刘文杰助理教授

刘文杰博士，助理教授  

个人简介:  

      硕士研究生导师，主要从事皮肤区域免疫特性（Skin Immunity）、DNA损伤与修复（DNA Damage and Repair）与相关疾病的机理及其药物开发的研究。2016年至2018年先后在美国Scripps研究所（TSRI），北卡罗莱纳大学教堂山分校（University of North Carolina at Chapel hill）从事免疫与DNA损伤修复的科研工作。近年来以第一作者/通讯作者在Journal of Biological Chemistry等国际知名期刊发表多篇研究论文，同时为多个SCI杂志审稿人。目前主持/参加国家重点研发计划1项，国家自然科学基金项目1项、福建省自然科学基金面上项目1项、与企业合作项目1项。

科研背景：

2016.1-2016.8 美国Scripps研究所（TSRI），Research Associate

2016.8-2018.2 美国北卡罗莱纳大学教堂山分校（University of North Carolina at Chapel hill），Research Associate

2005.9-2010.7 中国农业大学, 博士

主要研究兴趣：

1.皮肤区域免疫特性与疾病的机理

2.紫外线对DNA分子损伤机理

3.共生菌抗病的机制与药物开发

4. DNA损伤修复与疾病及其药物开发

近期发表文章:

1.        Identification of competing endogenous RNA (ceRNA) and micro-RNA profiles and regulatory networks in 4-nonylphenol-induced impairment of sertoli cells. Front. Pharmacol., 18 May 2021 | https://doi.org/10.3389/fphar.2021.644204

2.        Nucleotide excision repair capacity increases during differentiation of human embryonic carcinoma cells into neurons and muscle cells. Journal of Biological Chemistry. 2019.294(15),5914-5922.

3.        Screening of a natural compound library identifies emodin, a natural compound from Rheum palmatum Linn that inhibits DPP4. PeerJ, 2017.52017, e3283.

4.        Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. FASEB J. 2017.31(12):5530-5542.

5.        Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver disease. Journal of Molecular Cell Biology.2016.8(6), 492–504.

6.        Deletion of tyrosine phosphatase Shp2 in Sertoli cells causes infertility in mice. Scientific Reports. 2015.05:12982. 

7.        Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen membrane receptor. Plos One,2014.07: e102847. 

8.        Effects of monochromatic light on quality properties and antioxidation of meat in broilers.Poult Sci, 2011 90:2632-2637.

9.        The role of sympathectomy on the distribution of intraepithelial lymphocyte, Mast Cell, IgA+, CD4+ and CD8+ Cell in intestine of mice.Asian Journal of Animal and Veterinary Advances, 2011. 6: 935-943.

10.     Effects of monochromatic light on developmental changes in satellite population of pectoral muscle in broilers during early posthatch. The Anatomical Record. 2010.293:1315–1324.

联系方式：

地址：福建省厦门市翔安区厦门大学药学院

邮编：361102

Email: wjliu@xmu.edu.cn