王雅蓁助理教授，硕士生导师
个人简介：
王雅蓁博士长期致力于肿瘤免疫治疗与超分子纳米递药系统的研究。其研究聚焦于肿瘤免疫治疗相关靶点的蛋白质靶向降解分子的设计与递送，以提高药物分子的成药性及靶向性。相关成果发表在Science Advances, Advanced Science等国际学术期刊。
教育及工作经历：
2025/7-今，厦门大学，药学院，助理教授
2021/09-2025/06，四川大学，生物医学工程学院，博士
2018/09-2021/06，四川大学，华西药学院，硕士
研究方向：
1. 超分子纳米递药系统的设计、合成与评价
2. 靶向蛋白降解分子的靶向递送
代表性论文：
[1]. Yazhen Wang, Lianyi Yang, Chenxing Yan, Yufan Du, Tinghua Li, Wenqing Yang, Lei Lei, Bin He, Huile Gao *, Nicholas A. Peppas, Jun* Cao. Supramolecular artificial Nano-AUTACs enable tumor-specific metabolism protein degradation for synergistic immunotherapy. Sci Adv, 2024, 10(25): eadn8079.
[2] Yazhen Wang, Yang Zhou, Lianyi Yang, Lei Lei, Bin He, Jun Cao*, Huile Gao*. Challenges coexist with opportunities: spatial heterogeneity expression of PD-L1 in cancer therapy. Adv Sci, 2024,11(1):2303175.
[3] Yazhen Wang, Huilin Zhang, Wei Xiao, Yuwei Liu, Yang Zhou, Xueqin He, Xue Xia, Tao Gong, Ling Wang*, Huile Gao*. Unmasking CSF protein corona: effect on targeting capacity of nanoparticles. J Control Release, 2021, 333: 352-361.
[4] Lianyi Yang, Yazhen Wang, Yujun Song, Zeya Li, Lei Lei, Hanmei Li, Bin He, Jun Cao*, Huile Gao*. Metal coordination nanotheranostics mediated by nucleoside metabolic inhibitors potentiate STING pathway activation for cancer metalloimmunotherapy. J Control Release, 2024, 370: 354-366.
[5] Wei Xiao, Yazhen Wang, Huilin Zhang, Yuwei Liu, Rou Xie, Xueqin He, Yang Zhou, Luqing Liang, Huile Gao*. The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood–brain barrier and attenuates their targeting ability to brain tumor. Biomaterials, 2021, 274: 120888.
联系方式：
邮箱：wangyazhen@xmu.edu.cn
