李明玉教授 博士生导师
福建省高层次引进人才（2017）
福建省高层次人才（2021）
个人简介：
李明玉博士主要研究方向为糖尿病疾病机理及药物开发、海洋药物的筛选和作用机理等研究工作。研究围绕斑马鱼、小鼠、细胞系为模型；应用高通量药物筛选技术、组学技术、活体成像技术、现代分子生物学技术等手段。至今在Cell Metabolism, Nature Communications, Science Advances, Diabetes等国际主流杂志共发表文章70多篇。现为Frontiers in Endocrinology、药学研究等刊物编委，受邀为eLife, Phytomedicine等20多个杂志审稿人。先后主持国家自然基金面上项目、福建省科技计划对外合作项目、厦门大学校长基金、漳州片仔癀药业横向课题等30多个项目。
教育与工作经历：
1999-2003中国海洋大学本科（生物技术）
2003-2006中国海洋大学硕士（细胞生物学）
2006-2010中国海洋大学博士（药物化学）
2010-2011国家海洋局第三海洋研究所 助理研究员
2011-2016美国范德堡大学（Vanderbilt University）博士后
2016-2024厦门大学药学院 副教授
2024-至今 厦门大学药学院 教授
主要研究方向：
1. 胰岛α细胞及胰高血糖素信号通路的分子调控机理;
2. 胰岛α细胞在糖尿病中的功能调控
3. 促胰岛β细胞再生药物的研究和开发;
4. 糖尿病模型的构建及抗糖尿病药物的筛选;
5. 降血糖药物的功能评价;
6. 海洋药物筛选及作用机理;
学术兼职：
《Frontiers in Endocrinology》副主编（Experimental Section）；
中国药理学会内分泌与代谢分会常务委员；
中国药理学会海洋药物药理专业委员会副秘书长；
厦门市药学会医药教育分会副主任委员。
科研项目：
1. 国家自然科学基金面上项目, 82470841, 拮抗胰高血糖素受体导致胰岛α细胞高分泌胰高血糖素的分子机制研究, 2025.1-2028.12，在研，主持。
2. 国家自然科学基金面上项目, 81670709, 表皮生长因子受体（ErbB）家族在胰岛α-细胞增生中的作用机理研究, 2017.1-2020.12，结题，主持。
3. 福建省科技计划对外合作项目，2023I0002，1型糖尿病发生过程中α-细胞的病理生理学与功能研究，2023.1-2025.12, 结题，主持。
4. 福建省自然科学基金面上项目，2017J01145，利用斑马鱼进行药物筛选寻找抑制α-细胞增生的因子，2017.4-2020.4，结题，主持。
5. 厦门市自然科学基金面上项目, 3502Z20227162, 海洋源促胰岛β细胞再生化合物的筛选和药理学研究，2022.7-2025.6, 结题，主持。
6. 厦门大学校长基金，20720170104，斑马鱼α-细胞增生高通量药物筛选模型的建立及其应用，2017.1-2017.12，结题，主持。
7. 厦门大学校长基金，20720180044，斑马鱼高血糖模型的构建和药物筛选，2018.1-2018.12，结题，主持。
8. 海洋药物教育部重点实验室开放基金，海洋源吲哚二萜类化合物促胰岛α细胞向β细胞转分化的药理学研究，2023.7-2025.7, 结题，主持。
近5年发表的论文（* 通讯作者；#共同一作）：
2026
1. Li, Z#., Wu, X#., Ma, S#., Zeng, Q., Wang, X., Xi, Q., Jin, Q. W., Jie, Z*., Wong, F. S*., and Li, M*. (2026) Pancreatic alpha cells function as MHC class II-dependent antigen-presenting cells in type 1 diabetes. Sci Adv 12, eaei0410
2. Deng, L., Deng, T., Deng, Y., Zhang, T., Guo, J., Wang, X., Wu, X., and Li, M*. (2026) Mosloflavone induces pancreatic alpha cells transdifferentiation into beta cells through PDX1. J Nat Med 80, 156-171
3. Bai, X., Zhang, T., Zhang, C*., and Li, M*. (2026) Glucagon receptor deficiency is associated with glucocorticoid receptor activation and proteolytic remodeling in gastrocnemius of male mice. Am J Physiol Endocrinol Metab 331, E425-E438
4. Zhang, W#., Li, Z#., Qiu, Y., Yu, Z., Liu, S., Liu, X., Niu, W., Xiao, J., Wu, Z*., and Li, M*. (2026) Extract from crown-of-thorns starfish promotes zebrafish caudal fin regeneration by inhibition of neutrophil migration. PeerJ 14, e20863
5. Zhao, L#., Wang, L#., Aierken, R., Zeng, Q., Tan, Y., Zhang, Y., Zeng, Q., Wang, X*., and Li, M*. (2026) Identification of insulin and glucagon genes in the finless porpoise and the developmental distribution of their producing endocrine cells. Front Endocrinol (Lausanne) 17, 1777351
6. Zhang, Y., Lu, G., Xie, W., Xu, P., Liu, C., Babosova, O., Reilly, J. C., Li, Z., Chen, L., Zhou, L., Gao, J., Enders, L., Xiong, X., Li, M., Kubicek, S., Zhao, B., Feng, Z., Yu, B., Zhou, L., Huang, H., and Li, J. (2026) Metabolic reprogramming drives pancreatic beta cell neogenesis from alpha cells. Nat Chem Biol
2025
1. Jia, J., Bai, X., Kang, Q., Jiang, F., Wong, F. S., Jin, Q*., and Li, M*. (2025) Blockade of glucagon receptor induces alpha-cell hypersecretion by hyperaminoacidemia in mice. Nat Commun 16, 2473
2. Jia, J., Li, Z., Zhao, L*., and Li, M*. (2025) Glucagon receptor antagonism requires further mechanistic attention on alpha-cell physiology. Trends Endocrinol Metab 36(9), 785-788
3. Li, Z., Wu, X., Kang, Q., Ren, Q., Zhang, Y., Zhang, Y., Jin, Q., Wong, F. S*., and Li, M*. (2025) Alpha cells transdifferentiate into delta cells during the progression of autoimmunity in nondiabetic NOD mice. Am J Physiol Endocrinol Metab 329, E692-E706
4. Yu, Z., Zhang, Y., Wang, W., Wu, X., Liu, S., Bin, Y., Li, H., Cai, B., Wang, Z., Fang, M., Qi, R., Li, M*., and Qiu, Y*. (2025) Novel araucarene diterpenes from Agathis dammara exert hypoglycemic activity by promoting pancreatic beta cell regeneration and glucose uptake. Chin J Nat Med 23, 492-503
5. Wang, L. K., Kong, C. C., Yu, T. Y., Sun, H. S., Yang, L., Sun, Y., Li, M. Y*., and Wang, W*. (2025) Endoplasmic reticulum stress and forkhead box protein O1 inhibition mediate palmitic acid and high glucose-induced beta-cell dedifferentiation. World J Diabetes 16, 95431
2024
1. Kang Q, Jia J, Dean ED, Yuan H, Dai C, Li Z, Jiang F, Zhang XK, Powers AC, Chen W*, Li M*. (2024) ErbB3 is required for hyperaminoacidemia induced pancreatic α cell hyperplasia. J Biol Chem, 107499.
2. Xiang, P., Bai, X., Xing, B., Li, J., Zhang, C., and Li, M*. (2024) Full-length transcriptome annotation of a pyrosome, Pyrosoma atlanticum (Chordata, Thaliacea). Sci Data 11, 1433
3. Yu, Z. W., Cai, B. P., Xie, S. Z., Zhang, Y., Wang, W. H., Liu, S. Z., Bin, Y. L., Chen, Q., Fang, M. J., Qi, R., Li, M. Y*., and Qiu, Y. K*. (2024) Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others. Nat Prod Bioprospect 14, 23.
4. Wang, Z., Yu, Z. W., Zhang, Y., Wang, W. H., Wu, X. Y., Liu, S. Z., Bin, Y. L., Cai, B. P., Huang, S. Y., Fang, M. J., Qi, R., Li, M. Y. *, and Qiu, Y. K*. (2024) Hinokione: an abietene diterpene with pancreatic beta cells regeneration and hypoglycemic activity, and other derivatives with novel structures from the woods of Agathis dammara. J Nat Med.
5. Wu, Y., Ma, F., Yu, L., Lin, R., Lin, S., Guo, Z., Zhou, M., Li, M., Zhang, Y., and Xie, J. (2024) Unique Advantages of Dendrimers-Structured Mesoporous Silica Nanoparticles over Traditional Hollow Ones in Delivering Bcl2-Functional Converting Peptide for Multidrug Resistant Cancer Treatment. Adv Healthc Mater, e2400888.
6. Chen, S., Peng, H., Zhuang, H., Wang, J., Yan, P., Zhang, W., Zheng, W., Li, M., and Wu, X. (2024) Optimized strategy to improve the outcomes of acute type A aortic dissection with malperfusion syndrome. J Thorac Cardiovasc Surg
2023
1. Yuan H., Kang Q., Li Z., Bai X., Jia J., Han D., Wu X.*, Li M. * (2023) Crispr-Cas9 mediated complete deletion of glucagon receptor in mice display hyperglucagonemia and α-cell hyperplasia. Biochem Biophys Res Commun. 643: 121-128.
2. Gao, S., Lin, X., Shi, Y., Zhou, H., Zheng, X., Li, M*., and Lin, T*. (2023) A New Hypoglycemic Prenylated Indole Alkaloid N-Oxide from Endophytic Fungus Pallidocercospora crystalline. Int J Mol Sci 24.
3. Lu X, Yang B, Qi R, Xie Q, Li T, Yang J, Tong T, Niu K, Li M, Pan W, Zhang Y, Shi D, Li S, Dai C, Shen C, Wang X, Wang Y, Song J. (2023) Targeting WWP1 ameliorates cardiac ischemic injury by suppressing KLF15-ubiquitination mediated myocardial inflammation. Theranostics. 13(1):417-437.
4. Li, Y., Liu, C., Bai, X., Li, M., and Duan, C*. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS Lett 597, 1868-1879.
5. Kuang, Z., Guo, K., Cao, Y., Jiang, M., Wang, C., Wu, Q., Hu, G., Ao, M., Huang, M., Qin, J., Zhao, T., Lu, S., Sun, C., Li, M., Wu, T., Liu, W., and Fang, M. (2023) The novel CDK9 inhibitor, XPW1, alone and in combination with BRD4 inhibitor JQ1, for the treatment of clear cell renal cell carcinoma. Br J Cancer 129, 1915-1929.
2022
1. Jia J., Kang Q., Liu S., Song Y., Wong F.S., Qiu Y.,*, Li M.* (2022) Artemether and aspterric acid induce pancreatic α cells to transdifferentiate into β cells in zebrafish. Br J Pharmacol. 179(9):1962-1977.
2. Kang, Q#., Zheng, J#., Jia, J#., Xu, Y., Bai, X., Chen, X., Zhang, X. K., Wong, F. S., Zhang, C.*, and Li, M.* (2022) Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish. J Biol Chem, 102665
3. Xu, Y#., Tian, J#., Kang, Q., Yuan, H., Liu, C., Li, Z., Liu, J*., and Li M.* (2022) Knockout of Nur77 leads to amino acid, lipid and glucose metabolism disorders in zebrafish. Front Endocrinol (Lausanne). 13:864631.
4. Chen, Y., Jia, J., Zhao, Q., Zhang, Y., Huang, B., Wang, L., Tian, J., Huang, C., Li, M.*, and Li, X. (2022) Novel Loss-of-Function Variant in HNF1a Induces β-Cell Dysfunction through Endoplasmic Reticulum Stress. Int J Mol Sci.,23(21):13022
5. Wang W#, Shi Y#, Liu Y, Zhang Y, Wu J, Zhang G, Che Q, Zhu T, Li M*, Li D*. (2022) Brasilterpenes A-E, Bergamotane Sesquiterpenoid Derivatives with Hypoglycemic Activity from the Deep Sea-Derived Fungus Paraconiothyrium brasiliense HDN15-135. Marine Drugs. 20(5):338.
6. Yu, G., Sun,P., Aierken, R., Sun, C., Zhang, Z., Che, Q., Zhang, G., Zhu,T., Gu, Q., Li, M*., and Li, D*. (2022) Linear Polyketides Produced by Co-Culture of Penicillium crustosum and Penicillium fellutanum. Marine Life Science & Technology 4: 237–244.
7. Zhu, C#., Jiang, X#., Tian, J#., Chen, J., Lin, C., Wang, C., Tie, C*., Li, M*., and Wu, C*. (2022). Integrated approach toward absorption, distribution, metabolism, and excretion of Xiaoke pills in zebrafish based on UPLC-HRMS and DESI-MS techniques. J Chromatogr B Analyt Technol Biomed Life Sci 1200, 123276.
8. Tie, C., Zhu, C., Jin, Y., Liang, H., Li, M., Tian, J., and Wu, C*. (2022) Instantaneous Phosphatidylcholine spatial specific regulation induced by formononetin revealed by DESI-MSI. International Journal of Mass Spectrometry 471, 116759
9. Liu, S.-Z.; Xu, G.-X.; He, F.-M.; Zhang, W.-B.; Wu, Z.; Li, M.-Y.; Tang, X.-X.; Qiu, Y.-K*. New Sorbicillinoids with Tea Pathogenic Fungus Inhibitory Effect from Marine-Derived Fungus Hypocrea jecorina H8. Mar. Drugs 2022, 20, 213.
10. Wang Q, Tu X, Wang X, Cai Q, Yu L, Zhang X, Yi J, Wu Y, Xie G, Yuan H, Li M, Zhang X, Zeng Z*, Su Y. * (2022) Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents. Bioorg Chem, 2022 Nov;128:106069.
11. Ding, Y., Tao, C., Chen, Q., Chen, L., Hu, X., Li, M., Wang, S., and Jiang, F.* (2022) Cynarin inhibits PDGF-BB-induced proliferation and activation in hepatic stellate cells through PPARγ. Open Chemistry 20, 1121-1129
12. Wang, M., Wang, X., Jiang, B., Zhai, Y., Zheng, J., Yang, L., Tai, X., Li, Y., Fu, S., Xu, J., Lei, X., Kuang, Z., Zhang, C., Bai, X., Li, M., Zan, T., Qu, S., Li, Q., and Zhang, C*. (2022) Identification of MRAP protein family as broad-spectrum GPCR modulators. Clin Transl Med 12, e1091
13. Qin, J., Chen, X., Liu, W., Chen, J., Liu, W., Xia, Y., Li, Z., Li, M., Wang, S., Yuan, Q., Qiu, Y.*, Wu, Z.*, and Fang, M*. (2022) Discovery of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carboxamide derivatives as novel anti-cancer agents targeting Nur77. Eur J Med Chem 244, 114849
全部论文请见：
Pubmed: https://www.ncbi.nlm.nih.gov/myncbi/mingyu.li.1/bibliography/public/
Google Scholar: https://scholar.google.com/citations?hl=en&user=PJwD5TwAAAAJ
招聘：本实验室诚招助理教授，博士后，博士及硕士研究生。
联系方式：
地址：福建省厦门市翔安区翔安南路厦门大学药学院
Email：limingyu@xmu.edu.cn
