严小胜副教授

发布者:张欧扬发布时间:2022-01-13浏览次数:2216

PI: 严小胜博士副教授

厦门大学“南强青年拔尖B类人才”


个人简介:

严小胜博士,主要致力于超分子化学、手性化学和药物化学学科的交叉研究。发展了新型折叠短肽结构基元,构筑了卤键、硫键驱动的超分子螺旋,藉以实现手性自发拆分结晶和新型超分子手性特征,并施行分子识别和离子跨膜转运应用研究,助力短肽类手性药物的开发。目前,已在Nat. Commun., Adv. Mater., J. Am. Chem. Soc., Chem. Commun., J. Org. Chem. 等国际权威期刊上发表论文20余篇。主持国家自然科学基金青年基金项目,参与国家自然科学基金重点国际合作项目、重大研究计划项目和厦门市科技计划项目。获教育部自然科学奖二等奖(第三完成人)。202112月加入厦门大学药学院,主要研究方向:(1) 肽基组装材料的生物医学应用;(2) 手性药物的识别、输送和拆分;(3) 卤键、硫键在药物开发中的应用。

 

工作经历:

2021.12-至今厦门大学药学院,副教授

2020.08-2021.11 厦门大学化学化工学院,科研助理(合作导师:江云宝教授)

2016.07-2020.07 厦门大学生命科学学院/化学化工学院,博士后(合作导师:韩家淮院士/江云宝教授)

 

教育背景:

2010.09-2016.06 厦门大学,博士,专业:分析化学(指导老师:江云宝教授)

2006.09-2010.06 华中农业大学,学士,专业:应用化学

 

代表性论文:

1. Xiaosheng Yan, Kunshan Zou, Jinlian Cao, Xiaorui Li, Zhixing Zhao, Zhao Li, Anan Wu, Wanzhen Liang, Yirong Mo, and Yunbao Jiang*. Single-handed supramolecular double helix of homochiral bis(N-amidothiourea) supported by double crossed C−I···S halogen bonds. Nat. Commun. 2019, 10, 3610. (Editors’ highlights)

2. Xiaosheng Yan, Qian Wang, Xuanxuan Chen, and Yun-Bao Jiang*. Supramolecular Chiral Aggregates Exhibiting Nonlinear CD–ee Dependence. Adv. Mater. 2020, 32, 1905667.

3. Zhixing Zhao, Bailing Tang, Xiaosheng Yan,* Xin Wu,* Zhao Li, Philip A. Gale,* and Yun-Bao Jiang*. Crown ether-thiourea conjugates as ion transporters. Front. Chem. Sci. Eng. 2022, 16, 81−91.

4. Xiaosheng Yan,* Peimin Weng, Di Shi and Yun-Bao Jiang*. Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions. Chem. Commun. 2021, 57, 12562−12574. (Inside cover)

5. Xiaosheng Yan, Jinlian Cao, Yanhan Zhang, Peimin Weng, Daiyu Miao, Zhixing Zhao, Zhao Li and Yun-Bao Jiang*. Solvophobic interaction promoted supramolecular helical assembly of building blocks of weak intermolecular halogen bonding. Chem. Commun. 2021, 57, 1802−1805. (Equal contribution)

6. Di Shi, Jinlian Cao, Peimin Weng, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals. Org. Biomol. Chem. 2021, 19, 6397−6401.

7. Zhixing Zhao, Miaomiao Zhang, Bailing Tang, Peimin Weng, Yueyang Zhang, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Transmembrane Fluoride Transport by a Cyclic Azapeptide With Two β-Turns. Front. Chem. 2021, 8, 621323.

8. Su-Li Dong, Yan Xu, Yin-Zhu Chen, Xiao-Sheng Yan, Zhao Li, Jian-Wei Xie,* and Yun-Bao Jiang*. Chiral Recognition by Flexible Coordination Polymers of Ag+ with a Cysteine-Based Chiral Thiol Ligand That Bears a Binding Site. Inorg. Chem. 2021, 60, 5413−5418.

9. Yan Xu, Su-Li Dong, Xiao-Sheng Yan, Qian Wang, Zhao Li and Yun-Bao Jiang*. Nanosphere [Ag(SR)]n: coordination polymers of Ag+ with a combination of hydrophilic and hydrophobic thiols. Chem. Commun. 2021, 57, 4311−4314.

10. Yan Xu, Xiao-Sheng Yan, Si-Bo Zhang, Shao-Wei Li, Ning-Shao Xia, Tao Jiang, Zhao Li and Yun-Bao Jiang*. Nanospheres from coordination polymers of Ag+ with a highly hydrophilic thiol ligand formed in situ from dynamic covalent binding and a hydrophobic thiol. New J. Chem. 2021, 45, 19957−19962.

11. Yanhan Zhang,Xiaosheng Yan, Jinlian Cao, Peimin Weng, Daiyu Miao, Zhao Li, and Yun-Bao Jiang*. Turn Conformation of β-Amino Acid-Based Short Peptides Promoted by an Amidothiourea Moiety at C-Terminus. J. Org. Chem. 2020, 85, 9844−9849. (Equal contribution)

12. Dan-Dan Tao, Jin-Hong Wei, Xiao-Sheng Yan, Qian Wang, Bo-Han Kou, Na Chen, and Yun-Bao Jiang*. Helical nanofibers of N-(perfluorooctanoyl)cysteine ethyl ester in coordination polymers of Ag+. Chem. Commun. 2020, 56, 15133−15136.

13. Lin-E Guo, Yu-Xin Tang, Shu-Ying Zhang, Yuan Hong, Xiao-Sheng Yan, Zhao Li, and Yun-Bao Jiang*. Balancing interactions in proline-based receptors for chiral recognition of L-/D-DOPA. Org. Biomol. Chem. 2020, 18, 4590−4598.

14. Yuan Yuan, Yu-Wei Xiao, Xiao-Sheng Yan, Si-Xian Wu, Huan Luo, Jian-Bin Lin, Zhao Li,* and Yun-Bao Jiang*. Supramolecular chirality of coordination polymers of Ag+ with a chiral thiol ligand that bears a β-turn structure. Chem. Commun. 2019, 55, 12849−12852.

15. Xiao-Sheng Yan, Huan Luo, Kun-Shan Zou, Jin-Lian Cao, Zhao Li, and Yun-Bao Jiang*. Short Azapeptides of Folded Structures in Aqueous Solutions. ACS Omega 2018, 3, 4786−4790. (Equal contribution)

16. Lin-E Guo, Yuan Hong, Shu-Ying Zhang, Miao Zhang, Xiao-Sheng Yan, Jin-Lian Cao, Zhao Li, Tony D. James,* and Yun-Bao Jiang*. Proline-Based Boronic Acid Receptors for Chiral Recognition of Glucose. J. Org. Chem. 2018, 83, 15128−15135.

17. Jinlian Cao, Xiaosheng Yan, Wenbin He, Xiaorui Li, Zhao Li, Yirong Mo, Maili Liu, and Yun-Bao Jiang*. C−I···π Halogen Bonding Driven Supramolecular Helix of Bilateral N-Amidothioureas Bearing β-Turns. J. Am. Chem. Soc. 2017, 139, 6605−6610. (Cover story, spotlights on JACS)

18. Yuan Yuan, Xiao-Sheng Yan, Xiao-Rui Li, Jin-Lian Cao, Zhao Li,* and Yun-Bao Jiang*. Folded short azapeptide for conformation switching-based fluorescence sensing. Chem. Commun. 2017, 53, 13137−13140.

19. Dan-Dan Tao, Qian Wang, Xiao-Sheng Yan, Na Chen, Zhao Li, and Yun-Bao Jiang*. Ag+ coordination polymers of a chiral thiol ligand bearing an AIE fluorophore. Chem. Commun. 2017, 53, 255−258.

20. Xiao-Sheng Yan, Kun Wu, Yuan Yuan, Ying Zhan, Jin-He Wang, Zhao-Li, and Yun-Bao Jiang*. β-Turn structure in glycinylphenylalanine dipeptide based N-amidothioureas. Chem. Commun. 2013, 49, 8943−8945.

21. Fang Wang, Wen-Bin He, Jin-He Wang, Xiao-Sheng Yan, Ying Zhan, Ying-Ying Ma, Li-Cai Ye, Rui-Yang, Fu-Cai, Zhao-Li, and Yun-Bao Jiang*. Amino acid based chiral N-amidothioureas. Acetate anion binding induced chirality transfer. Chem. Commun. 2011, 47, 11784−11786.

 

联系方式:

电子邮箱:xshyan@xmu.edu.cn

地址:福建省厦门市翔安区翔安南路厦门大学翔安校区药学院

邮编:361102

 

诚招博士后、科研助理、硕士/博士研究生!如有意向,欢迎来信垂询!