霍帅东
PI：博士、教授、博士生导师
国家级青年人才项目入选者
福建省“闽江学者”特聘教授
厦门大学“南强青年拔尖A类人才”
个人简介：
霍帅东博士（课题组网页www.huo-lab.com）从事药物创新制剂的构建与基础研究，主要围绕“克服生物屏障，实现高效递送”以及“调控药物活性，降低毒副作用”两个关键方面展开系列研究，目前所取得的创新科研成果主要包括：（1）系统揭示了纳米载体克服多重生物屏障的生物规律和机制，设计构建了能有效克服体内多重生物屏障的多级次纳米载药系统；（2）首次提出并验证了超声机械力在分子水平调控化疗药物活性、蛋白质活性的新概念和新策略。迄今已在Nature Chemistry，Nature Nanotechnology，Science Advances，PNAS，Cancer Research，Materials Today，Advanced Materials，Advanced Science，ACS Nano，Angewandte Chemie等国际学术期刊上发表学术论文50余篇。相关研究成果为消除药物毒副作用、实现精准治疗提供了理论依据和创新策略。
1．教育背景及研究经历
2020-至今：厦门大学，教授
2017-2019：德国莱布尼兹交互材料研究所/亚琛工业大学，博士后（合作导师：Andreas Herrmann教授）
2016-2017：荷兰格罗宁根大学Zernike先进材料研究所，博士后（合作导师：Andreas Herrmann教授）
2014-2015：美国麻省大学阿莫斯特分校，联培博士生（导师：Vincent M. Rotello教授）
2013-2016：国家纳米科学中心，化学-纳米科学与技术专业，理学博士（导师：梁兴杰研究员）
2010-2013：国家纳米科学中心与天津工业大学联培，材料工程专业，工学硕士（导师：梁兴杰研究员，何声太教授）
2006-2010：东华理工大学，材料科学与工程专业，工学学士
2．学术兼职
中国生物物理学会纳米生物学分会委员
Community Member of Nanoscale Horizons
Exploration青年编委
3．主要代表论文(†Equal contribution, *Corresponding author)
1) Shuaidong Huo,† Pengkun Zhao,† Zhiyuan Shi,† Miancheng Zou, Xintong Yang, Eliza Warszawik, Mark Loznik, Robert Göstl,* and Andreas Herrmann* Mechanochemical bond scission for the activation of drugs. Nature Chemistry, 2021, 13, 131-139. (ESI highly cited paper)
News&Views:Roman Boulatov. The liberating force of ultrasound. Nature Chemistry 2021, 13, 112-114.
2) Shuaidong Huo,†,* Ningqiang Gong,† Ying Jiang, Fei Chen, Hongbo Guo, Yaling Gan, Zhisen Wang, Andreas Herrmann, and Xing-Jie Liang.* Gold-DNA nanosunflowers for efficient gene silencing with controllable transformation. Science Advances, 2019, 5 (10), eaaw6264.
3) Shuaidong Huo,†,* Minseok Kwak,† Jingbo Qin, and Andreas Herrmann* Dynamic DNA-based Biomaterials Interacting with External, Macroscopic, and Molecular Stimuli, Materials Today, 2021, 49, 378-390.
4) Shuaidong Huo,* Zhihuan Liao, Pengkun Zhao, Yu Zhou, Robert Göstl, Andreas Herrmann,* Mechano- Nanoswitches for Ultrasound-Controlled Drug Activation, Advanced Science, 2022, 9, 2104696.
5) Li Tu,† Zhihuan Liao,† Zheng Luo, Yun-Long Wu, Andreas Herrmann,* and Shuaidong Huo* Ultrasound-controlled drug release and drug activation for cancer therapy, Exploration, 2021, 1, 20210023.
6) Shuaidong Huo,† Huili Ma,† Keyang Huang, Juan Liu, Tuo Wei, Shubin Jin, Jinchao Zhang, Shengtai He,* and Xing-Jie Liang.* Superior penetration and retention behavior of 50 nm gold nanoparticles in tumors. Cancer Research, 2013, 73, 319-330. (ESI highly cited paper)
7) Shuaidong Huo,† Shubin Jin,† Xiaowei Ma, Xiangdong Xue, Keni Yang, Anil Kumar, Paul C. Wang, Jinchao Zhang, Zhongbo Hu,* and Xing-Jie Liang.* Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry. ACS Nano, 2014, 8, 5852-5862.
8) Shuaidong Huo,† Ying Jiang,† Akash Gupta, Ziwen Jiang, Ryan F. Landis, Singyuk Hou, Xing-Jie Liang,* and Vincent M. Rotello.* Fully zwitterionic nanoparticle antimicrobial agents through tuning of core size and ligand structure. ACS Nano, 2016, 10, 8732-8737.
9) Ning qiang Gong, Xiaowei Ma, Xiaoxia Ye, Qunfang Zhou, Xiaoai Chen, Xiaoli Tan, Shengkun Yao, Shuaidong Huo, Tingbin Zhang, Shizhu Chen, Xucong Teng, Xixue Hu, Jie Yu, Yaling Gan, Huaidong Jiang, Jinghong Li,* and Xing-Jie Liang.* Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment. Nature Nanotechnology, 2019, 14, 379-387. (ESI highly cited paper)
10) Ningqiang Gong, Yuxuan Zhang, Xucong Teng, Yongchao Wang, Shuaidong Huo, Guangchao Qing, Qiankun Ni, Xianlei Li, Jinjin Wang, Xiaoxia Ye, Tingbin Zhang, Shizhu Chen, Yongji Wang, Jie Yu, Paul C. Wang, Yaling Gan, Jinchao Zhang, Michael J. Mitchell, Jinghong Li* and Xing-Jie Liang* Proton-driven transformable nanovaccine for cancer immunotherapy. Nature Nanotechnology, 2020, 15, 1053-1064.
4．课题组目前研究方向
1) 活性可调（纳米）药物的设计及研发;
2) 细胞器靶向的药物放大器研究;
3) 机械力化学与药物制剂的交叉研究;
4) 超声药物治疗的生物机制研究。
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