陈海峰教授

发布者:张欧扬发布时间:2016-03-14浏览次数:27163

陈海峰,教授,博士生导师,课题组长(PI),厦门大学药学院副院长



学习工作经历:

1996.08-2000.07,沈阳药科大学,中药学院,中药制药专业,学士学位;

2000.08-2005.07,沈阳药科大学,中药学院,天然药物化学专业,博士学位,导师姚新生院士;

2005.08-2007.07,清华大学深圳研究院博士后工作站工作,导师王钊教授、姚新生院士;

2007.07-2010.08,厦门大学生物医学研究院,副教授;

2010.08-2013.07,厦门大学药学院,副教授,院长助理,仪器分析测试中心主任;

2013.08至今,厦门大学药学院,教授,博士生导师,院长助理,院党委委员,院仪器分析测试中心主任;

2012-2013,台湾中国医药大学药学院,访问学者

2018-2019,美国凯斯西储大学药学院,访问学者


社会兼职:

国家药典委员会委员(第十二届)

厦门市药学会副理事长

中国老年学和老年医学学会中西医结合分会常务委员

中国仪器仪表学会药物质量分析与过程控制分会常务理事

中国医师协会临床精准医疗专业委会青年委员

白求恩医学专家委员会青年科学家委员会委员

福建省药械不良反应/事件监测评价专家委员会委员

福建省食品安全促进会专家组成员

厦门市药学会中药及健康专委会、两岸专委会副主任委员

中国中药杂志编委

中国药物化学杂志编委

JAFCPhytochemistryPhytomedicineBMCLEJMCFitoterapiaBioorganic ChemistryMolecules等多家杂志的特约审稿人。


科研团队:

教授、副教授、助理教授及科研助理、博硕士研究生共20余人。


研究方向及简介:

主要从事中药及天然药物活性物质及中药二次研究开发工作。


利用多种与重大疾病相关的药物评价模型,从闽台特色中草药资源、微生物资源及海洋资源中发现500余种天然活性物质,包括100余种新结构物质,3个分子以原型或者修饰后的衍生物进入临床前研究阶段。以第一或通讯作者,在核心期刊以上杂志共发表学术论文60余篇,其中SCI收录40余篇;申请发明专利15项,其中11项获得授权;获福建省新世纪优秀人才计划支持,获评2018年度中国产学研合作创新奖(个人);主持国家自然科学基金、福建省区域重大专项、厦门市重大科技计划项目及企业合作项目等各类科研课题30余项,科研经费达2000多万元。熟悉企业产业发展的规律与技术需求,作为课题负责人,协助神威药业集团、片仔癀药业股份有限公司、上药集团厦门中药厂有限公司等多家企业完成产业项目升级及产品二次开发课题。作为具体执行人完成国家中药一类新药“GD79注射剂”、国家六类新药“瓜蒌薤白颗粒”以及“薤白脉爽饮露”临床前药学研究工作。


近年主持部分科研项目:

国家及区域研究课题项目:

1. 基于APP-appoptosin通路及体内过程的土黄芪抗老年痴呆药效物质及其作用机制研究。国家自然科学基金面上项目81773866),66万元,负责人(2018.01-2021.12)

2. 台海海绵共生体中抗肿瘤干细胞激酶抑制剂的发现及作用机制,国家自然科学基金委海峡联合重点项目U1605221),258万元(77万元),(2017.01-2020.12),合作单位负责人

3. 海洋药源生物种子资源库建设子课题(12PYY001SF08)国家海洋局区域示范专项,40万元,负责人(2014.01-2016.12

4. 天然全左旋高纯度虾青素作为高端健康产品原料的规模化制备与开发,福建省海洋经济发展专项FJHJF-L-2021-5),150万元,负责人,(2021.01-2022.12

5. 高品质皿培式栽培牛樟芝量产技术与活性物质研发,厦门市科技局台港澳科技合作项目3502Z20161235),30万元(2016.01-2018.12),负责人

6. 海峡中医药科技平台(3502Z20100006),厦门市重大科技计划项目子课题100万元,负责人(2011.01-2014.12

7. 基于创新靶点的天然小分子调节剂及其作用机制研究,中央高校基本科研业务费专项100万元,负责人(2012.06-2015.06


企业合作课题项目:

1. 通脉降脂胶囊药效物质及作用机制研究/笔管草化学成分及质量标准研究。厦门中药厂有限公司145万元,负责人(2018.01-2025.12

2. 古代经典名方颗粒剂的开发研究。神威药业集团有限公司450万元,负责人(2017.11-2027.06

3. 双孢蘑菇多糖分离纯化和抗肿瘤活性研究技术开发。片仔癀药业股份有限公司45万,负责人,(2018.03-2019.03

4. 皿培式栽培牛樟芝量产技术与活性物质及指纹图谱研究/牛樟芝抗肿瘤功能性评价研究,厦门卓登生物科技有限公司153万元,负责人(2015.03-2019.03

5. 恩再适镇痛活性物质的研究,企业合作项目,江苏威世药业股份有限公司50万元,负责人,(2013.01-2015.01

6. 异黄酮抗肿瘤靶点药物及治疗皮肤烫伤创新药物临床前成药性开发,福建归真堂药业股份有限公司100万元,项目负责人(2011.04-2014.04


近年部分代表性论文:

1. Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Jiang, Jun Gao, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, and Hai-Feng Chen*. Synthesis and anti-hepatoma activities of U12 derivatives arresting G0/G1 phase and inducing apoptosis by PI3K/AKT/mTOR pathway. Pharmaceuticals, 2022, 15:107

2. Cong Wang#, Huasong Lu#, Xiangzhong Liu, Xiang Gao, Wenjing Tian, Haifeng Chen*, Yuhua Xue*, and Qiang Zhou*.A natural product targets BRD4 to inhibit phase separation and gene transcription. iScience, 2022, 25, 103719

3. Xiangzhong Liu†, Mi Zhou†, Chunchun Du, Honghong Zhu, Xi Lu, Shoulun He, Guanghui Wang, Ting Lin, Wenjing Tian*, Haifeng Chen*. Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response. Biomedicines. 2021, 9, 1473

4.Junjie Chen, Wenjing Tian, Ye Yun, Yingpu Tian, Cuiling Sun, Rong Ding, Haifeng Chen*. A discussion on the affecting factors of the fitting procedures’ reliability in isothermal titration calorimetry analysis. Archives of Biochemistry and Biophysics. 2021,713, 109045.

5. Chunlan Xie, Qingmei Liu, Zhihui He, Yingbao Gai, Zhengbiao Zou, Zongze Shao, Guangming Liu, Haifeng Chen*, Xianwen Yang*. Discovery of andrastones from the deep-sea-derived Penicillium allii-sativi MCCC 3A00580 by OSMAC strategy. Bioorganic Chemistry, 2021,108:104671

6. Xiansheng Ye, Wenjing Tian, Xiangzhong Liu, Mi Zhou, Dequan Zeng, Ting
Lin, Guanghui Wang, Xinsheng Yao*,
Haifeng Chen*. Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities. Natural Product Research. 2021,doi.org/10.1080/14786419.2021.1892099

7. Yanlan Yang#, Mi Zhou#, Dongni Wang, Xiangzhong Liu, Xiansheng Ye, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk1Pathway. Journal of Natural Products, 2021, 82:339-351

8. Chunlan Xie#, Duo Zhang#, Ting Lin, Zhihui He, Qingxiang Yan, Qi Cai, Xiaokun Zhang*, Xianwen Yang*, Haifeng Chen*. Antiproliferative Sorbicillinoids From the Deep-Sea-Derived Penicillium allii-sativi.Frontiers in Microbiology. 2021,11: 636948

9. Xiansheng Ye, Wenjing Tian, Mi Zhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xinsheng Yao*, Haifeng Chen*. Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways. Bioorg. Med. Chem. Lett.2021, 38: 127859

10. Jie Feng#, Danyang Zhao#, Qiannan Xu, Xiangzhong Liu, Mi Zhou, Xiansheng Ye, Ting Lin, Guanghui Wang, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities. Natural Product Research. 2020, doi.org/10.1080/14786419.2020.1855166

11. Xiansheng Ye, Wenjing Tian, Guanghui Wang, Xian Zhang, Mi Zhou, Dequan Zeng, Xiangzhong Liu, Xinsheng Yao*, Yunwu Zhang*, and Haifeng Chen*.Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities. Journal of Agricultural and Food Chemistry. 2020, 68: 4196-4204

12. Qiannan Xu, Dan Zhu, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum. Natural Product Research, 2020, doi.org/10.1080/14786419.2020.1739044

13. Xiaoyao Wang, Xiansheng Ye, Shuo Gao, Jinji Liu, Wenjing Tian, Guanghui Wang, Haifeng Chen*, Ting Lin*. Cytotoxic compound triacremoniate from Marine Fungus Acremonium citrinum. MMF4. Fitoterapia,2020, 147, doi.org/10.1016/j.fitote.2020.104766

14. Daren Qiu, Mi Zhou, Xiangzhong Liu, Junjie Chen, Guanghui Wang, Ting Lin, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRα. Bioorganic Chemistry, 2020,170: doi.org/10.1016/j.bioorg.2020.104578

15. Daren Qiu, Mi Zhou, Junjie Chen, Guanghui Wang, Ting Lin, Yujie Huang, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα. Phytochemistry, 2020, 170:doi.org/10.1016/j.phytochem.2019.112216

16. Mi Zhou, Borong Peng, Wenjing Tian, Juihsin Su, Guanghui Wang, Ting Lin, Dequan Zeng, Jyhhorng Sheu*, and Haifeng Chen*. 2-Deacetyl-12-epi-Scalaradial, a Scalarane Sesterterpenoid from a Marine Sponge Hippospongia sp., Induces HeLa Cells Apoptosis via MAPK/ERK Pathway and Modulates Nuclear Receptor Nur77. Marine Drugs, 2020, 18: 375-388

17. Shuiyuan Yang, Wenjing Tian, Zhenrui Pan, Ting Lin, Guanghui Wang, Qiang Zhou, Yuhua Xue*, and Haifeng Chen*. POLYPHENOLS FROM Polygonum cuspidatum REACTIVATE LATENT HIV. Chemistry of Natural Compounds, 2020, 56(2): 318-322

18. Shuo Gao, Wenjing Tian, Zujian Liao, Guangjui Wang, Dequan Zeng, Xiangzhong Liu, Xiaoyao Wang, Hu Zhou, Haifeng Chen*, and Ting Lin*. Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii. Chemistry &Biodiversity,2020, (17)9,DOI: 10.1002/cbdv.202000424

19. Shengmei Zhang, Feirong Huang, Wenjin Tian, Jiashuang Lai, Lixia Qian, Wanjin Hong*, Haifeng Chen*, Liang-cheng Li*. Andrographolide promotes pancreatic duct cells differentiation into insulin-producing cells by targeting PDX-1.Biochemical Pharmacology, 2020, (174), doi.org/10.1016/j.bcp.2019.113785

20. ChunLan Xie, Duo Zhang, Jinmei Xia, Chaochao Hu, Ting Lin, Yukun Lin, Guanghui Wang, Wenjing Tian, Zengpeng Li, Xiaokun Zhang, Xianwen Yang*, Haifeng Chen*. Steroids from the Deep-Sea-Derived Fungus Penicillium granulatum MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor (RXR)- Pathway. Marine Drugs, 2019, 17,178-191

21. Daren Qiu, Mi Zhou, Ting Lin, Junjie Chen, Guanghui Wang, Yujie Huang, Xin Jiang, Wenjing Tian*, Haifeng Chen*. Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage. Journal of Natural Products, 2019, 82(5):1072-1080

22. Xiangzhong Liu, Wenjing Tian, Guanghui Wang, Qiannan Xu, Mi Zhou, Shuo Gao, Daren Qiu, Xin Jiang, Cuiling Sun, Rong Ding, Ting Lin*, Haifeng Chen*.Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina. Phytochemistry, 2019, 158: 67-76


近年部分授权专利:

1. 陈海峰,王光辉,林挺,田文静,周宓。海洋来源二倍半萜类化合物作为治疗宫颈癌药物的应用。(授权专利号:ZL 2018 1 1473282.1

2. 陈海峰,林挺,罗吉孟,田文静,吴雨。一种皿培式培养牛樟芝的质量控制方法。(授权专利号:ZL 2018 1 0819036.0

3. 陈海峰,张云武,徐士兰,许华曦,胥俊越,胡进. 一种多酚类化合物在制备治疗老年痴呆药物中的应用。(授权专利号:ZL 2012 1 0391191.X; 公告号:CN102846591BIPC分类号:A61P25/28 ; A61K31/343

4. 陈海峰,区文超,刘世明,孙翠玲,姚新生,张晓坤. 皂苷类化合物及其应用。(授权公告号:CN 101775063 B

5. 陈海峰,纪益群.长寿果的人工栽培及成分检测方法。(专利授权号:ZL 2010 1 0183445.X

6. 陈海峰, 吕忠显, 陈全成,刘东萍,崔传文,孔桂萍,李阳.脂肪酸类化合物在制备预防和治疗肝癌药物中的应用。(专利授权号:  ZL 2013 1 0112138.6).


招聘:

本实验室诚招科研助理、博士后、博士及硕士研究生(长期有效)。


联系方式:

地址:福建省厦门市翔安区翔安南路厦门大学药学院

邮编:361102

电话:0592-2187225

E-mailhaifeng@xmu.edu.cn