吴云龙，教授，博士生导师，厦门大学药学院副院长
个人简介：
2005年获得中国科学技术大学材料化学专业理学学士学位，2011年获新加坡国立大学生物工程博士学位。2010年-2012年在南洋理工大学材料科学与工程学院从事博士后工作。2012年应聘为厦门大学药学院助理教授，2014年聘为厦门大学药学院副教授，2019年聘为厦门大学药学院教授。以改善药物时空分布及成药性的高分子聚合物载体及其超分子结构为出发点，从事药物、基因缓控释递送研究。在药物/基因载体等药剂学相关领域内，以第一或通讯作者（含共同通讯）发表文章60余篇（包括Adv. Mater.（2022、2020、2017，IF 32.086）、Small Methods（2021， IF 15.367）、Bioactive Materials（2021， IF 16.874）、ACS Nano（2017，IF 18.027）、Small（2018、2017，IF 15.153）、Chemical Engineering Journal（2021、2020，IF 16.744）、Advanced Healthcare Materials（2019、2018、2017、2016， IF 11.092）、Nanoscale（2017、2016，IF 8.307）、Biomacromolecules（2018，IF 6.978）等），且有多篇文章入选ESI高被引文章；个人H因子为39（Google Scholar）。主持3项国家自然科学基金面上项目（82173750、81971724、81773661）、国家自然科学基金青年基金项目（21303145）、国家重点研发计划“合成生物学”重点专项子课题、“福建省高校杰出青年科研人才培育计划”项目、福建省自然科学基金面上基金项目（2014J01063）等多个科研基金项目。
教育及科研工作经历：
2019/08-至今，厦门大学，药学院，教授；
2014/08-2019/07，厦门大学，药学院，副教授；
2012/06-2014/08，厦门大学，药学院，助理教授；
2010/05-2012/05，新加坡南洋理工大学，材料科学与工程学院，博士后；
2005/08-2011/06，新加坡国立大学，工程学院生物工程系，博士；
2001/09-2005/07，中国科学技术大学，化学与材料科学学院材料科学与工程系，学士。
代表性论文目录（*通讯作者）：
1、 Zhu, C.; Ke, L.; Ao, X.; Chen, Y.; Cheng, H.; Xin, H.; Xu, X.*; Loh, X. J.; Li, Z.; Lyu, H.; Wang, Q.; Zhang, D.; Ping, Y.*; Wu, C.*; Wu, Y.-L.* “Injectable Supramolecular Hydrogels for in Situ Programming of Car-T Cells Towards Solid Tumor Immunotherapy.” Advanced Materials, 2023, doi: 10.1002/adma.202310078. (SCI impact factor: 29.4)
2、 Liu, M.; Luo, Z.; Li, Z.; Lai, X.; Loh, X. J.; Wu, C.*; Li, Z.*; Wu, Y.-L.* “EngineeredCelastrol and Plasmid Co-Delivery for In Situ Expression and Targeted Mitochondrial Relocation of Nur77 Protein Towards Effective Drug Resistance Reversion.”Chemical Engineering Journal, 2023, 453: 139879. (SCI impact factor: 15.1)
3、 Ma, P.; Luo, Z.; Li, Z.; Lin, Y.; Li, Z.*; Wu, Z.; Ren, C.*; Wu, Y.-L.* “Mitochondrial Artificial K+ Channel Construction Using MPTPP@5F8 Nanoparticles for Overcoming Cancer Drug Resistance via Disrupting Cellular Ion Homeostasis.” Advanced Healthcare Materials, 2023, doi: 10.1002/adhm.202302153. (SCI impact factor: 10.0)
4、Mao, L.; Ma, P.; Luo, X.; Cheng, H.; Wang, Z.*; Ye, E.; Loh, X. J.; Wu, Y.-L.*; Li, Z.* “Stimuli-Responsive Polymeric Nanovaccines Toward Next-Generation Immunotherapy.” ACS Nano, 2023, 17(11): 9826-9849. (SCI impact factor: 17.1)
5、 Ma, P.; Wang, Q.; Luo, X.; Mao, L.; Wang, Z.*; Ye, E.; Loh, X. J.; Li, Z.*; Wu, Y.-L.* “Recent Advances of Stimuli-Responsive Polymeric Carriers for Controllable CRISPR/Cas9 Gene Editing System Delivery.” Biomaterials Science, 2023, 11(15): 5078-5094. (SCI impact factor: 6.6)
6、 Chen, Y.; Wang, X.; Tao, S.; Wang, Q.; Ma, P.; Li, Z.*; Wu, Y.-L.*; Li, D.-W.* “Research Advances in Smart Responsive-Hydrogel Dressings with Potential Clinical Diabetic Wound Healing Properties.” Military Medical Research, 2023, 10: 37. (SCI impact factor: 21.1)
7、 Han, Y.; Jiang, L.; Xu, C.; Liu, M.; Li, Q.; Zheng, L.; Chi, H.; Wang, X.; Liu, Z.; You, M.; Loh, X. J.; Wu, Y.-L.*; Li, Z.*; Li, C.* “Effectiveness of an Ocular Adhesive Polyhedral Oligomeric Silsesquioxane Hybrid Thermo-Responsive FK506 Hydrogel in a Murine Model of Dry Eye.”Bioactive Materials, 2022, 9: 77-91. (SCI impact factor: 16.874)
8、Fan, X.; Luo, Z.; Chen, Y.; Yeo, J. C. C.; Li, Z.*; Wu, Y.-L.*; He, C.* “Oxygen Self-Supplied Enzyme Nanogels for Tumor Targeting with Amplified Synergistic Starvation and Photodynamic Therapy.”Acta Biomaterialia, 2022, 142: 274-283. (SCI impact factor: 10.633)
9、Cheng, H.; Fan, X.; Ye, E.; Chen, H.; Yang, J.; Ke, L.; You, M.; Liu, M.; Zhang, Y.-W.; Wu, Y.-L.*; Liu, G.*; Loh, X. J.*; Li, Z.* “Dual Tumor Microenvironment Remodeling by Glucose-Contained Radical Copolymer for MRI Guided Photo-Immunotherapy.”Advanced Materials, 2022, 34(25): 2107674. (SCI impact factor: 32.086)
10、Liu, M.; Wu, C.; Ke, L.; Li, Z.; Wu, Y.-L.*“Emerging Biomaterials-Based Strategies for Inhibiting Vasculature Function in Cancer Therapy.”Small Methods, 2021, 5(7): 2100347. (SCI impact factor: 15.367)
11、Han, Y.; Xu, C.; Shi, H.; Yu, F.; Zhong, Y.; Liu, Z.; Loh, X. J.; Wu, Y.-L.*; Li, Z.*; Li, C.* “Engineered Bio-adhesive Polyhedral Oligomeric Silsesquioxane Hybrid Nanoformulation of Amphotericin B for Prolonged Therapy of Fungal Keratitis.”Chemical Engineering Journal, 2021, 421: 129734. (SCI impact factor: 16.744)
12、Jiang, X.; Li, Z.; Young, D. J.; Liu, M.; Wu, C.*; Wu, Y.-L.*; Loh, X.* “Towards the Prevention of Coronavirus Infection: What Role Can Polymers Play?” Materials Today Advances, 2021, 10: 100140. (SCI impact factor: 10.0)
13、Luo, Z.; Fan, X.; Chen, Y.; Lai, X.; Li, Z.*; Wu, Y.-L.*; He, C.* “Mitochondria Targeted Composite Enzyme Nanogels for Synergistic Starvation and Photodynamic Therapy.” Nanoscale, 2021, 13(42): 17737-17745. (SCI impact factor: 8.307)
14、Fan, X.; Ke, L.; Cheng, H.; Chen, H.; Li, Z.; Ye, E.*; Loh, X. J.; Wu, Y.-L.*; Liu, G.*; Li, Z.* “Enhanced Drug Retention by Anthracene Crosslinked Nanocomposites for Bimodal Imaging-Guided Phototherapy.” Nanoscale, 2021, 13(35): 14713-14722. (SCI impact factor: 8.307)
15、Luo, Z.; Jiang, L.; Xu, C.; Kai, D.; Fan, X.; You, M.; Hui, C.M.; Wu, C.*; Wu, Y.-L.*; Li, Z.* “Engineered Janus Amphipathic Polymeric Fiber Films with Unidirectional Drainage and Anti-Adhesion Abilities to Accelerate Wound Healing.”Chemical Engineering Journal, 2021, 421: 127725. (SCI impact factor: 16.744)
16、Hu, B.; Berkey, C.; Feliciano, T.; Chen, X.; Li, Z.; Chen, C.; Amini, S.; Nai, M.H.; Lei, Q.-L.; Ni, R.; Wang, J.; Leow, W.R.; Pan, S.; Li, Y.-Q.; Cai, P.; Miserez, A.; Li, S.; Lim, C.T.*; Wu, Y.-L.*; Odom, T.W.*; Dauskardt, R.H.*; Chen, X.* “Thermal-Disrupting Interface Mitigates Intercellular Cohesion Loss for Accurate Topical Antibacterial Therapy.”Advanced Materials, 2020, 32(12): 1907030. (SCI impact factor: 32.086)
17、Luo, Z.; Jiang, L.; Yang, S.; Li, Z.*; Soh, W. M. W.; Zheng, L.*; Loh, X. J.*; Wu, Y.-L.*“Light-Induced Redox-Responsive Smart Drug Delivery System by Using Selenium-Containing Polymer@MOF Shell/Core Nanocomposite.” Advanced Healthcare Materials, 2019, 8(15): 1900406. (SCI impact factor: 11.092)
18、Wu Y.-L.*; Li, Z* “The Perspectives of Using Unimolecular Micelles in Nanodrug Formulation.”Therapeutic Delivery, 2019, 10(6): 333-335.
19、Liu, X.; Li, Z.; Loh, X.; Chen, K.; Li, Z.; Wu Y.-L.*“Targeted and Sustained Co-Release of Chemotherapeutics and Gene by Injectable Supramolecular Hydrogel for Drug-Resistant Cancer Therapy.”Macromolecular Rapid Communications, 2019, 40(5): 1800117. (SCI impact factor: 4.078)
20、Cheng, H.; Fan, X.; Wu, C.; Wang, X.; Wang, L.-J.; Loh, X.-J.*; Li, Z.*; Wu Y.-L.*“Cyclodextrin-Based Star-Like Amphiphilic Cationic Polymer as a Potential Pharmaceutical Carrier in Macrophages.”Macromolecular Rapid Communications, 2019, 40(5): 1800207. (SCI impact factor: 4.078)
21、Luo, Z.; Jiang, L.; Ding, C.; Hu, B.; Loh, X. J.; Li, Z.*; Wu, Y.-L.*“Surfactant Free Delivery of Docetaxel by Poly[(R)-3-hydroxybutyrate-(R)-3-hydroxyhexanoate]-Based Polymeric Micelle for Effective Melanoma Treatments.”Advanced Healthcare Materials, 2018, 7(23): 1801221. (SCI impact factor: 11.092)
22、Cheng, H.; Fan, X.; Wang, X.; Ye, E.; Loh, X. J.*; Li, Z.*; Wu, Y.-L.*“Hierarchically Self-Assembled Supramolecular Host-Guest Delivery System for Delivery of Chemotherapeutics to Drug Resistant Cancer Tumors.” Biomacromolecules, 2018, 19(6): 1926-1938. (SCI impact factor: 5.738)
23、Chen, X.; Chen, Z.; Hu, B.; Cai, P.; Wang, S.; Xiao, S.; Wu, Y.-L.*; Chen, X.* “Synergistic Lysosomal Activatable Polymeric Nanoprobe Encapsulating pH Sensitive Imidazole Derivative for Tumor Diagnosis.” Small, 2018, 14(9): 1703164. [Highlighted by Materials Views China: http://www.materialsviewschina.com/2018/02/27859/] (SCI impact factor: 9.598)
24、Fan, X.; Cheng, H.; Wang, X.; Ye, E.; Loh, X. J.; Wu, Y.-L.*; Li, Z.* “Thermo-responsive Supramolecular Chemotherapy by “V”-shape Armed b-Cyclodextrin Star Polymer to Overcome Drug Resistance.” Advanced Healthcare Materials, 2018, 7(7): 1701143. (SCI impact factor: 11.092)
25、Wu, Y.-L.; Engl, W.; Hu, B.; Cai, P.; Leow, W. R.; Tan, N. S.; Lim, C. T.; Chen, X.* “Nanomechanically Visualizing Drug-Cell Interaction at the Early Stage of Chemotherapy.”ACS Nano, 2017, 11(7): 6996-7005. (SCI impact factor: 13.942)
26、Cai, P.; Leow, W. R.; Wang, X.; Wu, Y.-L.*; Chen, X.* “Programmable Nano-Bio Interfaces for Functional Biointegrated Devices.” Advanced Materials, 2017, 29(26): 1605529. [Featured as Inside Back Cover] [Highlighted by Materials Views China: http://www.materialsviewschina.com/2017/05/24998/] (SCI impact factor: 19.791)
27、 Liu, X.; Chen, X.; Chua, M. X.; Li, Z.*; Loh, X. J.*; Wu, Y.-L.* “Injectable Supramolecular Hydrogels as Delivery Agents of Bcl-2 Conversion Gene for the Effective Shrinkage of Therapeutic Resistance Tumors.” Advanced Healthcare Materials, 2017, 6(11): 1700159. [Featured as Front Cover] [Highlighted by Advanced ScienceNews: http://www.advancedsciencenews.com/cover-art-featuring-cancer-therapy-angiogenesis-tissue-engineering/] [Highlighted by Materials Views China: http://www.materialsviewschina.com/2017/07/25828/] (SCI impact factor: 11.092)
28、Liow, S. S.; Dou, Q.; Kai, D.; Sugiarto S.; Yu, C. Y. Y.; Kwok, R. T. K.; Chen, X.; Wu, Y.-L.*; Ong, S. T.; Kizhakeyil, A.; Verma N. K.; Tang, B. Z.; Loh, X. J.* “Long-term Real-time in vivo Drug Release Monitoring with AIE Thermogelling Polymer.” Small, 2017, 13(7): 1603404. [Featured as Back Cover] (SCI impact factor: 8.643)
29、Chen, X.; Qiu, Y.-K.; Owh, C.; Loh, X. J.*; Wu, Y.-L.* “Supramolecular Cyclodextrin Nanocarriers for Chemo- and Gene Therapy towards the Effective Treatment of Drug Resistant Cancers.” Nanoscale, 2016, 8(45): 18876-18881. (SCI impact factor: 7.367)
30、Wu, Y.-L.*; Wang, H.; Qiu, Y.-K.; Liow, S. S; Li, Z.; Loh, X. J.* “PHB-based Gels as Delivery Agents of Chemotherapeutics for the Effective Shrinkage of Tumors.” Advanced Healthcare Materials, 2016, 5(20): 2679-2685. [Highlighted by http://www.advancedsciencenews.com/injectable-hydrogels-for-precise-chemotherapy/] (SCI impact factor: 11.092)
31、Wu, Y.-L.; Putcha, N.; Ng, K.W.; Leong, D.; Lim, C.T.; Loo, S.C.; Chen, X.* “Biophysical Responses upon the Interaction of Nanomaterials with Cellular Interfaces.” Accounts of Chemical Research, 2013, 46(3):782-791. (SCI impact factor: 20.268)
32、Wu, Y.-L.; Yin, H.; Zhao, F.; Li, J.* “Multifunctional Hybrid Nanocarriers Consisting of Supramolecular Polymers and Quantum Dots for Simultaneous Dual Therapeutics Delivery and Cellular Imaging.” Advanced Healthcare Materials, 2013, 2(2): 297-301. (SCI impact factor: 11.092)
33、Wu, Y.-L.; Li, J.*“Synthesis of Supramolecular Nanocapsules Based on Threading Multiple Cyclodextrins over Polymer on Gold Nanoparticles.” Angewandte Chemie International Edition, 2009, 48(21): 3842-3845. [Highlighted by Nature Asia-Pacific: http://www.nature.com/am/journal/2009/200908/full/am2009185a.html] (SCI impact factor: 11.994)
联系方式：
地址：厦门市翔安区厦门大学药学院203室
Email： wuyl@xmu.edu.cn
