李明玉副教授

发布者:张欧扬发布时间:2016-07-15浏览次数:11893

福建省高层次引进人才(2017



个人简介:

李明玉博士主要研究方向为糖尿病疾病机理及药物开发、高通量药物筛选、海洋药物的筛选和作用机理等研究工作。研究围绕斑马鱼、小鼠、细胞系为模型;应用高通量药物筛选技术、组学技术、活体成像技术、现代分子生物学技术等手段。至今Cell Metabolism, Trends in Genetics, Diabetes, Journal of Endocrinology等国际主流杂志共发表文章三十多篇,共被引用1000多次。现为Frontiers in Endocrinology、药学研究等刊物编委,受邀为Molecular Neurobiology, Frontiers in Pharmacology, Scientific Reports等十多个杂志审稿人。先后主持国家自然基金面上项目、福建省自然基金面上项目、厦门大学校长基金等多个项目。同美国范德堡大学、美国密歇根大学、英国卡迪夫大学等国际著名高校的相关实验室建立了良好的合作研究关系。

 

教育与工作经历:

1999-2003中国海洋大学本科(生物技术)

2003-2006中国海洋大学硕士(细胞生物学)

2006-2010中国海洋大学博士(药物化学)

  

2010-2011国家海洋局第三海洋研究所助理研究员

2011-2016美国范德堡大学(Vanderbilt University)博士后

2016-至今厦门大学药学院副教授

  

  

主要研究方向:

1、胰岛α和β-细胞增生的分子机理。

2、糖尿病模型的构建及抗糖尿病药物的筛选。

3、斑马鱼疾病模型的建立及药物筛选。

4、海洋药物筛选及作用机理。

5、高通量药物筛选技术。

6CRISPR基因组编辑技术。

 

代表性论文(* 通讯作者;#共同一作):

2020

1.    Gan Q#., Lin C#., Lu C., Chang Y., Che Q., Zhang G., Zhu T., Gu Q., Wu Z., Li M*. and Li D*. (2020) Staprexanthones, Xanthone-Type Stimulators of Pancreatic β-cell Proliferation from a Mangrove Endophytic Fungus. J Nat Prod (In Press)

2.  Kang, Q., Hu, M., Jia, J., Bai, X., Liu, C., Wu, Z., Chen, W., and Li, M*. (2020) Global Transcriptomic Analysis of Zebrafish Glucagon Receptor Mutant Reveals Its Regulated Metabolic Network. Int J Mol Sci, 21(3)

3.    Zhao, L., Wang, L., Aierken, R., Wang, W., Wang, X*., and Li, M*. (2020) Characterization of Insulin and Glucagon Genes and Their Producing Endocrine Cells From Pygmy Sperm Whale (Kogia breviceps). Front Endocrinol (Lausanne) 11, 174

4.    Wu, Y., Ge, P., Xu, W., Li, M., Kang, Q., Zhang, X., and Xie, J. (2020) Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment. Mater Sci Eng C Mater Biol Appl 108, 110386

5.    Ge, P., Niu, B., Wu, Y., Xu, W., Li, M., Sun, H., Zhou, H., Zhang, X., and Xie, J. (2020) Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety. Chemical Engineering Journal 383, 123228

6. 林春雨,郏建新,康琪,吴志强,李明玉*. (2020) 斑马鱼胰岛α细胞细胞核特异表达mCherry转基因模型的构建. 药学研究 39 (5), 256-260.

 

2019

1.    Chen, Z., Zhang, D., Yan, S., Hu, C., Huang, Z., Li, Z., Peng, S., Li, X., Zhu, Y., Yu, H., Lian, B., Kang, Q., Li, M., Zeng, Z., Zhang, X. K., and Su, Y. (2019) SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway. Eur J Med Chem 177, 171-187

2. 王冲, 林春雨, 吴志强, 李明玉*. (2019) 促胰岛 β 细胞增生的黄酮类化合物的活体筛选. 药学研究 38 (3), 135-139.

 

2017

1.    Dean, E. D., Li, M., Prasad, N., Wisniewski, S. N., Von Deylen, A., Spaeth, J., Maddison, L., Botros, A., Sedgeman, L. R., Bozadjieva, N., Ilkayeva, O., Coldren, A., Poffenberger, G., Shostak, A., Semich, M. C., Aamodt, K. I., Phillips, N., Yan, H., Bernal-Mizrachi, E., Corbin, J. D., Vickers, K. C., Levy, S. E., Dai, C., Newgard, C., Gu, W., Stein, R., Chen, W., and Powers, A. C. (2017) Interrupted Glucagon Signaling Reveals Hepatic alpha Cell Axis and Role for L-Glutamine in alpha Cell Proliferation. Cell Metab 25, 1362-1373 e1365

2.    Liu, J., Wang, G. H., Duan, Y. H., Dai, Y., Bao, Y., Hu, M., Zhou, Y. Q., Li, M., Jiang, F., Zhou, H., Yao, X. S., and Zhang, X. K. (2017) Modulation of the Nur77-Bcl-2 apoptotic pathway by p38alpha MAPK. Oncotarget 8, 69731-69745

 

2016

1.    Li, M., Page-McCaw, P., and Chen, W. (2016) FGF1 Mediates Overnutrition-Induced Compensatory beta-Cell Differentiation. Diabetes 65, 96-109

2.    Li, M#., Zhao#, L., Page-McCaw, P. S., and Chen, W. (2016) Zebrafish Genome Engineering Using the CRISPR-Cas9 System. Trends Genet 32, 815-827

 

2015

1.    Li, M., Dean, E. D., Zhao, L., Nicholson, W. E., Powers, A. C., and Chen, W. (2015) Glucagon receptor inactivation leads to alpha-cell hyperplasia in zebrafish. J Endocrinol 227, 93-103

2.    Yin, L., Maddison, L. A., Li, M., Kara, N., LaFave, M. C., Varshney, G. K., Burgess, S. M., Patton, J. G., and Chen, W. (2015) Multiplex Conditional Mutagenesis Using Transgenic Expression of Cas9 and sgRNAs. Genetics 200, 431-441

3.    Varshney, G. K., Pei, W., LaFave, M. C., Idol, J., Xu, L., Gallardo, V., Carrington, B., Bishop, K., Jones, M., Li, M., Harper, U., Huang, S. C., Prakash, A., Chen, W., Sood, R., Ledin, J., and Burgess, S. M. (2015) High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome Res 25, 1030-1042

4.    Ao, J., Mu, Y., Xiang, L. X., Fan, D., Feng, M., Zhang, S., Shi, Q., Zhu, L. Y., Li, T., Ding, Y., Nie, L., Li, Q., Dong, W. R., Jiang, L., Sun, B., Zhang, X., Li, M., Zhang, H. Q., Xie, S., Zhu, Y., Jiang, X., Wang, X., Mu, P., Chen, W., Yue, Z., Wang, Z., Wang, J., Shao, J. Z., and Chen, X. (2015) Genome sequencing of the perciform fish Larimichthys crocea provides insights into molecular and genetic mechanisms of stress adaptation. PLoS Genet 11, e1005118

 

 

2015之前论文:

1.    Li, M., Maddison, L. A., Page-McCaw, P., and Chen, W. (2014) Overnutrition induces beta-cell differentiation through prolonged activation of beta-cells in zebrafish larvae. Am J Physiol Endocrinol Metab 306, E799-807

2.    Li, M., Li, Q., Yang, Z., Hu, G., Li, T., Chen, X., and Ao, J. (2014) Identification of cathepsin B from large yellow croaker (Pseudosciaena crocea) and its role in the processing of MHC class II-associated invariant chain. Dev Comp Immunol 45, 313-320

3.    Mu, Y.#, Li, M.#, Ding, F., Ding, Y., Ao, J., Hu, S., and Chen, X. (2014) De novo characterization of the spleen transcriptome of the large yellow croaker (Pseudosciaena crocea) and analysis of the immune relevant genes and pathways involved in the antiviral response. PLoS One 9, e97471

4.    Maddison, L. A., Li, M., and Chen, W. (2014) Conditional gene-trap mutagenesis in zebrafish. Methods Mol Biol 1101, 393-411

5.    Li, M., Maddison, L. A., Crees, Z., and Chen, W. (2013) Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional beta-cell number through enhanced self-replication in zebrafish. Zebrafish 10, 170-176

6.    Li, M., Ding, Y., Mu, Y., Ao, J., and Chen, X. (2011) Molecular cloning and characterization of caspase-3 in large yellow croaker (Pseudosciaena crocea). Fish Shellfish Immunol 30, 910-916

7.    Xiao, X.#, Li, M.#, Wang, K.#, Qin, Q., and Chen, X. (2011) Characterization of large yellow croaker (Pseudosciaena crocea) beta-actin promoter supports beta-actin gene as an internal control for gene expression modulation and its potential application in transgenic studies in fish. Fish Shellfish Immunol 30, 1072-1079

8.    Li, M., Li, Y., Lu, L., Wang, X., Gong, Q., and Duan, C. (2009) Structural, gene expression, and functional analysis of the fugu (Takifugu rubripes) insulin-like growth factor binding protein-4 gene. Am J Physiol Regul Integr Comp Physiol 296, R558-566

9.    Fan, T., Li, M., Wang, J., Yang, L., and Cong, R. (2009) Purification and characterization of phenoloxidase from Octopus ocellatus. Acta Biochim Biophys Sin (Shanghai) 41, 865-872

10.  Zhao, L., Mi, T., Zhen, Y., Li, M., He, S., Sun, J., and Yu, Z. (2009) Cloning of proliferating cell nuclear antigen gene from the dinoflagellate Prorocentrum donghaiense and monitoring its expression profiles by real-time RT-PCR. Hydrobiologia 627, 19-30

11.  Wang, X., Lu, L., Li, Y., Li, M., Chen, C., Feng, Q., Zhang, C., and Duan, C. (2009) Molecular and functional characterization of two distinct IGF binding protein-6 genes in zebrafish. Am J Physiol Regul Integr Comp Physiol 296, R1348-1357

 

 

 

联系方式:

地址:福建省厦门市翔安区翔安南路厦门大学药学院

Emaillimingyu@xmu.edu.cn

 

 

Google Scholar: https://scholar.google.com/citations?hl=en&user=PJwD5TwAAAAJ

ResearchGate: https://www.researchgate.net/profile/Mingyu_Li6

Publons: https://publons.com/researcher/1455179/mingyu-li/