宋华副教授

宋华博士、副教授

个人简历：

    宋华，男，副教授，硕士研究生导师，从事药剂学药物新剂型与新制剂、纳米药物靶向递送与控制释放领域研究。河南中医药大学（原河南中医学院）药学院中药学专业本科，硕士从事“胃内滞留漂浮型缓控释给药系统”方向研究，上海中医药大学中药药剂学、上海海军军医大学（原第二军医大学）药学院药剂学联培博士，从事“难溶性抗肿瘤药物混合胶束给药系统”方向研究；上海交通大学“材料科学与工程”专业博士后，从事“抗肿瘤药物聚合物胶束靶向给药系统”研究，获博士后奖励基金；2010年于上海交通大学留校任教，获“晨星青年学者”称号及上海市科技进步三等奖等；2013年于厦门大学药学院任副教授，获 “鹭燕”奖等。主持国家自然科学基金、教育部博士点基金、福建省自然科学基金等项目，作为学术骨干参与“973”、“863”、“国家科技重大专项”等多项国家级重大课题研究；在Biomaterials、Theranostics、Nanomedicine等期刊发表学术论文多篇。担任教育部学位中心论文评审专家、国家自然科学基金通讯评审专家、厦门市科技局评审专家、Theranostics等杂志审稿人等社会职务。指导本科生校长基金、国家级省级等大创项目10余项；参与省级教改项目“双一流建设背景下“以学生为中心”创新型教学改革策略研究与实践”等。目前研究领域侧重于利用纳米技术、干细胞技术等策略治疗炎症及耐药乳腺癌等重大疾病方向，近年与上海交通大学等合作单位在该领域开展学生联合培养、课题合作等取得一些重要进展，欢迎对药剂学药物递送与分析等多学科交叉领域研究感兴趣者加盟。

教育及工作背景：

1997-2004：河南中医药大学（原河南中医学院）药学院，本硕（合作导师：广东药科大学周毅生教授）

2004-2007：上海中医药大学，博士（合作导师：徐莲英教授）；

2005-2007： 海军军医大学（原第二军医大学）药学院，联培博士（合作导师：陈建明教授）；

2007-2010：上海交通大学 “材料科学与工程”博士后流动站，博士后（合作导师：崔大祥教授）；

2010-2013：上海交通大学，讲师；

2013-至今：厦门大学，副教授。

主要研究：

1、药物新剂型与新制剂研究；

2、纳米药物靶向递送与控制释放研究；

3、利用纳米技术、干细胞技术等策略诊疗炎症及耐药乳腺癌等重大疾病研究。

主讲课程：

《药剂学实验》（厦门大学一流课程）、《药剂学》（福建省一流课程）、《药物分析实验》、《用药常识与误区》、《药学导论》、《高等药剂学》、《高等药物分析学》等。

科研成果：

国家发明专利：

1、宋华,崔大祥,贺蓉.聚氧乙烯-聚氧丙烯-聚氧乙烯嵌段共聚物羧基化方法（授权公告号CN101293954B）；

2、宋华,崔大祥,高峰.氨基酸修饰聚酰胺胺型树形分子的制备方法（授权公告号CN101343359B）；

科研项目：

学术论文：

1.    Xia Peng, Yiqin Ge, Weize Li, Xiuke Lin, Hua Song, Lihui Lin, Jinyan Zhao, Yanting Gao, Juan Wang, Jia Li, Yuji Huang, Yanning Li, Li Li. Targeting Lewis X oligosaccharide-modified liposomes encapsulated with house dust mite allergen Derf2 to dendritic cells inhibits Th2 immune response. European Journal of Pharmaceutical Sciences, 2023,190, 106570.

2.    Huayu Yang#, Hua Song#(co-first author), Ziqin Suo, Funan Li, Quanyi Jin, Xuan Zhu, Qing Chen. A molecularly imprinted electrochemical sensor based on surface imprinted polymerization and boric acid affinity for selective and sensitive detection of P-glycoproteins.Analytica Chimica Acta, 2022, 1207,339797. (JCR二区)

3.     Pingyun Ge, Yuqing Liu, Qing Chen, Zaiji Su, Yuting Du, Shuting Luo, Xuemei Zhao, Xiufeng Cao*, Hua Song*(corresponding author), Xuan Zhu. Transferrin Receptors/Magnetic Resonance Dual-Targeted Nanoplatform for Precise Chemo-Photodynamic Synergistic Cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 39, 102467. (JCR二区)

4.    Lu Xu, Hua Song, Qi Qiu, Ting Jiang, Pingyun Ge, Zaiji Su, Wenhui Ma, Ran Zhang, Caihua Huang, Shanhua Li, Donghai Lin, Jiaxing Zhang. Different Expressions of HIF-1α and Metabolism in Brain and Major Visceral Organs of Acute Hypoxic Mice. International Journal of Molecular Sciences, 2021, 22(13), 6705. (JCR二区)

5.    Dan Zhao#, Hua Song#(co-first author), Xinyi Zhou, Yilin Chen, Qiuhong Liu, Xuemin Gao, Xuan Zhu, Dengyue Chen. Novel facile thermosensitive hydrogel as sustained and controllable gene release vehicle for breast cancer treatment. European Journal of Pharmaceutical Sciences, 2019,134:145-152. (JCR二区)

6.    Qing Chen, Xiaoxue Wu, Xuemin Gao, Hua Song*(corresponding author), Xuan Zhu*. Development and Validation of an Ultra-Performance Liquid Chromatography Method for the Determination of Wedelolactone in Rat Plasma and its Application in a Pharmacokinetic Study. Molecules, 2019, 24(4), 762.

7.    Xiaoxue Wu, Xuemin Gao, Xuan Zhu, Shuyi Zhang, Xinmei Liu, Huayu Yang, Hua Song*(corresponding author), Qing Chen*. Fingerprint Analysis of Cnidium monnieri (L.) Cusson by High-Speed Counter-Current Chromatography. Molecules, 2019,24(24), 4496.

8.    Dan Zhao, Qing Chen, Hua Song*(corresponding author), Shuting Luo, Pingyun Ge, Yingjun Wang,Jinyuan Ma, Zhi Li, Xuemin Gao, Xuemei Zhao, Xiayiding Subinuer, Huayu Yang, Xiaojuan Jiang, Yanxin Chen,  Xuan Zhu. Theranostic micelles combined with multiple strategies toeffectively overcome multidrug resistance. Nanomedicine, 2018, 13(13):1517-1533. (JCR二区)

9.    Qing Chen, Hongjian Lin, Xiaoxue Wu, Hua Song*(corresponding author), Xuan Zhu*. Preparative separation of six terpenoids from Wedelia prostrata Hemsl. by two-step high-speed counter-current chromatography. Journal of Liquid Chromatography & Related Technologies. 2018,41(7):408-414. 

10.  Qing Chen, Lichao Diao, Hua Song, Xuan Zhu. Vitis amurensis Rupr: A review of chemistry and pharmacology, Phytomedicine. 2018, 49: 111-122.

11.  Jing Wang#, Hua Song#(co-first author), Xiaoxue Wu, Shuyi Zhang, Xuemin Gao, Funan Li, Xuan Zhu, Qing Chen. Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity. Molecules, 2018, 23(3):579.

12.  Yuxin Guo, Yang Zhang, Jinyuan Ma, Qi Li, Yang Li, Xinyi Zhou, Dan Zhao, Hua Song, Qing Chen, Xuan Zhu. Light/magnetic hyperthermia triggered drug released from multi-functional thermo-sensitive magnetoliposomes for precise cancer synergetic theranostics. Journal of Controlled Release. 2018, 272: 145-158.

13.  赵学美, 王颖君, 赵丹, 宋华*（通讯作者）. 紫杉烷类抗肿瘤药研究进展. 中国科技论文在线精品论文, 2018, 5(11):467-482.

14.  Guihua Liu, Jinyuan Ma, Yang Li, Qi Li, Chunhua Tan, Hua Song, Shuhui Cai, Dengyue Chen, Zhengqing Hou, Qing Chen, Xuan Zhu, Core-interlayer-shell Fe3O4@mSiO2@lipid-PEG- methotrexate nanoparticle for multimodal imaging and multistage targeted chemo-photodynamic therapy. International Journal of Pharmaceutics, 2017, 521(1-2):19-32.

15.  Hua Song, Jianhong Lin, Xuan Zhu, Qing Chen. Developments in high-speed countercurrent chromatography and its applications in the separation of terpenoids and saponins.Journal of Separation Science, 2016, 39(8):1574-1591.

16.  Guo Gao, Qiang Zhang, Kan Wang, Hua Song, Peiyu Qiu, Daxiang Cui. Axial compressive α-Fe2O3 microdisks prepared from CSS template for potential anode materials of lithiumion batteries. Nano Energy, 2013, 2(5): 1010–1018.

17.  Guo Gao, Peiyu Qiu, Qirong Qian, Na Zhou, Kan Wang, Hua Song, Hualin Fu, Daxiang Cui. PEG-200-assisted hydrothermal method for the controlled-synthesis of highly dispersed hollow Fe3O4 nanoparticles. Journal of Alloys and Compounds, 2013, 574(15): 340–344.

18.  Jing Ruan, Hua Song, Qirong Qian, Chao Li, Kan Wang, Chenchen Bao, Daxiang Cui. HER2 monoclonal antibody conjugated RNase-A-associated CdTe quantum dots for targeted imaging and therapy of gastric cancer, Biomaterials, 2012, 33(29): 7093–7102. (JCR一区)

19.  Ping Sun, Hua Song*(corresponding author), Daxiang Cui, Jun Qi, Mousheng Xu, Hongquan Geng*. Preparation and optimization of matrix metalloproteinase-1-loaded poly (lactide-co-glycolide-co-caprolactone) nanoparticles with rotatable central composite design and response surface methodology. Nanoscale Research Letters, 2012, 7:359. (JCR二区)

20.  Xia Peng, Juan Wang, Hua Song*(corresponding author), Daxiang Cui, Li Li, Jia Li, Lihui Lin, Juan Zhou, Yanan Liu. Optimized Preparation of Celastrol-loaded Polymeric Nanomicelles Using Rotatable Central Composite Design and Response Surface Methodology. Journal of Biomedical Nanotechnology, 2012, 8:1-9. (JCR二区)

21.  Jing Ruan, Jiajia Ji, Hua Song, Qirong Qian, Kan Wang, Can Wang, Daxiang Cui. Fluorescent magnetic nanoparticles-labeled mesenchymal stem cells for targeted imaging and hyperthermia therapy of gastric cancer. Nanoscale Research Letters, 2012, 7:309. (JCR二区)

22.  Jing Ruan, Hua Song, Chao Li, Chenchen Bao, Hualin Fu, Kan Wang, Jian Ni, Daxiang Cui. DiR-labeled Embryonic Stem Cells for Targeted Imaging of in vivo Gastric Cancer Cells. Theranostics, 2012,2(6): 618-628. (JCR一区)

23.  Hongquan Geng#, Hua Song1#*(co-first author and corresponding author), Jun Qi, Daxiang Cui. Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix. Nanoscale Research Letters, 2011, 6 (1):312. (JCR二区)

24.  Hua Song, Hongquan Geng, Jing Ruan, Kan Wang, Chenchen Bao, Juan Wang, Xia Peng, Xueqing Zhang, Daxiang Cui. Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models. Nanoscale Research Letters, 2011, 6 (1):354. (JCR二区)

25.  Hengguang Yuan, Shanglian Hu, Peng Huang, Hua Song, Kan Wang, Jing Ruan, Rong He, Daxiang Cui. Single Walled Carbon Nanotubes Exhibit Dual-Phase Regulation to Exposed Arabidopsis Mesophyll Cells. Nanoscale Research Letters, 2011, 6 (44):1-9.

26.  Jing Ruan, Kan Wang, Hua Song, Xin Xu, Jiajia Ji, Daxiang Cui. Biocompatibility of hydrophilic silica-coated CdTe quantum dots and magnetic nanoparticles. Nanoscale Research Letters, 2011, 6:299. (JCR二区)

27.  Hua Song, Xiufeng Cao, Jing Ruan, Xia Peng, Juan Wang, Can Wang, Chenchen Bao. Application of rotatable central composite design in the preparation and optimization of poly(lactic-co-glycolic acid) nanoparticles for controlled delivery of HSA. Nano Biomedicine and Engineering, 2011, 3 (1):34-41.

28.  Jing Ruan, Jie Shen, Zheng Wang, Jiajia Ji, Hua Song, Kan Wang, Bin Liu, Jinhui Li, Daxiang Cui. Efficient preparation and labeling of human induced pluripotent stem cells by nanotechnology. International Journal of Nanomedicine, 2011, 6:425-435.

29.  Kan Wang, Jing Ruan, Qirong Qian, Hua Song, Chenchen Bao, Xueqing Zhang, Yifei Kong, Chunlei Zhang, Guohan Hu. BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer. Journal of Nanobiotechnology, 2011, 9 (1):23.

30.  Hua Song, Rong He, Kan Wang, Jing Ruan, Chenchen Bao, Na Li, Jiajia Ji, Daxiang Cui. Anti-HIF-1 Antibody-conjugated Pluronic Triblock Copolymers encapsulated with Paclitaxel for tumor targeting therapy. Biomaterials, 2010, 31(8):2302-2312. (JCR一区)

31.  Kan Wang, Jing Ruan, Hua Song, Jiali Zhang, Yan Wo, Shouwu Guo, Daxiang Cui. Biocompatibility of Graphene Oxide. Nanoscale Research Letters, 2010, 6 (8). (JCR二区)

32.  Jing Ruan, Jie Shen, Hua Song, Jiajia Ji, Kan Wang, Daxiang Cui, Zheng Wang. Viability and pluripotency studying of human embryo stem cells labeled with quantum dots. Nano Biomedicine and Engineering, 2010, 2 (4):245-251.

33.  Chenchen Bao, Hao Yang, Ping Sheng, Juxiang Chen, Hua Song, Xuehua Ding, Bin Liu, YichengLu, Guohan Hu, Daxiang Cui. Cloning, Expression, Monoclonal Antibody Preparation of Human Gene NBEAL1 and Its Application in Targeted Imaging of Mouse Glioma. Nano Biomedicine and Engineering, 2009, 1(1):50-56.

34.  Daxiang Cui, Yuedong Han, Zhiming Li, Hua Song, Kan Wang, Rong He, Bing Liu, Heliang Liu, Chenchen Bao, Peng Huang, Jin Ruan, Feng Gao, Hao Yang, Hoon Sung Cho, Qiushi Ren, Donglu Shi. Fluorescent Magnetic Nanoprobes for in vivo Targeted Imaging and Hyperthermia Therapy of Prostate Cancer. Nano Biomedicine and Engineering, 2009, 1(1):94-112.

35.   刘彬, 崔大祥, 杜彤, 李智铭, 宋华, 杨浩, 鲍晨晨, 甘慧. 沉默 BRCAA1基因对胃癌 MGC-803细胞的抑制作用及其可能的机制. 中国肿瘤生物治疗杂志, 2008, 15(6): 522-526.

36.   韩月东, 崔大祥, 宦怡, 李智铭, 刘贺亮, 宋华, 刘彬, 杜彤, 高峰. 荧光磁性纳米粒子与PSA单链抗体复合探针对前列腺癌的靶向显像和治疗. 中国肿瘤生物治疗杂志, 2008, 15(5): 406-411.

37.   宋华, 陈建明, 梁慧君, 徐莲英. 采用均匀设计法研制多西紫杉醇聚山梨酯80/磷脂混合胶束注射液. 中国药学杂志, 2008, 43(17):1327-1332.

38.   梁慧君, 陈建明, 宋华, 卢建忠. 应用混合胶束制备紫杉醇注射液. 中国医药工业杂志, 2008, 39(4): 258-260.

39.   宋华, 陈建明, 徐莲英. 核磁共振法在胶束体系研究中的应用. 药物分析杂志, 2007, 27(7): 1131-1137.

40.   宋华, 郑杭生, 张亚军, 熊阳, 徐莲英. 全缘千里光碱脂质体凝胶剂的HPLC测定. 中国医药工业杂志, 2006, 37(8): 557-558.

41.   宋华, 周毅生. 胃内滞留漂浮型缓释制剂技术研究进展及其在中药制剂中的应用. 中南药学, 2004, 2(3): 161-163.

联系方式：

地址：福建省厦门市翔安区翔安南路厦门大学药学院251室

邮编：361102

E-mail：songhua@xmu.edu.cn