吴彩胜副教授

发布者:张欧扬发布时间:2017-09-12浏览次数:5741

吴彩胜 副教授


个人简历:

   本科毕业于中国药科大学中药学院,2011年获北京协和医学院药物分析学博士学位。2011-2015年在中国医学科学院药物研究所国家药物及代谢产物分析研究中心工作。201510月调动到厦门大学药学院从事药物分析和药物代谢相关专业研究。主要研究方向有:复杂体系的吸收、分布、代谢、排泄全过程研究、常用中草药及其复方药效物质基础研究、纳米药物体内分析方法研究、新药质量控制、临床前和临床药物代谢研究等。主持国家自然科学基金联合基金、面上项目、青年基金、福建省科技计划项目引导性项目、福建省自然科学基金面上项目等20余项基金课题。以通讯作者或者第一作者在Acta Pharmaceutica Sinica BAnalytical ChemistryAnalytica Chimica ActaChemical Engineering JournalPharmacological ResearchDrug Metabolism and Dispostion等杂志上发表研究论文30余篇,担任10余种SCI杂志的同行评议员。担任中国医药生物技术协会药物分析技术分会委员、中国药理学会临床药理学专业委员会委员、中国药理学会药物代谢专业委员会青年委员会常务委员、厦门药学会理事等学术兼职。

 

教育和工作经历

2015-10至现在,   厦门大学,药学院

2011-82015-9  中国医学科学院药物研究所,国家药物及代谢产物分析研究中心

2006.9-2011.6  北京协和医学院 药物研究所 专业:药物分析学

2002.9-2006.7  中国药科大学,中药学院,专业:中药学

 

主持研究项目情况

主持各类课题20余项,其中省部级以上项目6项:

  1. 国家自然科学基金新疆联合基金培育项目:基于“AcquireX 智能数据采集”等非靶向质谱分析技术策略探究天山雪莲的体内药效物质基础(U1903119

  2. 国家自然科学基金面上项目:基于HRMS/MSn数据集挖掘技术的斑马鱼体内ADME分析策略的建立及其在中药降糖药效物质群快速筛选中的应用(81773688

  3. 国家自然科学基金青年基金:中药名方二仙汤调节脂代谢紊乱的物质基础及其作用通路研究(81302740

  4. 福建省科技厅,引导性项,基于HRMS/MSn数据集挖掘技术的食品中非靶向未知残留物检测标准化研究(2020Y0013

  5. 福建省自然科学基金面上项目:基于“体内ADME过程-多元信息统计-计算机辅助找靶”技术策略探究大黄甘草汤的体内药效物质基础

  6. 北京市自然科学基金预探索项目:中药名方小续命汤有效成分组在大鼠脑内代谢分布特点研究(7133252

 

代表性成果

部分发表论文

  1. Xiaofei Chen#, Yunlong Wu#, Chun Chen#, Yanqiu Gu, Chunyan Zhu, Suping Wang, Jiayun Chen, Lei Zhang, Lei Lv, Guoqing Zhang, Yongfang Yuan, Yifeng Chai*, Mingshe Zhu*, Caisheng Wu*. Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening. Acta Pharamaceutica Sinica B, 2021, 11222-236.

  2. Chunyan Zhu, Tingting Cai*, Ying Jin, Jiayun Chen, Guoqiang Liu, Niusheng Xu, Rong Shen, Yuhong Chen, Luying Hana, Suping Wang, Caisheng Wu*, Mingshe Zhu. Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes. Pharmacological Research, 2020, 159:104935.

  3. Zheng Luo, Lu Jiang, Chenfang Xu, Dan Kai, Xiaoshan Fan, Mingliang You, Chua Ming Hui, Caisheng Wu*, Yun-Long Wu*, Zibiao Li*. Engineered Janus amphipathic polymeric fiber films with unidirectional drainage and anti-adhesion abilities to accelerate wound healing. Chemical Engineering Journal, 2020, online.

  4. Haiyan Lyu#, Binbin Chen#, Xaingzhen Xu, Chunyan Zhu, Chunling Ma, Yu Du, Farong Liu*, Caisheng Wu*. Rapid Simultaneous Determination of Fourteen Antidepressants and Thirteen Antipsychotics in Human Plasma by Using High-performance Liquid Chromatography Tandem Mass Spectrometry with Dynamic Multiple Reaction Monitoring and Its Application to Therapeutic Drug Monitoring. Therapeutic Drug Monitoring, 2020, online.

  5. Haiyan Lyu#, Suping Wang#, Ying Jin, Rong Shen, Jiayun Chen, Chunyan Zhu, Binbin Chen*, Caisheng Wu*. Simultaneous determination of VD2, VD3, 25(OH) D2, and 25(OH) D3 in human plasma using electrospray LC-MS/MS as well as its application to evaluate VD plasma levels in depressive, schizophrenic patients and healthy individuals. Biomedical Chromatography, 2020, e4932.

  6. Chunyan Zhu#, Mimi Wan# , Huilin Cheng, Hui Wang*, Mingshe Zhu,Caisheng Wu*. Rapid detection and structural characterization of verapamil metabolites in rats by UPLC–MSE and UNIFI platform, Biomedical Chromatography, 2020, e4702.

  7. Luying Han, Yunlong Wu, Chunyan Zhu, Caisheng Wu*, Chunrong Yang*. Improved Pharmacokinetics of Icariin (ICA) within Formulation of PEG-PLLA/PDLA-PNIPAM Polymeric Micelles. Pharmaceutics, 2019, E51.

  8. Kaifeng Chen, Shan Jiang, Yun Hong, Zibiao Li*, Yunlong Wu*, Caisheng Wu*, Cationic polymeric nanoformulation: Recent advances in material design for CRISPR/Cas9 gene therapy, Progress in Natural Science: Materials International, 2019, 617-627.

  9. Caihong Wang#, Caisheng Wu#, Lin Zhang, Jinlan Zhang*. Ultraperformance liquid chromatography-tandem mass spectrometry method for profiling ketolic and phenolic sex steroids using an automated injection program combined with diverter valve switch and step analysis, Analytical Chemistry, 2016, 7878-7884.

  10. Caisheng Wu, Haiying Zhang, Caihong Wang, et al. An integrated approach for studying exposure, metabolism, and disposition of multiple component herbal medicines using high-resolution mass spectrometry and multiple data processing tools. Drug Metabolism and Disposition 44 (2016) 800-808.

  11. Caihong Wang, Zhixin Jia, Zhe Wang, Ting Hu, Hailin Qin, Guanhua Du, Caisheng Wu*, Jinlan Zhang*. Pharmacokinetics of 21 active components in focal cerebral ischemic rats after oral administration of the active fraction of Xiao-Xu-Ming decoction. Journal of Pharmaceutical and Biomedical Analysis 122 (2016) 110-117.

  12. Thibaud Thiollier#Caisheng Wu#, Hugues Contamin, et al. Permeability of blood-brain barrier in macaque model of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson disease. Synapse 70 (2016) 231-239.

 

 

国家标准制定:

参与制定了国家计量技术规范《傅立叶变换质谱仪校准规范》(JJF1531-2015)以及多个国家食品药品监督管理局颁布的化妆品违禁成分检定标准。

 

专著和教材:

药物分析学(第三版),高等教育出版社,2021年,参编

生物药剂学与药物动力学,华中科技大学出版社,2019年,副主编

毒代动力学,电子科技大学出版社,2014年,编著

 

联系方式:wucsh@xmu.edu.cn