1805. (†Equal contribution)
13. Di Shi, Jinlian Cao, Peimin Weng, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals. Org. Biomol. Chem.2021, 19, 6397−6401. (Editor’s Collection)
14. Zhixing Zhao, Miaomiao Zhang, Bailing Tang, Peimin Weng, Yueyang Zhang, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Transmembrane Fluoride Transport by a Cyclic Azapeptide With Two β-Turns. Front. Chem.2021, 8, 621323.
15. Yanhan Zhang,†Xiaosheng Yan,† Jinlian Cao, Peimin Weng, Daiyu Miao, Zhao Li, and Yun-Bao Jiang*. Turn Conformation of β-Amino Acid-Based Short Peptides Promoted by an Amidothiourea Moiety at C-Terminus. J. Org. Chem.2020, 85, 9844−9849. (†Equal contribution)
16. Xiao-Sheng Yan,† Huan Luo,† Kun-Shan Zou, Jin-Lian Cao, Zhao Li, and Yun-Bao Jiang*. Short Azapeptides of Folded Structures in Aqueous Solutions. ACS Omega2018, 3, 4786−4790. (†Equal contribution)
17. Xiao-Sheng Yan, Kun Wu, Yuan Yuan, Ying Zhan, Jin-He Wang, Zhao-Li, and Yun-Bao Jiang*. β-Turn structure in glycinylphenylalanine dipeptide based N-amidothioureas. Chem. Commun.2013, 49, 8943−8945.
联系方式：
电子邮箱：xshyan@xmu.edu.cn
地址：福建省厦门市翔安区翔安南路厦门大学翔安校区药学院213室
邮编：361102
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