薛玉花博士、副教授、 博士生导师
个人简介：
薛玉花博士，主要从事真核生物基因转录调控与重大疾病发生的相关分子机制研究以及相关靶向的小分子药物的开发。 2010年7月—2011年9月在美国加州伯克利大学从事博士后研究，博士后期间，与美国Novartis公司合作开发研究新型抗癌药物及其作用机制。2011年9月至今在厦门大学药学院从事教学科研工作。已主持完成国家自然科学基金2项（面上项目和青年项目），福建省级项目3项（面上项目、青年项目和教育科研项目）、国家卫生部基金1项、与企业合作项目3项、厦门大学“校长基金”2项，以项目骨干参加国家重大研发专项2项。
教育与工作经历：
2004．9-2010.6 厦门大学生命科学学院 生化与分子生物学博士；
2007．10-2010.6 美国加州大学伯克利分校 细胞与分子生物学联合培养博士；
2010.7-2011.8 美国加州大学伯克利分校 细胞与分子生物学 博士后
2011.9-2016.8 厦门大学药学院 助理教授
2016.9-至今 厦门大学药学院 副教授
主要研究方向：
基因转录延伸调控分子机制研究
基因转录与肿瘤、艾滋病、眼表疾病的发病机制及其药物开发
个人奖励：
厦门大学第九届青年教师教学技能比赛二等奖；
2020年厦门大学药学院“优秀党务工作者”
2019 年度厦门大学“中国工商银行奖教金”
2015年度厦门大学“春雨奖教金”；
2015年厦门大学药学院“优秀共产党员”
2014年度厦门大学药学院“优秀党务工作者”；
2014年度厦门大学药学院教学工作先进个人；
已发表论文：（#第一作者，*通讯作者）
[1]Zhou Xiaoping#, Wang Guoliang#, An Xiaoya, Wu Jun, Fan Kai, Xu Lina, Li Cheng, Xue Yuhua*. Polystyrene microplastic particles: In vivo and in vitro ocular surface toxicity assessment [J]. Environmental Pollution 2022, 303(119126.
[2]Wang Yanzi#, Kang Honghua, Jin Mengyi, Wang Guoliang, Ma Weifang, Liu Zhen, Xue Yuhua*, Li Cheng*. Phenotypic and Transcriptomics Analyses Reveal Underlying Mechanisms in a Mouse Model of Corneal Bee Sting [J]. Toxins (Basel), 2022, 14(7):
[3]Wang Cong#, Wang Huiru, Pan Zhenrui, Wu Jun, Guo Yafei, Zhang Jing, Xiang Zixun, Lu Wei*, Xue Yuhua*. Polyphenol Extracts from Grape Seeds and Apple Can Reactivate Latent HIV-1 Transcription through Promoting P-TEFb Release from 7SK snRNP [J]. Disease Markers, 2022, 2022(6055347.
[4]Wang Cong#, Lu Huasong, Liu Xiangzhong, Gao Xiang, Tian Wenjing, Chen Haifeng*, Xue Yuhua*, Zhou Qiang*. A natural product targets BRD4 to inhibit phase separation and gene transcription [J]. iScience, 2022, 25(1): 103719.
[5]Fu Huanyi#, Liu Rongdiao, Jia Zixuan, Li Ran, Zhu Feifeng, Zhu Wenxuan, Shao Yangqing, Jin Yiyang, Xue Yuhua, Huang Jun, Luo Kunxin, Gao Xiang*, Lu Huasong*, Zhou Qiang*. Poly(ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage [J]. Nature Cell Biology, 2022, 24(4): 513-25.
[6]Zong Rong-Rong#, Zhu Fei-Feng, Han Wei, Wang Yi-Xin, Wang Guo-Liang, Wang Yan-Zi, Mao Yu-Bin, Guan Tian-Jun, Liu Zu-Guo, Xue Yu-Hua*, Li Cheng*. Tear dynamics testing and quantitative proteomics analysis in patients with chronic renal failure [J]. Journal of Proteomics 2021, 248(104351.
[7]Wu Jun#, Hu Hongyu#, Ao Mingtao#, Cui Zhenzhen, Zhou Xiaoping, Qin Jingbo, Guo Yafei, Chen Jingwei*, Xue Yuhua*, Fang Meijuan*. Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent [J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36(1): 1436-53.
[8]Wu Jun#, Guo Yafei, Chen Jun, Hu Sangsang, Sun Ke, Hu Hongyu*, Fang Meijuan*, Xue Yuhua*. Synthesis and Antiproliferative Activity of New Thiosemicarboxamide Derivatives [J]. Chemistry Biodiversity, 2021, 18(12): e2100671.
[9]Wang Guoliang#, An Xiaoya, Zhou Xiaoping, Jin Mengyi, Wang Xuemei, Zong Rongrong, Liu Zhen, Liu Zuguo, Xue Yuhua*, Li Cheng*. Real-time confocal microscopy imaging of corneal cytoarchitectural changes induced by different stresses [J]. Experimental Eye Research 2021, 210(108706.
[10]Jin Mengyi#, Wang Yanzi, An Xiaoya, Kang Honghua, Wang Yixin, Wang Guoliang, Gao Yang, Wu Shuiping, Reinach Peter S, Liu Zuguo, Xue Yuhua, Li Cheng*. Phenotypic and transcriptomic changes in the corneal epithelium following exposure to cigarette smoke [J]. Environmental Pollution 2021, 287(117540.
[11]Feng Zeming#, Yang Zhengrong, Gao Xiang, Xue Yuhua, Wang Xiaohui*. Resveratrol Promotes HIV-1 Tat Accumulation via AKT/FOXO1 Signaling Axis and Potentiates Vorinostat to Antagonize HIV-1 Latency [J]. Current HIV Research, 2021, 19(3): 238-47.
[12]An Xiaoya#, Wang Guoliang, Jin Mengyi, Zhou Xiaoping, Gao Shubin, Chen Jingyao, Reinach Peter S, Liu Zuguo, Xue Yuhua*, Li Cheng*. Novel Cell Culture Paradigm Prolongs Mouse Corneal Epithelial Cell Proliferative Activity in vitro and in vivo [J]. Frontiers in Cell and Developmental Biology, 2021, 9(675998.
[13]Yang Shuiyuan#, Tian Wenjing , Pan Zhenrui , Lin Ting , Wang Guanghui , Zhou Qiang , Xue Yuhua* , Haifeng Chen*. POLYPHENOLS FROM Polygonum cuspidatum REACTIVATE LATENT HIV [J]. Chemistry of Natural Compounds, 2020, 56(2): 318-22.
[14]Wu Jun#, Xue Yuhua, Gao Xiang, Zhou Qiang*. Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2 [J]. Nucleic Acids Research, 2020, 48(13): 7321-32.
[15]Wang Guoliang#, Chen Pei, Wang Yanzi, Wang Yixin, Reinach Peter S, Xue Yuhua*, Liu Zuguo*, Li Cheng*. Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery [J]. Advanced Healthcare Materials, 2020, 9(14): e2000469.
[16]Tang Dan#, Chen Chunjing, Liao Ga, Liu Jiaming, Liao Banghua, Huang Qingqing, Chen Qianqian, Zhao Jiahui, Jiang Hui, Duan Jinsong, Huang Jin, Wang Kunjie, Wang Jiawei, Zhou Cuiyan, Chu Wendan, Li Wenqi, Sun Bo, Li Zhonghan, Dai Lunzhi,, Fu Xianghui, Cheng Wei, Xue Yuhua*, Qi Shiqian*. Structural and functional insight into the effect of AFF4 dimerization on activation of HIV-1 proviral transcription [J]. Cell Discovery, 2020, 6(7.
[17]Liu Rongdiao#, Chen Chunjing#, Li Yun#, Huang Qingqing, Xue Yuhua*. ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation [J]. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2020, 1863(5): 194508.
[18]Li Baicun#, Zhu Feifeng, He Fengming, Huang Qingqing, Liu Xiaoguang, Wu Tong, Zhao Taige, Qiu Yingkun, Wu Zhen, Xue Yuhua*, Fang Meijuan*. Synthesis and biological evaluations of N'-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents [J]. Bioorganic Chemistry, 2020, 96(103592.
[19]Lee Schuyler#, Liu Haolin, Hill Ryan, Chen Chunjing, Hong Xia, Crawford Fran, Kingsley Molly, Zhang Qianqian, Liu Xinjian, Chen Zhongzhou, Lengeling Andreas, Bernt Kathrin Maria, Marrack Philippa, Kappler John, Zhou Qiang, Li Chuan-Yuan, Xue Yuhua, Hansen Kirk*, Zhang Gongyi*. JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes [J]. Elife, 2020, 9(
[20]Jin Mengyi#, Wang Yanzi, Wang Yixin, Li Yunpeng, Wang Guoliang, Liu Xuezhi, Xue Yuhua*, Liu Zuguo, Li Cheng*. Protective Effects Oncorneal Endothelium During Intracameral Irrigation Using N-(2)-l-alanyl-l-Glutamine [J]. Frontiers in Cell and Developmental Biology, 2020, 11(369.
[21]Hu Hongyu#, Wu Jun, Ao Mingtao, Zhou Xiaoping, Li Boqun, Cui Zhenzhen, Wu Tong, Wang Lijuan, Xue Yuhua*, Wu Zhen*, Fang Meijuan*. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors [J]. Bioorganic Chemistry, 2020, 102(104064.
[22]Yu Dan#, Cattoglio Claudia, Xue Yuhua, Zhou Qiang*. A complex between DYRK1A and DCAF7 phosphorylates the C-terminal domain of RNA polymerase II to promote myogenesis [J]. Nucleic Acids Research, 2019, 47(9): 4462-75.
[23]Wang Guoliang#, Xue Yuhua#, Wang Yanzi, Dong Fei, Shen Mei, Zong Rongrong, Liu Zuguo, Li Cheng*. The role of autophagy in the pathogenesis of exposure keratitis [J]. Journal of Cellular and Molecular Medicine, 2019, 23(6): 4217-28..
[24]Wang Guoliang#, Dong Nuo#, Wang Yanzi, Li Jing, Dong Fei, Jeyalatha Vimalin, Wu Jingwen, Shen Mei, Yang Qichen, Chen Pei, Xue Yuhua, Liu Zuguo, Li Cheng*. Epithelial dysplasia in pterygium postoperative granuloma [J]. Experimental Eye Research 2018, 175(199-206.
[25]Ao Mingtao#, Pan Zhenrui, Qian Yuqing, Tang Bowen, Feng Zeming, Fang Hua, Wu Zhen, Chen Jingwei*, Xue Yuhua*, Fang Meijuan*. Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1 [J]. RSC Advances, 2018, 8(31): 17279-92.
[26]Zhang Shanshan#, Shi Jinwen, Shan Changkai, Huang Chengting, Wu Yile, Ding Rong, Xue Yuhua, Liu Wen, Zhou Qiang, Zhao Yufen, Xu Pengxiang*, Gao Xiang*. Stable isotope N-phosphoryl amino acids labeling for quantitative profiling of amine-containing metabolites using liquid chromatography mass spectrometry [J]. Analytica Chimica Acta, 2017, 978(24-34.
[27]Wu Jun#, Ao Ming-Tao, Shao Rui, Wang Hui-Ru, Yu Diao, Fang Mei-Juan, Gao Xiang, Wu Zhen*, Zhou Qiang*, Xue Yu-Hua*. A chalcone derivative reactivates latent HIV-1 transcription through activating P-TEFb and promoting Tat-SEC interaction on viral promoter [J]. Scientific Reports, 2017, 7(1): 10657.
[28]Wang Jun#, Zhang Yu#, Xu Qiping#, Qiu Jinhua, Zheng Honghua, Ye Xiang, Xue Yuhua, Yin Yongmei, Zhang Zhou, Liu Ying, Hao Yanling, Wei Qiang, Wang Wei, Mori Kazuyasu, Izumo Shuji, Kubota Ryuji, Shao Yiming*, Xing Hui Qin*. Menin mediates Tat-induced neuronal apoptosis in brain frontal cortex of SIV-infected macaques and in Tat-treated cells [J]. Oncotarget, 2017, 8(11): 18082-94.
[29]Hu Hongyu#, Wu Jun#, Ao Mingtao, Wang Huiru, Zhou Tongtong, Xue Yuhua, Qiu Yingkun, Fang Meijuan*, Wu Zhen*. Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents [J]. Chemical Biology & Drug Design, 2016, 88(5): 766-78.
[30]Wang Cong#, Yang Shuiyuan#, Lu Huasong, You Hongchao, Ni Man, Shan Wenjun, Lin Ting, Gao Xiang, Chen Haifeng, Zhou Qiang, Xue Yuhua*. A Natural Product from Polygonum cuspidatum Sieb. Et Zucc. Promotes Tat-Dependent HIV Latency Reversal through Triggering P-TEFb's Release from 7SK snRNP [J]. PloS One, 2015, 10(11): e0142739.
[31]Lu Huasong#, Xue Yuhua#, Yu Guoying K, Arias Carolina, Lin Julie, Fong Susan, Faure Michel, Weisburd Ben, Ji Xiaodan, Mercier Alexandre, Sutton James, Luo Kunxin, Gao Zhenhai*, Zhou Qiang*. Compensatory induction of MYC expression by sustained CDK9 inhibition via a BRD4-dependent mechanism [J]. Elife, 2015, 4(e06535.
[32]Lu Huasong#, Li Zichong, Zhang Wei, Schulze-Gahmen Ursula, Xue Yuhua, Zhou Qiang*. Gene target specificity of the Super Elongation Complex (SEC) family: how HIV-1 Tat employs selected SEC members to activate viral transcription [J]. Nucleic Acids Research, 2015, 43(12): 5868-79.
[33]Lu Huasong#, Li Zichong, Xue Yuhua, Schulze-Gahmen Ursula, Johnson Jeffrey R, Krogan Nevan J, Alber Tom, Zhou Qiang*. AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation [J]. Proceedings of the National Academy of Sciences USA
2014, 111(1): E15-24.
[34]Liu Rong-Diao#, Wu Jun#, Shao Rui, Xue Yu-Hua*. Mechanism and factors that control HIV-1 transcription and latency activation [J]. Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology), 2014, 15(5): 455-65.
[35]Dong Nuo#, Li Cheng, Chen Wen-Sheng, Qin Wen-Juan, Xue Yu-Hua, Wu Hu-Ping*. Fibrin glue-assisted for the treatment of corneal perforations using glycerin-cryopreserved corneal tissue [J]. International Journal of Ophthalmol, 2014, 7(1): 62-5.
[36]Huasong Lu#, Zichong Li, Yuhua Xue, Qiang Zhou*. Viral-host interactions that control HIV-1 transcriptional elongation [J]. Chemical Reviews, 2013, 113(11): 8567-82.
[37]Dong Nuo#, Qin Wenjuan, Xue Yuhua, Li Cheng*, Liu Zuguo*. Hypoxia affects in vitro proliferation and differentiation of mouse corneal epithelial progenitor cell [J]. In Vitro Cellular & Developmental Biology - Animal, 2013, 49(7): 508-14.
[38]Dey Siddharth S#, Xue Yuhua, Joachimiak Marcin P, Friedland Gregory D, Burnett John C, Zhou Qiang, Arkin Adam P*, Schaffer David V*. Mutual information analysis reveals coevolving residues in Tat that compensate for two distinct functions in HIV-1 gene expression [J]. The Journal of Biological Chemistry, 2012, 287(11): 7945-55.
[39]He Nanhai#, Chan Caleb K, Sobhian Bijan, Chou Seemay, Xue Yuhua, Liu Min, Alber Tom, Benkirane Monsef, Zhou Qiang*. Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin [J]. Proceedings of the National Academy of Sciences USA, 2011, 108(36): E636-45.
[40]Xue Yuhua#, Yang Zhiyuan, Chen Ruichuan,Zhou Qiang*. A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP [J]. Nucleic Acids Research, 2010, 38(2): 360-9.
[41]He Nanhai#, Liu Min, Hsu Joanne, Xue Yuhua, Chou Seemay, Burlingame Alma, Krogan Nevan J, Alber Tom, Zhou Qiang*. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription [J]. Molecular Cell, 2010, 38(3): 428-38.
[42]Chen Ruichuan#, Liu Min, Li Huan, Xue Yuhua, Ramey Wanichaya N, He Nanhai, Ai Nanping, Luo Haohong, Zhu Ying, Zhou Nan, Zhou Qiang*. PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling [J]. Genes & Development, 2008, 22(10): 1356-68.
联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院
邮编：361102
传真：0592-2189698
Email: xueyuhua@xmu.edu.cn
