谢静静助理教授

发布者:张欧扬发布时间:2016-03-14浏览次数:4792



个人简介

谢静静,女,研究生导师,2015年获福州大学生物化工博士学位,同年应聘为厦门大学药学院助理教授;主要从事以核受体靶点药物为基础的纳米药物传递系统设计、功能化纳米材料制备及生物安全性评估等在癌症诊断、治疗及转移预防方面的基础应用研究。近年来在Adv. Funct. MaterTheranosticsJ Control ReleaseBiotechnol AdvChem MaterInt J PharmaceutJ NanobiotechnolCurr Drug MetabSci RepBiochem PharmacolCancer lettCancerOncotarget等国际权威期刊累计发表SCI论文20篇。研究成果多次荣获福建省自然科学论文奖。目前主持国家自然科学基金1项,福建省自然科学基金1项,厦门大学校长基金1项(连续三年资助),完成校级专项资助基金1项,作为学术骨干参与国家自然基金项目多项。

教育背景

2010.09-2015.06,福州大学化学学院,生物化工博士

2015.09-至今,厦门大学药学院,助理教授


代表性论文

After 2015

1. Xie, J.*; Xu, W.; Wu, Y.; Niu, B; Zhang, X*. Macroporous organosilicon nanocomposites co-deliver Bcl2-converting peptide and chemotherapeutic agent for synergistic treatment against multidrug resistant cancer. Cancer Lett 469 (2020) 340–354. (First and Corresponding author)

2. Ge, P.; Niu, B.; Wu, Y.; Xu, W.; Li, M; Sun, H.; Zhou, H.; Zhang, X.*; Xie, J*. Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety. Chem Eng J. 2019, https://doi.org/10.1016/j.cej.2019.123228. (Corresponding author)

3. Wu, Y.; Ge, P.; Xu, W; Li, M.; Kang, Q.; Zhang, X., Xie, J*. Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment. Mat Sci & Eng C108 (2020) 110386. (Corresponding author)

4. Dong, H.; Lu, B.; Wang, J.; Xie, J.; Liu, K.; Jia, L.; Zhuang, J*.Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis. Chem. Commun., 2019, 55, 14797-14800.

5.      Xu, W.; Gao, X.; Ge, P.; Jiang, F.; Zhang, X.;Xie, J*. Dendrimer-like mesoporous silica nanospheres with suitable surface functionality to combat the multidrug resistance. Int J Pharm2018, 553, 349-362. (Corresponding author)

6.      Xu, W.; Ge, P.; Niu, B.; Zhang, X.; Liu, J.; Xie, J*. Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells. J Colloid Interface Sci2018, 527, 141-150. (Corresponding author)

7.      Dong, H.; Han, L.; Wang, J.;Xie, J.; Gao, Y.; Xie, F.; Jia, L. In vivo inhibition of circulating tumor cells by two apoptosis-promoting circular aptamers with enhanced specificity. J Control Release2018, 280, 99-112.

8.      Lu, Y.; Lian, S.; Ye, Y.; Yu, T.; Liang, H.; Cheng, Y.; Xie, J.; Zhu, Y.; Xie, X.; Yu, S.; Gao, Y.; Jia, L. S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells. Pharmacol Res2019, 139, 535-549.

9.      Dong, H. Y.; Han, L. Y.; Wu, Z. S.; Zhang, T.; Xie, J. J.; Ma, J.; Wang, J.; Li, T.; Gao, Y.; Shan, J. W.; Sinko, P. J.; Jia, L. Biostable Aptamer Rings Conjugated for Targeting Two Biomarkers on Circulating Tumor Cells in Vivo with Great Precision. Chem Mater2017, 29, 10312-10325.

10.    Wang, J.; Chen, J.; Zhu, Y.; Zheng, N.; Liu, J.; Xiao, Y.; Lu, Y.; Dong, H.; Xie, J.; Yu, S.; Shao, J.; Jia, L. In vitro and in vivo efficacy and safety evaluation of metapristone and mifepristone as cancer metastatic chemopreventive agents. Biomed Pharmacother 2016, 78, 291-300.

11.    Cheng, Y. L.; Lu, Y. S.; Zhang, D. D.; Lian, S.; Liang, H. Y.; Ye, Y. Y.; Xie, R. Z.; Li, S. H.; Chen, J. H.; Xue, X. H.; Xie, J. J.; Jia, L. Metastatic cancer cells compensate for low energy supplies in hostile microenvironments with bioenergetic adaptation and metabolic reprogramming. Int J Oncol2018, 53, 2590-2604.

 

Before 2015

1.      Xie, J. J.; Lu, Y. S.; Dong, H. Y.; Zhao, R. L.; Chen, H. N.; Shen, W. Y.; Sinko, P. J.; Zhu, Y. W.; Wang, J. C.; Shao, J. W.; Gao, Y.; Xie, F. W.; Jia, L. Enhanced Specificity in Capturing and Restraining Circulating Tumor Cells with Dual Antibody-Dendrimer Conjugates. Adv Funct Mater2015, 25, 1304-1313. (First author)

2.      Xie, J.; Gao, Y.; Zhao, R.; Sinko, P. J.; Gu, S.; Wang, J.; Li, Y.; Lu, Y.; Yu, S.; Wang, L.; Chen, S.; Shao, J.; Jia, L. Ex vivo and in vivo capture and deactivation of circulating tumor cells by dual-antibody-coated nanomaterials. J Control Release 2015, 209, 159-69. (First author)

3.      Xie, J.; Dong, H.; Chen, H.; Zhao, R.; Sinko, P. J.; Shen, W.; Wang, J.; Lu, Y.; Yang, X.; Xie, F.; Jia, L. Exploring cancer metastasis prevention strategy: interrupting adhesion of cancer cells to vascular endothelia of potential metastatic tissues by antibody-coated nanomaterial. J Nanobiotechnol 2015, 13, (First author)

4.      Xie, J.; Wang, J.; Chen, H.; Shen, W.; Sinko, P. J.; Dong, H.; Zhao, R.; Lu, Y.; Zhu, Y.; Jia, L. Multivalent conjugation of antibody to dendrimers for the enhanced capture and regulation on colon cancer cells. Sci Rep2015, 5, 9445. (First author)

5.      Dong, H.; Yang, X.; Xie, J.; Xiang, L.; Li, Y.; Ou, M.; Chi, T.; Liu, Z.; Yu, S.; Gao, Y.; Chen, J.; Shao, J.; Jia, L. UP12, a novel ursolic acid derivative with potential for targeting multiple signaling pathways in hepatocellular carcinoma. Biochem Pharmacol 2015, 93, 151-62.

6.      Dong, H.; Wu, Z. S.; Xu, J.; Ma, J.; Zhang, H.; Wang, J.; Shen, W.; Xie, J.; Jia, L. Novel multifunction-integrated molecular beacon for the amplification detection of DNA hybridization based on primer/template-free isothermal polymerization. Biosens Bioelectron2015, 72, 182-90.

7.      Lu, Y.; Liang, H.; Yu, T.; Xie, J.; Chen, S.; Dong, H.; Sinko, P. J.; Lian, S.; Xu, J.; Wang, J.; Yu, S.; Shao, J.; Yuan, B.; Wang, L.; Jia, L. Isolation and characterization of living circulating tumor cells in patients by immunomagnetic negative enrichment coupled with flow cytometry. Cancer2015, 121, 3036-45.

8.      Wan, L.; Dong, H.; Xu, H.; Ma, J.; Zhu, Y.; Lu, Y.; Wang, J.; Zhang, T.; Li, T.; Xie, J.; Xu, B.; Xie, F.; Gao, Y.; Shao, J.; Tu, X.; Jia, L. Aspirin, lysine, mifepristone and doxycycline combined can effectively and safely prevent and treat cancer metastasis: prevent seeds from gemmating on soil. Oncotarget 2015, 6, 35157-72.

9.      Xie, J.; Zhao, R.; Gu, S.; Dong, H.; Wang, J.; Lu, Y.; Sinko, P. J.; Yu, T.; Xie, F.; Wang, L.; Shao, J.; Jia, L. The architecture and biological function of dual antibody-coated dendrimers: enhanced control of circulating tumor cells and their hetero-adhesion to endothelial cells for metastasis prevention. Theranostics2014, 4, 1250-63. (First author)

10.    Gao, Y.#; Xie, J.#; Chen, H.; Gu, S.; Zhao, R.; Shao, J.; Jia, L. Nanotechnology-based intelligent drug design for cancer metastasis treatment. Biotechnol Adv2014, 32, 761-77. (Co-First author)

11.    Lu, Y.; Yu, T.; Liang, H.; Wang, J.; Xie, J.; Shao, J.; Gao, Y.; Yu, S.; Chen, S.; Wang, L.; Jia, L. Nitric oxide inhibits hetero-adhesion of cancer cells to endothelial cells: restraining circulating tumor cells from initiating metastatic cascade. Sci Rep2014, 4, 4344.

12.    Xie, J.; Shao, J.; Lu, Y.; Chen, J.; Wang, J.; Yu, S.; Jia, L. Separation of ginseng active ingredients and their roles in cancer metastasis supplementary therapy. Curr Drug Metab 2013, 14, 616-23. (First author)

13.    Shao, J.; Dai, Y.; Zhao, W.; Xie, J.; Xue, J.; Ye, J.; Jia, L. Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells. Cancer lett2013, 330, 49-56.

 

联系方式:

地址:福建省厦门市翔安区翔安南路厦门大学药学院509

邮箱:xiejj@xmu.edu.cn