方美娟副教授

发布者:张欧扬发布时间:2016-03-14浏览次数:5957

方美娟博士,副教授


个人简历

方美娟博士,厦门大学药学院副教授。教学上,主讲本科生《波谱解析》、《药物合成反应》、《药物化学实验》、《药学综合科研训练》等课程;科研上,主要研究方向是发现人类疾病关键靶标(例如核受体,蛋白激酶和表观遗传酶)的选择性小分子调控剂。

工作经历:

2011起,厦门大学药学院,副教授,硕导。

2014.06-2015.06, 美国加州大学旧金山分校, Research Associate

2006-2011起,厦门大学药学院,药学系,讲师,硕导。

教育背景:

2001.9—2006.7  厦门大学化学化工学院,有机化学专业,理学博士

1997.9—2001.7  厦门大学化学化工学院化学系,理学学士

研究兴趣

1)核受体调控剂:核受体RXRαNur77RARγ等生物大分子是炎症,痤疮和肿瘤治疗的良好靶标。我们发现不饱和脂肪酸,吲哚,氮杂吲哚和喹啉衍生物可以充当核受体调节剂,产生抗癌、抗炎、减肥等作用。

2)蛋白激酶抑制剂和表观遗传酶调节剂:基于结构的药物设计方法发现新型的蛋白激酶(CDKsCKs)抑制剂和表观遗传酶(乙酰基转移酶和甲基转移酶)调控剂,用于治疗各种疾病,包括癌症、HIV、神经性疾病等。

3)生物活性化合物的靶标确证和作用机制分析:基于差异蛋白质组学和代谢组学的联合技术,探索活性化合物的网络调控作用,阐明其治疗疾病和产生毒性的机制,并探索潜在的靶标。

1. 相关研究工作及其成果

代表论文:

  1. Jingbo Qin#, Jie Liu#,, Chunxiao Wu, Jianwen Xu, Bowen Tang, Kaiqiang Guo, Xiaohui Chen, Weihao Liu, Tong Wu, Hu Zhou*, Meijuan Fang*, Zhen Wu*. Synthesis and biological evaluation of (3/4-(pyrimidin-2-ylamino)benzoyl)-based hydrazine-1-carboxamide/carbothioamide derivatives as novel RXRα antagonists. Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35(1), 880–896.

  2. Hua Fang, Jianyu Zhang, Mingtao Ao, Fengming He, Weizhu Chen, Yuqing Qian, Yuxiang Zhang, Yang Xu*, Meijuan Fang*. Synthesis and discovery of ω-3 polyunsaturated fatty acid- alkanolamine (PUFA-AA) derivatives as anti-inflammatory agents targeting Nur77. Bioorganic Chemistry 105 (2020) 104456.

  3. Hongyu Hu#, Jun Wu#, Mingtao Ao#, Xiaoping Zhou, Boqun Li, Zhenzhen Cui, Tong Wu, Lijuan Wang, Yuhua Xua⁎, Zhen Wu⁎, Meijuan Fang*. Design, synthesis and biological evaluation of methylenehydrazine-1-carboxamide derivatives with (5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole scaffold: Novel potential CDK9 inhibitors. Bioorganic Chemistry 102 (2020) 104064.

  4. Kaiqiang Guo#, Yin Cao#, Zan Li, Xiaoxiao Zhou, Rong Ding, Kejing Chen, Yan Liu, Yingkun Qiu, Zhen Wu*, Meijuan Fang*. Amino Acids, 2020, 5, 793~809.

  5. Baicun Li#, Jie Yao#, Kaiqiang Guo#, Fengming He, Kun Chen, Zongxin Lin, Shunzhi Liu, Jiangang Huang, Qiaoqiong Wu, Meijuan Fang*, Jinzhang Zeng*, Zhen Wu*. Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. European Journal of Medicinal Chemistry 204 (2020) 112608.

  6. Baicun Li#, Feifeng Zhu#, Fengming He#, Qingqing Huang, Xiaoguang Liu, Tong Wu, Taige Zhao, Yingkun Qiu, Zhen Wu, Yuhua Xue, Meijuan Fang. Synthesis and biological evaluations of N′-substituted methylene-4-(quinoline-4-amino) benzoylhydrazides as potential anti-hepatoma agents. Bioorganic Chemistry 96 (2020) 103592.

  7. Hua Fang, Jianlin He, Tan Ran, Hui Chen, Wenhui Jin, Bowen Tang, Zhuan Hong, and Meijuan Fang. Synthesis, biological activities, and docking studies of D-pantolactone derivatives as novel FAS inhibitors. Bioorganic & Medicinal Chemistry. 2019, 27, 115069.

  8. Guozhang Lu, Jun Chen, Xinlei Huangfu,a Xueyan Li, Meijuan Fang,* Guo Tang* and Yufen Zhao. Visible-light-mediated direct synthesis of phosphorotrithioates as potent anti-inflammatory agents from white phosphorus. Organic Chemistry Frontiers.  2019, 6(2): 190-194.  DOI: 10.1039/c8qo01087k.

  9. Shanshan Shi, Jun Chen, Shaohua Zhuo, Zi’ang Wu, Meijuan Fang,* Guo Tang,* and Yufen Zhao. Iodide-Catalyzed Phosphorothiolation of Heteroarenes Using P(O)H Compounds and Elemental Sulfur, Advanced Synthesis & Catalysis. 2019, 361, 3210–3216. DOI: 10.1002/adsc.201900291.

  10. Bowen Tang#, Baicun Li#, Boqun Li, Jingbo Qin, Junming Zhao, Jianwenn Xu, Yingkun Qiu, Zhen Wu* and Meijuan Fang*. Insights into the Stereoselectivity of human SETD7 methyltransferase. RSC Advances, 2019, 9: 9218.

  11. Mingtao Ao#, Zhenrui Pan#, Yuqing Qian#, Bowen Tang, Zeming Feng, Hua Fang, Zhen Wu, Jingwei Chen*, Yuhua Xue* and Meijuan Fang*, Design, synthesis, and biological evaluation of AV6 derivatives as novel dual reactivators of latent HIV-1. RSC Advances, 2018, 8: 17279-17292. DOI: 10.1039/c8ra01216d.

  12. Hongyu Hu#, Chunrong Lin#, Mingtao Ao, Yufen Ji, Bowen Tang, Xiaoxiao Zhou, Meijuan Fang*, Jinzhang Zeng*, and Zhen Wu*, Synthesis and biological evaluation of 1-(2-(adamantane-1-yl)-1H-indol-5-yl)-3-substituted urea/thiourea derivatives as anticancer agents. RSC Advances, 2017, 7(81): 51640-51651. DOI: 10.1039/c7ra08149a.

  13. Bowen Tang#, Baicun Li#, Boqun Li, Zan Li, Jingbo Qin; Xiaoxiao Zhou, Yingkun Qiu, Zhen Wu*, and Meijuan Fang*, The effect of V155M mutation on the complex of hSTING and 2'3'-cGAMP: an in silico study case. RSC Advances, 2017, 7(62): 39185-39196. DOI: 10.1039/c7ra05959k

  14. Bowen Tang, Boqun Li, Yuqin Qian, Mingtao Ao, Kaiqiang Guo, Meijuan Fang*, and Zhen Wu*, The molecular mechanism of hPPAR alpha activation. RSC Advances, 2017, 7(28): 17193-17201. DOI: 10.1039/c6ra27740c.

  15. Hongyu Hu#, Jun Wu#, Mingtao Ao, Huiru Wang, Tongtong Zhou, Yuhua Xue, Yingkun Qiu, Meijuan Fang* and Zhen Wu*, Synthesis, structure-activity relationship studies and biological evaluation of novel 2,5-disubstituted indole derivatives as anticancer agents. Chemical Biology & Drug Design, 2016.11.01, 88: 766-778. DOI: 10.1111/cbdd.12808.

  16. Hongyu Hu#, Xudong Yu#, Fei Wang, Chunrong Lin, Jinzhang Zeng, Yingkun Qiu, Meijuan Fang* and Zhen Wu*, Novel N-substituted 2-(2-(adamantan-1-yl)- 1H-indol-3-yl)-2-oxoacetamide derivatives: synthesis and biological evaluation, Molecules, 2016, 21, 530. doi:10.3390/molecules21050530.

  17. Xia Yan#, Lijuan Wang#, Zhen Wu, Yunlong Wu, Xiuxiu Liu, Fangrong Chang, Meijuan Fang* and Yingkun Qiu*, New on-line separation workflow of microbial metabolites viahyphenation of analytical and preparative comprehensive two-dimensional liquid chromatography, Journal of Chromatography B, 2016.10.15, 1033: 1–8. DOI: 10.1016/j.jchromb.2016.07.053.

  18. Liu, L. N. #; Fu, T. T. #; Xu, X. F.; Fu, C.; Fang, M. J.*; Liu, Y.; Xu, P. X. and Zhao, Y. F.*. Tracing the nitrogen metabolites of glycine using 15N-glycine and mass spectrometry. Rapid Commun. Mass Spectrom. 2015, 29, 645-653.

  19. Fang, M. J.*; Zhang, H.; Liao, C.; Qiu, Y. K.; Fang, H.; Zheng, Z. Y.; Gao, X.; Zhao, Y. F.;  Wu, Z.; Fragmentation Mechanisms about "Phosphorylation-Dephosphorylation" Involved in Amino Acid Ester Isopropyl Phosphoramidates of Brefeldin A Studied by Tandem Mass Spectrometry and Stable Isotopic Labeling, Analytica Chimica Acta. 853 (2015) 391-401.