吴彩胜教授

发布者:张欧扬发布时间:2017-09-12浏览次数:14151

PI:吴彩胜博士,教授,博士研究生导师,药学院院长助理


个人简历:

       本科毕业于中国药科大学,2011年获北京协和医学院药物分析学博士学位。2011-2015年在中国医学科学院药物研究所国家药物及代谢产物分析研究中心工作。201510月调动到厦门大学药学院负责药物分析研究工作。主要研究方向有:药物复杂体系体内分析,智能质谱数据处理技术研发,中药复杂体系吸收、分布、代谢、排泄全过程研究、常用中草药及其复方药效物质基础研究等。主持国家自然科学基金面上项目、联合基金项目、专项项目、青年科学基金、福建省科技计划项目引导性项目、福建省自然科学基金面上项目等20余项基金课题。以通讯或一作发表研究论文40余篇,担任20余种SCI杂志的同行评议员。担任中国医药生物技术协会药物分析技术分会委员、中国药理学会临床药理学专业委员会委员、中国药理学会药物代谢专业委员会青年委员会常务委员、中国药理学会治疗药物监测研究专业委员会青年委员会委员等学术兼职。

 

教育和工作经历

2015-10至现在,   厦门大学,药学院

2011-082015-09  中国医学科学院药物研究所,国家药物及代谢产物分析研究中心

2006-092011-06  北京协和医学院,药物分析学博士

2002-092006-07  中国药科大学,理学学士

 

主持研究项目情况

截止2021年,主持各类课题30余项,包括国家自然科学基金项目5项:

1. 国家自然科学基金委员会面上项目, 82173779, 基于智能质谱数据处理和多维组合衍生化探究土鳖虫药效物质及其作用机制

2. 国家自然科学基金委员会专项项目, 82141215, 基于智能质谱数据处理和生物色谱探究麻杏石甘汤治疗新冠肺炎的药效物质及其作用机制

3. 国家自然科学基金委员会联合基金项目, U1903119, 基于“AcquireX 智能数据采集”等非靶向质谱分析技术策略探究天山雪莲的体内药效物质基础

4. 国家自然科学基金委员会面上项目, 81773688, 基于HRMS/MSn数据集挖掘技术的斑马鱼体内ADME分析策略的建立及其在中药降糖药效物质群快速筛选中的应用

5. 国家自然科学基金委员会青年科学基金项目, 81302740,中药名方二仙汤调节脂代谢紊乱的物质基础及其作用通路研究

代表性成果

部分发表论文

[1] Suping Wang#; Xiaojuan Jiang#; Rong Ding; Binbin Chen; Haiyan Lyu; Junyang Liu; Chunyan Zhu; Rong Shen; Jiayun Chen; Yun Hong; Yunlong Wu; Jiyang Dong*; Caisheng Wu*; MS-IDF: A Software Tool for Nontargeted Identification of Endogenous Metabolites after Chemical Isotope Labeling Based on a Narrow Mass Defect Filter, Analytical Chemistry, 2022, 94: 3194-3202.

[2] Chunyan Zhu#, Guoyin Lai#, Ying Jin, Dunming Xu, Jiayun Chen, Xiaojuan Jiang, Suping Wang, Guoqiang Liu, Niusheng Xu, Rong Shen,, Luxiao Wang, Mingshe Zhu*, Caisheng Wu*. Suspect screening and untargeted analysis of veterinary drugs in food by LC-HRMS: Application of background exclusion-dependent acquisition for retrospective analysis of unknown xenobiotics. Journal of Pharmaceutical and Biomedical Analysis, 2022, 210: 114583.

[3] Jiayun Chen#, Rong Ding#, Ying Jin, Chunyan Zhu, Xiaojuan Jiang, Suping Wang, Zhen Li, Weihua Li*, Caisheng Wu*. HRPIF data mining based on data-dependent/independent acquisition for Rhei Radix et Rhizoma metabolite screening in rats. Journal of Chromatography B, 2022, 1190: 123095.

[4] Cai Tie#, Chunyan Zhu#, Ying Jin, Handong Liang, Mingyu Li, Juanjuan Tian, Caisheng Wu*. Instantaneous phosphatidylcholine spatial specific regulation induced by formononetin revealed by DESI-MSI. International Journal of Mass Spectrometry, 2022, 471: 116759.

[5] Xue Bai#, Chunyan Zhu#, Jiayun Chen, Xiaojuan Jiang, Ying Jin, Rong Shen, Mingshe Zhu, Caisheng Wu*. Recent Progress on Mass Spectrum Based Approaches for Absorption, Distribution, Metabolism, and Excretion Characterization of Traditional Chinese Medicine, Current Drug Metabolism, 2022, online

[6] Xiaofei Chen#, Yunlong Wu#, Chun Chen#, Yanqiu Gu, Chunyan Zhu, Suping Wang, Jiayun Chen, Lei Zhang, Lei Lv, Guoqing Zhang, Yongfang Yuan, Yifeng Chai*, Mingshe Zhu*Caisheng Wu*. Identifying potential anti-COVID-19 pharmacological components of traditional Chinese medicine Lianhuaqingwen capsule based on human exposure and ACE2 biochromatography screening. Acta Pharamaceutica Sinica B, 2021, 11: 222-236.

[7] Zheng Luo, Lu Jiang, Chenfang Xu, Dan Kai, Xiaoshan Fan, Mingliang You, Chua Ming Hui, Caisheng Wu*, Yun-Long Wu*, Zibiao Li*. Engineered Janus amphipathic polymeric fiber films with unidirectional drainage and anti-adhesion abilities to accelerate wound healing. Chemical Engineering Journal, 2021, 127725.

[8] Haiyan Lyu#, Binbin Chen#, Xaingzhen Xu, Chunyan Zhu, Chunling Ma, Yu Du, Farong Liu*, Caisheng Wu*. Rapid Simultaneous Determination of Fourteen Antidepressants and Thirteen Antipsychotics in Human Plasma by Using High-performance Liquid Chromatography Tandem Mass Spectrometry with Dynamic Multiple Reaction Monitoring and Its Application to Therapeutic Drug Monitoring. Therapeutic Drug Monitoring, 2021,43: 577-588.

[9] Haiyan Lyu#, Suping Wang#, Ying Jin, Rong Shen, Jiayun Chen, Chunyan Zhu, Binbin Chen*, Caisheng Wu*. Simultaneous determination of VD2, VD3, 25(OH) D2, and 25(OH) D3 in human plasma using electrospray LC-MS/MS as well as its application to evaluate VD plasma levels in depressive, schizophrenic patients and healthy individuals. Biomedical Chromatography, 2020, e4932.

[10] Chunyan Zhu#, Mimi Wan# , Huilin Cheng, Hui Wang*, Mingshe Zhu, Caisheng Wu*. Rapid detection and structural characterization of verapamil metabolites in rats by UPLC–MSE and UNIFI platform, Biomedical Chromatography, 2020, e4702.

[11] Chunyan Zhu, Tingting Cai*, Ying Jin, Jiayun Chen, Guoqiang Liu, Niusheng Xu, Rong Shen, Yuhong Chen, Luying Hana, Suping Wang, Caisheng Wu*, Mingshe Zhu. Artificial intelligence and network pharmacology based investigation of pharmacological mechanism and substance basis of Xiaokewan in treating diabetes. Pharmacological Research, 2020, 159:104935.

[12] Luying Han, Yunlong Wu, Chunyan Zhu, Caisheng Wu*, Chunrong Yang*. Improved Pharmacokinetics of Icariin (ICA) within Formulation of PEG-PLLA/PDLA-PNIPAM Polymeric Micelles. Pharmaceutics, 2019, 11: 51.

 

 

国家标准制定:

        参与制定了国家计量技术规范《傅立叶 变换质谱仪校准规范》(JJF1531-2015)、《食品安全国家标准 食品中香兰素、甲 基香兰素、乙基香兰素和香豆素的测定》(GB 5009.284 - 2021)等国家校准规范和检测标准。

 

专著和教材:

药物分析学(第三版),高等教育出版社,2021年,编委

生物药剂学与药物动力学,华中科技大学出版社,2019年,副主编

毒代动力学,电子科技大学出版社,2014年,参编

 

联系方式:wucsh@xmu.edu.cn