张凌娟教授

发布者:张欧扬发布时间:2018-07-09浏览次数:41995

PI:张凌娟 博士、教授、博士生导师

国家海外高层次“青年人才”、福建省“杰出青年”、厦门市“双百”、

厦门大学“南强青年拔尖A类人才”等人才项目获得者,“闽江学者”特聘教授


个人简介:

 张凌娟博士15年海外(美国)药理学/皮肤医学领域科研经历,在皮肤天然免疫功能和调控机制研究领域开展了一系列独创性的研究工作,发现dsRNA-MAVS通路在上皮角质形成细胞参与损伤诱发银屑病炎症的天然免疫机制 (Immunity, 2016);还开创性地发现皮肤中的脂肪谱系细胞 (Preadipocytes/Adipocytes) 有免疫抑菌功能,可通过大量释放多肽抗生素来抵御细菌感染(Science, 2015),这一过程被定义为reactive adipogenesis (JID, 2019);近年来还阐述了在衰老 (Immunity, 2019) 和饮食诱发肥胖 (Sci. Transl. Med., 2021) 过程中真皮脂肪丢失抗菌功能的机制和潜在新靶点,并进一步揭示了真皮脂肪在发育和伤口愈合过程中可塑性变化的分子调控机制 (Cell Reports, 2023);共发表学术论著或论文40多篇,总引用3000多个,单篇最高他引800多个,多次受邀在国际学术会议上做学术报告。学术兼职包括SCI期刊EXP DERMATOL副主编; SEMIN CELL DEV BIOL客座主编;中国免疫学会皮肤免疫分会、中华医学会皮肤性病学分会实验学组、中华中医药学会免疫学分会、厦门市医学会转化医学分会等学会的常务委员。自2018年加入厦门大学药学院,紧密围绕真皮脂肪谱系细胞参与维持皮肤稳态调控皮肤免疫系统伤口愈合、纤维化、毛发生长等过程开展新机制和新靶点研究,为多种皮肤病,包括炎症性皮肤病、慢性伤口、瘢痕、雄激素性脱发等提供新病理机制和药物研发靶点,拟在药学院组建以皮肤病免疫调控为靶点策略的全新药物研发平台,利用原代细胞库、3D皮肤模型等前沿手段,与厦大附属医院相关科室开展的临床转化研究合作,促进科研成果应用于临床。

 

教育背景与科研经历:

2018-至今教授,厦门大学药学院

2014-2018项目科学家,美国加州大学圣地亚哥分校,皮肤医学系,医学院

2011-2014博士后,美国加州大学圣地亚哥分校,皮肤医学系,医学院

2009-2011博士后,美国俄勒冈州立大学,药学院

2009博士,美国俄勒冈州立大学,专业:药理学

2003学士,北京理工大学,专业:生物工程


实验室网址:http://lingjuanzhang-lab.mysxl.cn/


代表性论文 (共发表论著或SCI论文40多篇,总引用3000多个,单篇最高他引800多个)

1.    1、   Ling-juan Zhang, Christian F. Guerrero-Juarez, Tissa Hata, Sagar P. Bapat, Raul Ramos, Maksim V. Plikus, Richard L. Gallo*. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science, 2015, Jan 2, 347(6217):67-71. doi: 10.1126/science.1260972.

2.    2、  Ling-juan Zhang, George L. Sen, Nicole L. Ward, Andrew Johnston, Kimberly Chun, Yifang Chen, Christopher Adase, James A. Sanford, Nina Gao, Melanie Chensee, Emi Sato, Yi Fritz, Jaymie Baliwag, Michael R. Williams, Tissa Hata, Richard L. Gallo*. Antimicrobial Peptide LL37 and MAVS Signaling Drive Interferon-β Production by Epidermal Keratinocytes during Skin Injury. Immunity, 2016 Jul 19;45(1):119-30. doi: 10.1016/j.immuni.2016.06.021.

3.    3、  Ling-juan Zhang*(第一兼共同通讯作者), Stella Xiang Chen, Christian F. Guerrero-Juarez Fengwu Li, Yun Tong, Yuqiong Liang, Marc Liggins, Xu Chen, Hao Chen, Min Li, Tissa Hata, Ye Zheng, Maksim V. Plikus, Richard L. Gallo*. Age-related loss of innate immune antimicrobial function of dermal fat is mediated by TGFβ. Immunity. 2019 Jan 15;50(1):121-136.e5. doi: 10.1016/j.immuni.2018.11.003.

4.    4、  Ling-juan Zhang*第一兼共同通讯作者, Christian F. Guerrero-Juarez, Stella X. Chen, Xiaowei Zhang, Meimei Yin, Fengwu Li, Shuai Wu, Joyce Chen, Min Li, Yingzi Liu, Shang I. B. Jiang, Tissa Hata, Maksim V. Plikus, Richard L. Gallo*Diet-induced obesity promotes infection by impairment of the innate antimicrobial defense function of dermal adipocyte progenitors20 January 2021SCIENCE TRANSLATIONAL MEDICINE13, eabb5280 (2021) DOI10.1126/scitranslmed.abb5280

5.    5、  Sun L, Zhang X, Wu S, Liu Y, Guerrero-Juarez CF, Liu W, Huang J, Yao Q, Yin M, Li J, Ramos R, Liao Y, Wu R, Xia T, Zhang X, Yang Y, Li F, Heng S, Zhang W, Yang M, Tzeng CM, Ji C, Plikus MV, Gallo RL, Zhang LJ*. Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration. Cell Reports. 2023 Jun 16;42(6):112647. doi: 10.1016/j.celrep.2023.112647.

6.    6、  Yanhang Liao; Lixiang Sun; Jiacheng Li; Meifeng Nie; Xiaofen Huang; Shujun Heng; Wenlu Zhang; Tian Xia; Zhuolin Guo; Qinjian Zhao; Ling-juan Zhang*. Modulation of skin inflammatory responses by aluminum adjuvant. Pharmaceutics, 2023, 15(2), 576; Published: 8 February 2023; doi.org/10.3390/pharmaceutics15020576

7.    7、  Ling-juan Zhangand Richard Gallo*. Antimicrobial peptides. Current Biology, 2016 Jan 11;26(1):R14-9. doi: 10.1016/j.cub.2015.11.017.

8.    8、  Xiaowei Zhang, Meimei Yin and Ling-juan Zhang*. Keratin 6, 16 and 17—Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis. Cells, 1 August 2019, 8(8), 807; doi:10.3390/cells8080807.

9.    9、  Jinwen Huang, Shujun Heng, Wenlu Zhang, Youxi Liu, Tian Xia, Chao Ji, and Ling-juan Zhang*, Dermal Extracellular Matrix molecules in skin development, homeostasis, wound regeneration and diseases, Seminars in Cell & Developmental Biology, 2022 Mar 23;S1084-9521(22)00064-7. doi: 10.1016/j.semcdb.2022.02.027.

1.   10、Lixiang Sun, Wenjie Liu, and Ling-juan Zhang*. The role of toll-like receptors in skin host defense, psoriasis and atopic dermatitis. Journal of Immunology Research, 2019 Nov 14, Volume 2019, Article ID 1824624, 13 pages. https://doi.org/10.1155/2019/1824624. 

11  11、  Ling-juan Zhang*. Type1 interferons potential initiating factors linking skin wounds with psoriasis pathogenesis. Frontiers in Immunology, 2019 Jun 25;10:1440, doi: 10.3389/fimmu.2019.01440 2019.

12  12、  Zhuolin Guo, Yichun Yang, Yanhang Liao, Yulin Shi, and Ling-juan Zhang*, Emerging Roles of Adipose Tissue in the Pathogenesis of Psoriasis and Atopic Dermatitis in Obesity, JID Innovations,2021 Oct 13;2(1):100064. doi: 10.1016/j.xjidi.2021.100064.

13  13、 Ling-juan Zhang*, Recent progress at the psoriasis and atopic dermatitis research front: An experimental dermatology perspective. Experimental Dermatology, 2021 Jun;30(6):756-764. doi: 10.1111/exd.14388     

14  14、  孙礼祥,吴帅,张小薇,刘文杰,张凌娟*, 基于单细胞RNA测序探讨小鼠全层皮肤缺损创面中真皮成纤维细胞的生长因子调控网络,中华烧伤与创面修复杂志, 2022,38(7) : 629-639. DOI: 10.3760/cma.j.cn501225-20220215-00029

15  15、  周凡凡, 姚虔, 刘文杰, 张凌娟*. 皮肤共生菌在皮肤健康和疾病中的作用研究进展[J]. 微生物学通报, Mar. 20, 2022, 49(3): 11351146DOI10.13344/j.microbiol.china.210654 Zhou Fanfan, Yao Qian, Liu Wenjie, Zhang Lingjuan. Emerging roles of commensal bacteria in skin health and diseases[J]. Microbiology China, Mar. 20, 2022, 49(3): 11351146

16  16、  专著: Ling-juan Zhang*. Isolation, Culture and Characterization of Primary Mouse Epidermal Keratinocytes(Book chapter title). Mouse Cell Culture: Methods and Protocols (Springer Book Series), Ivan Bertoncello (Editor), Ed.; Springer, Humana Press: New York, NY, USA, 2019; Volume 1940, pp. 205–215. Published: Feb 21th. doi: 10.1007/978-1-4939-9086-3_15.(出版社:Springer

17  17、 专著: Ling-juan Zhang*. Keratins in Skin Epidermal Development and Diseases. Keratin (Biochemistry Book Series). Published: November 5th 2018DOI: 10.5772/intechopen.79050. ISBN 978-953-51-6296-4.(出版社:IntechOpen


招聘:本实验室诚招副教授,助理教授,博士后,博士及硕士研究生。

 

联系方式:

地址:厦门市翔安区翔安南路厦门大学翔安校区跃进楼A506

邮箱: lingjuan.zhang@xmu.edu.cn