吕忠显教授

发布者:张欧扬发布时间:2016-03-14浏览次数:17907


PI:吕忠显博士、教授、博士生导师  


个人简历

福建省高等学校新世纪优秀人才。2006年担任加利福尼亚大学Irvine分校医学院助理研究员,20077月,以厦门大学“985”平台重点引进人才任厦门大学教授、代谢性疾病研究中心执行主任。现任代谢性疾病厦门市重点实验室主任、“生殖调控与生殖健康研究”福建省高校重点实验室副主任。在Nature CommunicationsPNASPLoS GeneticsCell Death & Disease等学术期刊上发表了40多篇论文,获得发明专利5项。研究工作得到国家重大科学研究计划项目(科技部973计划)课题、科技部重点研发计划重点专项课题、国家自然科学基金、福建省卫教联合公关项目、厦门市科技项目等多项课题资助。获全国妇幼健康科学技术奖自然科学奖一等奖(2021-Z-F-12-04)、2020 年度厦门市科学技术进步奖三等奖(2020-J-3-51-R2),以及厦门大学 “清源”、“鹭燕”科教奖。中国生理学会生殖科学专委会委员、中国动物学会生殖生物学分会理事。担任Human GeneticsBiology of ReproductionJournal of Cellular and Molecular MedicineScientific ReportsExperimental Cell Research 等多种国际学学术杂志的审稿人。

主要研究方向:

生殖生理、糖脂代谢中的信号调控机制研究,旨在通过原创性研究为代谢性疾病、不孕不育等疾病提供分子治疗靶点。近年来主要专注配子发生和胚胎着床的信号调控,并开展相关的靶向药物研发。

 

近期主要科研论文  (* corresponding author)

1.       Yinan Zhao#, Dandan Bai#, You Wu#, Dan Zhang, Mengying Liu, Yingpu Tian, Jinhua Lu, Haibin Wang*, Shaorong Gao*, Zhongxian Lu*. Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse. Development,2022,149(15):dev200316

2.       Xiaoli Wei, Lanping Zheng, Yingpu Tian, Haibin Wang, Youqiang Su, Gensheng Feng, Chao Wang*, Zhongxian Lu*. Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling. Journal of Molecular Cell BiologyJ Mol Cell Biol. 2022 Aug 24doi: 10.1093/jmcb/mjac048

3.       Shuai Chen#, Jianghong Cheng#, Yanhong Zhong, Ruimin Liu, Zhongxian Lu* and Xianyang Luo*. Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells. Oncogene, 2022, 41(24):3316-3327

4.       Mengying Liu#, Wenbo Deng #, Lu Tang, Meng Liu, Haili Bao, Chuanhui Guo, Changxian Zhang, Jinhua Lu, Haibin Wang*, Zhongxian Lu*, Shuangbo Kong*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling. Nature Communications,2022,13: 1006

5.       Ruimin Liu#, Yan Sun#, Shuai Chen, Xinhui Wang, Yun Hong, Zhongxian Lu*. FOXD3 and GAB2 as a pair of rivals antagonistically control hepatocellular carcinogenesis. FEBS J, 2022, 289(15):4536-4548

6.       Jianghong Cheng#, Jia Liang#, Yingzhe Li#, Xia Gao, Mengjun Ji, Mengying Liu, Yingpu Tian, Gensheng Feng, Wenbo Deng, Haibin Wang*, Shuangbo Kong* and Zhongxian Lu.* Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy. PLoS Genetics202218(1): e1010018

7.       You-Zhu Li#, Na Li#, Wen-Sheng Liu#, Yan-Wei Sha, Rong-Feng Wu, Ya-Ling Tang, Xing-Shen Zhu, Xiao-Li Wei, Xiao-Ya Zhang, Yi-Feng Wang, Zhong-Xian Lu*, Fu-Xing Zhang*. Biallelic mutations in spermatogenesis and centriole-associated 1 like (SPATC1L) cause acephalic spermatozoa syndrome and male infertility. Asian Journal of Andrology, 2022,24(1): 6772.

8.       Liu Wensheng#, Zhao Yinan#, Liu Xiaohua#, Zhang Xiaoya, Ding Jiancheng, Li Yang, Tian Yingpu, Wang, Haibin*, Liu Wen*, Lu Zhongxian*. A Novel Meiosis-Related lncRNA, Rbakdn, Contributes to Spermatogenesis by Stabilizing Ptbp2. Frontiers in Genetics, 2021,12:1963

9.       Xiaoli Wei#, Yanwei Sha#, Zijie Wei#, Xingshen Zhu, Fengming He, Xiaoya Zhang, Wensheng Liu*, Yifeng Wang*, Zhong-Xian Lu*. Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure. Acta Biochimica et Biophysica Sinica, 2021, 53(10), 13001309

10.   Xiaoli Wei#, Wensheng Liu#, Xingshen Zhu, Youzhu Li, Xiaoya Zhang, Jing Chen, Vladimir Isachenko, Yanwei Sha*, Zhongxian Lu*. Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia. Clinical Genetics, 2021;100376-385

11.   Xinhui Wang, Yinan Zhao, Dekun Zhou, Yingpu Tian, Gensheng Feng, Zhongxian Lu*. Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice. Cell Death & Disease, 2021,12: 212.

12.   Yang Li#, Wensheng Liu#, Jia Yi, Shuangbo Kong, Jiancheng Ding, Yinan Zhao, Yingpu Tian, Gen-Sheng Feng, Chaojun Li, Wen Liu*, Haibin Wang, and Zhongxian Lu*. The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis.  Asian Journal of Andrology, 2020;22:79-87

13.   Jianbo Zhu#, Lijuan Deng#, Baozhen Chen#, Wenqing Huang, Xiandong Lin, Gang Chen, Chi-Meng Tzeng*, Mingang Ying, Zhongxian Lu*. Magnesium-dependent phosphatase (MDP) 1 is a potential suppressor of gastric cancer. Current Cancer Drug Targets, 2019;19(10):817-827

14.   Yanwei Sha#, Wensheng Liu#, Xianjin Huang#, Yang Li, Zhiyong Ji, Libin Mei, Shaobin Lin, Shuangbo Kong, Jinhua Lu, Lingyuan Kong, Xingshen Zhu, Zhongxian Lu*, Lu Ding*. EIF4G1 is a novel candidate gene associated with severe asthenozoospermia. Molecular Genetics & Genomic Medicine, 2019, 7(8):e807

15.   Wensheng Liu#, Yanwei Sha#, Yang Li#, Libin Mei, Shaobin Lin, Xianjin Huang, Jinhua Lu, Lu Ding, Shuangbo Kong and Zhongxian Lu*. Loss-of-function mutations in SPEF2 cause multiple morphological abnormalities of the sperm flagella (MMAF). Journal of Medical Genetic, 2019, 56(10):678-684

16.   Yang Li#, Yanwei Sha#, Xiong Wang#, Lu Ding#, Wensheng Liu, Zhiyong Ji, Libin Mei, Xianjing Huang, Shaobin Lin, Shuangbo Kong, Jinhua Lu, Weibing Qin, Xinzhong Zhang, Jianmin Zhuang*, Yunge Tang* and Zhongxian Lu*. DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella (MMAF). Clinical Genetics 2019; 95(5):590-600

17.   Jianghong Cheng#, Yanhong Zhong#, Shuai Chen#, Yan Sun, Lantang Huang, Yujia Kang, Baozhen Chen, Gang Chen, Fengli Wang, Yingpu Tian, Wenjie Liu, Gen-Sheng Feng, and Zhongxian Lu.*Gab2 mediates hepatocellular carcinogenesis by integrating multiple signaling pathways. FASEB J 2017,31: 5530–5542

18.   Hao Ran#, Shuangbo Kong#Shuang Zhang#, Jianghong Cheng,Chan ZhouBo He Qiliang Xin, John P Lydon, Francesco J DeMayo, Gen-Sheng Feng, Guoliang Xia, Zhongxian Lu*, Chao Wang*, Haibin Wang*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.Proc Natl Acad Sci U S A. 2017,114(18):4816-4821

19.   Jin Tao, Lianping ZhengMinghui Meng, Yanli Li, Zhongxian Lu*. Shp2 suppresses the adipogenic differentiation of preadipocyte 3T3-L1 cells at the early stage.Cell Death Discovery, 2016, 2:16051

20.   Shuai Chen#, Yujia Kang#, Yanli Li, Jin Tao, Baozhen Chen, Gang Chen, Yang Li, Yingpu Tian, Yinan Zhao, jianghong Cheng, Wenjie Liu, Gen-Sheng Feng*, Zhongxian Lu*. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver diseases.Journal of Molecular Cell Biology,2016,8(6),492–504

 

招聘:欢迎兴趣相投的助理教授、博士后、博士及硕士研究生加盟。

 

地址:福建省厦门市翔安区翔安南路厦门大学药学院

邮编:361102

电话:0592-2187227

电子邮箱:zhongxian@xmu.edu.cn