曾子晏教授级高级工程师

发布者:张欧扬发布时间:2016-03-14浏览次数:17862


PI:曾子晏(曾用名曾骥孟)执行主任、教授级高级工程师、博士生导师


个人简介:

曾子晏博士,教授级高级工程师,博士生导师,主要研究方向为:细胞诊疗及细胞质量管理体系建立、药物基因组学与个体化诊疗产品开发、微生态与肿瘤、慢病的关联性研究、肿瘤多肽药物研发,涉及脑白质疏松症(Leukoaraiosis)、腺癌(adenocarcinoma)、不孕症(A-/Oligo-zoospermia) 等多个领域,曾在国际学术期刊发表SCI/IEEE学术论文70余篇,申报4PCT专利,20项中国发明专利,并开发出超过六项生技市场产品,对生物医药技术的研发、转化商品应用、市场与资本运作等方面均有丰富的实践经验。于厦大任职期间承担国家自然科学基金两项,省市级科技项目四项。引领的药学院转化医学平台期间合作建立了标准化的生物样本资源库并开展了多项基于高通量芯片技术(甲基化芯片、表达谱芯片、小RNA芯片等)的研究,先后与福建肿瘤医院,厦门中山医院,厦门第一医院合作,并联合台北病理中心,台大医学院基因蛋白组中心,筛选出甲状腺癌、乳腺癌、胃癌、癫 痫、脑白质疏松症、少精无精等多种疾病中的关键基因和潜在靶向治疗生物标志物进行基础研究。且与佰香汇生技,艾德生医药、上海逍鹏、台湾芮宝生化、山东铂 源等多家生物医学产业公司合作,将科研成果转化到市场中,将开发出相关检测类试剂盒(EGFR, SMA, VitD3, PD等检测试剂盒)及医药产品(Terpenoid vs Psoriasis牛皮鲜Osteoporosis骨质疏松vs Protos and MSC间充质干细胞vs wound healing伤口愈合),充分实现了产学研相结合概念与产业化。

2012年获厦门市引进高层次人才双百计划领军型创业人才称号,厦门大学2013优秀教师,为霍英东基金评审专家,厦门市科技局评审专家,国家自然科学基金评审专家,国家火炬科技园招商与技术顾问,福建省及厦门市医疗器械体外诊断试剂类专家委员。2015-2016年,曾博士分别荣获福建省特殊支持科技创新双百计划人才, 厦门市海納百川特聘台湾专家人才, 扬州市绿扬金凤计划创业领军人才及江苏省双创人才一等首奖、第四届中国“互联网+”大学生创新创业大赛优秀指导教师,2019-2020年任Current Medicinal ChemistryFrontiers in Aging Neuroscience编审委员和特刊主编;2021年获福建省高层次人才现有人才B类。

教育经历:

1989.06-1993.05台湾清华大学原子科学院辐射生物博士;

1995.07-1996.06:美国斯坦福大学医学院,结构生物及免疫学博士后;

1996.07-1999.07美国斯坦福大学医学院生物化学博士后

 

主持/参与项目:

1. 2020.122021.12,新型冠状病毒肺炎(NCP)的诊疗研究与临床转化,国家科技部高端外国专家引进项目

2. 2020.092025.08,间充质干细胞治疗银屑病及银屑病型关节炎的临床研究,国家重点研发计划项目

3. 2020.022021.02,新型冠状病毒肺炎(NCP)的诊疗研究与临床转化,厦门大学新型冠状病毒防治应急科研攻关项目

4. 2019.062021.12,免疫抑制肿瘤细胞糖基化细胞库的建立和细胞质量检测中心管理控制体系的建立,厦门市科技计划项目

5. 2018.012021.12Gab2促进髓源性抑制细胞(MDSCs)功能介导肝癌发展的机制探究,国家自然科学基金

6. 2017.092020.09IL-2激活NK细胞杀伤肿瘤的分子机制,XDHT2017359A

7. 2016.042018.04,非梗阻性无精症患者易感基因ZCCHC13甲基化位点筛查及其致病机理研究,福建省自然科学基金

8. 2014.012016.12,胃高分化与低分化腺癌分化差异的P53PTEN等关键基因分子机理探索研究,国家自然科学基金

9. 2013.012014.12,深度测序技术筛选中国人华法林剂量相关基因,国家自然科学基金

10. 2012.062014.07,甲状腺癌早期诊断检测产品的研制,厦门市科技局“2012国家对台科技合作与交流基地项目

11. 2012.032015.02,中国人群脑白质疏松症高风险基因多态性的研究及其分子诊断试剂的研发,福建省科技厅重点项目

12. 2012.012014.12,新型白血病分子诊断平台的建立,福建省科技厅自然科学基金计划资助项目

13. 2011.102013.09,白血病快速筛查分子诊断平台建设及闽南地区白血病流行病学研究,厦门科技计划项目

14. 2011.052013.05,精油的分子毒理研究及其安全性与功效评估体系建设,XDHT2011154A

15. 2011.072012.07PD致病基因的预测研究,XDH2011309A

16. 2011.082014.07,华夏白血病和乳腺癌分子生物库的建立,XDH2011367A

 

代表性论文:

1.    Chen Lin, Xuzhu Liu, Bingyi Zheng, Rongqin Ke, and Chi-Meng Tzeng, Liquid Biopsy, ctDNA Diagnosis through NGS, Life 2021, 11(9), 890, MDPI. doi: https://doi.org/10.3390/life11090890

2.    Huang WQ, Lin Q, Chen S, Sun L, Chen Q, Yi K, Li Z, Ma Q, Tzeng CM. Correction for: Integrated analysis of microRNA and mRNA expression profiling identifies BAIAP3 as a novel target of dysregulated hsa-miR-1972 in age-related white matter lesions. Aging (Albany NY). 2021 Jun 14;13(11):15688-15689. doi:10.18632/aging.203217. Epub 2021 Jun 14. Erratum for: Aging (Albany NY).13:4674. PMID: 34127571; PMCID: PMC8221320.

3.    Jianghong Cheng, Mingli Li , Chi-Meng Tzeng , Xingchun Gou and Shuai Chen, Suppression of Tumorigenicity 5 Ameliorates Tumor Characteristics of Invasive Breast Cancer Cells via ERK/JNK Pathway. Frontiers in Oncology, 28 July 2021, https://doi.org/10.3389/fonc.2021.621500

4.    Zhao Y, Lu C, Wang H, Lin Q, Cai L, Meng F, Tesfaye EB, Lai HC, Tzeng CM. Identification of hsa-miR-1275 as a Novel Biomarker Targeting for Human Epilepsy of Unknown Etiology. Mol Ther Methods Clin Dev. 2020 Oct14;19:398-410. doi:10.1016/j.omtm.2020.10.005. PMID: 33251277; PMCID:PMC7677659.

5.    Lin TL, Lu CC, Lai WF, Wu TS, Lu JJ, Chen YM, Tzeng CM, Liu HT, Wei H, Lai HC. Role of gut microbiota in identification of novel TCM-derived active metabolites. Protein Cell. 2021 May;12(5):394-410. doi:10.1007/s13238-020-00784-w. Epub 2020 Sep 15. PMID: 32929698; PMCID: PMC8106560.

6.    Lin TL, Shu CC, Chen YM, Lu JJ, Wu TS, Lai WF, Tzeng CM, Lai HC, Lu CC. LikeCures Like: Pharmacological Activity of Anti-Inflammatory Lipopolysaccharides From Gut Microbiome. Front Pharmacol. 2020 Apr 30;11:554. doi:10.3389/fphar.2020.00554. PMID: 32425790; PMCID: PMC7212368.

7.    Zhao Y, Wang HL, Li TT, Yang F, Tzeng CM. Baicalin Ameliorates Dexamethasone-Induced Osteoporosis by Regulation of the RANK/RANKL/OPG Signaling Pathway. Drug Des Devel Ther. 2020 Jan 15;14:195-206. doi:10.2147/DDDT.S225516. PMID:32021104; PMCID: PMC6970258.

8.    Huang WQ, Ye HM, Cai LL, Ma QL, Lu CX, Tong SJ, Tzeng CM, Lin Q. The Associations of Variants With Leukoaraiosis in Chinese Population. Front Genet. 2019 Jul 23;10:615. doi:10.3389/fgene.2019.00615. PMID: 31396257; PMCID: PMC6664056.

9.    Zhu J, Deng L, Chen B, Huang W, Lin X, Chen G, Tzeng CM, Ying M, Lu Z. Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer. Curr Cancer Drug Targets. 2019;19(10):817-827. doi:10.2174/1568009619666190620112546. PMID: 31218958.

10.  Huang J, Alexey S, Li J, Jones T, Grande G, Douthit L, Xie J, Chen D, Wu X, Michael M, Xiao C, Zhao J, Xie X, Xie J, Chen XL, Fu G, Alexander G, Tzeng CM. Correction: Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies. Leukemia. 2019 Sep;33(9):2341. doi:10.1038/s41375-019-0484-y. Erratum for: Leukemia. 2019 Sep;33(9):2315-2319.PMID: 31097784.

11.  Zhao Y, Cai LL, Wang HL, Shi XJ, Ye HM, Song P, Huang BQ, Tzeng CM. 1,25-Dihydroxyvitamin D3 affects gastric cancer progression by repressing BMP3 promoter methylation. Onco Targets Ther. 2019 Mar 28;12:2343-2353. doi:10.2147/OTT.S195642. PMID: 30992671; PMCID: PMC6445188.

12.  Huang WQ, Lin HN, Lin Q, Tzeng CM. Susceptibility Weighted Imaging (SWI) Recommended as a Regular Magnetic Resonance Diagnosis for Vascular Dementia to Identify Independent Idiopathic Normal Pressure Hydrocephalus Before Ventriculo-Peritoneal (V-P) Shunt Treatment: A Case Study. Front Neurol. 2019 Mar 29;10:262. doi:10.3389/fneur.2019.00262. PMID: 30984097; PMCID: PMC6449466.

13.  Huang J, Alexey S, Li J, Jones T, Grande G, Douthit L, Xie J, Chen D, Wu X,Michael M, Xiao C, Zhao J, Xie X, Xie J, Chen XL, Fu G, Alexander G, Tzeng CM. Unique CDR3 epitope targeting by CAR-T cells is a viable approach for treating T-cell malignancies. Leukemia. 2019 Sep;33(9):2315-2319. doi:10.1038/s41375-019-0455-3. Epub 2019 Apr 8. Erratum in: Leukemia. 2019 May 16; PMID: 30962578.

14.  Chen S, Wang H, Li Z, You J, Wu QW, Zhao C, Tzeng CM, Zhang ZM. Interaction of WBP2 with ERα increases doxorubicin resistance of breast cancer cells by modulating MDR1 transcription. Br J Cancer. 2018 May 1;119(2):182-192. doi:10.1038/s41416-018-0119-5. PMID: 29937544; PMCID: PMC6048156.

 

15.  Huang WQ, Yi KH, Li Z, Wang H, Li ML, Cai LL, Lin HN, Lin Q, Tzeng CM. DNA Methylation Profiling Reveals the Change of Inflammation-Associated ZC3H12D in Leukoaraiosis. Front Aging Neurosci. 2018 May 23;10:143. doi:10.3389/fnagi.2018.00143. PMID: 29875652; PMCID: PMC5974056.

16.  Li Z, Chen S, Yang Y, Zhuang X, Tzeng CM. Novel biomarker ZCCHC13 revealed by integrating DNA methylation and mRNA expression data in non-obstructive azoospermia. Cell Death Discov. 2018 Feb 26;4:36. doi:10.1038/s41420-018-0033-x. PMID: 29531833; PMCID: PMC5841273.

17.  Chen S, Zhang Y, Wang H, Zeng YY, Li Z, Li ML, Li FF, You J, Zhang ZM, Tzeng CM. WW domain-binding protein 2 acts as an oncogene by modulating the activity of the glycolytic enzyme ENO1 in glioma. Cell Death Dis. 2018 Mar 1;9(3):347. doi:10.1038/s41419-018-0376-5. PMID: 29497031; PMCID: PMC5832848.

18.  Li Z, Tzeng CM. Integrated Analysis of miRNA and mRNA Expression Profiles to Identify miRNA Targets. Methods Mol Biol. 2018;1720:141-148. doi:10.1007/978-1-4939-7540-2_10. PMID: 29236256.

19.  Cai LL, Huang WQ, Su ZY, Ye HM, Wang LS, Wu Y, Zhang ZY, Zhang W, Tzeng CM. Identification of two novel genes SLC15A2 and SLCO1B3 associated with maintenance dose variability of warfarin in a Chinese population. Sci Rep. 2017 Dec 12;7(1):17379. doi:10.1038/s41598-017-17731-1. PMID: 29234073; PMCID:PMC5727167.

20.  Lin Q, Huang WQ, Ma QL, Lu CX, Tong SJ, Ye JH, Lin HN, Gu L, Yi KH, Cai LL, Tzeng CM. Incidence and risk factors of leukoaraiosis from 4683 hospitalized patients: A cross-sectional study. Medicine (Baltimore). 2017 Sep;96(39):e7682. doi:10.1097/MD.0000000000007682. PMID: 28953609; PMCID: PMC5626252.

21.  Chen S, Wang H, Huang YF, Li ML, Cheng JH, Hu P, Lu CH, Zhang Y, Liu N, Tzeng CM, Zhang ZM. WW domain-binding protein 2: an adaptor protein closely linked to the development of breast cancer. Mol Cancer. 2017 Jul 19;16(1):128. doi:10.1186/s12943-017-0693-9. PMID: 28724435; PMCID: PMC5518133.

22.  Kang C, Xia L, Chen Y, Zhang T, Wang Y, Zhou B, You M, Yuan Q, Tzeng CM, An Z, Luo W, Xia N. A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys. Protein Cell. 2018 Jan;9(1):130-134. doi:10.1007/s13238-017-0438-y. PMID: 28677103; PMCID:PMC5777975.

23.  Li Z, Zhuang X, Zeng J, Tzeng CM. Integrated Analysis of DNA Methylation and mRNA Expression Profiles to Identify Key Genes in Severe Oligozoospermia. Front Physiol. 2017 May 12;8:261. doi:10.3389/fphys.2017.00261. PMID: 28553232; PMCID: PMC5427114.

24.  Huang WQ, Lu CX, Zhang Y, Yi KH, Cai LL, Li ML, Wang H, Lin Q, Tzeng CM. A Novel CCM2 Gene Mutation Associated with Familial Cerebral Cavernous Malformation. Front Aging Neurosci. 2016 Sep 21;8:220. doi:10.3389/fnagi.2016.00220. PMID: 27708576; PMCID: PMC5030299.

25.  Cai LL, Liu GY, Tzeng CM. Genome-wide DNA methylation profiling and its involved molecular pathways from one individual with thyroid malignant/benign tumor and hyperplasia: A case report. Medicine (Baltimore). 2016 Aug;95(35):e4695. doi:10.1097/MD.0000000000004695. PMID: 27583899; PMCID:PMC5008583.

26.  Huang WQ, Ye HM, Li FF, Yi KH, Zhang Y, Cai LL, Lin HN, Lin Q, Tzeng CM. Analysis of genetic polymorphisms associated with leukoaraiosis in the southern Chinese population: A case-control study. Medicine (Baltimore). 2016 Aug;95(35):e3857. doi:10.1097/MD.0000000000003857. PMID: 27583843; PMCID: PMC5008527.

27.  Li Z, Zheng Z, Ruan J, Li Z, Zhuang X, Tzeng CM. Integrated analysis miRNA and mRNA profiling in patients with severe oligozoospermia reveals miR-34c-3p downregulates PLCXD3 expression. Oncotarget. 2016 Aug 16;7(33):52781-52796. doi:10.18632/oncotarget.10947. PMID: 27486773; PMCID: PMC5288148.

28.  Li Z, Zheng Z, Ruan J, Li Z, Tzeng CM. Chronic Inflammation Links Cancer and Parkinson's Disease. Front Aging Neurosci. 2016 Jun 3;8:126. doi:10.3389/fnagi.2016.00126. PMID: 27375474; PMCID: PMC4891345.

29.  Zhan L, Pan YZ, Chen L, Zhang H, Zhang H, Song J, Tzeng CM, Sun CY. Prevalence of ABCB4 polymorphisms in gallstone disease in han-Chinese population. Am J Transl Res. 2016 Feb 15;8(2):1218-27. PMID: 27158408; PMCID: PMC4846965.

30.  Hu P, Hsieh MH, Lei MJ, Cui B, Chiu SK, Tzeng CM. A Simple Algorithm for Population Classification. Sci Rep. 2016 Mar 31;6:23491. doi: 10.1038/srep23491.PMID: 27030001; PMCID: PMC4814818.

31.  Li Z, Lin H, Gu L, Gao J, Tzeng CM. Herba Cistanche (Rou Cong-Rong): One of the Best Pharmaceutical Gifts of Traditional Chinese Medicine. Front Pharmacol. 2016 Mar 1;7:41. doi:10.3389/fphar.2016.00041. PMID: 26973528; PMCID: PMC4771771.

32.  Hu P, Han DX, Ruan RS, Zheng LM, Chou SH, Tzeng CM. Transtinib, a potent tyrosine kinase inhibitor inhibits L858R/T790M mutant NSCLC cell lines and xenografts. Oncotarget. 2016 Jun 14;7(24):35741-35752. doi:10.18632/oncotarget.7140. PMID: 26848869; PMCID: PMC5094958.

33.  Li Z, Zhong L, Gu L, Huang W, Shi X, Zhang X, An X, Lin Q, Tzeng CM. Association study of TREM2 polymorphism rs75932628 with leukoaraiosis or Parkinson's disease in the Han Chinese population. BMJ Open. 2016 Jan 12;6(1):e009499. doi: 10.1136/bmjopen-2015-009499. PMID: 26758262; PMCID:PMC4716257.

34.  Lin Q, Huang WQ, Tzeng CM. Corrigendum to: Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology. Rev Neurosci. 2015;26(5):607-8. doi:10.1515/revneuro-2015-0026. Erratum for: Rev Neurosci. 2015;26(3):343-58. PMID: 26267230.

35.  Li Z, Lin Q, Huang W, Tzeng CM. Target gene capture sequencing in Chinese population of sporadic Parkinson disease. Medicine (Baltimore). 2015 May;94(20):e836. doi:10.1097/MD.0000000000000836. PMID: 25997059; PMCID:PMC4602860.

36.  Lin Q, Huang WQ, Tzeng CM. Genetic associations of leukoaraiosis indicate pathophysiological mechanisms in white matter lesions etiology. Rev Neurosci. 2015;26(3):343-58. doi:10.1515/revneuro-2014-0082. Erratum in: Rev Neurosci. 2015;26(5):607-8. PMID: 25781674.

37.  Zhuang X, Li Z, Lin H, Gu L, Lin Q, Lu Z, Tzeng CM. Integrated miRNA and mRNA expression profiling to identify mRNA targets of dysregulated miRNAs in non-obstructive azoospermia. Sci Rep. 2015 Jan 28;5:7922. doi:10.1038/srep07922. PMID: 25628250; PMCID: PMC4310093.

38.  Sun C, Yan G, Li Z, Tzeng CM. A meta-analysis of the effect of preoperative biliary stenting on patients with obstructive jaundice. Medicine (Baltimore). 2014 Nov;93(26):e189. doi:10.1097/MD.0000000000000189. PMID: 25474436; PMCID: PMC4616392.

39.  Cai LL, Ye HM, Zheng LM, Ruan RS, Tzeng CM. Circulating tumor cells (CTCs) as a liquid biopsy material and drug target. Curr Drug Targets. 2014;15(10):965-72. PMID: 25182470.

40.  Huang S, Shen H, Li Z, Chiu SK, Ruan R, Xiao L, Tzeng CM. Identification of Vβ7.1_H3F7 as a therapeutic gene encoding TCR specific to hepatocellular carcinoma. Curr Gene Ther. 2014;14(5):389-99. doi:10.2174/1566523214666140825124733. PMID: 25174578.

41.  Huang WQ, Lin Q, Zhuang X, Cai LL, Ruan RS, Lu ZX, Tzeng CM. Structure, function, and pathogenesis of SHP2 in developmental disorders and tumorigenesis. Curr Cancer Drug Targets. 2014;14(6):567-88. doi:10.2174/1568009614666140717105001. PMID: 25039348.

42.  Lu CX, Qing Lin, Huang WQ, Tzeng CM. New mutations and polymorphisms of the ATP7B gene in sporadic Wilson disease. Eur J Med Genet. 2014 Sep;57(9):498-502. doi:10.1016/j.ejmg.2014.04.016. Epub 2014 May 28. PMID: 24878384.

43.  Ye HM, Lu YZ, Liang XM, Lin YZ, Li Y, Zhang ZY, Tzeng CM. Clinical significance of combined testing of YKL-40 with CEA in Chinese colorectal cancer patients. Clin Lab. 2014;60(3):397-405. doi:10.7754/clin.lab.2013.121027. PMID: 24697115.

44.  Li Z, Lin Q, Ma Q, Lu C, Tzeng CM. Genetic predisposition to Parkinson's disease and cancer. Curr Cancer Drug Targets. 2014;14(3):310-21. doi:10.2174/1568009614666140312145936. PMID: 24628274.

45.  Wang YQ, Song JJ, Han X, Liu YY, Wang XH, Li ZM, Tzeng CM. Effects of angiopoietin-1 on inflammatory injury in endothelial progenitor cells and blood vessels. Curr Gene Ther. 2014;14(2):128-35. doi:10.2174/1566523214666140307111138. PMID: 24606182.

46.  Cai LL, Ye HM, Lv XN, Wu YL, Zhang HJ, Zheng LM, Tzeng CM. 25-(OH)VitD3, as a risk indicator in diagnosis of adenocarcinoma. Curr Drug Targets. 2013 Oct;14(11):1367-76. doi:10.2174/13894501113149990204. PMID: 23962296.

47.  Ma Q, An X, Li Z, Zhang H, Huang W, Cai L, Hu P, Lin Q, Tzeng CM. P268S in NOD2 associates with susceptibility to Parkinson's disease in Chinese population. Behav Brain Funct. 2013 May 7;9:19. doi:10.1186/1744-9081-9-19. PMID: 23651603; PMCID: PMC3662627.

48.  Lv XN, Liu ZJ, Zhang HJ, Tzeng CM. Aromatherapy and the central nerve system (CNS): therapeutic mechanism and its associated genes. Curr Drug Targets. 2013 Jul;14(8):872-9. doi:10.2174/1389450111314080007. PMID: 23531112.

49.  Liu GY, Liu KH, Li Y, Pan C, Su JQ, Liao HF, Yv RX, Li ZH, Yuan L, Zhang HJ, Tzeng CM, Xiong B. Novel cancerization marker, TP53, and its role in distinguishing normal tissue adjacent to cancerous tissue from normal tissue adjacent to benign tissue. World J Surg Oncol. 2012 Nov 21;10:252. doi:10.1186/1477-7819-10-252. PMID: 23170979; PMCID: PMC3544683.

50.  Zhang HL, Ruan L, Zheng LM, Whyte D, Tzeng CM, Zhou XW. Association between class III β-tubulin expression and response to paclitaxel/vinorebine-based chemotherapy for non-small cell lung cancer: a meta-analysis. Lung Cancer. 2012 Jul;77(1):9-15. doi:10.1016/j.lungcan.2012.01.005. Epub 2012 Feb 4. PMID:22306125.

51.  Chiu SK, Hsieh MH, Tzeng CM. Unique marker finder algorithm generates molecular diagnostic markers. Int J Bioinform Res Appl. 2011;7(1):24-42. doi:10.1504/IJBRA.2011.039168. PMID: 21441095.

52.  Lin MF, Tzeng CM, Dyakov YA, Ni CK. Photostability of amino acids: internal conversion versus dissociation. J Chem Phys. 2007 Jun 28;126(24):241104. doi:10.1063/1.2751150. PMID: 17614530.

53.  Lin E, Hwang Y, Tzeng CM. A case study of the utility of the HapMap database for pharmacogenomic haplotype analysis in the Taiwanese population. Mol Diagn Ther. 2006;10(6):367-70. doi:10.1007/BF03256213. PMID: 17154653.

54.  Jiang B, Zhu ZZ, Liu F, Hou LF, Gu J, Chen E, Tzeng CM, Zhu G. Prevalence of mutation in the epidermal growth factor receptor gene in Chinese patients with non-small cell lung cancer. Clin Oncol (R Coll Radiol). 2006 Oct;18(8):635. doi:10.1016/j.clon.2006.06.001. PMID: 17051955.

55.  Tsai NP, Wu YC, Chen JW, Wu CF, Tzeng CM, Syu WJ. Multiple functions of l0036 in the regulation of the pathogenicity island of enterohaemorrhagic Escherichia coli O157:H7. Biochem J. 2006 Jan 15;393(Pt 2):591-9. doi:10.1042/BJ20051201. PMID: 16248852; PMCID: PMC1360710.

56.  Shyur LF, Chen CH, Lo CP, Wang SY, Kang PL, Sun SJ, Chang CA, Tzeng CM, Yang NS. Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus. J Biomed Sci. 2004 Nov-Dec;11(6):928-39. doi:10.1159/000081840. PMID: 15591790.

57.  Yang NS, Shyur LF, Chen CH, Wang SY, Tzeng CM. Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in mcf-7 cells. J Biomed Sci. 2004 May-Jun;11(3):418-22. doi:10.1159/000077111. PMID:15067226.

58.  Ku WC, Lau WK, Tseng YT, Tzeng CM, Chiu SK. Dextran sulfate provides a quantitative and quick microarray hybridization reaction. Biochem Biophys Res Commun. 2004 Feb 27;315(1):30-7. doi:10.1016/j.bbrc.2004.01.013. PMID:15013421.

59.  Chiu SK, Hsu M, Ku WC, Tu CY, Tseng YT, Lau WK, Yan RY, Ma JT, Tzeng CM. Synergistic effects of epoxy- and amine-silanes on microarray DNA immobilization and hybridization. Biochem J. 2003 Sep 15;374(Pt 3):625-32. doi:10.1042/BJ20030486. PMID: 12809552; PMCID: PMC1223638.

60.  Hsieh MH, Hsu WC, Chiu SK, Tzeng CM. An efficient algorithm for minimal primer set selection. Bioinformatics. 2003 Jan 22;19(2):285-6. doi:10.1093/bioinformatics/19.2.285. PMID: 12538252.

61.  Lau WK, Chiu SK, Ma JT, Tzeng CM. Linear amplification of catalyzed reporter deposition technology on nylon membrane microarray. Biotechniques. 2002 Sep;33(3):564, 566-70. doi:10.2144/02333st07. PMID: 12238767.

62.  Ogawa N, Tzeng CM, Fraley CD, Kornberg A. Inorganic polyphosphate in Vibrio cholerae: genetic, biochemical, and physiologic features. J Bacteriol. 2000 Dec;182(23):6687-93. doi:10.1128/JB.182.23.6687-6693.2000. PMID: 11073913;PMCID: PMC111411.

63.  Tzeng CM, Kornberg A. The multiple activities of polyphosphate kinase of Escherichia coli and their subunit structure determined by radiation target analysis. J Biol Chem. 2000 Feb 11;275(6):3977-83. doi:10.1074/jbc.275.6.3977.PMID: 10660553.

64.  Tzeng CM, Kornberg A. Polyphosphate kinase is highly conserved in many bacterial pathogens. Mol Microbiol. 1998 Jul;29(1):381-2. doi:10.1046/j.1365-2958.1998.00887.x. PMID: 9701829.

65.  Ault-Riché D, Fraley CD, Tzeng CM, Kornberg A. Novel assay reveals multiple pathways regulating stress-induced accumulations of inorganic polyphosphate in Escherichia coli. J Bacteriol. 1998 Apr;180(7):1841-7. doi:10.1128/JB.180.7.1841-1847.1998. PMID: 9537383; PMCID: PMC107098.

66.  Tzeng CM, Percival L, Barber LD, Cooper S, Adams EJ, Stewart D, Parham P. HLA class I genotyping by cDNA sequence of a Vietnamese family expressing a weak B46 antigen. Tissue Antigens. 1997 May;49(5):519-22. doi:10.1111/j.1399-0039.1997.tb02790.x. PMID: 9174148.

67.  Tzeng CM, Adams EJ, Gumperz JE, Percival L, Wells RS, Parham P, Barber LD. Peptides bound endogenously by HLA-Cw*0304 expressed in LCL 721.221 cells include a peptide derived from HLA-E. Tissue Antigens. 1996 Oct;48(4 Pt1):325-8. doi: 10.1111/j.1399-0039.1996.tb02652.x. PMID: 8946687.

68.  Tzeng CM, Yang CY, Yang SJ, Jiang SS, Kuo SY, Hung SH, Ma JT, Pan RL. Subunit structure of vacuolar proton-pyrophosphatase as determined by radiation inactivation. Biochem J. 1996 May 15;316 ( Pt 1)(Pt 1):143-7. doi:10.1042/bj3160143. PMID: 8645197; PMCID: PMC1217314.

69.  Yang SJ, Jiang SS, Tzeng CM, Kuo SY, Hung SH, Pan RL. Involvement of tyrosine residue in the inhibition of plant vacuolar H(+)-pyrophosphatase by tetranitromethane. Biochim Biophys Acta. 1996 May 2;1294(1):89-97. doi:10.1016/0167-4838(96)00005-2. PMID: 8639720.

70.  Chien LF, Wu JJ, Tzeng CM, Pan RL. ATPase of Rhodospirillum rubrum requires three functional copies of beta subunit as determined by radiation inactivation analysis. Biochem Mol Biol Int. 1993 Sep;31(1):13-8. PMID: 8260936.

71.  Ma JT, Wu JJ, Tzeng CM, Pan RL. Functional size analysis of F-ATPase from Escherichia coli by radiation inactivation. J Biol Chem. 1993 May 25;268(15):10802-7. PMID: 7684367.

72.  Hsu LH, Tzeng CM, Pan RL. Functional size of the thylakoid phosphatases determined by radiation inactivation. FEBS Lett. 1993 Feb 22;318(1):1-3. doi:10.1016/0014-5793(93)81314-p. PMID: 8436218.

73.  Tzeng CM, Hsu LH, Pan RL. Inhibition of tonoplast ATPase from etiolated mung bean seedlings by fluorescein 5'-isothiocyanate. Biochem J. 1992 Aug 1;285 ( Pt3)(Pt 3):737-43. doi:10.1042/bj2850737. PMID: 1386733; PMCID: PMC1132857.

74.  Chow WM, Tzeng CM, Chen CS, Kuo SY, Wang MY, Pan RL. Inhibition of tonoplast ATPase by 2',3'-dialdehyde derivative of ATP. Plant Physiol. 1992 Jan;98(1):44-52. doi:10.1104/pp.98.1.44. PMID: 16668647; PMCID: PMC1080148.

 

 

中文:

吕晓楠、叶辉铭、顾龙、曾骥孟*.多重RT-PCR联合毛细管电泳法检测BCR-ABL融合基因.检验医学2014,03(9),227-233.

顾龙、肖芸、吕晓楠、叶辉铭、刘祝君、曾骥孟*.厦门大学附属中山医院 20052012 年新发急性髓性白血病初步分析中华临床医师杂志2013,7(24):11388-11391.

 

李志明、安兴凯、林青、马琪林、曾骥孟*. 帕金森病LRRK2基因单核苷酸rs34778348GA多态性分析.厦大学报2013,52(6).

张换敬,李怡,刘国彦,曾骥孟*. 新型靶向治疗HER2过表达乳腺癌广东医学. 2013.34(3):476-479.(影响因子:0.14

李怡,张换敬吕晓楠刘国彦叶辉铭林青曾骥孟*. 生物样本信息资源库的国内外研究进展中国医药生物技术. 2012,7(5): 369-372.(影响因子:0.286).

曾骥孟.临床病毒学北京.科学出版社,2012. (2 chapters)

李怡,刘国彦,张换敬,郑立谋,曾骥孟*.新型环状引物荧光定量PCR检测乳腺癌组织HER2基因mRNA表达水平方法的建立中华检验医学杂志. 2012.35(11):1000-1005.(影响因子:0.916

万巍巍,张换敬,叶辉铭,万丽琴,蔡良良,郑立谋,曾骥孟*.25-羟基维生素D3完全抗原的合成与鉴定.细胞与分子免疫学杂志. 2011,27(11): 1173-1179.

 

专利

曾子晏,一种妇科抗菌抗炎中药复方组合物及其应用,厦门大学,CN202210071145.5

曾子晏,一种用于女性生殖道抑菌抗炎的中药组合物及其应用,厦门大学,CN202210046346.X

曾子晏、杨长明、郑炳义、王薛婷、曾晓玲、曾才英,厦门大学,一种体外诱导外周血单个核细胞扩增NK细胞的培养基组合,CN202111329534.5

曾子晏、杨长明、郑炳义、王薛婷、曾晓玲、曾才英,一种增强人外周血单核细胞免疫杀伤能力的方法及其应用,CN202111469797.6

曾子晏、李浩、陆荣森、王薛婷、杨长明、张卿红,中药组合物及其应用,郎中堂药业(厦门)有限公司,CN202110552366.X

曾子晏、李浩、陆荣森、王薛婷、杨长明、张卿红,促进伤口愈合的组合物及其用途,郎中堂药业(厦门)有限公司,CN202110553287.0

曾子晏、杨长明、郑炳义,一种抗肿瘤活性多肽及其应用,庶安永康(厦门)健康产业有限公司,CN2021104975392

曾子晏、刘祝君,一种能缓解忧郁症的天然植物萃取组合物及其制备方法,佰香汇生物科技(厦门)有限公司,CN202110279763.4

曾子晏、刘祝君,一种能舒缓焦虑症的天然植物萃取组合物及其制备方法,佰香汇生物科技(厦门)有限公司,CN202110279768.7

曾子晏、胡敏煌、王薛婷、郑炳义、曾才英、曾晓玲,一种预防冠状病毒的消毒剂组合物,厦门大学,CN202110039450.1

曾子晏、胡敏煌、王薛婷、郑炳义、曾才英、曾晓玲,一种预防冠状病毒的多肽消毒剂组合,厦门大学,CN202110034714.4

曾子晏、王薛婷,一种用于核酸扩增的预装pcr反应试剂及其制备方法,厦门大学,CN202011500628X

曾骥孟、宋萍、赵烨、胡鹏、陈帅、黄宝琪,一种加氏乳杆菌及其在制备预防早产药物中的应用,南京工业大学,CN201811292997.7

曾骥孟、许晓玲、龚剑、唐乃平、蒙明慧、聂礼绵,一种利用免疫磁珠负向吸附联合流式细胞法检测循环肿瘤细胞的试剂盒的检测方法,江苏医诺万细胞诊疗有限公司,CN201810168914.7

曾骥孟、唐乃平、龚剑、方月、许晓玲,一种用于检测外周血EGFR基因T790M突变的特异性引物和探针及试剂盒,江苏医诺万细胞诊疗有限公司,CN201810489633.1

李芳芳、曾骥孟、胡鹏,一种应用微流体芯片分离外泌体的方法,江苏医诺万细胞诊疗有限公司,CN201710158638.1曾骥孟、胡鹏、李芳芳,一种应用于外泌体捕获的微流体芯片及其制备方法,庶安永康(厦门)健康产业有限公司,CN201710158652.1

胡鹏、曾骥孟、庄莉莉,一种用于间充质干细胞体外培养和扩增的无血清培养基,江苏医诺万细胞诊疗有限公司,CN201611222344.2

曾骥孟、蒙明慧、许晓玲、唐振洲、胡鹏,一种microRNA组合作为肿瘤标志物辅助诊断多种肿瘤的试剂盒及其检测方法,江苏医诺万细胞诊疗有限公司,CN201610517797.1

曾骥孟、胡鹏、唐振州、蒙明慧、陈彪,一种喹唑啉类化合物的合成方法,江苏医诺万细胞诊疗有限公司,CN201610352749.1

曾骥孟 李志明 顾龙 庄炫,一种血清miRNA生物标志物的应用,厦门大学,CN201410819428.9

曾骥孟 李志明 顾龙 庄炫,一种血清miRNA生物标志物组合物与应用,厦门大学,CN201410819430.6

曾骥孟;蔡良良;刘国彦;叶辉铭;顾龙,人类甲状腺癌组织基因特异位点甲基化水平检测引物及其应用,厦门大学,CN201410135857.4

刘祝君;曾骥孟;刘节喜;林天送;谢加凤,一种脱除柑橘属精油中农药残留的方法,佰香汇生物科技(厦门)有限公司,CN201310226414.1

刘祝君;曾骥孟;张换敬;吕晓楠,一种去除精油中呋喃香豆素的方法,厦门大学/佰香汇生物科技(厦门)有限公司,CN201310058217.3

曾骥孟;郑立谋;李怡;张换敬,检测HER2基因表达水平的实时荧光定量PCR试剂盒,厦门大学,CN201210227940.5

刘祝君;曾骥孟;陈康;刘节喜;朱洪珍;郑声煊;谢加凤;伍宏;李煌基,一种脱除柑橘属植物精油中呋喃香豆素类成分的方法,佰香汇生物科技(厦门)有限公司,CN201210005247.3

王蓟斌;张海龙;阮力;曾骥孟;郑立谋,用于预测乙肝病毒引起的肝癌的引物、探针及试剂盒,厦门艾德生物技术研究中心有限公司,CN201110146841.X

朱冠山;赵翊均;曾骥孟,非小细胞肺癌疗效相关的egfr基因突变的快速检测,庶安永康(厦门)生物科技有限公司,CN200610027918.0


Chi-chan ChenWei-chi KuSung-kay ChiuChi-meng Tzeng*. Photovoltaic device to accelerate the interaction among biomolecules. U-Vision Biotech Co.,Ltd. WO2003035825.

Chi-meng  Tzeng*, Kung-ming Hsu,Wei-chi Ku,Grace Lau, Jing-tyan Ma and Sung-kay  Chiu. Combination of epoxy and amine silanes for immobilizing and  hybridizing nucleic acid molecules on a solid support. U-Vision Biotech  Co.,Ltd. US20030059819.

Shean-jen  Chen,Feng-ming Hsiu,Chien-hung Tsai,Chia-yuan Tsou and Chi-meng Tzeng*.  Surface plasmon resonance shifting interferometry imaging system for  biomolecular interaction analysis. U-Vision Biotech Co.,Ltd.  US20030219809.

Chi-chan ChenSung-kay  Chiu,Chi-meng Tzeng and Wei-chi Ku. Photovoltaic device to accelerate  the interaction among biomolecules. U-Vision Biotech  Co.,Ltd..US20030077600.

 

团队成员

林青、叶辉铭、张换敬、胡鹏、黄文清、李怡、李志明、蔡良良、吕晓楠、雷茗杰、林辉暖、顾龙。


联系方式:

地址:福建省厦门市翔安区翔安南路厦门大学药学院259

邮编:361102

电话:0592-2881110

Emailcmtzeng@xmu.edu.cn