李明玉副教授
福建省高层次引进人才（2017）
个人简介：
李明玉博士主要研究方向为糖尿病疾病机理及药物开发、海洋药物的筛选和作用机理、疾病模型构建等研究工作。研究围绕斑马鱼、小鼠、细胞系为模型；应用高通量药物筛选技术、组学技术、活体成像技术、现代分子生物学技术等手段。至今在Cell Metabolism, Trends in Genetics, Diabetes, British Journal Pharmacology等国际主流杂志共发表文章50多篇，共被引用2200多次。现为Frontiers in Endocrinology、药学研究等刊物编委，受邀为eLife, Phytomedicine等20多个杂志审稿人。先后主持国家自然基金面上项目、福建省自然基金面上项目、厦门大学校长基金等多个项目。同美国范德堡大学、美国密歇根大学、英国卡迪夫大学等国际著名高校的相关实验室建立了良好的合作研究关系。
教育与工作经历：
1999-2003中国海洋大学本科（生物技术）
2003-2006中国海洋大学硕士（细胞生物学）
2006-2010中国海洋大学博士（药物化学）
2010-2011国家海洋局第三海洋研究所助理研究员
2011-2016美国范德堡大学（Vanderbilt University）博士后
2016-至今厦门大学药学院副教授
主要研究方向：
1、胰岛α细胞及胰高血糖素信号通路的分子调控机理;
2、促胰岛β细胞再生药物的研究和开发;
3、糖尿病模型的构建及抗糖尿病药物的筛选;
4、疾病模型的建立及药物筛选;
5、海洋药物筛选及作用机理;
6、动物毒理学研究与评价。
学术兼职：
《Frontiers in Endocrinology》副主编（Experimental Section）；
《Molecules》Reviewer Board；
《药学研究》刊物编委；
《应用海洋学学报》青年编委；
中国动物学会斑马鱼分会理事；
中国老年医学会内分泌代谢分会胰岛代谢组委员；
中国药理学会海洋药物药理专业委员会副秘书长；
中国药学会海洋药物分会青年委员；
福建省药理学会理事；
厦门市医学会转化医学分会委员。
科研项目：
1. 国家自然科学基金面上项目, 82470841, 拮抗胰高血糖素受体导致胰岛α细胞高分泌胰高血糖素的分子机制研究, 2025.1-2028.12，在研，主持。
2. 国家自然科学基金面上项目, 81670709, 表皮生长因子受体（ErbB）家族在胰岛α-细胞增生中的作用机理研究, 2017.1-2020.12，结题，主持。
3. 福建省科技计划对外合作项目，2023I0002，1型糖尿病发生过程中α-细胞的病理生理学与功能研究，2023.1-2025.12, 在研，主持。
4. 福建省自然科学基金面上项目，2017J01145，利用斑马鱼进行药物筛选寻找抑制α-细胞增生的因子，2017.4-2020.4，结题，主持。
5. 厦门市自然科学基金面上项目, 3502Z20227162,海洋源促胰岛β细胞再生化合物的筛选和药理学研究，2022.7-2025.6, 在研，主持。
6. 厦门大学校长基金，20720170104，斑马鱼α-细胞增生高通量药物筛选模型的建立及其应用，2017.1-2017.12，结题，主持。
7. 厦门大学校长基金，20720180044，斑马鱼高血糖模型的构建和药物筛选，2018.1-2018.12，结题，主持。
8. 海洋药物教育部重点实验室开放基金，海洋源吲哚二萜类化合物促胰岛α细胞向β细胞转分化的药理学研究，2023.7-2025.7, 在研，主持。
代表性论文（* 通讯作者；#共同一作）：
2024
1. Kang Q, Jia J, Dean ED, Yuan H, Dai C, Li Z, Jiang F, Zhang XK, Powers AC, Chen W*, Li M*. (2024) ErbB3 is required for hyperaminoacidemia induced pancreatic α cell hyperplasia. J Biol Chem, 107499.
2. Yu, Z. W., Cai, B. P., Xie, S. Z., Zhang, Y., Wang, W. H., Liu, S. Z., Bin, Y. L., Chen, Q., Fang, M. J., Qi, R., Li, M. Y*., and Qiu, Y. K. (2024) Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others. Nat Prod Bioprospect 14, 23.
3. Wang, Z., Yu, Z. W., Zhang, Y., Wang, W. H., Wu, X. Y., Liu, S. Z., Bin, Y. L., Cai, B. P., Huang, S. Y., Fang, M. J., Qi, R., Li, M. Y. *, and Qiu, Y. K. (2024) Hinokione: an abietene diterpene with pancreatic beta cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara. J Nat Med.
4. Wu, Y., Ma, F., Yu, L., Lin, R., Lin, S., Guo, Z., Zhou, M., Li, M., Zhang, Y., and Xie, J. (2024) Unique Advantages of Dendrimers-Structured Mesoporous Silica Nanoparticles over Traditional Hollow Ones in Delivering Bcl2-Functional Converting Peptide for Multidrug Resistant Cancer Treatment. Adv Healthc Mater, e2400888.
5. Chen, S., Peng, H., Zhuang, H., Wang, J., Yan, P., Zhang, W., Zheng, W., Li, M., and Wu, X. (2024) Optimized strategy to improve the outcomes of acute type A aortic dissection with malperfusion syndrome. J Thorac Cardiovasc Surg
2023
1. Yuan H., Kang Q., Li Z., Bai X., Jia J., Han D., Wu X.*, Li M. *(2023) Crispr-Cas9 mediated complete deletion of glucagon receptor in mice display hyperglucagonemia and α-cell hyperplasia. Biochem Biophys Res Commun. 643: 121-128.
2. Gao, S., Lin, X., Shi, Y., Zhou, H., Zheng, X., Li, M*., and Lin, T*. (2023) A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline. Int J Mol Sci 24.
3. Lu X, Yang B, Qi R, Xie Q, Li T, Yang J, Tong T, Niu K, Li M, Pan W, Zhang Y, Shi D, Li S, Dai C, Shen C, Wang X, Wang Y, Song J. (2023) Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation.Theranostics. 13(1):417-437.
4. Li, Y., Liu, C., Bai, X., Li, M., and Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS Lett 597, 1868-1879.
5. Kuang, Z., Guo, K., Cao, Y., Jiang, M., Wang, C., Wu, Q., Hu, G., Ao, M., Huang, M., Qin, J., Zhao, T., Lu, S., Sun, C., Li, M., Wu, T., Liu, W., and Fang, M. (2023) The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer 129, 1915-1929.
2022
1. Jia J., Kang Q., Liu S., Song Y., Wong F.S., Qiu Y.,*, Li M.* (2022) Artemether and aspterric acid induce pancreatic α cells to transdifferentiate into β cells in zebrafish. Br J Pharmacol. 179(9):1962-1977.
2. Kang, Q#., Zheng, J#., Jia, J#., Xu, Y., Bai, X., Chen, X., Zhang, X. K., Wong, F. S., Zhang, C.*, and Li, M.* (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. J Biol Chem, 102665
3. Xu, Y#., Tian, J#., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J*., and Li M.* (2022) Knockout of Nur77 leads to amino acid, lipid and glucose metabolism disorders in zebrafish. Front Endocrinol (Lausanne). 13:864631.
4. Chen, Y., Jia, J., Zhao, Q., Zhang, Y., Huang, B., Wang, L., Tian, J., Huang, C., Li, M.*, and Li, X. (2022) Novel Loss-of-Function Variant in HNF1a Induces β-Cell Dysfunction through Endoplasmic Reticulum Stress. Int J Mol Sci.,23(21):13022
5. Wang W#, Shi Y#, Liu Y, Zhang Y, Wu J, Zhang G, Che Q, Zhu T, Li M*, Li D*. (2022) Brasilterpenes A-E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135. Marine Drugs. 20(5):338.
6. Yu, G., Sun,P., Aierken, R., Sun, C., Zhang, Z., Che, Q., Zhang, G., Zhu,T., Gu, Q., Li, M*., and Li, D*. (2022) Linear Polyketides Produced by Co-Culture of Penicillium crustosum and Penicillium fellutanum. Marine Life Science & Technology 4: 237–244.
7. Zhu, C#., Jiang, X#., Tian, J#., Chen, J., Lin, C., Wang, C., Tie, C*., Li, M*., and Wu, C*. (2022). Integrated approach toward absorption, distribution, metabolism, and excretion of Xiaoke pills in zebrafish based on UPLC-HRMS and DESI-MS techniques. J Chromatogr B Analyt Technol Biomed Life Sci 1200, 123276.
8. Tie, C., Zhu, C., Jin, Y., Liang, H., Li, M., Tian, J., and Wu, C*. (2022) Instantaneous Phosphatidylcholine spatial specific regulation induced by formononetin revealed by DESI-MSI. International Journal of Mass Spectrometry 471, 116759
9. Liu, S.-Z.; Xu, G.-X.; He, F.-M.; Zhang, W.-B.; Wu, Z.; Li, M.-Y.; Tang, X.-X.; Qiu, Y.-K*. New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8. Mar. Drugs 2022, 20, 213.
10.Wang Q, Tu X, Wang X, Cai Q, Yu L, Zhang X, Yi J, Wu Y, Xie G, Yuan H, Li M, Zhang X, Zeng Z*, Su Y. * (2022) Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents.Bioorg Chem, 2022 Nov;128:106069.
11. Ding, Y., Tao, C., Chen, Q., Chen, L., Hu, X., Li, M., Wang, S., and Jiang, F.* (2022) Cynarin inhibits PDGF-BB-induced proliferation and activation in hepatic stellate cells through PPARγ. Open Chemistry 20, 1121-1129
12. Wang, M., Wang, X., Jiang, B., Zhai, Y., Zheng, J., Yang, L., Tai, X., Li, Y., Fu, S., Xu, J., Lei, X., Kuang, Z., Zhang, C., Bai, X., Li, M., Zan, T., Qu, S., Li, Q., and Zhang, C*. (2022) Identification of MRAP protein family as broad-spectrum GPCR modulators. Clin Transl Med 12, e1091
13. Qin, J., Chen, X., Liu, W., Chen, J., Liu, W., Xia, Y., Li, Z., Li, M., Wang, S., Yuan, Q., Qiu, Y.*, Wu, Z.*, and Fang, M*. (2022) Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77. Eur J Med Chem 244, 114849
2021
1. Bai, X#., Jia, J#., Kang, Q., Fu, Y., Zhou, Y., Zhong, Y*., Zhang, C*., and Li, M*. (2021). Integrated Metabolomics and Lipidomics Analysis Reveal Remodeling of Lipid Metabolism and Amino Acid Metabolism in Glucagon Receptor-Deficient Zebrafish. Front Cell Dev Biol 8, 605979
2. Wang, L#., Shi, Y#., Che, Q., Zhu, T., Zhang, G., Zhang X.K., Li, M*., Li, D.* (2021). Penipyrols C−G and methyl-penipyrol A, α-Pyrone Polyketides from the Mangrove Derived Fungus Penicillium sp. HDN-11-131. Bioorg Chem. 113,104975.
3. Li, M*., Rong, X., Lu, L., Li, Y., Yao, K., Ge, W., and Duan, C*. (2021) IGF-2 mRNA binding protein 2 regulates primordial germ cell development in zebrafish. General and Comparative Endocrinology, 113875
4. Xu, W., Zhou, M., Guo, Z., Lin, S., Li, M., Kang, Q., Xu, Y., Zhang, X., and Xie, J. (2021) Impact of macroporous silica nanoparticles at sub-50nm on bio-behaviors and biosafety in drug-resistant cancer models. Colloids Surf B Biointerfaces 206, 111912
2020
1. Kang, Q., Hu, M., Jia, J., Bai, X., Liu, C., Wu, Z., Chen, W., and Li, M*. (2020) Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network. Int J Mol Sci, 21(3)
2. Zhao, L., Wang, L., Aierken, R., Wang, W., Wang, X*., and Li, M*. (2020) Characterization of Insulin and Glucagon Genes and Their Producing Endocrine Cells From Pygmy Sperm Whale (Kogia breviceps). Front Endocrinol (Lausanne) 11, 174
3. Gan Q#., Lin C#., Lu C., Chang Y., Che Q., Zhang G., Zhu T., Gu Q., Wu Z., Li M*. and Li D*. (2020) Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-cell Proliferation from a Mangrove Endophytic Fungus. J Nat Prod, 83(10):2996-3003
4. Wu, Y., Ge, P., Xu, W., Li, M., Kang, Q., Zhang, X., and Xie, J. (2020) Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment. Mater Sci Eng C Mater Biol Appl 108, 110386
5. Ge, P., Niu, B., Wu, Y., Xu, W., Li, M., Sun, H., Zhou, H., Zhang, X., and Xie, J. (2020) Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety. Chemical Engineering Journal 383, 123228
6. Liu, S. Z., Tang, X. X., He, F. M., Jia, J. X., Hu, H., Xie, B. Y., Li, M. Y., and Qiu, Y. K. (2020) Two new compounds from a mangrove sediment-derived fungus Penicillium polonicum H175. Nat Prod Res, 1-9
7. 林春雨，郏建新，康琪，吴志强，李明玉*. (2020) 斑马鱼胰岛α细胞细胞核特异表达mCherry转基因模型的构建. 药学研究 39 (5), 256-260.
2019之前论文：
1. Chen, Z., Zhang, D., Yan, S., Hu, C., Huang, Z., Li, Z., Peng, S., Li, X., Zhu, Y., Yu, H., Lian, B., Kang, Q., Li, M., Zeng, Z., Zhang, X. K., and Su, Y. (2019) SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem 177, 171-187
2. 王冲, 林春雨, 吴志强, 李明玉*. (2019) 促胰岛 β 细胞增生的黄酮类化合物的活体筛选. 药学研究 38 (3), 135-139.
3. Dean, E. D., Li, M., Prasad, N., Wisniewski, S. N., Von Deylen, A., Spaeth, J., Maddison, L., Botros, A., Sedgeman, L. R., Bozadjieva, N., Ilkayeva, O., Coldren, A., Poffenberger, G., Shostak, A., Semich, M. C., Aamodt, K. I., Phillips, N., Yan, H., Bernal-Mizrachi, E., Corbin, J. D., Vickers, K. C., Levy, S. E., Dai, C., Newgard, C., Gu, W., Stein, R., Chen, W., and Powers, A. C. (2017) Interrupted Glucagon Signaling Reveals Hepatic alpha Cell Axis and Role for L-Glutamine in alpha Cell Proliferation. Cell Metab 25, 1362-1373 e1365
4. Liu, J., Wang, G. H., Duan, Y. H., Dai, Y., Bao, Y., Hu, M., Zhou, Y. Q., Li, M., Jiang, F., Zhou, H., Yao, X. S., and Zhang, X. K. (2017) Modulation of the Nur77-Bcl-2 apoptotic pathway by p38alpha MAPK. Oncotarget 8, 69731-69745
5. Li, M., Page-McCaw, P., and Chen, W. (2016) FGF1 Mediates Overnutrition-Induced Compensatory beta-Cell Differentiation. Diabetes 65, 96-109
6. Li, M#., Zhao#, L., Page-McCaw, P. S., and Chen, W. (2016) Zebrafish Genome Engineering Using the CRISPR-Cas9 System. Trends Genet 32, 815-827
7. Li, M., Dean, E. D., Zhao, L., Nicholson, W. E., Powers, A. C., and Chen, W. (2015) Glucagon receptor inactivation leads to alpha-cell hyperplasia in zebrafish. J Endocrinol 227, 93-103
8. Yin, L., Maddison, L. A., Li, M., Kara, N., LaFave, M. C., Varshney, G. K., Burgess, S. M., Patton, J. G., and Chen, W. (2015) Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics 200, 431-441
9. Varshney, G. K., Pei, W., LaFave, M. C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S. C., Prakash, A., Chen, W., Sood, R., Ledin, J., and Burgess, S. M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome Res 25, 1030-1042
10. Ao, J., Mu, Y., Xiang, L. X., Fan, D., Feng, M., Zhang, S., Shi, Q., Zhu, L. Y., Li, T., Ding, Y., Nie, L., Li, Q., Dong, W. R., Jiang, L., Sun, B., Zhang, X., Li, M., Zhang, H. Q., Xie, S., Zhu, Y., Jiang, X., Wang, X., Mu, P., Chen, W., Yue, Z., Wang, Z., Wang, J., Shao, J. Z., and Chen, X. (2015) Genome sequencing of the perciform fish Larimichthys crocea provides insights into molecular and genetic mechanisms of stress adaptation. PLoS Genet 11, e1005118
11. Li, M., Maddison, L. A., Page-McCaw, P., and Chen, W. (2014) Overnutrition induces beta-cell differentiation through prolonged activation of beta-cells in zebrafish larvae. Am J Physiol Endocrinol Metab 306, E799-807
12. Li, M., Li, Q., Yang, Z., Hu, G., Li, T., Chen, X., and Ao, J. (2014) Identification of cathepsin B from large yellow croaker (Pseudosciaena crocea) and its role in the processing of MHC class II-associated invariant chain. Dev Comp Immunol 45, 313-320
13. Mu, Y.#, Li, M.#, Ding, F., Ding, Y., Ao, J., Hu, S., and Chen, X. (2014) De novo characterization of the spleen transcriptome of the large yellow croaker (Pseudosciaena crocea) and analysis of the immune relevant genes and pathways involved in the antiviral response. PLoS One 9, e97471
14. Maddison, L. A., Li, M., and Chen, W. (2014) Conditional gene-trap mutagenesis in zebrafish. Methods Mol Biol 1101, 393-411
15. Li, M., Maddison, L. A., Crees, Z., and Chen, W. (2013) Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional beta-cell number through enhanced self-replication in zebrafish. Zebrafish 10, 170-176
16. Li, M., Ding, Y., Mu, Y., Ao, J., and Chen, X. (2011) Molecular cloning and characterization of caspase-3 in large yellow croaker (Pseudosciaena crocea). Fish Shellfish Immunol 30, 910-916
17. Xiao, X.#, Li, M.#, Wang, K.#, Qin, Q., and Chen, X. (2011) Characterization of large yellow croaker (Pseudosciaena crocea) beta-actin promoter supports beta-actin gene as an internal control for gene expression modulation and its potential application in transgenic studies in fish. Fish Shellfish Immunol 30, 1072-1079
18. Li, M., Li, Y., Lu, L., Wang, X., Gong, Q., and Duan, C. (2009) Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene. Am J Physiol Regul Integr Comp Physiol 296, R558-566
19. Fan, T., Li, M., Wang, J., Yang, L., and Cong, R. (2009) Purification and characterization of phenoloxidase from Octopus ocellatus. Acta Biochim Biophys Sin (Shanghai) 41, 865-872
20. Zhao, L., Mi, T., Zhen, Y., Li, M., He, S., Sun, J., and Yu, Z. (2009) Cloning of proliferating cell nuclear antigen gene from the dinoflagellate Prorocentrum donghaiense and monitoring its expression profiles by real-time RT-PCR. Hydrobiologia 627, 19-30
21. Wang, X., Lu, L., Li, Y., Li, M., Chen, C., Feng, Q., Zhang, C., and Duan, C. (2009) Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish. Am J Physiol Regul Integr Comp Physiol 296, R1348-1357
联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院
Email：limingyu@xmu.edu.cn
Google Scholar: https://scholar.google.com/citations?hl=en&user=PJwD5TwAAAAJ
ResearchGate: https://www.researchgate.net/profile/Mingyu_Li6
