陈登岳博士 助理教授 （特聘副研究员）
简介：
陈登岳博士主要从事靶向抗肿瘤药物的设计递送与定制微流控器件连续控制合成大/小分子药物的研究发工作。2008年于天津大学化工学院获得工学学士学位，2010年获得北京交通大学理学硕士学位，同年赴美 New Jersey Institute of Technology开展博士课题研究。2015年获得工学博士学位，同年进入Shire生物制药公司美国总部担任研发科学家，2016年底来厦任职。近年来以第一或通讯作者共发表了35篇文章（18篇JCR一区，14篇JCR二区），专利6项，主持国家自然基金项目1项、福建省自然基项目2项、教育部专项基金3项，及多项与上市企业合作横向课题。
研究方向：
1.基于计算驱动的mrna药物客制化制备与预测研究
2.基于微流控技术的靶向药物设计递送与诊疗一体化研究
3.计算流体力学模拟仿真(CFD)，化工设备优化，流场温度场模拟
教育与工作经历：
1. 2015/4-2016/4，美国Shire制药公司，研发科学家
2. 2010/9–2014/12，美国新泽西理工大学，化学与制药工程学院，博士
3. 2008/9–2010/7， 北京交通大学，理学院，硕士
4. 2004/9–2008/7， 天津大学，化工学院，学士
荣誉：
2022年获得福建省高层次人才称号
基金项目：
1. 福建省自然基金面上项目，基于集束微膜丝内液膜更新强化微观混合的纳米药物共结晶研究（2024J01041），2024.11-2027.11，10万人民币，主持。
2. 中央高校基本科研业务费专项，2024.12-2025.12，50万人民币，主持。
3. 校企合作横向课题，mRNA脂质体纳米粒制备技术探索开发，2022.2-2022.4，12万人民币，主持。
4. 校企合作横向课题，mRNA脂质体纳米粒制备芯片开发，2022.9-2022.12，36万人民币，主持。
5. 中国国家自然基金青年项目，微纤维管束结晶器内聚合物包覆纳米药物晶体的可控制备（21706221），2018.1-2020.12，21万人民币，主持。
6. 福建省自然基金青年项目，新型多孔微膜丝结晶器内纳米载药脂质体的可控制备（2018J05143），2018.4-2021.4，3万人民币，主持。
7. 中央高校基本科研业务费专项，基于计算流体力学的新冠病毒传播机制与防护措施的机理研究（20720200048），2020.2-2020.12，10万人民币，主持。
8. 中央高校基本科研业务费专项，快速冷却微膜丝结晶器内连续可控生产聚合物包覆的纳米药物晶（20720190077），2019.1-2019.12，25万人民币，主持。
9. 美国国家自然科学基金项目，GOALI: Continuous coating of ultrafine drug particles by heterogeneous polymer nucleation in a hollow fiber membrane module，2011/01-2013/12，30万美金，已结题，主要参与人。
第一或通讯作者发表论文：
1. Zhang X W1, Wu Y N1, Wang B1, Liu C, Guo J Q, Zhang J B, Chen C, Lin Q, Chen B Y, Lu Q P, Liu G*, Chen D*, Zhu X*, Ye M Z*. Nanocatalyst with Self-Strengthening Cascade Reaction for Enhanced Cancer Therapy. ACS Applied Materials & Interfaces. 2025, 17, 27, 39461-39472.（通讯作者, IF= 10.383, JCR一区）
2. Chen B, He C, Zhang J, Du Y, Guo J, Zhang X, Lu Q, Wang B, Zhu X*, Chen D*. Hydrogels containing composite of Ag3Sn intermetallic compounds and tin oxide for enhanced anti-bacterial and wound healing. Chemical Engineering Journal. 2024, 494, 153051. （通讯作者, IF= 16.744, JCR一区TOP）
3. He C1, Liu C1, Li M, Li M, Yin J, Han S, Xia J, Chen D*, Cao W*, Lu Q*, Rosei F*.3D hierarchical Cu-MOF nanosheets-based antibacterial mesh. Chemical Engineering Journal. 2022, 446, 137381. （通讯作者, IF= 16.744, JCR一区TOP）
4. Wang Y1, Zhou Y1, Wang J1, Zhang L, Liu C, Guo D, Yu Y, Ye R, Wang Y, Xu B*, Luo Y*, Chen D*, Nucleolin-targeted silicon-based nanoparticles for enhanced chemo-sonodynamic therapy of diffuse large B-cell lymphoma, International Journal of Pharmaceutics, 2025, 671, 125294.（通讯作者, IF= 6.510, JCR一区）
5. Yu J1, Chen D1, Wu J, Wang B*, Field R.Arch-type feed spacer with wide passage node design for spiral-wound membrane filtration with reduced energy cost. Desalination. 2022, 540, 115980. （共同第一作者, IF= 11.211, JCR一区TOP）
6. Fang Y1, Chen D1, Zhang Y, Field R, Wu J*, Wang B*. Wastewater treatment in large-scale novel corrugated-sheet MBR. Journal of Water Process Engineering. 2022, 50, 103215. （共同第一作者, IF= 7.340, JCR一区）
7. Min Y1, Chen D1, Yang S, Zhang Y, Wang B*, Wu J*, Field R. Water treatment with free-bubbling corrugated sheet MBR. Journal of Water Process Engineering. 2024, 59, 105097. （共同第一作者, IF= 7.340, JCR一区）
8. Li M1, Liu C1, Yin J, Liu G*, Chen D*. Single-step Synthesis of Highly Tunable Multifunctional Nanoliposomes for Synergistic Cancer Therapy. ACS Applied Materials & Interfaces. 2022, 14 (18), 21301-21309.（通讯作者, IF= 10.383, JCR一区）
9. Zuo W1, Fan Z, Chen L, Liu J, Wan Z, Xiao Z, Chen W, Wu L, Chen D*, Zhu X*. Copper-based theranostic nanocatalysts for synergetic photothermal-chemodynamic therapy. Acta Biomaterialia. 2022, 147, 258-269.（通讯作者, IF= 10.634, JCR一区TOP）
10. Liu C, Liu Q, Chen L, Li M, Yin J, Zhu X*, Chen D*. A pH-sensitive Self-assembled and Carrier-free Nanoparticle Based on Charge-reversal for Enhanced Synergetic Chemo-phototherapy. Advanced Healthcare Materials. 2020, 9, 2000899.（通讯作者, IF= 11.093, JCR一区）
11. Zuo W1, Chen D1, Fan Z, Chen L, Zhu Z, Zhu Q, Zhu X*. Design of Light/ROS Cascade-Responsive Tumor-Recognizing Nanotheranostics for Spatiotemporally Controlled Drug Release in Locoregional Photo-Chemotherapy. Acta Biomaterialia. 2020, 111, 327-340. （共同第一作者, IF= 10.634, JCR一区TOP）
12. Gao X, Wang B, Liu Q, Liu C, Li M, Sirkar K K*, Chen D*. Fluid Dynamic and Heat Transfer Simulations of Solid Hollow Fiber Cooling Crystallizer for Continuous Synthesis of Drug Nanoparticles. Crystal Growth & Design. 2020, 20, 6, 4020–4029. （通讯作者, IF= 4.010, JCR一区TOP）
13. Ma J1, Chen D1, Li Y, Chen Y, Liu Q, Zhou X, K. Qian, Li Z, Ruan H, Hou Z, Zhu X*. Zinc phthalocyanine-soybean phospholipid complex based drug carrier for switchable photoacoustic/fluorescence image, multiphase photothermal/ photodynamic treatment and synergetic therapy. Journal of Controlled Release, 2018, 284:1-14. （共同第一作者, IF= 11.467, JCR一区TOP）
14. Chen D1, Wang B1, Sirkar K K*. Hydrodynamic modeling of porous hollow fiber anti-solvent crystallizer for continuous production of drug crystals. Journal of Membrane Science, 2018, 556, 185-195.（第一作者, IF= 10.530, JCR一区TOP）
15. Zhou X, Zhu X, Wang B, Li J, Liu Q, Gao X, Sirka K K*, Chen D*, Continuous production of drug nanocrystals by porous hollow fiber-based anti-solvent crystallization, Journal of Membrane Science, 2018,564,682-690. （通讯作者, IF= 10.530, JCR一区TOP）
16. Liu C1, He C H1, Li M Y1,Yin J L, Li M, Guo J Q, Zhang H, Wang X M, Gao F, Wang B, Lu Q P*, Cao W B*, Chen D*, 2D MOF based-heterostructure with hierarchical architecture as antibacterial wound dressing, International Journal of Pharmaceutics, 2024, 651, 123745. （通讯作者, IF= 6.510, JCR一区）
17. Liu Q1, Zhu X1, Wang B, Zhou X, Liu C, Gao X, Sirkar K K*, Chen D*, Continuous synthesis of drug nanocrystals by solid hollow fiber cooling crystallization, International Journal of Pharmaceutics, 2020, 576, 118978. （通讯作者, IF= 6.510, JCR一区）
18. Chen D, Singh D, Sirkar K K*, Pfeffer R. Continuous preparation of polymer coated drug crystals by solid hollow fiber membrane-based cooling crystallization. International Journal of Pharmaceutics, 2016, 499(1), 395-402. （第一作者, IF= 6.510, JCR一区）
19. Wang Y1, Zhang L, Liu C, Luo Y*, Chen D*. Peptide-Mediated Nanocarriers for Targeted Drug Delivery: Developments and Strategies, Pharmaceutics, 2024; 12, 3509-3520. （通讯作者, IF= 5.400, JCR二区）
20. Ye M Z1, Ye R M1, Wang Y, Guo M Y, Zhu M S, Yin F Y, Wang Y B, Lai X Q, Wang Y, Qi Z Q, Wang J L*, Chen D*. Targeted pH-responsive biomimetic nanoparticle-mediated starvation-enhanced chemodynamic therapy combined with chemotherapy for ovarian cancer treatment, International Journal of Pharmaceutics, 2024, 661, 124424. （通讯作者, IF= 6.510, JCR一区）
21. Fang Y1, Xiao N1, Chen D1, Min Y, Field R W, Wang B*, Wu J J*, MBR Water Treatment: A CFD and Experimental Investigation with a Focus upon Shear Stress and the Role of c-di-GMP, Desalination and Water Treatment, 2025; 321:100942. （共同第一作者, IF= 1.000, JCR四区）
22. Min Y1, Chen D1, Wu J J, Wang B*, Field R W, Design, Optimization and Evaluation of Wavy Channels in a Flat-Sheet Membrane Bioreactor, Chemical Engineering Research and Design, 2025; 215:208-221.（共同第一作者, IF= 4.099, JCR三区）
23. Yin J L1, Liu C1, Guo J Q, Li M, Chen B Y, Zhang X W, Wang B, Zhu X *, Chen D*. A copper-loaded self-assembled nanoparticle for disturbing the tumor redox balance and triple anti-tumor therapy, Journal of Materials Chemistry B, 2024; 16(2):240. （通讯作者, IF= 6.997, JCR二区）
24. Liu Q1, Li M1, Liu C, Yin J, Zhu X *, Chen D*, Continuous Synthesis of Polymer-Coated Drug Nanoparticles by Heterogeneous Nucleation in a Hollow-Fiber Membrane Module, Industrial & Engineering Chemistry Research, 2022, 61, 1, 349-358. （通讯作者, IF= 4.326, JCR二区TOP）
25. Fang Y1, Xiao N1, Chen D1, Field R, Wu J*, Wang B*, Influence of shear stress on the intracellular bis-(3’-5’)-cyclic dimeric guanosine monophosphate (c-di-GMP) level within an MBR biofilm, Chemical Engineering Science, 2023, 280, 118989. （共同第一作者, IF= 4.889, JCR二区TOP）
26. Chen Y, Chen Q, Zhu Q, Liu J, Li Y, Gao X, Chen D*, Zhu X*. Small Molecular Theranostic Assemblies Functionalized by Doxorubicin–Hyaluronic Acid–Methotrexate Prodrug for Multiple Tumor Targeting and Imaging-Guided Combined Chemo-Photothermal Therapy, Molecular Pharmaceutics, 2019, 16, 2470-2480. （通讯作者, IF= 5.364, JCR二区）
27. Zhao D, Song H, Zhou X, Chen Y, Liu Q, Gao X, Zhu X*, Chen D*. Novel facile thermosensitive hydrogel as sustained and controllable gene release vehicle for breast cancer treatment. European Journal of Pharmaceutical Sciences, 2019, 134, 145-152. （通讯作者, IF= 5.112, JCR二区）
28. Jin C1, Chen D1, Pfeffer R, Sirkar K K*. An extended duration operation for solid hollow fiber membrane-based cooling crystallization. Powder Technology, 2020, 365, 106-114.（第一作者, IF= 5.640, JCR二区）
29. Zhou X, Wang B, Liu Q, Liu C, Gao X, Sirkar K K*, Chen D*. An Extended Duration Operation for Porous Hollow Fiber-Based Antisolvent Crystallization, Industrial & Engineering Chemistry Research, 2019, 58, 12431−12437. （第一作者, IF= 4.326, JCR二区TOP）
30. Ma J, Wu H, Li Y, Liu Z, Liu G, Guo Y, Hou Z, Zhao Q, Chen D*, Zhu X*. Novel Core-Interlayer-Shell DOX/ZnPc Co-loaded MSNs@ pH-Sensitive CaP@PEGylated Liposome for Enhanced Synergetic Chemo-Photodynamic Therapy, Pharmaceutical Research, 2018, 35(3):57. （通讯作者, IF= 4.580, JCR二区）
31. Chen D, Sirkar K K*, Jin C, Dhananjay S, Pfeffer R. Membrane-based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-coated Crystals/Particles, Current Pharmaceutical Design, 2017, 23(2):242-249. （第一作者, IF= 3.310, JCR三区）
32. Chen D, Singh D, Sirkar K K*. Continuous synthesis of polymer coated drug particles by a porous hollow fiber membrane-based anti-solvent crystallization method. Langmuir, 2015, 31, 432-441. （第一作者, IF= 4.331, JCR二区TOP）
33. Chen D, Singh D, Sirkar K K*. Porous hollow fiber membrane-based continuous technique of polymer coating on submicron and nanoparticles via anti-solvent crystallization. Industrial & Engineering Chemistry Research, 2015, 54(19), 5237-5245. （第一作者, IF= 4.326, JCR二区TOP）
34. Chen D, Singh D, Sirkar K K*. Continuous polymer nanocoating on silica nanoparticles. Langmuir, 2014, 30, 7804-7810. （第一作者, IF= 4.331, JCR二区TOP）
35. Chen D, Singh D, Sirkar K K*. Continuous polymer coating/encapsulation of submicron particles using a solid hollow fiber cooling crystallization method, Industrial & Engineering Chemistry Research, 2014, 53(15), 6388-6400. （第一作者, IF= 4.326, JCR二区TOP）
非第一或通讯作者发表论文：
1. Li Y, Lin J, Ma J, Song L, Lin H, Tang B, Chen D, Su G, Ye S, Zhu X, Luo F*, Hou Z*. Methotrexate-Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy, ACS Applied Materials & Interfaces, 2017, 9(40), 34650-34665.（第七作者, IF= 10.383, JCR一区TOP）
2. Li Y, Liu G, Ma J, Lin J, Lin H, Su G, Chen D,Ye S, Chen X, Zhu X, Hou Z. Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy, Journal of Controlled Release, 2017, 258:95-107. （第七作者, IF= 11.467, JCR一区TOP）
3. Li Q, Chen Y, Zhou X, Chen D, Li Y, Yang J*, Zhu X*. Hyaluronic Acid-Methotrexate Conjugates Coated Magnetic Polydopamine Nanoparticles for Multimodal Imaging-Guided Multistage Targeted Chemo-Photothermal Therapy, Molecular Pharmaceutics, 2018, 15(9), 4049-4062.（第四作者, IF= 5.364, JCR二区）
4. Ma J, Li Y, Liu G, Li A, Chen Y, Zhou X, Chen D, Hou Z*, Zhu X*. Novel theranostic zinc phthalocyanine–phospholipid complex self-assembled nanoparticles for imaging-guided targeted photodynamic treatment with controllable ROS production and shape-assisted enhanced cellular uptake, Colloids And Surfaces B-Biointerfaces, 2018, 162,76-89.（第七作者, IF= 5.999, JCR二区）
5. Wang Z, Guo K, Liu H*, Liu C, Geng Y, Lu Z, Jia B, Chen D. Effects of bubble size on the mass transfer of bubble swarms with Sauter mean diameters of 0.38–4.88 mm in a co-current up-flow bubble column, Journal of Chemical Technology and Biotechnology. https://doi.org/10.1002/jctb.6445. （第八作者，IF= 3.709, JCR 三区）
专利:
1.申请日: 2017年 02月 22日，申请号: 2017100951528，发明名称:“用实壁纤维管束结晶器制丙烯酸树脂包覆纳米药物的方法”
2.申请日: 2017年 02月 22日，申请号: 2017201595920，实用新型名称:“丙烯酸树脂包覆纳米药物的制备装置”
3.申请日: 2017年 02月 22日，申请号: 2017100951617，发明名称:“聚合物包覆纳米药物制备装置与制备方法”
4.申请日: 2017年 02月 22日，申请号: 2017201586739，实用新型名称:“一种聚合物包覆纳米药物制备装置”
5. Kamalesh K Sirkar(#), Robert Pfeffer, Dhananjay Singh ,Dengyue Chen , System and method for continuous polymer coating of particles.2015.5.7 ,美国, US: 201414532663:A.
6.Kamalesh K Sirkar(#), Robert Pfeffer, Dengyue Chen, Dhananjay Singh, Porous hollow fiber anti-solvent crystallization-based continuous method of polymer coating on submicron and nanoparticles.2016.6.16 ,美国, US: 201514968456:A.
团队建设与联系方式：
本研究组氛围好，科研经费充裕，所涉及的科研项目创新性高实用性强，文章可发表于SCI一区期刊。欢迎本科生、研究生报考！电子邮件：dchen@xmu.edu.cn
