严小胜博士，主要致力于超分子化学、手性化学和药物化学学科的交叉研究。目前，已在Nat. Commun., Adv. Mater., Angew. Chem. Int. Ed., J. Am. Chem. Soc., ACS Appl. Mater. Interfaces, Nanoscale, Chem. Commun., J. Org. Chem. 等国际权威期刊上发表论文30余篇。主持国家自然科学基金青年基金项目、福建省自然科学基金面上项目、厦门大学校长基金和企业科技合作项目，参与国家自然科学基金重大研究计划集成项目、化学部专项项目、重点国际合作项目、重大研究计划培育项目和高等学校学科“生命物质跨膜转运学科创新引智基地”项目。谱学分析与仪器教育部重点实验室成员。获教育部自然科学奖二等奖（第三完成人）。2021年12月加入厦门大学药学院，研究工作主要围绕拟肽和环肽，以高效合成、分子识别、仿生组装、跨膜转运和手性效应等研究为基础，发展抗癌、抗菌等应用研究，助力肽类药物研发。
工作经历：
2021.12-至今 厦门大学药学院，副教授
2020.08-2021.11 厦门大学化学化工学院，科研助理（合作导师：江云宝教授）
2016.07-2020.07 厦门大学生命科学学院/化学化工学院，博士后（合作导师：韩家淮院士/江云宝教授）
教育背景：
2010.09-2016.06 厦门大学，博士，专业：分析化学（指导老师：江云宝教授）
2006.09-2010.06 华中农业大学，学士，专业：应用化学
代表性论文：
1. Kexin Lin, Peimin Weng, Yuanwei Qi, Jinkui Teng, Zhikun Lei, and Xiaosheng Yan*. Evolution of Peptidomimetics-Based Chiral Assemblies of β-Sheet, α-Helix, and Double Helix Involving Chalcogen Bonds. ACS Appl. Mater. Interfaces 2025, 17, 2863−2870. (Cover art)
2. Peimin Weng, Xiang Lin, Yi-Lin Cai, Xiaosheng Yan*, Jinlian Cao, Zhao Li, and Yun-Bao Jiang*. Role of solvent in the spontaneous resolution of amino acids via formation of supramolecular helices. Cell Rep. Phys. Sci. 2025, 6, 102521.
3. Xiaosheng Yan, Jinlian Cao, Huan Luo, Zhao Li, Zexing Cao, Yirong Mo, and Yun-Bao Jiang*. Heterochiral coupling to bilateral β-turn structured azapeptides bearing two remote chiral centers. Nat. Commun. 2024, 15, 9271.
4. Xiaosheng Yan,* PeiminWeng, Jinlian Cao, Kexin Lin, Yuanwei Qi, Xin Wu and Yun-Bao Jiang*. Simultaneous formation of helical and sheet-like assemblies from short azapeptides enables spontaneous resolution. Nanoscale 2024, 16, 19221−19227.
5. Jinlian Cao, Peimin Weng, Yuanwei Qi, Kexin Lin and Xiaosheng Yan*. Noncovalent interaction network of chalcogen, halogen and hydrogen bonds for supramolecular β-sheet organization. Chem. Commun. 2024, 60, 1484−1487.
6. Xiang Lin, Bohan Kou, Jinlian Cao, Peimin Weng, Xiaosheng Yan,* Zhao Li,* and Yun-Bao Jiang*. Spontaneous Resolution of Helical Building Blocks through the Formation of Homochiral Helices in Two Dimensions. Angew. Chem. Int. Ed. 2022, 61, e202205914.
7. Peimin Weng, Xiaosheng Yan,* Jinlian Cao, Zhao Li and Yun-Bao Jiang*. Intramolecular chalcogen bonding to tune the molecular conformation of helical building blocks for a supramolecular helix. Chem. Commun. 2022, 58, 6461−6464.
8. Qingqing Fang, Yan Xu, Xiaosheng Yan,* Tao Jiang,* and Yunbao Jiang*. Synthetic approaches to metal-coordination-directed macrocyclic complexes. Front. Chem. 2022, 10, 1078432.
9. Zhixing Zhao, Bailing Tang, Xiaosheng Yan,* Xin Wu,* Zhao Li, Philip A. Gale,* and Yun-Bao Jiang*. Crown ether-thiourea conjugates as ion transporters. Front. Chem. Sci. Eng. 2022, 16, 81−91.
10. Xiaosheng Yan,* Peimin Weng, Di Shi and Yun-Bao Jiang*. Supramolecular helices from helical building blocks via head-to-tail intermolecular interactions. Chem. Commun. 2021, 57, 12562−12574. (Inside cover)
11. Xiaosheng Yan,† Jinlian Cao,† Yanhan Zhang, Peimin Weng, Daiyu Miao, Zhixing Zhao, Zhao Li and Yun-Bao Jiang*. Solvophobic interaction promoted supramolecular helical assembly of building blocks of weak intermolecular halogen bonding. Chem. Commun. 2021, 57, 1802−1805. (†Equal contribution)
12. Di Shi, Jinlian Cao, Peimin Weng, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Chalcogen bonding mediates the formation of supramolecular helices of azapeptides in crystals. Org. Biomol. Chem. 2021, 19, 6397−6401. (Editor’s Collection)
13. Zhixing Zhao, Miaomiao Zhang, Bailing Tang, Peimin Weng, Yueyang Zhang, Xiaosheng Yan,* Zhao Li and Yun-Bao Jiang*. Transmembrane Fluoride Transport by a Cyclic Azapeptide With Two β-Turns. Front. Chem. 2021, 8, 621323.
14. Xiaosheng Yan, Qian Wang, Xuanxuan Chen, and Yun-Bao Jiang*. Supramolecular Chiral Aggregates Exhibiting Nonlinear CD–ee Dependence. Adv. Mater. 2020, 32, 1905667.
15. Yanhan Zhang,† Xiaosheng Yan,† Jinlian Cao, Peimin Weng, Daiyu Miao, Zhao Li, and Yun-Bao Jiang*. Turn Conformation of β-Amino Acid-Based Short Peptides Promoted by an Amidothiourea Moiety at C-Terminus. J. Org. Chem. 2020, 85, 9844−9849. (†Equal contribution)
16. Xiaosheng Yan, Kunshan Zou, Jinlian Cao, Xiaorui Li, Zhixing Zhao, Zhao Li, Anan Wu, Wanzhen Liang, Yirong Mo, and Yunbao Jiang*. Single-handed supramolecular double helix of homochiral bis(N-amidothiourea) supported by double crossed C−I···S halogen bonds. Nat. Commun. 2019, 10, 3610. (Editors’ highlights)
17. Xiao-Sheng Yan,† Huan Luo,† Kun-Shan Zou, Jin-Lian Cao, Zhao Li, and Yun-Bao Jiang*. Short Azapeptides of Folded Structures in Aqueous Solutions. ACS Omega 2018, 3, 4786−4790. (†Equal contribution)
18. Xiao-Sheng Yan, Kun Wu, Yuan Yuan, Ying Zhan, Jin-He Wang, Zhao-Li, and Yun-Bao Jiang*. β-Turn structure in glycinylphenylalanine dipeptide based N-amidothioureas. Chem. Commun. 2013, 49, 8943−8945.
联系方式：
电子邮箱：xshyan@xmu.edu.cn
地址：福建省厦门市翔安区翔安南路厦门大学翔安校区药学院213室
邮编：361102
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