PI：曾锦章博士、教授、博士生导师
福建省特支计划“双百计划”科技创新领军人才，福建省高层次人才，“核受体靶点药物”教育部创新团队核心骨干。
教育和主要学术履历：中国人民解放军第一军医大学医疗系本科（1984-1989）、医学硕士（1992-1995）和医学博士（1995-1998）；中国人民解放军第二军医大学临床博士后流动站博士后研究人员（1998-2000，师从王红阳院士和吴孟超院士）；博士后出站后留任上海东方肝胆外科研究所助理研究员（2000-2001）和副研究员（2001-2005）；2005-2006于中科院上海生命科学研究院建立核受体药物研究实验室（与裴钢院士合作）；2006-2007，美国Sanford-Burnham Institute for Medical Research访问学者；2007-2011，厦门大学生物医学研究院总支书记，生物医学研究院癌症研究中心中心执行主任/教授；2011-2022，厦门大学药学院副院长，教授。
学术任职情况：中国医师协会临床精准医疗专业委员会委员，福建省药理学学会理事,国家重点研发计划专项会评专家，高等学校科学研究优秀成果奖（科学技术）通讯评审专家，福建省博士后创新创业大赛会评专家，担任Cancer Research, JMC, Chem Biology, Theranostics, Acta Pharmacol Sin, Curr Top Med Chem, Biochem Pharmacology, Cancers, Cells等十余种杂志资深审稿人。
主持项目及获奖情况：近年来主持了国家高技术研究发展计划（国家863项目，科技部）、国家重点研发计划（国际科技合作项目，科技部）、国家自然科学基金与香港研究资助局联合科研基金（NSFC-RGC）和国家自然科学基金面上项目等十余项国家级科研项目，并主持多个福建省重点项目、海洋专项以及与企业联合横向项目等；获上海市医学科技奖一等奖和上海市科技进步奖二等奖各1项；获厦门市科技进步二等奖1项。
课程讲授情况：担任本科生药理学课程组组长，承担本科生课程《药理学》（48学时）、《药理学实验》（60学时）和《分子生物学》（32学时）的主讲，以及《药学导论》和《医学统计学》的讲授；独立开设研究生课程《核受体与人类健康和疾病》（32学时），并担任研究生课程《化学生物学》、《细胞生物学》和《高级药理学》的讲授。
课题组研究工作：主要从事研究核受体在调控细胞生长、凋亡、代谢和免疫中的作用，研究其信号转导调控机制，以鉴定新的治疗靶点，并籍此新的信号转导的理解，对可能的治疗药物进行改进与优化。
团队成员：刘杰，助理教授。先后在Developmental Cell, FEBS Journal, JBC等杂志上发表文章。承担国家自然科学基金，福建省自然科学基金，福建省卫生厅等多个科研项目。实验室每年招收博士生1-2名，硕士生3-4名，同时欢迎博士后研究人员加入团队。
联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院
邮编：361102
电话：0592-2187221 (办);
Email: jzzeng@xmu.edu.cn
近年发表的文章（Selected）
1. Zhang M, Shi Z, Zhang S, Li X, To SKY, Peng Y, Liu J, Chen S, Hu H, Wong AST, Zeng JZ*. The Ginsenoside Compound K Suppresses Stem-Cell-like Properties and Colorectal Cancer Metastasis by Targeting Hypoxia-Driven Nur77-Akt Feed-Forward Signaling. Cancers (Basel). 2022 Dec 20;15(1):24. doi: 10.3390/cancers15010024.
2. Li X, Chen Q, Liu J, Lai S, Zhang M, Zhen T, Hu H, Gao X, Wong AST*, Zeng JZ*. Orphan Nuclear Receptor Nur77 Mediates the Lethal Endoplasmic Reticulum Stress and Therapeutic Efficacy of Cryptomeridiol in Hepatocellular Carcinoma. Cells. 2022 Dec 1;11(23):3870. doi: 10.3390/cells11233870.
3. Wu Z, Cheng H, Liu J, Zhang S, Zhang M, Liu F, Li Y, Huang Q, Jiang Y, Chen S, Lv L, Li D*, Zeng JZ*. The Oncogenic and Diagnostic Potential of Stanniocalcin 2 in Hepatocellular Carcinoma. J Hepatocellular Carcinoma 2022; 9:141-155. doi.org/10.2147/JHC.S351882
4. Li B, Huang J, Liu J, He F, Wen F, Yang C, Wang W, Wu T, Zhao T, Yao J, Liu S, Qiu Y, Fang M, Zeng JZ*, Wu Z. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Feb 12;121:105651. doi: 10.1016/j.bioorg.2022.105651. Online ahead of print. PMID: 35182885
5. Shi Z, To SKY, Zhang S, Deng S, Artemenko M, Zhang M, Tang J, Zeng JZ*, Wong AST*. Hypoxia-induced Nur77 activates PI3K/Akt signaling via suppression of Dicer/let-7i-5p to induce epithelial-to-mesenchymal transition. Theranostics. 2021 Jan 19;11(7):3376-3391. doi: 10.7150/thno.52190. PMID: 33537093; PMCID: PMC7847671.
6. Li B, Yao J, He F, Liu J, Lin Z, Liu S, Wang W, Wu T, Huang J, Chen K, Fang M, Chen J, Zeng JZ*. Synthesis, SAR study, and bioactivity evaluation of a series of Quinoline-Indole-Schiff base derivatives: Compound 10E as a new Nur77 exporter and autophagic death inducer. Bioorg Chem. 2021 Aug;113:105008. doi: 10.1016/j.bioorg.2021.105008. Epub 2021 May 23. PMID: 34089944.
7. Zhu X, Li J, Ning H, Yuan Z, Zhong Y, Wu S, Zeng JZ*. α-Mangostin Induces Apoptosis and Inhibits Metastasis of Breast Cancer Cells via Regulating RXRα-AKT Signaling Pathway. Front Pharmacol. 2021 Aug 30;12:739658. doi: 10.3389/fphar.2021.739658. PMID: 34539418; PMCID: PMC8444262.
8. Zhang S, Gao W, Tang J, Zhang H, Zhou Y, Liu J, Chen K, Liu F, Li W, To SKY, Wong AST, Zhang XK, Zhou H, Zeng JZ*. The Roles of GSK-3β in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma. Theranostics. 2020 Jan 1;10(3):1230-1244. doi: 10.7150/thno.38711. PMID: 31938062; PMCID: PMC6956800.
9. Li B, Yao J, Guo K, He F, Chen K, Lin Z, Liu S, Huang J, Wu Q, Fang M, Zeng JZ*, Wu Z. Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators. Eur J Med Chem. 2020 Oct 15;204:112608. doi: 10.1016/j.ejmech.2020.112608. Epub 2020 Jul 19. PMID: 32717483.
10. Liu J, Huang JG, Zeng JZ*. Targeting Non-Genomic Activity of Retinoic Acid Receptor-Gamma by Acacetin.Methods Mol Biol. 2019;2019:15-31. doi: 10.1007/978-1-4939-9585-1_2.PMID: 31359386
11. Chai D*, Lin X, Zheng Q, Xu C, Xie H, Ruan Q, Lin J, Liu J and Zeng JZ. Retinoid X Receptor Agonists Attenuates Cardiomyopathy in Streptozotocin-Induced Type 1 Diabetes Through LKB1-dependent Anti-Fibrosis Effects. Clinical Science2020; 134 609–628.
12. Shi ZY, Zeng JZ, Wong AST*. Chemical Structures and Pharmacological Profiles of Ginseng Saponins. Molecules. 2019 Jul 3;24(13):2443. doi: 10.3390/molecules24132443.
13. Li SS, Ip CKM, Tang MYH, Tang MKS, Tong Y, Zhang J, Hassan AA, Mak ASC, Yung S, Chan TM, Ip PP, Lee CL, Chiu PCN, Lee LTO, Lai HC, Zeng JZ, Shum HC, Wong AST*. Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow. Nat Commun.2019 Jun 3;10(1):2406. doi: 10.1038/s41467-019-10334-6.
14. Li SS, Ip CKM, Tang MYH, Tang MKS, Tong Y, Zhang J, Hassan AA, Mak ASC, Yung S, Chan TM, Ip PP, Lee CL, Chiu PCN, Lee LTO, Lai HC, Zeng JZ, Shum HC, Wong AST. Sialyl Lewisx-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow.Nat Commun. 2019 Jun 3;10(1):2406. doi: 10.1038/s41467-019-10334-6. PMID: 31160622
15. Zeng W, Zhang C, Cheng H, Wu YL, Liu J, Chen Z, Huang JG, Ericksen RE, Chen L, Zhang H, Wong AS, Zhang XK, Han W, Zeng JZ*. Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma.Sci Rep. 2017 Mar 23;7(1):348. doi: 10.1038/s41598-017-00233-5.PMID: 28336971
16. Wang PY, Zeng WJ, Liu J, Wu YL, Ma Y, Zeng Z, Pang JY, Zhang XK, Yan X, Wong AST, Zeng JZ*. TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells.Biochem Pharmacol. 2017 Jan 15;124:19-28. doi: 10.1016/j.bcp.2016.10.014. Epub 2016 Oct 31.PMID: 27810320
17. Ren J, Liu D, Tian L, Wei Y, Proksch P, Zeng JZ*, Lin W. Venezuelines A-G, new phenoxazine-based alkaloids and aminophenols from Streptomyces venezuelae and the regulation of gene target Nur77.Bioorg Med Chem Lett. 2013 Jan 1;23(1):301-4. doi: 10.1016/j.bmcl.2012.10.096. Epub 2012 Oct 30.PMID: 23164710
18. To SK, Zeng JZ, Wong AS. Nur77: a potential therapeutic target in cancer.Expert Opin Ther Targets. 2012 Jun;16(6):573-85. doi: 10.1517/14728222.2012.680958. Epub 2012 Apr 26.PMID: 22537097 Review.
19. Lu N, Liu J, Liu J, Zhang C, Jiang F, Wu H, Chen L, Zeng W, Cao X, Yan T, Wang G, Zhou H, Lin B, Yan X, Zhang XK, Zeng JZ*. Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha.PLoS One. 2012;7(4):e35722. doi: 10.1371/journal.pone. 0035722. Epub 2012 Apr 24.PMID: 22545132.
20. Wu H, Lin Y, Li W, Sun Z, Gao W, Zhang H, Xie L, Jiang F, Qin B, Yan T, Chen L, Zhao Y, Cao X, Wu Y, Lin B, Zhou H, Wong AS, Zhang XK, Zeng JZ*. Regulation of Nur77 expression by β-catenin and its mitogenic effect in colon cancer cells.FASEB J. 2011 Jan;25(1):192-205. doi: 10.1096/fj.10-166462. Epub 2010 Sep 16.PMID: 20847229.
21. Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.Cancer Cell. 2010 Jun 15;17(6):560-73. doi: 10.1016/j.ccr. 2010.04.023.PMID: 20541701.
22. Yan TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, Lin YY, He JY, Gao WW, Zhao Y, Xie L, Chen JB, Zhang XK, Zeng JZ*. Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.Cancer Res. 2010 Mar 15;70(6):2285-95. doi: 10.1158/0008-5472.CAN-09-2968. Epub 2010 Mar 2.PMID: 20197465
23. Liu J, Zhou W, Li SS, Sun Z, Lin B, Lang YY, He JY, Cao X, Yan T, Wang L, Lu J, Han YH, Cao Y, Zhang XK, Zeng JZ*. Modulation of orphan nuclear receptor Nur77-mediated apoptotic pathway by acetylshikonin and analogues.Cancer Res. 2008 Nov 1;68(21):8871-80. doi: 10.1158/0008-5472.CAN-08-1972.PMID: 18974131.
24. Zeng JZ*, Sun DF, Wang L, Cao X, Qi JB, Yang T, Hu CQ, Liu W, Zhang XK. Hypericum sampsonii induces apoptosis and nuclear export of retinoid X receptor-alpha.Carcinogenesis. 2006 Oct;27(10):1991-2000. doi: 10.1093/carcin/bgl046. Epub 2006 Apr 18.PMID: 16621885
25. Zeng JZ, Wang HY, Chen ZJ, Ullrich A, Wu MC. Molecular cloning and characterization of a novel gene which is highly expressed in hepatocellular carcinoma.Oncogene. 2002 Jul 25;21(32):4932-43. doi: 10.1038/sj.onc.1205652.PMID: 12118372
