吴振教授博导（wuzhen，Ph.D.，Professor）
Email：wuzhen@xmu.edu.cn
Tel：+86-592-2182976
2005.7-至今厦门大学药学系、药学院教授
2011-2023，厦门大学药学院副院长
社会兼职：
国家药品监督管理局执业药师资格认证中心专家
厦门市医学会理事
厦门大学学报自然科学版编委
海峡药学编委
主要研究方向及简介：
以核受体筛选平台、基因转录调控与疾病研究平台和深海宏基因组学研究平台为基础，开展创新药物研究。1. 基于核受体靶点、细胞周期依赖激酶和表观遗传调控靶点等先导化合物合成与分子机制研究。基于Nur77、CDK9和PHF8等靶点药物筛选模型和活性调控的先导化合物评价体系，开展复杂活性天然产物、先导化合物、手性药物的设计、合成、构效关系及作用机制研究；2. 源于海洋生物活性物质发现及生合成规律研究。基于深海宏基因组学研究平台和深海微生物次生代谢产物库，开展海洋活性物质的发现、筛选、结构修饰及生物合成规律研究。
近年来承担国家科技重大专项“重大新药创制”、国家科技重大专项子课题、国家自然科学基金面上项目、省高校产学研重大项目、省科技厅对外合作项目、厦门市重大科技专项及其他省市项目。设计合成新化合物3000余个，分离鉴定天然产物1000余个，目前拥有自主化合物库2000余个。在国际学术期刊发表100余篇研究论文，其中SCI收录80余篇；获得中国发明专利32项，申请8项。
近年主持部分项目：
1. 抗肿瘤新药临床评价与基础研究转化关键技术平台建设（国家科技重大专项，平台建设子课题）
2. 国家一类新药XMD0治疗艾滋病的开发研究（国家科技重大专项，“重大新药创制）
3. 深海细菌B5及突变文库活性化合物的二维有序分离及核受体靶点生物学机制研究（国家自然科学基金面上项目）
4．源于深海热液烟囱和多金属结核区的抗肿瘤活性物质及化学生态学研究（国家自然科学基金面上项目）
5. 源于深海热液烟囱和多金属结核区的抗肿瘤活性物质及化学生态学研究（国家自然科学基金面上项目）
6. 基于宁夏固原地区马铃薯的低血糖指数食品的开发与产业化（省科技厅对外合作项目）
7. 药用植物种植开发关键技术与产业化示范（一二三产融合）-药用植物开发公共服务中试平台（市重大科技专项）
8. 铁皮石斛的种植与产业化研究（省高校产学合作科技重大项目）
代表性论文:
1. Jun Chen, Taige Zhao, Fengming He, Yijing Zhong, Susu Wang, Ziqing Tang, Yingkun Qiu, Zhen Wu*, Meijuan Fang*. Discovery of bipyridine amide derivatives targeting pRXRα-PLK1 interaction for anticancer therapy. European Journal of Medicinal Chemistry 254 (2023) 115341
2. Mingtao Ao; Jun Wu; Yin Cao; Yaohui He; Yuxiang Zhang; Xiang Gao; Yuhua Xue; MeiJuan Fang*; Zhen Wu*; The synthesis of PROTAC molecule and new target KAT6A identification of CDK9 inhibitor iCDK9, Chinese Chemical Letters, 2023, 34: 107741
3. Qingbo Qin, Xiaohui Chen, Weihao Liu, Jun Chen, Weirong Liu, Yongzhen Xia , Zhehui Li, Mingyu Li, Shaojuan Wang, Quan Yuan, Yingkun Qiu, Zhen Wu*, Meijuan Fang*, Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agentstargeting Nur77. European Journal of Medicinal Chemistry 2022, 244:114849
4. Mingtao Ao; Jianyu Zhang; Yuqing Qian; Boqun Li; Xiumei Wang; Jun Chen; Yuxiang Zhang; Yin Cao; Yingkun Qiu; Yang Xu; Zhen Wu*; Meijuan Fang*; Design and synthesis of adamantyl- substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo, Bioorganic Chemistry, 2022, 120: 105645
5. Yuqing Qian; Mingtao Ao; Boqun Li; Zhijian Kuang; Xiumei Wang; Yin Cao; Jiayi Li; Yingkun Qiu; Kaiqiang Guo; Meijuan Fang*; Zhen Wu*; Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors, Bioorganic Chemistry, 2022, 129: 106119
6. Bowen Tang, Fengming He, Dongpeng Liu, Fei He, Tong Wu, Meijuan Fang, Zhangming Niu, Zhen Wu*, Dong Xu*. AI-Aided Design of Novel Targeted Covalent Inhibitors against SARS-CoV-2, Biomolecules 2022, 12:746
7. Baicun Li, Jiangang Huang, Jie Liu, Fengming He, Fangfang Wen, Changming Yang, Wang Wang, Tong Wu, Taige Zhao, Jie Yao, Shunzhi Liu, Yingkun Qiu, Meijuan Fang*, Jinzhang Zeng*, Zhen Wu*. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorganic Chemistry 2022,121:105651.
8. Mingtao Ao, Jianyu Zhang, Yuqing Qian, Boqun Li, Xiumei Wang, Jun Chen, Yuxiang Zhang, Yin Cao, Yingkun Qiu, Yang Xu*, Zhen Wu* and Meijuan Fang*. Design and synthesis of adamantyl-substituted flavonoid derivatives as anti-inflammatory Nur77 modulators: Compound B7 targets Nur77 and improves LPS-induced inflammation in vitro and in vivo. Bioorganic Chemistry 2022,120 :105645.
9. Mingtao Ao; Xianwen hu; Yuqing Qian; Boqun Li; Jianyu Zhang; Yin Cao; Yuxiang Zhang; Kaiqiang Guo; Yingkun Qiu; Fuquan Jiang; Zhen Wu*; Meijuan Fang*; Discovery of new chalone adamantyl arotinoids having RXRα-modulating and anticancer activities, Bioorganic Chemistry, 2021, 113: 104961
10.Baicun Li; Jie Yao; Kaiqiang Guo; Fengming He; Kun Chen; Zongxin Lin; Shunzhi Liu; Jiangang Huang; Qiaoqiong Wu; Meijuan Fang*; Jinzhang Zeng*; Zhen Wu*; Design, synthesis, and biological evaluation of 5-((8-methoxy-2- methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators, European Journal of Medicinal Chemistry, 2020, 204: 112608
11.Bowen Tang, Skyler T. Kramer, Meijuan Fang, Yingkun Qiu, Zhen Wu* and Dong Xu*. A self-attention based message passing neural network for predicting molecular lipophilicity and aqueous solubility. Journal of Cheminformatics. 2020, 12:15.
12.Jingbo Qin; Jie Liu; Chunxiao Wu; Jianwen Xu; Bowen Tang; Kaiqiang Guo; Xiaohui Chen; Weihao Liu; Tong Wu; Hu Zhou; Meijuan Fang*; Zhen Wu*; Synthesis and biological evaluation of (3/4-(pyrimidin-2-ylamino)benzoyl)-based hydrazine-1-carboxamide/carbothioamide derivatives as novel RXRa antagonists, JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2020, 35(1): 880- 896
13.Wu J, Ao MT, Shao R, Wang HR, Yu D, Fang MJ, Gao X, Wu Z*, Zhou Q*, Xue YH*. A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter，SCIENTIFIC REPORTS, 2017,7: 10657
14.Tang BW, Li BC, Li BQ, Li Z, Qin JB, Zhou XX, Qiu YK, Wu Z* , Fang MJ*. The effect of V155M mutation on the complex of hSTING and 2'3'-cGAMP: an in silico study case. RSC ADVANCES, 2017, 7(62): 39185~39196
15.Tang BW, Li BQ, Qian YQ, Ao MT, Guo KQ, Fang MJ*, Wu, Zhen*. The molecular mechanism of hPPAR alpha activation. RSC ADVANCES, 2017, 7(28): 17193~17201
16.Hu HY，Lin CR, Ao MT, Ji, YF, Tang BW, Zhou XX, Fang MJ*, Zeng JZ*, Wu Z*. Synthesis and biological evaluation of 1-(2-(adamantane-1-yl)-1H-indol-5-yl)-3-substituted urea/thiourea derivatives as anticancer agents. RSC ADVANCES, 2017, 7(81): 51640~51651
17.Hongyu Hu, Jun Wu, Mingtao Ao, Huiru Wang, Tongtong Zhou, Yuhua Xue, Yingkun Qiu, Meijuan Fang* and Zhen Wu*. Synthesis, structure–activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents. Chem. Biol. Drug Des. 2016, 88: 766-778
18. X. Yan, X.-X. Tang, D. Qin, Z.-W. Yi, M.-J. Fang, Z. Wu*, Y.-K. Qiu*, Biosynthetic Functional Gene Analysis of Bis-Indole Metabolites from 25D7, a Clone Derived from a Deep-Sea Sediment Metagenomic Library, Mar Drugs 2016，14：107
19.Xia Yan, Yun-Xia Zhou, Xi-Xiang Tang, Xiu-Xiu Liu, Zhi-Wei Yi, Mei-Juan Fang, Zhen Wu, Fu-Quan Jiang and Ying-Kun Qiu. Macrolactins from Marine-Derived Bacillus subtilis B5 Bacteria as Inhibitors of Inducible Nitric Oxide and Cytokines Expression, Mar Drugs 2016,14 : 195
20.X. Yan, L.J. Wang, Z. Wu, Y.L. Wu, X.X. Liu, F.R. Chang, M.J. Fang, Y.K. Qiu, New on-line separation workflow of microbial metabolites via hyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography, J Chromatogr B 2016，1033:1
21.J.F. Li, H. Fang, X. Yan, F.R. Chang, Z. Wu, Y.L. Wu, Y.K. Qiu, On-line comprehensive two-dimensional normal-phase liquid chromatographyxreversed-phase liquid chromatography for preparative isolation of toad venom, J Chromatogr A 2016, 1456:169-175.
22.W. Li, X.-X. Tang, X. Yan, Z. Wu, Z.-W. Yi, M.-J. Fang, X. Su *, Y.-K. Qiu *, A new macrolactin antibiotic from deep sea-derived bacteria Bacillus subtilis B5, Nat Prod Res 2016,1-6.
23.X.-Y. Wang, J.-F. Li, Y.-M. Jian, Z. Wu, M.-J. Fang, Y.-K. Qiu, On-line comprehensive two-dimensional normal-phase liquid chromatography × reversed-phase liquid chromatography for preparative isolation of Peucedanum praeruptorum, J Chromatogr A 2015, 1387 : 60-68.
24.D. Wang, L.J. Chen, J.L. Liu, X.Y. Wang, Y.L. Wu, M.J. Fang, Z. Wu, Y.K. Qiu, On-line two-dimensional countercurrent chromatographyxhigh performance liquid chromatography system with a novel fragmentary dilution and turbulent mixing interface for preparation of coumarins from Cnidium monnieri, J Chromatogr A 2015, 1406 :215-223.
25.Mei-Juan Fang, He Zhang, Chao Liao, Ying-Kun Qiu, Hua Fang, Zhen-Yu Zheng, Xiang Gao, Yu-Fen Zhao, Zhen Wu*. Using positive-ion electrospray ionization mass spectrometry and H/D exchange study phosphoryl group transfer reactions involved in amino acid ester isopropyl phosphoramidates of Brefeldin A. Analytica Chimica Acta, 2015, 853: 391–401.
通讯地址：福建省厦门市翔安区翔安南路厦门大学药学院
邮编：361102
