吴彩胜教授

发布者:张欧扬发布时间:2017-09-12浏览次数:25409

PI:吴彩胜博士,教授,博士研究生导师

国家优秀青年科学基金获得者;厦门大学“南强青年拔尖A类人才”


个人简历:

吴彩胜博士主要从事体内药物分析与药物代谢研究,主持国家自然科学基金优秀青年科学基金、面上项目、联合基金项目、专项项目、青年科学基金、福建省科技计划项目引导性项目、福建省自然科学基金面上项目等30余项基金课题。以通讯或一作发表研究论文50余篇,担任20余种SCI杂志的同行评议员。担任中国药理学会药物代谢专业委员会青年委员会副主任委员、中国医药生物技术协会药物分析技术分会委员、中国药理学会临床药理学专业委员会委员、中国药理学会治疗药物监测研究专业委员会青年委员会委员、厦门市药学会理事、厦门市药学会药物监测与评价专委会副主任委员等学术兼职。同时受邀担任Acta Pharm Sin BJ Pharm AnalChin Chem LettChin Med4SCI期刊,沈阳药科大学学报和世界科学技术-中医药现代化共2本中文期刊的青年编委。

 

教育和工作经历:

2015-10至现在,   厦门大学,药学院

2011-082015-09  中国医学科学院药物研究所,国家药物及代谢产物分析研究中心

2006-092011-06  北京协和医学院,药物分析学博士

2002-092006-07  中国药科大学,理学学士

 

主要研究方向:

1、药物复杂体系体内分析方法学研究:聚焦于智能质谱数据处理技术研发,通过药物分析方法学的创新,在中药等药物复杂体系体内活性物质及其药效生物标志物分析方法学研究上取得多项原创性研究成果;

2、中药吸收、分布、代谢、排泄(ADME)全过程研究:建立从动物到人体,从靶向到非靶向,从数据采集到数据后处理全方位的中药ADME全过程研究策略,实现从人体暴露视角高效筛选中药药效物质(群)。

 

代表性成果:

近三年代表性论文:

[1] Suping Wang#; Xiaojuan Jiang#; Rong Ding; Binbin Chen; Haiyan Lyu; Junyang Liu; Chunyan Zhu; Rong Shen; Jiayun Chen; Yun Hong; Yunlong Wu; Jiyang Dong*Caisheng Wu*; MS-IDF: A Software Tool for Nontargeted Identification of Endogenous Metabolites after Chemical Isotope Labeling Based on a Narrow Mass Defect Filter, Analytical Chemistry, 2022, 94: 3194-3202.

[2] Xiaojuan Jiang#, Yihua Lin#, Yunlong Wu, Caixia Yuan, Xuli Lang, Jiayun Chen, Chunyan Zhu, Xinyi Yang, Yu Huang, Hao Wang*, Caisheng Wu*. Identification of potential anti-pneumonia pharmacological components of Glycyrrhizae Radix et Rhizoma after the treatment with Gan An He Ji oral liquid. Journal of Pharmaceutical Analysis, 2022, 12: 840-851.

[3] Lu Yang#, Haiyan Lyu#, Ayixianmuguli Yiming, Xiangzhen Xu, Chunling Ma, Shun Tu, Binbin Chen*, Mingyuan Liu*, Caisheng Wu*. Integrated metabolism, network pharmacology, and pharmacokinetics to explore the exposure differences of the pharmacodynamic material basis in vivo caused by different extraction methods for Saussurea involucrata. Journal of Ethnopharmacology, 2022, 298: 115648.

[4] Cui Yang#, Chunyan Zhu#, Yanling Li, Zibiao Li, Zhenghao Zhang, Jiajia Xu, Minwei Chen, Runjing Li, Shixiao Liu, Yunlong Wu*, Zhengrong Huang*, Caisheng Wu*. Injectable selenium-containing polymeric hydrogel formulation for effective treatment of myocardial infarction. Frontiers in Bioengineering and Biotechnology, 2022, 10: 912562.

[5] Chunyan Zhu#, Xiaojuan Jiang#, Juanjuan Tian#, Jiayun Chen, Chunyu Lin, Chong Wang, Cai Tie*, Mingyu Li*, Caisheng Wu*. Integrated approach toward absorption, distribution, metabolism, and excretion of Xiaoke pills in zebrafish based on UPLC-HRMS and DESI-MS techniques. Journal of Chromatography B, 2022, 1200: 123276.

[6] Chunyan Zhu#, Guoyin Lai#, Ying Jin, Dunming Xu, Jiayun Chen, Xiaojuan Jiang, Suping Wang, Guoqiang Liu, Niusheng Xu, Rong Shen, Luxiao Wang, Mingshe Zhu*Caisheng Wu*. Suspect screening and untargeted analysis of veterinary drugs in food by LC-HRMS: Application of background exclusion-dependent acquisition for retrospective analysis of unknown xenobiotics. Journal of Pharmaceutical and Biomedical Analysis, 2022, 210: 114583.

[7] Jiayun Chen#, Xiaojuan Jiang#, Chunyan Zhu, Lu Yang, Mingting Liu, Mingshe Zhu, Caisheng Wu*. Exploration of Q-Marker of Rhubarb Based on Intelligent Data Processing Techniques and the AUC Pooled Method. Frontiers in Pharmacology, 2022, 865066.

[8] Jiayun Chen#, Rong Ding#, Ying Jin, Chunyan Zhu, Xiaojuan Jiang, Suping Wang, Zhen Li, Weihua Li*Caisheng Wu*. HRPIF data mining based on data-dependent/independent acquisition for Rhei Radix et Rhizoma metabolite screening in rats. Journal of Chromatography B, 2022, 1190: 123095.

[9] Cai Tie#*, Chunyan Zhu#, Ying Jin, Handong Liang, Mingyu Li, Juanjuan Tian, Caisheng Wu*. Instantaneous phosphatidylcholine spatial specific regulation induced by formononetin revealed by DESI-MSI. International Journal of Mass Spectrometry, 2022, 471: 116759.

[10] Xue Bai#, Chunyan Zhu#, Jiayun Chen, Xiaojuan Jiang, Ying Jin, Rong Shen, Mingshe Zhu, Caisheng Wu*. Recent Progress on Mass Spectrum Based Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Traditional Chinese Medicine, Current Drug Metabolism, 2022, 23: 99-112.

[11] Xiaofei Chen#, Yunlong Wu#, Chun Chen#, Yanqiu Gu, Chunyan Zhu, Suping Wang, Jiayun Chen, Lei Zhang, Lei Lv, Guoqing Zhang, Yongfang Yuan, Yifeng Chai*, Mingshe Zhu*Caisheng Wu*. Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening. Acta Pharamaceutica Sinica B, 2021, 11: 222-236.

[12] Zheng Luo, Lu Jiang, Chenfang Xu, Dan Kai, Xiaoshan Fan, Mingliang You, Chua Ming Hui, Caisheng Wu*, Yun-Long Wu*, Zibiao Li*. Engineered Janus amphipathic polymeric fiber films with unidirectional drainage and anti-adhesion abilities to accelerate wound healing. Chemical Engineering Journal, 2021, 127725.

[13] Haiyan Lyu#, Binbin Chen#, Xaingzhen Xu, Chunyan Zhu, Chunling Ma, Yu Du, Farong Liu*Caisheng Wu*. Rapid Simultaneous Determination of Fourteen Antidepressants and Thirteen Antipsychotics in Human Plasma by Using High-performance Liquid Chromatography Tandem Mass Spectrometry with Dynamic Multiple Reaction Monitoring and Its Application to Therapeutic Drug Monitoring. Therapeutic Drug Monitoring, 2021,43: 577-588.

[14] Chunyan Zhu, Tingting Cai*, Ying Jin, Jiayun Chen, Guoqiang Liu, Niusheng Xu, Rong Shen, Yuhong Chen, Luying Hana, Suping Wang, Caisheng Wu*, Mingshe Zhu. Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes. Pharmacological Research, 2020, 159:104935.

[15] Haiyan Lyu#, Suping Wang#, Ying Jin, Rong Shen, Jiayun Chen, Chunyan Zhu, Binbin Chen*Caisheng Wu*. Simultaneous determination of VD2, VD3, 25(OH) D2, and 25(OH) D3 in human plasma using electrospray LC-MS/MS as well as its application to evaluate VD plasma levels in depressive, schizophrenic patients and healthy individuals. Biomedical Chromatography, 2020, e4932.

[16] Chunyan Zhu#, Mimi Wan#, Huilin Cheng, Hui Wang*, Mingshe Zhu, Caisheng Wu*. Rapid detection and structural characterization of verapamil metabolites in rats by UPLC–MSE and UNIFI platform, Biomedical Chromatography, 2020, e4702.

 

国家标准制定:

参与制定了国家计量技术规范《傅立叶变换质谱仪校准规范》(JJF1531-2015)、《食品安全国家标准食品中香兰素、甲基香兰素、乙基香兰素和香豆素的测定》(GB 5009.284 - 2021)等国家校准规范和检测标准。

 

专著和教材:

药物分析学(第三版),高等教育出版社,2021年,编委

生物药剂学与药物动力学,华中科技大学出版社,2019年,副主编

毒代动力学,电子科技大学出版社,2014年,参编

 

联系方式:wucsh@xmu.edu.cn

招聘:本实验室诚招助理教授,博士后,博士及硕士研究生(长期有效)。