Prof. Gao received his Ph.D. from Xiamen University in 2010. Subsequently, he conducted postdoctoral research at the State Key Laboratory of Environmental and Biological Analysis at Hong Kong Baptist University (2011-2012), developing new strategies for protein quantification analysis. In 2013, he joined the School of Pharmaceutical Sciences at Xiamen University. Prof. Gao mainly focuses on the development of novel mass spectrometry techniques for exploring scientific issues in the fields of bioorganic phosphorus chemistry and chemical proteomics. Dr. Gao has published over 60 research papers in leading journals such as Nature Cell Biology, Angew Chem, Cell Reports Physical Science, Anal. Chem. and J. Proteome Res.

Research:

1. Stable isotope labeling phosphorus reagents for quantitative omics analysis;

2. Function and chemical evolution of phosphorus-containing biomolecules;

3. Gene transcription regulation and drug screening.

Selected Publications (last 3 years):

1.Yumeng Zhang, Long Zhou, Chunjing Chen, Xiaoyu Wang, Yan Liu, Guo Tang, Yufen Zhao,* Xiang Gao*. Homochiral ligations of amino acids by N-phosphorylation in water. Cell Reports Physical Science 2025, DOI: 10.1016/j.xcrp.2025.102495.

2.Xiaoyu Wang, Lianshuai Ding, Yufen Zhao,* and Xiang Gao*. 6‑Plex Tandem Phosphorus Tags (TPT) for Accurate Quantitative Proteomics. Analytical Chemistry 2024, DOI: 10.1021/acs.analchem.4c01865.

3.Xingxing Liu, Yifan Wu, Lei Guo, Xiaoyu Wang, Changkai Shan, Yaru Liu, Hanxiang An, Xinmei Kang, Rong Ding, Zongwei Cai, Jiyang Dong*, Yufen Zhao*; Xiang Gao*. Comprehensive Profiling of Amine-Containing Metabolite Isomers with Chiral Phosphorus Reagents. Anal. Chem. 2023, 95, 46, 16830-16839.

4.Wang, C.; Chen, C. J.; Pan, Z. R.; He, Y. H.; Zhang, Z. M.; Liu, R. D.; Xue, Y. H.*; Zhou, Q.; Gao, X*. Quantitative Proteomics of the CDK9 Interactome Reveals a Function of the HSP90-CDC37-P-TEFb Complex for BETi-Induced HIV-1 Latency Reactivation. J. Proteome Res. 2023, 22, 9, 2880-2889.

5.Dong Huang, L.-S. D., Fang-Yu Yuan, Shu-Qi Wu, Han-Zhuang Weng, Xiao-Qing Tian, Gui-Hua Tang, Cheng-Qi Fan*, Xiang Gao*, Sheng Yin* Discovering a New Okadaic Acid Derivative, a Potent HIV Latency Reversing Agent from Prorocentrum lima PL11: Isolation, Structural Modification, and Mechanistic Study. Mar. Drugs 2023, 21 (158).

6.Wang, C.; He, F.; Sun, K.; Guo, K.; Lu, S.; Wu, T.*; Gao, X. *; Fang, M*. Identification and characterization of 7-azaindole derivatives as inhibitors of the SARS-CoV-2 spike-hACE2 protein interaction. Int J Biol Macromol 2023, 244, 125182.

7.Xiao-Yu Wang, Chun-Jing Chen, Yao-Hui He, Lian-Shuai Ding, Yi-Fan Wu,Cheng-Ting Huang, Jun Wu, Rong Ding, Yu-Hua Xue, Zhi-Wei Lin, Peng-Xiang Xu, Yi-Le Wu, Wen Liu, Ji-Jun Li, Si-Ming Chen, Yu-Fen Zhao, Ji-Yang Dong*, Qiang Zhou*, Xiang Gao*. Isobaric Stable Isotope N-Phosphorylation Labeling (iSIPL) for Ultrasensitive Proteome Quantification. Angew Chem Int Ed Engl 2023, e202303656. DOI: 10.1002/anie.202303656

8.Huanyi Fu, Rongdiao Liu, Zixuan Jia, Ran Li, Feifeng Zhu, Wenxuan Zhu, Yangqing Shao, Yiyang Jin, Yuhua Xue, Jun Huang, Kunxin Luo, Xiang Gao*, Huasong Lu*, Qiang Zhou*. Poly (ADP-ribosylation) of P-TEFb by PARP1 disrupts phase separation to inhibit global transcription after DNA damage. Nat Cell Biol 2022, 24 (4), 513-525. DOI: 10.1038/s41556-022-00872-5

9.Liu, X.; Li, Y.; Chen, C.; Dong, J.; Zhou, J.; Tong, D.; Wang, L.; Gao, X. *; Kang, X*. Exosomal EphA2 promotes tumor metastasis of triple-negative breast cancer by damaging endothelial barrier. Clin Exp Metastasis 2022. DOI: 10.1007/s10585-022-10194-3

E-mail: xgao@xmu.edu.cn