柯毅宏助理教授、硕士生导师
个人简介：
柯毅宏，2020年10月至今，任职厦门大学药学院助理教授，目前工作于张晓坤教授课题组。获得香港大学医学院微生物系博士学位（2017年）并从事博士后工作（2017-2018年）。曾先后工作于香港浸会大学理学院化学系中心实验室、美国约翰霍普金斯医学院、香港大学医学院微生物系微生物组学研究中心，新加坡南洋理工医学院。自2020年加入厦门大学药学院“核受体肿瘤分子靶点与药物开发”创新团队以来，在药学院建立了先进的结构生物学研究平台。同时以细胞信号转导和核受体为研究对象，寻找新的核受体调节配体分子和细胞信号转导调控分子，揭示新的药物作用靶点。工作主要集中在探索RXRα在乳腺癌、结肠癌和代谢性疾病中的非基因型功能，并以“构象选择”这一全新而独特的分子生物学视角，筛选靶向RXRα的创新型抗癌药物小分子。负责多个创新型核受体靶点药物的临床前研究工作，目前，均已处于临床试验阶段。
代表性论文：
1. Ke, Yihong, and Suk-Yin Lai. Comparison of the Catalytic Benzene Oxidation Activity of Mesoporous Ceria Prepared via Hard-template and Soft-template. Microporous and Mesoporous Materials 198 (2014): 256- 62.
2. Sze, Kong-Hung, Wai-Hei Lam, Hongmin Zhang,Yi-Hong Ke (co-first),Man-Kit Tse, Patrick C.y. Woo, Susanna K.p. Lau, Candy C.y. Lau, Jian-Piao Cai, Edward T.k. Tung, Raymond K.c. Lo, Simin Xu, Richard Y.t. Kao, Quan Hao, and Kwok-Yung Yuen. Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response. Cell Chemical Biology 24.2 (2017): 182-94.
3. Lam, W., Sze, K., Ke, Y. (co-first), Tse, M., Zhang, H., Woo, P., Lau, S., Lau, C., Xu, S., Lai, P., Zhou, T., Antonyuk, S., Kao, R., Yuen, K. and Hao, Q. (2019). Talaromyces marneffei Mp1 protein, a novel virulence factor, carries two arachidonic acid-binding domains to suppress inflammatory responses in hosts. Infection and Immunity DOI: 10.1128/IAI.00679-18.
4. Tse, Man-Kit, Stanley K. K. Cheung, Yi-Hong Ke, Candy C. Y. Lau, Kong-Hung Sze, and Kwok-Yung Yuen. Backbone and Side-chain 1H, 13C and 15N Assignments of the PPIase Domain of Macrophage Infectivity Potentiator (Mip) Protein from Coxiella Burnetii. Biomolecular NMR Assignments 8.1 (2013): 173-76.
5. To, Kelvin K.w., Kim-Chung Lee, Samson S.y. Wong, Ka-Ching Lo, Yin-Ming Lui, Akhee S. Jahan, Andrea L. Wu, Yi-Hong Ke, Chun-Yiu Law, Kong-Hung Sze, Susanna K.p. Lau, Patrick C.y. Woo, Ching-Wan Lam, and Kwok-Yung Yuen. Lipid Mediators of Inflammation as Novel Plasma Biomarkers to Identify Patients with Bacteremia. Journal of Infection 70.5 (2015): 433-44.
6. Lau, Susanna, Kim-Chung Lee, George Lo, Vanessa Ding, Wang-Ngai Chow, Yi-Hong Ke, Shirly Curreem, Kelvin To, Deborah Ho, Siddharth Sridhar, Sally Wong, Jasper Chan, Ivan Hung, Kong-Hung Sze, Ching-Wan Lam, Kwok-Yung Yuen, and Patrick Woo. Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC- QTOF MS Reveals Novel Biomarkers for Diagnosis. IJMS International Journal of Molecular Sciences 17.3 (2016): 307.
7. Kelvin K. W. To, Kim-Chung Lee, Samson S. Y. Wong, Kong-Hung Sze, Yi-Hong Ke, Yin-Ming Lui, Bone S. F. Tang, Iris W. S. Li, Susanna K. P. Lau, Ivan F. N. Hung, Chun-Yiu Law, Ching-Wan Lam, Kwok-Yung Yuen. Lipid Metabolites as Potential Diagnostic and Prognostic Biomarkers for Acute Community Acquired Pneumonia. (2016). Diagnostic Microbiology and Infectious Disease, 85(2), 249-254.
8. Tse, Herman, Qiangshuai Gu, Kong-Hung Sze, Ivan K. Chu, Richard Y.-T. Kao, Kam-Chung Lee, Ching-Wan Lam, Dan Yang, Sherlock Shing-Chiu Tai, Yihong Ke, Elaine Chan, Wan-Mui Chan, Jun Dai, Sze-Pui Leung, Suet- Yi Leung, and Kwok-Yung Yuen. A tricyclic pyrrolobenzodiazepine produced byKlebsiella oxytocais associated with cytotoxicity in antibiotic-associated hemorrhagic colitis. Journal of Biological Chemistry 292, no. 47 (2017): 19503-9520. doi:10.1074/jbc.m117.791558.
9. To, Kelvin K.w., Lu Lu, Carol H.y. Fong, Alan K.l. Wu, Ka-Yi Mok, Cyril C.y. Yip, Yi-Hong Ke, Kong-Hung Sze, Susanna K.p. Lau, Ivan F.n. Hung, and Kwok-Yung Yuen. Rhinovirus Respiratory Tract Infection in Hospitalized Adult Patients Is Associated with T H 2 Response Irrespective of Asthma. Journal of Infection 76, no. 5 (2018): 465-74. doi:10.1016/j.jinf.2018.02.005.
联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院247
邮编：361102
E-mail：yhke@xmu.edu.cn
