Dr. Hua Song
Position: Associate Professor/Master's supervisor
Address: Room 251, School of Pharmaceutical Sciences,
Xiangan Campus of Xiamen University,
Xiangan South Road, Xiamen 361102, P.R. China
E-mail: songhua@xmu.edu.cn
Research Areas and Interests
Mainly focuses on the pharmaceutics interdisciplinary research areas:
1. Targeted release and controlled release of drug delivery;
2. New type of drug delivery system and frontier technology for pharmaceutical preparation.
Academic Experience
05/2013-Present Unit: School of Pharmaceutical Sciences,Xiamen University, Xiamen, China
Position: Associate Professor
Duty: Teaching & Scientific Research
05/2010-04/2013 Unit: Shanghai Jiao Tong University, Shanghai, China
Position: Lecturer
Duty: Teaching & Scientific Research
Research:New carriers for drug delivery
07/2007-05/2010 Unit: School of Materials Science and Engineering,Shanghai Jiao Tong University, Shanghai, China
Position: Post-doctoral researcher
Advisor: Prof. Daxiang Cui
Research: Study on block copolymer immunomicelles encapsulated with antineoplastic drug paclitaxel for tumor targeting therapy
Honors
1. Luyan Award of Xiamen University (2020);
2. The Third-class of Award of Shanghai Science and Technology Progress (2013);
3. Title of Morning Star Young Researcher of Shanghai Jiao Tong University (2011);
4. Postdoctoral Award of Shanghai Jiao Tong University (2011);
5. Outstanding Doctoral Graduate Award of Shanghai University of Traditional Chinese Medicine (2007);
6. Outstanding Ph.D. Award of Shanghai University of Traditional Chinese Medicine (2006);
7. Innovation Award of Huiren Group Corp. (2006);
Selected Publications
1. Huayu Yang#, Hua Song#(co-first author), Ziqin Suo, Funan Li, Quanyi Jin, Xuan Zhu, Qing Chen. A molecularly imprinted electrochemical sensor based on surface imprinted polymerization and boric acid affinity for selective and sensitive detection of P-glycoproteins.Analytica Chimica Acta, 2022, 1207,339797.
2. Pingyun Ge, Yuqing Liu, Qing Chen, Zaiji Su, Yuting Du, Shuting Luo, Xuemei Zhao, Xiufeng Cao*, Hua Song*(corresponding author), Xuan Zhu. Transferrin Receptors/Magnetic Resonance Dual-Targeted Nanoplatform for Precise Chemo-Photodynamic Synergistic Cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine, 2022, 39, 102467.
3. Lu Xu, Hua Song, Qi Qiu, Ting Jiang, Pingyun Ge, Zaiji Su, Wenhui Ma, Ran Zhang, Caihua Huang, Shanhua Li, Donghai Lin, Jiaxing Zhang. Different Expressions of HIF-1α and Metabolism in Brain and Major Visceral Organs of Acute Hypoxic Mice. International Journal of Molecular Sciences, 2021, 22(13), 6705.
4. Xiaoxue Wu, Xuemin Gao, Xinmei Liu, Shuyi Zhang, Huayu Yang, Xuan Zhu, Hua Song, Funan Li, Qing Chen. Quality Control of Psoralea corylifolia L. Based on High-Speed Countercurrent Chromatographic Fingerprinting. Molecules, 2020, 25(2), 279.
5. Dan Zhao#, Hua Song#(co-first author), Xinyi Zhou, Yilin Chen, Qiuhong Liu, Xuemin Gao, Xuan Zhu, Dengyue Chen. Novel facile thermosensitive hydrogel as sustained and controllable gene release vehicle for breast cancer treatment. European Journal of Pharmaceutical Sciences, 2019,134:145-152.
6. Qing Chen, Xiaoxue Wu, Xuemin Gao, Hua Song*(corresponding author), Xuan Zhu*. Development and Validation of an Ultra-Performance Liquid Chromatography Method for the Determination of Wedelolactone in Rat Plasma and its Application in a Pharmacokinetic Study. Molecules, 2019, 24(4), 762.
7. Xiaoxue Wu, Xuemin Gao, Xuan Zhu, Shuyi Zhang, Xinmei Liu, Huayu Yang, Hua Song*(corresponding author), Qing Chen*. Fingerprint Analysis of Cnidium monnieri (L.) Cusson by High-Speed Counter-Current Chromatography. Molecules, 2019,24(24), 4496.
8. Dan Zhao, Qing Chen, Hua Song*(corresponding author), Shuting Luo, Pingyun Ge, Yingjun Wang,Jinyuan Ma, Zhi Li, Xuemin Gao, Xuemei Zhao, Xiayiding Subinuer, Huayu Yang, Xiaojuan Jiang, Yanxin Chen, Xuan Zhu. Theranostic micelles combined with multiple strategies toeffectively overcome multidrug resistance. Nanomedicine, 2018, 13(13):1517-1533.
9. Qing Chen, Hongjian Lin, Xiaoxue Wu, Hua Song*(corresponding author), Xuan Zhu*. Preparative separation of six terpenoids from Wedelia prostrata Hemsl. by two-step high-speed counter-current chromatography. Journal of Liquid Chromatography & Related Technologies. 2018,41(7):408-414.
10. Qing Chen, Lichao Diao, Hua Song, Xuan Zhu. Vitis amurensis Rupr: A review of chemistry and pharmacology, Phytomedicine. 2018, 49: 111-122.
11. Jing Wang#, Hua Song#(co-first author), Xiaoxue Wu, Shuyi Zhang, Xuemin Gao, Funan Li, Xuan Zhu, Qing Chen. Steroidal Saponins from Vernonia amygdalina Del. and Their Biological Activity. Molecules, 2018, 23(3):579.
12. Guihua Liu, Jinyuan Ma, Yang Li, Qi Li, Chunhua Tan, Hua Song, Shuhui Cai, Dengyue Chen, Zhengqing Hou, Qing Chen, Xuan Zhu, Core-interlayer-shell Fe3O4@mSiO2@lipid-PEG- methotrexate nanoparticle for multimodal imaging and multistage targeted chemo-photodynamic therapy. International Journal of Pharmaceutics, 2017, 521(1-2):19-32.
13. Hua Song, Jianhong Lin, Xuan Zhu, Qing Chen. Developments in high-speed countercurrent chromatography and its applications in the separation of terpenoids and saponins.Journal of Separation Science, 2016, 39(8):1574-1591.
14. Guo Gao, Qiang Zhang, Kan Wang, Hua Song, Peiyu Qiu, Daxiang Cui. Axial compressive α-Fe2O3 microdisks prepared from CSS template for potential anode materials of lithiumion batteries. Nano Energy, 2013, 2(5): 1010–1018.
15. Guo Gao, Peiyu Qiu, Qirong Qian, Na Zhou, Kan Wang, Hua Song, Hualin Fu, Daxiang Cui. PEG-200-assisted hydrothermal method for the controlled-synthesis of highly dispersed hollow Fe3O4 nanoparticles. Journal of Alloys and Compounds, 2013, 574(15): 340–344.
16. Jing Ruan, Hua Song, Qirong Qian, Chao Li, Kan Wang, Chenchen Bao, Daxiang Cui. HER2 monoclonal antibody conjugated RNase-A-associated CdTe quantum dots for targeted imaging and therapy of gastric cancer, Biomaterials, 2012, 33(29): 7093–7102.
17. Ping Sun, Hua Song*(corresponding author), Daxiang Cui, Jun Qi, Mousheng Xu, Hongquan Geng. Preparation and optimization of matrix metalloproteinase-1-loaded poly (lactide-co-glycolide-co-caprolactone) nanoparticles with rotatable central composite design and response surface methodology. Nanoscale Research Letters, 2012, 7:359.
18. Xia Peng, Juan Wang, Hua Song*(corresponding author), Daxiang Cui, Li Li, Jia Li, Lihui Lin, Juan Zhou, Yanan Liu. Optimized Preparation of Celastrol-loaded Polymeric Nanomicelles Using Rotatable Central Composite Design and Response Surface Methodology. Journal of Biomedical Nanotechnology, 2012, 8:1-9.
19. Jing Ruan, Jiajia Ji, Hua Song, Qirong Qian, Kan Wang, Can Wang, Daxiang Cui. Fluorescent magnetic nanoparticles-labeled mesenchymal stem cells for targeted imaging and hyperthermia therapy of gastric cancer. Nanoscale Research Letters, 2012, 7:309.
20. Jing Ruan, Hua Song, Chao Li, Chenchen Bao, Hualin Fu, Kan Wang, Jian Ni, Daxiang Cui. DiR-labeled Embryonic Stem Cells for Targeted Imaging of in vivo Gastric Cancer Cells. Theranostics, 2012,2(6): 618-628.
21. Hongquan Geng#, Hua Song1#*(co-first author and corresponding author), Jun Qi, Daxiang Cui. Sustained release of VEGF from PLGA nanoparticles embedded thermo-sensitive hydrogel in full-thickness porcine bladder acellular matrix. Nanoscale Research Letters, 2011, 6 (1):312.
22. Hua Song, Hongquan Geng, Jing Ruan, Kan Wang, Chenchen Bao, Juan Wang, Xia Peng, Xueqing Zhang, Daxiang Cui. Development of Polysorbate 80/Phospholipid mixed micellar formation for docetaxel and assessment of its in vivo distribution in animal models. Nanoscale Research Letters, 2011, 6 (1):354.
23. Hengguang Yuan, Shanglian Hu, Peng Huang, Hua Song, Kan Wang, Jing Ruan, Rong He, Daxiang Cui. Single Walled Carbon Nanotubes Exhibit Dual-Phase Regulation to Exposed Arabidopsis Mesophyll Cells. Nanoscale Research Letters, 2011, 6 (44):1-9.
24. Jing Ruan, Kan Wang, Hua Song, Xin Xu, Jiajia Ji, Daxiang Cui. Biocompatibility of hydrophilic silica-coated CdTe quantum dots and magnetic nanoparticles. Nanoscale Research Letters, 2011, 6:299.
25. Hua Song, Xiufeng Cao, Jing Ruan, Xia Peng, Juan Wang, Can Wang, Chenchen Bao. Application of rotatable central composite design in the preparation and optimization of poly(lactic-co-glycolic acid) nanoparticles for controlled delivery of HSA. Nano Biomedicine and Engineering, 2011, 3 (1):34-41.
26. Jing Ruan, Jie Shen, Zheng Wang, Jiajia Ji, Hua Song, Kan Wang, Bin Liu, Jinhui Li, Daxiang Cui. Efficient preparation and labeling of human induced pluripotent stem cells by nanotechnology. International Journal of Nanomedicine, 2011, 6:425-435.
27. Kan Wang, Jing Ruan, Qirong Qian, Hua Song, Chenchen Bao, Xueqing Zhang, Yifei Kong, Chunlei Zhang, Guohan Hu. BRCAA1 monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo targeted magnetofluorescent imaging of gastric cancer. Journal of Nanobiotechnology, 2011, 9 (1):23.
28. Hua Song, Rong He, Kan Wang, Jing Ruan, Chenchen Bao, Na Li, Jiajia Ji, Daxiang Cui. Anti-HIF-1 Antibody-conjugated Pluronic Triblock Copolymers encapsulated with Paclitaxel for tumor targeting therapy. Biomaterials, 2010, 31(8):2302-2312.
29. Kan Wang, Jing Ruan, Hua Song, Jiali Zhang, Yan Wo, Shouwu Guo, Daxiang Cui. Biocompatibility of Graphene Oxide. Nanoscale Research Letters, 2010, 6 (8).
30. Jing Ruan, Jie Shen, Hua Song, Jiajia Ji, Kan Wang, Daxiang Cui, Zheng Wang. Viability and pluripotency studying of human embryo stem cells labeled with quantum dots. Nano Biomedicine and Engineering, 2010, 2 (4):245-251.
31. Chenchen Bao, Hao Yang, Ping Sheng, Juxiang Chen, Hua Song, Xuehua Ding, Bin Liu, YichengLu, Guohan Hu, Daxiang Cui. Cloning, Expression, Monoclonal Antibody Preparation of Human Gene NBEAL1 and Its Application in Targeted Imaging of Mouse Glioma. Nano Biomedicine and Engineering, 2009, 1(1):50-56.
32. Daxiang Cui, Yuedong Han, Zhiming Li, Hua Song, Kan Wang, Rong He, Bing Liu, Heliang Liu, Chenchen Bao, Peng Huang, Jin Ruan, Feng Gao, Hao Yang, Hoon Sung Cho, Qiushi Ren, Donglu Shi. Fluorescent Magnetic Nanoprobes for in vivo Targeted Imaging and Hyperthermia Therapy of Prostate Cancer. Nano Biomedicine and Engineering, 2009, 1(1):94-112.
Patents
1. Hua Song, Daxiang Cui, Rong He, Feng Gao. A carboxylation method of polyethylene-polypropylene- polyethylene block copolymer, Chinese National Invention Patent, Application No.: 200810038537.1 (Authorized).
2. Hua Song, Daxiang Cui, Feng Gao, Rong He. A preparation method of amino acid functioned PAMAM dendrimer, Chinese National Invention Patent, Application No.: 200810042488.9 (Authorized).
3. Hua Song, Daxiang Cui, Rong He, Feng Gao. A preparation method of targeted drug copolymer micelle delivery system, Chinese National Invention Patent, Application No.: 200910046344.5(Issued).
