夏琳博士
厦门市高层次留学人才
福建省高层次人才
个人简介：
夏琳，2010-2015年博士就读于厦门大学生命科学学院，并于2016-2018年厦门大学公共卫生学院以及德克萨斯州立大学休斯顿健康科学中心进行博士后研究，现任药学院刘文课题组助理教授。主要从事肿瘤免疫治疗靶点的开发、分子机制及其特异性靶向抗体、CAR-T在内的治疗策略研究，并结合表观遗传学探索肿瘤发生发展的分子机制，以增强肿瘤的免疫治疗效果。相关成果发表于Nature Cancer，Cellular & Molecular Immunology，Nucleic Acids Research等期刊，授权发明专利4项，主持国家自然科学基金面上项目和青年项目及多个省自然科学基金项目等，作为项目骨干参与国家重点研发计划项目；担任国家自然科学基金项目评审，SCI期刊审稿人，福建省预防医学会预防与专业委员会委员，厦门市药学会药物监测与评价专业委员会委员等。
研究方向：
1、肿瘤免疫治疗新靶点的开发、机制及其靶向抗体及CAR-T等免疫治疗策略研究。
2、表观遗传调控因子在肿瘤免疫治疗中的功能及分子机制研究；
代表性论文（#第一作者，*通讯作者）：
1、Lin Xia#*, Jun-yi Liu#, Chao Yu#, Hong-wei Lin, Ya-hong Hu, Guo-sheng Hu, Yao-hui He, Yun-yao Chen, Wen-xin Luo*, Ning-shao Xia*, Wen Liu*. PILRα on tumor cells interacts with the T cell surface protein CD99 to suppress antitumor immunity. Nature Cancer. 2025 May 1.doi: 10.1038/s43018-025-00958-7.
2、Lin Xia#，Lun-zhi Yuan#, Ya-hong Hu#, Jun-yi Liu#, Guo-sheng Hu#, Ruo-yao Qi, Tian-ying Zhang, Hua-long Xiong, Zao-zao Zheng, Hong-wei Lin, Jia-mo Zhang, Chao Yu, Ming Zhou, Jian Ma, Tong Cheng, Ri-rong Chen, Yi Guan, Ning-shao Xia* and Wen Liu*. A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19. Cellular & Molecular Immunology. 2023 Apr;20(4):351-364.
3、Zao-zao Zheng#, Lin Xia#, Guo-sheng Hu#, Jun-yi Liu, Ya-hong Hu, Yu-jie Chen, Jia-yin Peng, Wen-juan Zhang*, and Wen Liu* Super-enhancer-controlled positive feedback loop BRD4/ERα-RET-ERα promotes ERα-positive breast cancer. Nucleic Acids Research. 2022 Oct 14;50(18):10230-10248.
4、Xia Lin#, Liu JY#, Zheng ZZ#, Chen YJ#, Ding JC#, Hu YH, Hu GS, Xia NS, Liu W*. BRD4 inhibition boosts the therapeutic effects of epidermal growth factor receptor-targeted chimeric antigen receptor T cells in glioblastoma. Molecular Therapy. 2021 Oct 6;29(10):3011-3026.
5、Xia Lin#, Zheng Z#, Liu JY#, Chen YJ#, Ding J#, Hu GS, Hu YH, Liu S, Luo WX, Xia NS, Liu W*. Targeting Triple-Negative Breast Cancer with Combination Therapy of EGFR CAR T Cells and CDK7 Inhibition. Cancer Immunology Research. 2021 Jun;9(6):707-722.
6、Xia Lin#, Zheng ZZ#, Liu JY#, Chen YJ#, Ding JC#, Xia NS, Luo WX*, Liu W*. EGFR-targeted CAR-T cells are potent and specific in suppressing triple-negative breast cancer both in vitro and in vivo. Clinical & Translational Immunology. 2020 May 3;9(5):e01135.
7、Zhou B#, Xia Lin#, Zhang T, You M, Huang Y, He M, Su R, Tang J, Zhang J, Li S, An Z, Yuan Q, Luo W*, Xia N*. Structure guided maturation of a novel humanized anti-HBV antibody and its preclinical development. Antiviral Research. 2020 Aug;180:104757.
8、Lin Xia#，Ruopeng Su#，Zhiqiang An，Tong-Ming Fu & Wenxin Luo*，Human cytomegalovirus vaccine development: Immune responses to look into vaccine strategy.，Human Vaccines & Immunotherapeutics，2018，14（2）：292-303.
9、Ciming Kang#，Lin Xia#，Yuanzhi Chen，Tianying Zhang，Yiwen Wang，Bing Zhou，Min You，Quan Yuan，Chi-Meng Tzeng，Zhiqiang An，Wenxin Luo*，Ningshao Xia，A novel therapeutic anti-HBV antibody with increased binding to human FcRn improves in vivo PK in mice and monkeys.，Protein & Cell，2018，9（1）：130-134.
10、Xia Lin#, Tang A#, Meng W#, Freed DC, He L, Wang D, Li F, Li L, Xiong W, Gui X, Schultz RD, Chen H, He X, Swoyer R, Ha S, Liu Y, Morris CD, Zhou Y, Wang IM, Zhao Q, Luo W, Xia N, Espeseth AS, Hazuda DJ, Rupp RE, Barrett AD, Zhang N, Zhu J, Fu TM, An Z. Active evolution of memory B-cells specific to viral gH/gL/pUL128/130/131 pentameric complex in healthy subjects with silent human cytomegalovirus infection. Oncotarget. 2017 Jun 3;8(43):73654-73669.
11、Xia, Lin#，Xian, Yangfei#，Wang, Daning，Chen, Yuanzhi，Huang, Xiaofen，Bi, Xingjian，Yu, Hai，Fu, Zheng，Liu, Xinlin，Li, Shaowei，An, Zhiqiang，Luo, Wenxin*，Zhao, Qinjian*，Xia, Ningshao，A human monoclonal antibody against HPV16 recognizes an immunodominant and neutralizing epitope partially overlapping with that of H16.V5.，Scientific Reports，2016，6：19042-19042.
12、Xia, Lin#，Zhang, Juan#，Cui, Chuanjia，Bi, Xingjian，Xiong, Junhui，Yu, Hai，An, Zhiqiang，Luo, Wenxin*，Xia, Ningshao，In vitro affinity maturation and characterization of anti-P24 antibody for HIV diagnostic assay.，J Biochem，2015，158（6）：531-538.
13、Freed, Daniel C(#)，Tang, Qi，Tang, Aimin，Li, Fengsheng，He, Xi，Huang, Zhao，Meng, Weixu，Xia, Lin，Finnefrock, Adam C，Durr, Eberhard，Espeseth, Amy S，Casimiro, Danilo R，Zhang, Ningyan，Shiver, John W，Wang, Dai，An, Zhiqiang，Fu, Tong-Ming，Pentameric complex of viral glycoprotein H is the primary target for potent neutralization by a human cytomegalovirus vaccine.，Proc Natl Acad Sci U S A，2013，110（51）：E4997-E5005.
14、Zheng Qingbing#; Xia Lin#; Wu Wai Lan; Zheng Zhenhua; Huo Yongting; Wu Jun; Liu Yanning; Yu Hai; Chen Yixin; Lau Siu Ying; Chen Honglin*; Luo Wenxin*; Xia Ningshao, Properties and Therapeutic Efficacy of Broadly Reactive Chimeric and Humanized H5-Specific Monoclonal Antibodies against H5N1 Influenza Viruses, Antimicrobial Agents and Chemotherapy, 2011, 55(4): 1349~1357.
招聘:本课题组诚招博士后，博士及硕士研究生（长期有效）
联系方式:
电子邮箱：xialin@xmu.edu.cn
地址：福建省厦门市翔安区翔安南路厦门大学翔安校区药学院223室
邮编：361102
