Professor GEORGE MICHAEL BLACKBURN 将于2007年11月26日至12月7日开设四次讲座课程,涉及化学与生物相关学科,具体安排如下:
一，11月26日(周一) 下午2：30， 化四112
Seminar 1 will deal with How to Write a Research Paper
二，11月30日（周五）下午2：30，化四112
Seminar 2 will discuss How to Do Research in Chemistry and Chemical Biology
三，12月3日（周一）下午2：30， 化四112
Seminars 3 will look at some important recent developments in Medicinal Chemistry
四，12月7日（周五）下午2：30，化四112
Seminars 4 will look at some important recent developments in Medicinal Chemistry
Blackburn教授的简介详见附件.
CURRICULUM VITAE
Professor George Michael
1. Academic Career:
with Professor Lord Todd
1990-date Co-Director, Krebs Institute for Biomolecular Science
2. IUPAC activity
Secretary IUPAC Division-3 Biomolecular Chemistry S/C, 2000-2002, Secretary IUPAC Division-3 Committee, 2002-2006.
Chairman IUPAC Div-3 Biomolecular Chemistry 2006-2008.
3. Research Activity
Since 1961 supervised some 66 Ph.D. students and 5 M.Sc. students. I have directed the work of over 40 post-doctoral research workers.
4. Publications.
Authored over 200 primary publications in refereed journals, some 10 patents, and 3 books (the 3rd Edition of “Nucleic Acids: Chemistry & Biology” is launched this week: Editors � RSC London).
Keywords
Enzyme mechanisms: transition states and transition state analogues for phosphoryl transfer and other reactions, nucleotide mimics, analogues of S-adenosyl methionine, DNA repair enzymes.
Research Interests
My work in chemical biology is directed at recognition processes between small and large biological molecules. It seeks to achieve a better understanding of the mechanisms of biological processes and drug design and apply them to medical problems. This subject makes equal demands on synthesis of new compounds and the quantitative evaluation of their behaviour in a real biological context.
A major theme of the programme is the stereochemically controlled synthesis of phosphonic acids, especially of a-fluorophosphonic acids as analogues of biological phosphates. These have been developed particularly in relation to nucleotide mimics for inhibiting cell-signalling processes. The synthesis of a stable, charge-switchable analogue of S-adenosyl L-methionine (AzaSAM) has led to a high definition of enzyme catalysis for some SN2 biological methylation reactions.
Our recent, controversial proposal that the magnesium trifluoride anion is an isosteric and isoelectronic transition state analogue of metaphosphate in several enzyme-catalysed phosphoryl transfer reactions has been amply verified. Its application to understanding the nature of enzyme catalysis is expanding rapidly.
Selected Recent Publications
The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Russell, R. J.; Haire, L.F.; Stevens, D. J.; Collins, P. J.; Lin, Y. P.; Blackburn, G. M.; Hay, A. J.; Gamblin, S. J.; Skehel, J. J. Nature (
Catalytic Roles for Carbon-Oxygen Hydrogen Bonding in SET Domain Lysine Methyltransferases. Couture, J.-F.; Hauk, G.; Thompson, M. J.;
X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes. Fisher, S. Z.; Govindasamy, L.; Boyle, N.; Agbandje-McKenna, M.; Silverman, D. N.; Blackburn, G. M.; McKenna, R. Acta Cryst., F: Struct. Biol. Cryst. Commun., 2006, F62(7), 618-622.
Evidence Supporting a cis-enediol-based Mechanism for Pyrococcus furiosus Phosphoglucose Isomerase. Berrisford, J. M.; Hounslow, A. M.; Akerboom, J.r; Hagen, W. R.; Brouns, S. J. J.; van der Oost, J.; Murray, I. A.; Blackburn, G. M.; Waltho, J. P.; Rice, D. W.; Baker, P. J. J. Mol. Biol. 2006, 358(5), 1353-1366.
Methylene analogues of adenosine 5'-tetraphosphate. Their chemical synthesis and recognition by human and plant mononucleoside tetraphosphatases and dinucleoside tetraphosphatases. Guranowski, A.; Starzynska, Elzbieta; Pietrowska-Borek, M.; Jemielity, J.; Kowalska, J.; Darzynkiewicz, E.; Thompson, M. J.; Blackburn, G. M. FEBS Journal 2006, 273(4), 829-838.
A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site. Baxter N. J; Olguin L. F.; Golicnik M.; Feng G.; Hounslow A. M.; Bermel W.; Blackburn G. M.; Hollfelder F.; Waltho J. P.; Williams N. H. Proc. Nat. Acad. Sci.
Antibiotic Recognition by Binuclear Metallo-b-Lactamases Revealed by X-ray Crystallography. Spencer, J.; Read, J.; Sessions, R. B.; Howell, S.; Blackburn, G. M.; Gamblin, S. J. J. Amer. Chem. Soc., 2005, 127(41), 14439-14444.
Synthesis of a-fluoro- and a,a-difluorobenzenemethanesulfonamides: new inhibitors of carbonic anhydrase.
