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夏琳助理教授

发布者:张欧扬发布时间:2019-04-03浏览次数:932

夏琳助理教授



个人简介:

夏琳,2010-2015年博士就读于厦门大学生命科学学院,从事与抗体工程改造相关的研究。随后在美国德克萨斯州立大学开展免疫应答的科研工作,并于2016-2018年厦门大学公共卫生学院进行博士后研究,现任药学院刘文课题组助理教授。主要从事肿瘤免疫治疗平台的开发,并结合表观遗传学探索肿瘤发生发展的分子机制,以增强肿瘤的免疫治疗效果。


教育经历:

 2018/07-今,厦门大学药学院,助理教授

 2016/03-2018/05,厦门大学公共卫生学院,博士后

 2012/12 – 2013/12,德克萨斯州立大学,休斯顿健康科学中心,项目合作

 2010/9–2015/12,厦门大学生命科学学院,博士

 2007/09-2010/09,厦门大学医学院,硕士

研究方向:

  1. 结合表观遗传学,聚焦肿瘤免疫治疗平台及联合治疗方法的开发和应用;

  2. 表观遗传调控子,转录因子和超级增强子在癌症或炎症反应中的作用分子机制;

  3. 肿瘤免疫治疗的新靶点开发及作用机制研究


参与或主持的科研项目:

  1. 国家自然科学面上项目,人巨细胞病毒自然感染过程中体液免疫应答机制研究,316709272017/01-2020/1260万,主要参与人;

  2. 国家自然青年科学基金项目,31600748,结构生物学指导的HBV治疗性抗体人源化及其关键技术研究,2017/01-2019/1220万,项目负责人;

  3. 中国博士后科学基金面上项目一等资助,2016M600504,基于恒定区改造延长HBV治疗性抗体半衰期及其药动研究,2016/12-2018/048万,项目负责人;

  4. 传染病重大专项,2013ZX10002002,乙肝表面抗原清除的新策略新机制研究,2013/01-2015/12317.9万,参与人,已结题。


代表性论文:

    1. Lin Xia#Ruopeng Su#Zhiqiang AnTong-Ming Fu & Wenxin Luo*Human cytomegalovirus vaccine development: Immune responses to look into vaccine strategy.Human Vaccines & Immunotherapeutics2018142):292-303

    2. Ciming Kang#Lin Xia#Yuanzhi ChenTianying ZhangYiwen WangBing ZhouMin YouQuan YuanChi-Meng TzengZhiqiang AnWenxin Luo*Ningshao Xia.A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys.Protein & Cell201891):130-134

    3. Lin Xia#Aimin Tang#Weixu Meng#Daniel C. FreedLinling HeDai WangFengsheng LiLeike LiWei XiongXun GuiRobbie D. SchultzHaotai ChenXi HeRyan SwoyerSha HaYaping LiuCharles D. MorrisYu ZhouI-MingWangQinjian ZhaoWenxin LuoNingshao XiaAmy S. EspesethDaria J.HazudaRichard E. RuppAlan D. BarrettNingyan ZhangJiang Zhu*TongMing Fu* and Zhiqiang An*Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection.Oncotarget2017843):73654-73669

    4. Xia, Lin#Xian, Yangfei#Wang, DaningChen, YuanzhiHuang, XiaofenBi, XingjianYu, HaiFu, ZhengLiu, XinlinLi, ShaoweiAn, ZhiqiangLuo, Wenxin*Zhao, Qinjian*Xia, NingshaoA human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5.Sci Rep2016619042-19042

    5. Xia, Lin#Zhang, Juan#Cui, ChuanjiaBi, XingjianXiong, JunhuiYu, HaiAn, ZhiqiangLuo, Wenxin*Xia, NingshaoIn vitro affinity maturation and characterization of anti-P24 antibody for HIV diagnostic assay.J Biochem20151586):531-538

    6. Jiang, Tao(#)Guo, DaipingWang, QianWu, XinLi, ZhaoZheng, ZhenhuaYin, BoyuanXia, LinTang, JixianLuo, WenxinXia, NingshaoJiang, Yunbao(*)Developing a genetically encoded green fluorescent protein mutant for sensitive light-up fluorescent sensing and cellular imaging of Hg(II).Anal Chim Acta201587677-82

    7. Freed, Daniel C(#)Tang, QiTang, AiminLi, FengshengHe, XiHuang, ZhaoMeng, WeixuXia, LinFinnefrock, Adam CDurr, EberhardEspeseth, Amy SCasimiro, Danilo RZhang, NingyanShiver, John WWang, DaiAn, ZhiqiangFu, Tong-MingPentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine.Proc Natl Acad Sci U S A201311051):E4997-E5005

    8. Zheng Qingbing#; Xia Lin#; Wu Wai Lan; Zheng Zhenhua; Huo Yongting; Wu Jun; Liu Yanning; Yu Hai; Chen Yixin; Lau Siu Ying; Chen Honglin*; Luo Wenxin*; Xia Ningshao, Properties and Therapeutic Efficacy of Broadly Reactive Chimeric and Humanized H5-Specific Monoclonal Antibodies against H5N1 Influenza Viruses, Antimicrobial Agents and Chemotherapy, 2011, 55(4): 1349~1357

    9. Chen, Yingwei(#)Luo, WenxinWu, Wai LanFang, ZhongXia, LinGui, XunChen, YixinChen, HonglinShih, J Wai-KuoXia, NingshaoHumanized antibodies with broad-spectrum neutralization to avian influenza virus H5N1.Antiviral Res2010871):81-84

    10. 夏琳(#),罗文新,吴君,刘彦宁,傅雅娟,陈毅歆,陈鸿霖,金鑫,夏宁邵,高致病性禽流感病毒广谱嵌合抗体的构建表达及活性研究,厦门大学学报(自然科学版)2010,(06):845-849

联系方式:电话:0592-2881146 电子邮箱:xialin@xmu.edu.cn




 
 
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