Wenjing Tian, Ph.D.
Assistant Professor
Experience
2017.12-now Assistant Professor, School of Pharmaceutical Sciences, Xiamen University
2015.11-2017.12 Postdoctoral Fellow, School of Pharmaceutical Sciences, Xiamen University
2010.09-2015.07 PhD, College of Chinese Medicine, Natural product chemistry, Shenyang Pharmaceutical University
Research
Our research focus on the active constituents from natural products and their mechanism of action, especially for the polycyclic polyprenylated acylphloroglucinols (PPAPs). PPAPs are a structurally intriguing class of natural products, which featured a highly oxygenated acylphloroglucinol coresadorned with prenyl or geranyl side chains. Secondary cyclization of the decorated prenyl or geranyl groups led to a series of complex caged novel structures. We are interested in the discovering of PPAPs with novel structures, the mechanism of active PPAPs and the structure activity relationship.
Selected Publications (last 5 years):
1. Wen-Jing Tian,* Mi Zhou, Da-Ren Qiu, Jun-Jie Chen, Xiang-Zhong Liu, Jing-Dian Li, Ting Lin, Guang-Hui Wang, Haifeng Chen* Seco-polyprenylated acylphloroglucinols from Hypericum elodeoides induced cell cycle arrest and apoptosis in MCF-7 cells via oxidative DNA damage. Bioorganic Chemistry 2022,128, 106088.
2. Xiangzhong Liu, Renjing Yang, Qiannan Xu, Mi Zhou, Jie Feng, Guanghui Wang, Ting Lin, Wenjing Tian*, Haifeng Chen*. Tautomeric phytosterols from Vernonia amygdalina Delile and their anti-cervical cancer activity. Bioorganic Chemistry 2022,128, 106068.
3. Jie Feng, Fengming He, Yuhui Huang, Mi Zhou, Xiangzhong Liu, Xiansheng Ye, Renjing Yang, Wenjing Tian* and Haifeng Chen*. Inhibitory effects of phenolic glycosides from Trollius chinensis Bunge on α-glucosidase: inhibition kinetics and mechanisms. Food Function, 2022, 13, 2857.
4. Xiangzhong Liu, Mi Zhou, Shoulun He, Qiannan Xu, Chunchun Du, Honghong Zhu, Ting Lin, Guanghui Wang, Wenjing Tian* and Haifeng Chen*. Polyhydric Stigmastane-Type Steroids Derivative from Vernonia amygdalina and Their Anti-Neuroinflammatory Activity. Pharmaceuticals 2022, 15, 1160.
5. Renjing Yang, Chunchun Du, Ting Cao, Guanghui Wang, Xin Jiang, Jun Gao, Ting Lin, Cuiling Sun,Rong Ding, Wenjing Tian* and Haifeng Chen* Synthesis and Anti-Hepatoma Activities of U12 Derivatives Arresting G0/G1 Phase and Inducing Apoptosis by PI3K/AKT/mTOR Pathway. Pharmaceuticals, 2022, 15, 107.
6. Xiangzhong Liu, Wenjing Tian*, Mi Zhou, Qiannan Xu, Jie Feng, Renjing Yang, Shoulun He,Guanghui Wang, Ting Lin, Haifeng Chen*. Bisabolane-type sesquiterpenes from Vernonia amygdalina: Absolute configuration and anti-inflammatory activity. Phytochemistry, 2022, 201 113283.
7. Daren Qiu, Mi Zhou, Xiangzhong Liu, Junjie Chen, Guanghui Wang, Ting Lin, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Cytotoxic polyprenylated phloroglucinol derivatives from Hypericum elodeoides Choisy modulating the transactivation of RXRα. Bioorganic Chemistry, 2021, 107,104578.
8. Xiang-Zhong Liu, Mi Zhou, Chun-Chun Du, Hong-Hong Zhu, Xi Lu, Shou-Lun He, Guang-Hui Wang, Ting Lin, Wen-Jing Tian* and Hai-Feng Chen* Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response. Biomedicines 2021, 9, 1473.
9. Yanlan Yang#, Mi Zhou#, Dongni Wang, Xiangzhong Liu, Xiansheng Ye, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk 1Pathway. Journal of Natural Products, 2021, 82:339-351.
10. Xiansheng Ye#, Wenjing Tian#, Mi Zhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xinsheng Yao*, Haifeng Chen*. Prenylated flavonoids from Ficus hirta induces HeLa cells apoptosis via MAPK and AKT signaling pathways. Bioorg. Med. Chem. Lett. 2021, 38: 127859.
11. Xiansheng Ye#, Wenjing Tian#, Xiangzhong Liu, Mi Zhou, Dequan Zeng, Ting Lin, Guanghui Wang, Xinsheng Yao*, Haifeng Chen*. Lignans and phenylpropanoids from the roots of Ficus hirta and their cytotoxic activities. Natural Product Research. 2021, 1892099
12. Xiansheng Ye#, Wenjing Tian#, Guanghui Wang, Xian Zhang, Mi Zhou, Dequan Zeng, Xiangzhong Liu, Xinsheng Yao*, Yunwu Zhang*, and Haifeng Chen*.Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities. Journal of Agricultural and Food Chemistry. 2020, 68: 4196-4204.
13. Daren Qiu, Mi Zhou, Junjie Chen, Guanghui Wang, Ting Lin, Yujie Huang, Furong Yu, Rong Ding, Cuiling Sun, Wenjing Tian*, Haifeng Chen*. Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα. Phytochemistry, 2020, 170, 112216.
14. Jie Feng#, Danyang Zhao#, Qiannan Xu, Xiangzhong Liu, Mi Zhou, Xiansheng Ye, Ting Lin, Guanghui Wang, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. A new phenolic glycoside from Trollius chinensis Bunge with anti-inflammatory and antibacterial activities. Natural Product Research. 2020, doi.org/10.1080/14786419.2020.1855166.
15. Qiannan Xu, Dan Zhu, Guanghui Wang, Ting Lin, Cuiling Sun, Rong Ding, Wenjing Tian*, Haifeng Chen*. Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum. Natural Product Research, 2020, doi.org/10.1080/14786419.2020.1739044
16. Shuo Gao#, Wenjing Tian#, Zujian Liao, Guangjui Wang, Dequan Zeng, Xiangzhong Liu, Xiaoyao Wang, Hu Zhou, Haifeng Chen*, and Ting Lin*. Chemical Constituents from Endophytic Fungus Annulohypoxylon cf. stygium in Leaves of Anoectochilus roxburghii. Chemistry &Biodiversity, 2020, 17, 9.
17. Daren Qiu, Mi Zhou, Ting Lin, Junjie Chen, Guanghui Wang, Yujie Huang, Xin Jiang, Wenjing Tian*, Haifeng Chen*. Cytotoxic Components from Hypericum elodeoides Targeting RXRα and Inducing HeLa Cell Apoptosis through Caspase-8 Activation and PARP Cleavage. Journal of Natural Products, 2019, 82(5):1072-1080.
18. Xiangzhong Liu#, Wenjing Tian#, Guanghui Wang, Qiannan Xu, Mi Zhou, Shuo Gao, Daren Qiu, Xin Jiang, Cuiling Sun, Rong Ding, Ting Lin*, Haifeng Chen*.Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina. Phytochemistry, 2019, 158: 67-76.
Email: tianwj@xmu.edu.cn
