题 目：Molecular mechanisms of SRC-3-mediated cancer cell invasion and tumor metastasis: from the nucleus to the plasma membrane
报告人：龙伟文 教授
厦门大学生物医学研究院天然产物化学研究中心
时 间：
地 点：卢嘉锡楼202会议室
主办单位：生物医学研究院
讲座内容简介：
Oncogenic steroid receptor coactivator 3(SRC-3), also known as amplified in breast cancer-1 (AIB1), is overexpressed in multiple cancers. SRC-3 promotes cell proliferation and tumor growth by acting as a co-activator of steroid receptors and other transcription factors. SRC-3 also promotes cancer cell invasion and tumor metastasis, but the underlying mechanisms are largely unknown. Our recent findings demonstrate SRC-3 and its N-terminal truncated form SRC-3∆4cooperatively promote cancer cell invasion and tumor metastasis. SRC-3∆4 functions as a signaling adaptor for EGFR and focal adhesion kinase (FAK)on the plasma membrane and mediates EGF-induced FAK activation and cancer cell migration. In the nucleus, SRC-3 coactivates PEA-3 to regulate MMP genes’ expression and promotes cancer cell invasion, which is mediated by ERK3-mediated phosphorylation of SRC-3 at S857.
报告人
1999-2001 硕士，美国斯克兰顿大学(University of Scranton)生物化学系
2001-2005 博士，美国杜兰大学（Tulane University）结构与细胞生物学系
2005-2010 博士后, 美国休斯顿贝勒医学院(Baylor College of Medicine)分子细胞生物学系。 导师：Dr. Bert W. O’Malley，美国科学院和医学院两院院士。主要研究方向：细胞核受体共转录因子在癌症形成及扩散过程中的分子作用机制。
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