柯毅宏助理教授

发布者:张欧扬发布时间:2021-01-28浏览次数:4170


柯毅宏助理教授、硕士生导师


个人简介:

    柯毅宏,202010月至今,任职厦门大学药学院助理教授,目前工作于张晓坤教授课题组。获得香港大学医学院微生物系博士学位(2017年)并从事博士后工作(2017-2018年)。曾先后工作于香港浸会大学理学院化学系中心实验室、美国约翰霍普金斯医学院、香港大学医学院微生物系微生物组学研究中心,新加坡南洋理工医学院。自2020年加入厦门大学药学院核受体肿瘤分子靶点与药物开发创新团队以来,在药学院建立了先进的结构生物学研究平台。同时以细胞信号转导和核受体为研究对象,寻找新的核受体调节配体分子和细胞信号转导调控分子,揭示新的药物作用靶点。工作主要集中在探索RXRα在乳腺癌、结肠癌和代谢性疾病中的非基因型功能,并以构象选择这一全新而独特的分子生物学视角,筛选靶向RXRα的创新型抗癌药物小分子。负责多个创新型核受体靶点药物的临床前研究工作,目前,均已处于临床试验阶段。


代表性论文:

1. Ke, Yihong, and Suk-Yin Lai. Comparison of the Catalytic Benzene Oxidation Activity of Mesoporous Ceria Prepared via Hard-template and Soft-template. Microporous and Mesoporous Materials 198 (2014): 256- 62.

2. Sze, Kong-Hung, Wai-Hei Lam, Hongmin Zhang,Yi-Hong Ke (co-first),Man-Kit Tse, Patrick C.y. Woo, Susanna K.p. Lau, Candy C.y. Lau, Jian-Piao Cai, Edward T.k. Tung, Raymond K.c. Lo, Simin Xu, Richard Y.t. Kao, Quan Hao, and Kwok-Yung Yuen. Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response. Cell Chemical Biology 24.2 (2017): 182-94.

3. Lam, W., Sze, K., Ke, Y. (co-first), Tse, M., Zhang, H., Woo, P., Lau, S., Lau, C., Xu, S., Lai, P., Zhou, T., Antonyuk, S., Kao, R., Yuen, K. and Hao, Q. (2019). Talaromyces marneffei Mp1 protein, a novel virulence factor, carries two arachidonic acid-binding domains to suppress inflammatory responses in hosts. Infection and Immunity DOI: 10.1128/IAI.00679-18.

4. Tse, Man-Kit, Stanley K. K. Cheung, Yi-Hong Ke, Candy C. Y. Lau, Kong-Hung Sze, and Kwok-Yung Yuen. Backbone and Side-chain 1H, 13C and 15N Assignments of the PPIase Domain of Macrophage Infectivity Potentiator (Mip) Protein from Coxiella Burnetii. Biomolecular NMR Assignments 8.1 (2013): 173-76.

5. To, Kelvin K.w., Kim-Chung Lee, Samson S.y. Wong, Ka-Ching Lo, Yin-Ming Lui, Akhee S. Jahan, Andrea L. Wu, Yi-Hong Ke, Chun-Yiu Law, Kong-Hung Sze, Susanna K.p. Lau, Patrick C.y. Woo, Ching-Wan Lam, and Kwok-Yung Yuen. Lipid Mediators of Inflammation as Novel Plasma Biomarkers to Identify Patients with Bacteremia. Journal of Infection 70.5 (2015): 433-44.

6. Lau, Susanna, Kim-Chung Lee, George Lo, Vanessa Ding, Wang-Ngai Chow, Yi-Hong Ke, Shirly Curreem, Kelvin To, Deborah Ho, Siddharth Sridhar, Sally Wong, Jasper Chan, Ivan Hung, Kong-Hung Sze, Ching-Wan Lam, Kwok-Yung Yuen, and Patrick Woo. Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC- QTOF MS Reveals Novel Biomarkers for Diagnosis. IJMS International Journal of Molecular Sciences 17.3 (2016): 307.

7. Kelvin K. W. To, Kim-Chung Lee, Samson S. Y. Wong, Kong-Hung Sze, Yi-Hong Ke, Yin-Ming Lui, Bone S. F. Tang, Iris W. S. Li, Susanna K. P. Lau, Ivan F. N. Hung, Chun-Yiu Law, Ching-Wan Lam, Kwok-Yung Yuen. Lipid Metabolites as Potential Diagnostic and Prognostic Biomarkers for Acute Community Acquired Pneumonia. (2016). Diagnostic Microbiology and Infectious Disease, 85(2), 249-254.

8. Tse, Herman, Qiangshuai Gu, Kong-Hung Sze, Ivan K. Chu, Richard Y.-T. Kao, Kam-Chung Lee, Ching-Wan Lam, Dan Yang, Sherlock Shing-Chiu Tai, Yihong Ke, Elaine Chan, Wan-Mui Chan, Jun Dai, Sze-Pui Leung, Suet- Yi Leung, and Kwok-Yung Yuen. A tricyclic pyrrolobenzodiazepine produced byKlebsiella oxytocais associated with cytotoxicity in antibiotic-associated hemorrhagic colitis. Journal of Biological Chemistry 292, no. 47 (2017): 19503-9520. doi:10.1074/jbc.m117.791558.

9. To, Kelvin K.w., Lu Lu, Carol H.y. Fong, Alan K.l. Wu, Ka-Yi Mok, Cyril C.y. Yip, Yi-Hong Ke, Kong-Hung Sze, Susanna K.p. Lau, Ivan F.n. Hung, and Kwok-Yung Yuen. Rhinovirus Respiratory Tract Infection in Hospitalized Adult Patients Is Associated with T H 2 Response Irrespective of Asthma. Journal of Infection 76, no. 5 (2018): 465-74. doi:10.1016/j.jinf.2018.02.005.

 

联系方式:

地址:福建省厦门市翔安区翔安南路厦门大学药学院247

邮编:361102

E-mailyhke@xmu.edu.cn