田文静博士，助理教授
个人简介：
田文静博士，厦门大学药学院助理教授，硕士研究生导师，福建省高层次人才（C类）。主要从事天然药物化学生物学研究工作，致力于挖掘闽台地区特色药用植物中新颖间苯三酚杂萜类成分，并探索其药用功能及作用机制。以第一作者或通讯作者在Organic Letters、Journal of natural products、Bioorganic Chemistry、Phytochemistry等杂志上发表SCI论文28篇，申请发明专利8项（7项已授权）。主持国家自然科学基金面上项目、青年科学基金项目、博士后基金面上项目、福建省自然科学基金青年基金、厦门大学校长基金等多项基金项目，参与多个中药及中药复方药效物质与质量标准相关企业合作项目的研究工作。担任Phytochemistry、Chinese Journal of natural medicines、Fitoterapia等杂志的审稿人。
教育及工作经历:
2017/12-今，厦门大学，药学院，助理教授
2015/11-2017/12，厦门大学，药学院，师资博后
2010/09-2015/07，沈阳药科大学，中药学院，博士，导师：姚新生院士
主要研究方向：
1.新结构天然产物的发现与药用功能研究
2.中药及中药复方药效物质与质量标准研究
代表性论文（第一#或通讯作者*论文）：
1.Xiansheng Ye#, Wenjing Tian#, Guanghui Wang, Lijuan Hu, Changlong Leng, Binlian Sun, Wei Liu, Xiji Shu, Haifeng Chen*.Four undescribed coumarin derivatives, with ten amides from the roots of Ficus hirta and their cytotoxic activities.Bioorganic Chemistry, 2024, 144,107116.
2. Qiannan Xu#, Wenjing Tian#,*, Shoulun He, Mi Zhou, Yue Gao, Xiangzhong Liu, Cuiling Sun, Rong Ding, Guanghui Wang, Haifeng Chen* Apocarotenoids from Equisetum debile Roxb. ex Vaucher regulate the lipid metabolism via the activation of the AMPK/ACC/SREBP-1c signaling pathway. Bioorganic Chemistry 2023,138, 106639.
3. Wen-Jing Tian#,*Mi Zhou, Da-Ren Qiu, Jun-Jie Chen, Xiang-Zhong Liu, Jing-Dian Li, Ting Lin, Guang-Hui Wang, Haifeng Chen* Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage. Bioorganic Chemistry 2022,128, 106088.
4. Xiangzhong Liu, Renjing Yang, Qiannan Xu, Mi Zhou, Jie Feng, Guanghui Wang, Ting Lin*, Wenjing Tian*, Haifeng Chen*. Tautomeric phytosterols from Vernonia amygdalina Delile and their anti-cervical cancer activity. Bioorganic Chemistry 2022,128, 106068.
5. Jie Feng, Fengming He, Yuhui Huang, Mi Zhou, Xiangzhong Liu, Xiansheng Ye, Renjing Yang, Wenjing Tian* and Haifeng Chen*. Inhibitory effects of phenolic glycosides from Trollius chinensis Bunge on α-glucosidase: inhibition kinetics and mechanisms. Food Function, 2022, 13, 2857.
6. Xiangzhong Liu, Mi Zhou, Shoulun He, Qiannan Xu, Chunchun Du, Honghong Zhu, Ting Lin, Guanghui Wang, Wenjing Tian*and Haifeng Chen*. Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity. Pharmaceuticals 2022, 15, 1160.
7. Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Jiang, Jun Gao, Ting Lin, Cuiling Sun,Rong Ding, Wenjing Tian* and Haifeng Chen* Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway. Pharmaceuticals, 2022, 15, 107.
8. Xiangzhong Liu, Wenjing Tian*, Mi Zhou, Qiannan Xu, Jie Feng, Renjing Yang, Shoulun He,Guanghui Wang, Ting Lin, Haifeng Chen*. Bisabolane-type sesquiterpenes from Vernonia amygdalina: Absolute configuration and anti-inflammatory activity. Phytochemistry, 2022, 201 113283.
9. Daren Qiu, Mi Zhou, Xiangzhong Liu, Junjie Chen, Guanghui Wang, Ting Lin, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRα. Bioorganic Chemistry, 2021, 107,104578.
10. Xiang-Zhong Liu, Mi Zhou, Chun-Chun Du, Hong-Hong Zhu, Xi Lu, Shou-Lun He, Guang-Hui Wang, Ting Lin, Wen-Jing Tian* and Hai-Feng Chen* Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response. Biomedicines 2021, 9, 1473.
11. Yanlan Yang#, Mi Zhou#, Dongni Wang, Xiangzhong Liu, Xiansheng Ye, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk‑1Pathway. Journal of Natural Products, 2021, 82:339-351.
12. Xiansheng Ye#, Wenjing Tian#, Mi Zhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xinsheng Yao*, Haifeng Chen*. Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways. Bioorg. Med. Chem. Lett. 2021, 38: 127859.
13. Xiansheng Ye#, Wenjing Tian#, Xiangzhong Liu, Mi Zhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xinsheng Yao*, Haifeng Chen*. Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities. Natural Product Research. 2021, 1892099
14. Xiansheng Ye#, Wenjing Tian#, Guanghui Wang, Xian Zhang, Mi Zhou, Dequan Zeng, Xiangzhong Liu, Xinsheng Yao*, Yunwu Zhang*, and Haifeng Chen*.Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities. Journal of Agricultural and Food Chemistry. 2020, 68: 4196-4204.
15. Daren Qiu, Mi Zhou, Junjie Chen, Guanghui Wang, Ting Lin, Yujie Huang, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα. Phytochemistry, 2020, 170, 112216.
16. Jie Feng#, Danyang Zhao#, Qiannan Xu, Xiangzhong Liu, Mi Zhou, Xiansheng Ye, Ting Lin, Guanghui Wang, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities. Natural Product Research. 2020, 36(13), 3309–3316.
17. Qiannan Xu, Dan Zhu, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum. Natural Product Research, 2020, doi.org/10.1080/14786419.2020.1739044
18. Shuo Gao#, Wenjing Tian#, Zujian Liao, Guangjui Wang, Dequan Zeng, Xiangzhong Liu, Xiaoyao Wang, Hu Zhou, Haifeng Chen*, and Ting Lin*. Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii. Chemistry &Biodiversity, 2020, 17, 9.
19. Daren Qiu, Mi Zhou, Ting Lin, Junjie Chen, Guanghui Wang, Yujie Huang, Xin Jiang, Wenjing Tian*, Haifeng Chen*. Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage. Journal of Natural Products, 2019, 82(5):1072-1080.
20. Xiangzhong Liu#, Wenjing Tian#, Guanghui Wang, Qiannan Xu, Mi Zhou, Shuo Gao, Daren Qiu, Xin Jiang, Cuiling Sun, Rong Ding, Ting Lin*, Haifeng Chen*.Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina. Phytochemistry, 2019, 158: 67-76.
21. Yu Wu#, Wenjing Tian#, Shuo Gao, Zujing Liao, Guanghui Wang, LO, J. M.; Lin, P. H.; Dequan Zeng, Daren Qiu, Xiangzhong Liu; Mi Zhou,Tin Lin*, Haifeng Chen*. Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice. Chinese Journal of Natural Medicines, 2019, 17(1): 0033-0042.
22.Wenjing Tian#, Zujing Liao#, Mi Zhou#, Guanghui Wang, Suo Gao, Daren Qiu,. Xiangzhong Liu, Ting Lin*, Haifeng Chen*. Cytoskyrin C, an unusual asymmetric bisanthraquinone with cage-like skeleton from the endophytic fungus Diaporthe sp. Fitoterapia, 2018, 128, 253-257.
23. Wenjing Tian#, Yuqin Qiu, Junjie Chen, Xiaojun Yao, Yi Dai, Haifeng.Chen*, Xinsheng Yao*. Norsampsone E, an unprecedented decarbonyl polycyclic polyprenylated acylphloroglucinol with a homoadamantyl core from Hypericum sampsonii. RSC Advances, 2017, 7, 33113–33119.
24.Wenjing Tian#, Yuqin Qiu, Haifeng Chen, Xiaojie Jin, Yi Dai*, Xinsheng Yao*. Chiral separation and absolute configurations of two pairs of racemicpolyprenylated benzophenones from Hypericum sampsonii. Fitoterapia, 2017, 116, 39–44.
25. Wenjing Tian#, Yuqin Qiu, Xiaojie Jin, Haifeng Chen, Xiaojun Yao, Yi Dai, Xinsheng Yao* Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. RSC Advances 2016, 6, 50887–50894.
26 Wenjing Tian#, Yuqin Qiu, Xiaojie Jin, Haifeng Chen, Xiaojun Yao, Yi Dai, Xinsheng Yao* Novel polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. Tetrahedron 2014, 70, 7912−7916.
27. Wenjing Tian#, Yuqin Qiu, Xiaojun Yao, Haifeng Chen, Yi Dai, Xiaokun Zhang, Xinsheng Yao*. Dioxasampsones A and B, two polycyclic polyprenylated acylphloroglucinols with unusual epoxy ring fused skeleton from Hypericum sampsonii. Organic Letter 2014, 16, 6346–6349.
28 Wenjing Tian#, Yang Yu; Xiaojun Yao, Haifeng Chen, Yi Dai, Xiaokun Zhang*, Xinsheng Yao*. Norsampsones A−D, four new decarbonyl polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. Organic Letter 2014, 16, 3448–3451.
发明专利:
(1) 田文静; 陈海峰; 王光辉; 林挺; 邱大任; 周宓; 多环多异戊烯基酰基间苯三酚类化合物及其制备方法与应用, 2021-3-5, 中国, ZL 2019 1 0746187.2 (授权)
(2) 田文静; 陈海峰; 林挺; 王光辉; 邱大任; 周宓; 刘祥忠; 裂环酰基间苯三酚类化合物及其在制备抗癌药物中的应用, 2021-3-1, 中国, 202110227023.6 (授权)
(3) 田文静; 陈海峰; 王光辉; 林挺; 杨任靖; 杜春春; 一种甾体衍生物及其在制备抗肿瘤药物中的应用, 2022-1-5, 中国, 202210007419.4 (授权)
(4) 陈海峰; 姚新生; 田文静; 王光辉; 林挺; 叶贤胜; 一种异戊烯基黄酮的制备及其作为治疗宫颈癌药物的应用, 2021-1-21, 中国, 202110082934.4 (授权)
(5) 陈海峰; 张云武; 姚新生; 田文静; 张弦; 王光辉; 林挺; 叶贤胜; 一种新的香豆素二聚体及其制备方法与应用, 2021-8-18, 中国, 202110948421.7 (授权)
(6) 陈海峰; 王光辉; 林挺; 田文静; 周宓; 海洋来源二倍半萜类化合物作为治疗宫颈癌药物的应用, 2021-6-1, 中国, ZL201811473282.1 (授权)
(7) 陈海峰; 林挺; 罗吉孟; 田文静; 吴雨; 一种皿培式培养牛樟芝的质量控制方法, 2020-8-25, 中国, ZL201810819036.0 (授权)
(8) 陈海峰,蔡明刚,田文静,杨任靖,高玥,许倩楠；一种雨生红球藻提取物的制备及其应用，2022-11-18，中国，202211444477.X (申请）
联系方式：
Email: tianwj@xmu.edu.cn
