吴欣 / Xin Wu博士、教授
国家级青年人才项目入选者
ARC DECRA基金获得者
个人简介：
吴欣博士的研究兴趣包括超分子化学、分子识别、大环化学、自组装、膜生物物理学和药物化学等。目前的研究课题包括：（1）水溶性共价有机笼的设计、合成、主客体化学和生物医学应用（相关工作：代表性论文[1]）；（2）荧光光谱和高分辨核磁共振等方法研究磷脂双分子层内人工合成超分子化学主体的分子识别和自组装行为（相关工作：代表性论文[2]）；（3）仿生门控型、高选择性跨膜运输生物分子之体系的构建及药物化学应用（相关工作：代表性论文[7]、[10]、[11]）；（4）用于水纯化、污染治理和核废料处理的固体阴离子吸附材料的设计与合成（相关工作：代表性论文 [6]）。
已于Nat. Chem.、Chem、Nat. Commun.、J. Am. Chem. Soc.和Angew. Chem.等期刊发表论文52篇，H因子为28。曾获2016年分子传感器&分子逻辑门会议AP de Silva 青年学者奖、2016年英国皇家化学会大环超分子化学组博士论文奖，主持2022年澳大利亚研究理事会Discovery Early Career Research Award （DECRA）基金（资助金额：43万澳元）。担任Aggregate、Chemistry (MDPI)、Front. Chem.等期刊的编委会成员，Nat. Commun.、J. Am. Chem. Soc.和Chem. Sci.等期刊的审稿人。
课题组常年招聘博士后学者，有意者请致信吴欣博士。
工作经历：
2023–至今 厦门大学药学院 教授
2022–2023昆士兰大学 ARC DECRA研究员
2017–2021悉尼大学 博士后 （导师：Philip A. Gale教授）
教育经历：
2016年 南安普顿大学 化学专业 博士（导师：Philip A. Gale教授、江云宝教授）
2011年 厦门大学 化学专业 学士 （导师：江云宝教授）
代表性论文：
[1] L. Jing, E. Deplazes*, J. K. Clegg, X. Wu*, A charge-neutral organic cage selectively binds strongly hydrated sulfate anions in water. Nat. Chem. 2024, 16, 335–342.
[2] X. Wu, P. Wang, W. Lewis, Y. B. Jiang, P. A. Gale*, Measuring anion binding at biomembrane interfaces. Nat. Commun. 2022, 13, 4623.
[3] X. Wu, P. A. Gale*, Measuring anion transport selectivity: a cautionary tale. Chem. Commun. 2021, 57, 3979–3982.
[4] X. Wu, L. K Macreadie, P. A. Gale*, Anion binding in metal-organic frameworks. Coord. Chem. Rev. 2021, 432, 213708.
[5] X. Wu, A. Gilchrist, P. A. Gale*, Prospects and challenges in anion recognition and transport. Chem 2020, 6, 1296–1309.
[6] X. Wu, P. Wang, P. Turner, W. Lewis, O. Catal, D. S. Thomas, P. A. Gale*, Tetraurea macrocycles: aggregation-driven binding of chloride in aqueous solutions. Chem 2019, 5, 1210–1222.
[7] X. Wu, J. R. Small, A. Cataldo, A. M. Withecombe, P. Turner, P. A. Gale*,Voltage-switchable HCl transport enabled by lipid headgroup-transporter interactions. Angew. Chem. Int. Ed., 2019, 58, 15142–15147.
[8] X. Wu, E. Howe, P. A. Gale*, Supramolecular transmembrane anion transport: new assays and insights. Acc. Chem. Res. 2018, 51, 1870–1879.
[9] X. Wu, X.-X. Chen, Y.-B. Jiang*, Recent advances in boronic acid-based optical chemosensors. Analyst 2017, 142, 1403–1414.
[10] X. Wu, P. A. Gale*, Small-molecule uncoupling protein mimics: synthetic anion receptors as fatty acid-activated proton transporters. J. Am. Chem. Soc., 2016, 138, 16508–16514.
[11] X. Wu, L. W. Judd, E. N. W. Howe, A. M. Withecombe, V. Soto-Cerrato, H. Li, N. Busschaert, H. Valkenier, R. Pérez-Tomás, D. N. Sheppard, Y.-B. Jiang, A. P. Davis*, P. A. Gale*, Nonprotonophoric electrogenic chloride transport mediated by valinomycin-like carriers. Chem 2016, 1, 127–146.
[12] X. Wu, X.-X. Chen, M. Zhang, Z. Li, P. A. Gale, Y.-B. Jiang*, Self-assembly of a double dynamic covalent amphiphile featuring a glucose-responsive imine bond. Chem. Commun., 2016, 52, 6981–6984.
[13] X. Wu, N. Busschaert, N. J. Wells, Y.-B. Jiang, P. A. Gale*, Dynamic covalent transport of amino acids across lipid bilayers. J. Am. Chem. Soc. 2015, 137, 1476–1484.
[14] X. Wu, X.-X. Chen, B.-N. Song, Y.-J. Huang, W.-J. Ouyang, Z. Li, T. D. James, Y.-B. Jiang*, Direct sensing of fluoride in aqueous solutions using a boronic acid based sensor. Chem. Commun. 2014, 50, 13987–13989.
[15] X. Wu, X.-X. Chen, B.-N. Song, Y.-J. Huang, Z. Li, Z. Chen, T. D. James, Y.-B. Jiang*, Induced helical chirality of perylenebisimide aggregates allows for enantiopurity determination and differentiation of α-hydroxy carboxylates by using circular dichroism. Chem. Eur. J. 2014, 20, 11793–11799.
[16] X. Wu, Z. Li, X.-X. Chen, J. S. Fossey, T. D. James, Y.-B. Jiang*, Selective sensing of saccharides using simple boronic acids and their aggregates. Chem. Soc. Rev. 2013, 8032–8048.
[17] X. Wu, L.-R. Lin, Y.-J. Huang, Z. Li, Y.-B. Jiang*, A 2 : 2 stilbeneboronic acid-γ-cyclodextrin fluorescent ensemble highly selective for glucose in aqueous solutions. Chem. Commun. 2012, 48, 4362–4364.
联系方式:
电子邮箱：xin.wu@xmu.edu.cn
地址：福建省厦门市翔安区翔安南路厦门大学翔安校区药学院409室
邮编：361102
