Lu Zhongxian, Ph.D

Professor, School of Pharmaceutical Sciences，Xiamen University
Director of Xiamen City Key Lab of Metabolic Disease

Experience:

Zhongxian Lu received his Ph.D degree in Physiology from China Agricultural University, Beijing, China. He had postdoctoral training with Dr. Yeguang Chen at University of California Riverside, USA, from 2000-2002. Then, Dr. Lu moved to University of California Irvine and worked as a postdoctoral fellow from 2002-2006, and later as an assistant project scientist at Dr. Bogi Andersen’s Lab. In 2007, Dr. Lu was employed as a professor in Institute for Biomedical Research & School of Pharmaceutical Sciences, Xiamen University, China.  

Research Interests:

Our research focuses on the identification of original molecular therapeutic targets by discovering the regulation of important proteins (such as Shp2, Gab2, EZH2) on the reproductive defects and diseases，metabolic diseases and cancer with transgenic animal model and disease animal model. We also screen and develop potential new drugs against these targets from nature product and chemical molecule.

Selected  Publications (last 5 years, * corresponding author):

1. Yinan Zhao#, Dandan Bai#, You Wu#, Dan Zhang, Mengying Liu, Yingpu Tian, Jinhua Lu, Haibin Wang*, Shaorong Gao*, Zhongxian Lu*. Maternal Ezh1/2 deficiency in oocyte delays H3K27me2/3 restoration and impairs epiblast development responsible for embryonic sub-lethality in mouse. Development,2022,149(15):dev200316

2. Xiaoli Wei, Lanping Zheng, Yingpu Tian, Haibin Wang, Youqiang Su, Gensheng Feng, Chao Wang*, Zhongxian Lu*. Tyrosine phosphatase SHP2 in ovarian granulosa cells balances follicular development by inhibiting PI3K/AKT signaling. Journal of Molecular Cell Biology，J Mol Cell Biol. 2022, 14(7):mjac048.

3. Shuai Chen#, Jianghong Cheng#, Yanhong Zhong, Ruimin Liu, Zhongxian Lu* and Xianyang Luo*. Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells. Oncogene, 2022, 41(24):3316-3327

4. Mengying Liu#, Wenbo Deng #, Lu Tang, Meng Liu, Haili Bao, Chuanhui Guo, Changxian Zhang, Jinhua Lu, Haibin Wang*, Zhongxian Lu*, Shuangbo Kong*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling. Nature Communications, 2022,13: 1006

5. Ruimin Liu#, Yan Sun#, Shuai Chen, Xinhui Wang, Yun Hong, Zhongxian Lu*. FOXD3 and GAB2 as a pair of rivals antagonistically control hepatocellular carcinogenesis. FEBS J, 2022, 289(15):4536-4548

6. Jianghong Cheng#, Jia Liang#, Yingzhe Li#, Xia Gao, Mengjun Ji, Mengying Liu, Yingpu Tian, Gensheng Feng, Wenbo Deng, Haibin Wang*, Shuangbo Kong* and Zhongxian Lu.* Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy. PLoS Genetics，2022，18(1): e1010018

7. You-Zhu Li#, Na Li#, Wen-Sheng Liu#, Yan-Wei Sha, Rong-Feng Wu, Ya-Ling Tang, Xing-Shen Zhu, Xiao-Li Wei, Xiao-Ya Zhang, Yi-Feng Wang, Zhong-Xian Lu*, Fu-Xing Zhang*. Biallelic mutations in spermatogenesis and centriole-associated 1 like (SPATC1L) cause acephalic spermatozoa syndrome and male infertility. Asian Journal of Andrology, 2022, 24(1): 67–72.

8. Liu Wensheng#, Zhao Yinan#, Liu Xiaohua#, Zhang Xiaoya, Ding Jiancheng, Li Yang, Tian Yingpu, Wang, Haibin*, Liu Wen*, Lu Zhongxian*. A Novel Meiosis-Related lncRNA, Rbakdn, Contributes to Spermatogenesis by Stabilizing Ptbp2. Frontiers in Genetics, 2021,12:1963

9. Xiaoli Wei#, Yanwei Sha#, Zijie Wei#, Xingshen Zhu, Fengming He, Xiaoya Zhang, Wensheng Liu*, Yifeng Wang*, Zhong-Xian Lu*. Bi-allelic mutations in DNAH7 cause asthenozoospermia by impairing the integrality of axoneme structure. Acta Biochimica et Biophysica Sinica, 2021, 53(10), 1300–1309

10. Xiaoli Wei#, Wensheng Liu#, Xingshen Zhu, Youzhu Li, Xiaoya Zhang, Jing Chen, Vladimir Isachenko, Yanwei Sha*, Zhongxian Lu*. Biallelic mutations in KATNAL2 cause male infertility due to oligo-astheno-teratozoospermia. Clinical Genetics, 2021;100：376-385

11. Xinhui Wang, Yinan Zhao, Dekun Zhou, Yingpu Tian, Gensheng Feng, Zhongxian Lu*. Gab2 deficiency suppresses high-fat diet-induced obesity by reducing adipose tissue inflammation and increasing brown adipose function in mice. Cell Death & Disease, 2021,12: 212.

12. Yang Li#, Wensheng Liu#, Jia Yi, Shuangbo Kong, Jiancheng Ding, Yinan Zhao, Yingpu Tian, Gen-Sheng Feng, Chaojun Li, Wen Liu*, Haibin Wang, and Zhongxian Lu*. The role of tyrosine phosphatase Shp2 in spermatogonial differentiation and spermatocyte meiosis.  Asian Journal of Andrology, 2020;22:79-87

13. Wensheng Liu#, Yanwei Sha#, Yang Li#, Libin Mei, Shaobin Lin, Xianjin Huang, Jinhua Lu, Lu Ding, Shuangbo Kong and Zhongxian Lu*. Loss-of-function mutations in SPEF2 cause multiple morphological abnormalities of the sperm flagella (MMAF). Journal of Medical Genetic, 2019, 56(10):678-684

14. Yang Li#, Yanwei Sha#, Xiong Wang#, Lu Ding#, Wensheng Liu, Zhiyong Ji, Libin Mei, Xianjing Huang, Shaobin Lin, Shuangbo Kong, Jinhua Lu, Weibing Qin, Xinzhong Zhang, Jianmin Zhuang*, Yunge Tang* and Zhongxian Lu*. DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella (MMAF). Clinical Genetics 2019; 95(5):590-600

Tel: +86-592-2187227

Fax: +86-592-2187227

Email:  zhongxian@xmu.edu.cn