田文静助理教授

发布者:张欧扬发布时间:2018-01-16浏览次数:4668


个人简介

田文静,博士,硕士生导师。2015年于沈阳药科大学获天然药物化学专业博士学位,师从姚新生院士,博士期间获得国家奖学金。2015-2017年于厦门大学药学院开展师资博士后研究工作,现任药学院助理教授,主要从事中药与天然产物活性成分及作用机制研究工作。研究成果已发表在Organic LettersJournal of Natural ProductsPhytochemistryTetrahedronRSC AdvanceFitoterapia等天然药物化学领域权威学术期刊上,申请中国发明专利多项;主持国家自然科学基金青年基金(81602988)、博士后基金(2016M592094)、福建省自然科学基金(2019J05017)、厦门大学校长基金(20720190079)等多项基金,并参与多个中药及中药复方质量控制相关企业合作项目的研究工作。

 

教育背景与工作经历:

2017/12-今,厦门大学,药学院,助理教授

2015/11-2017/12,厦门大学,药学院,师资博后

2010/09-2015/07,沈阳药科大学,中药学院,博士(硕博连读)

 

研究方向:

1.中药及天然产物中活性成分与药物作用机制研究

2.中药及中药复方的质量控制研究

3.中药活性成分的体内代谢研究

 

代表性论文(第一#或通讯作者*论文):

[1] Ye, X. S.#; Tian, W. J.#; Wang, G. H.#; Zhang, X.; Zhou, M.; Zeng, D. Q.; Liu, X. Z.; Yao, X. S.*; Zhang, Y. W.*; Chen, H. F*. Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities. Journal of Agricultural and Food Chemistry, 2020, 68, 4196-4204.

[2] Qiu, D. R#.; Zhou, M.#; Chen, J. J.; Wang, G. H.; Lin, T.; Huang, Y. Y.; Yu, F. R.; Ding, R.; Sun, C. L.; Tian, W. J.*; Chen, H. F*. Hyperelodiones A-C, monoterpenoid polyprenylated acylphoroglucinols from Hypericum elodeoides, induce cancer cells apoptosis by targeting RXRα. Phytochemistry, 2020, 170,112216.

[3] Xu Q.N.; Zhu D.; Wang G.H.; Lin T.; Sun C.L.; Ding R.; Tian, W. J*.; Chen H.F. * Phenolic glycosides and flavonoids with antioxidant and anticancer activities from Desmodium caudatum, Natural Product Research, 2020, DOI: 10.1080/14786419.2020.1739044

[4] Qiu, D. R#.; Zhou, M.#; Lin, T.#; Chen, J. J.; Wang, G. H.; Huang, Y. J.; Jiang, X.; Tian, W. J*.; Chen, H. F*. Cytotoxic components from Hypericum elodeoides targeting RXRα and inducing HeLa cell apoptosis through Caspase‑8 activation and PARP Cleavage. J. Nat. Prod. 2019, 82, 1072−1080.

[5] Liu, X. Z.#; Tian, W. J.#; Wang, G. H.#; Xu, Q. N.; Zhou, M.; Gao, S.; Qiu, D. R.; Jiang, X.; Sun, C. L.; Ding, R.; Lin, T.*, Chen, H. F*. Stigmastane-type steroids with unique conjugated Δ7,9(11) diene and highly oxygenated side chains from the twigs of Vernonia amygdalina. Phytochemistry, 2019, 158, 67-76.

[6] Wu, Y.#; Tian, W. J.#; Gao, S.#; Liao, Z. J.; Wang, G. H.; LO, J. M.; Lin, P. H.; Zeng, D.Q.; Qiu, D. R.; Liu, X. Z.; Zhou, M.; Lin, T.*, Chen, H. F*. Secondary metabolites of petri-dish cultured Antrodia camphorata and their hepatoprotective activities against alcohol-induced liver injury in mice. Chinese Journal of Natural Medicines, 2019, 17(1): 0033-0042.

[7] Tian, W. J.#; Liao, Z. J.#; Zhou, M.#; Wang, G. H.;Gao, S.; Qiu, D. R.; Liu, X. Z.; Lin, T.*; Chen, H. F*. Cytoskyrin C, an unusual asymmetric bisanthraquinone with cage-like skeleton from the endophytic fungus Diaporthe sp. Fitoterapia, 2018, 128, 253-257.

[8] Tian, W. J.#; Qiu, Y. Q.; Chen, J. J.; Yao, X. J.; Dai, Y.; Chen, H. F.; Yao, X. S*. Norsampsone E, an unprecedented decarbonyl polycyclic polyprenylated acylphloroglucinol with a homoadamantyl core from Hypericum sampsoniiRSC Advances, 2017, 7, 33113–33119.

[9] Tian, W. J.#; Qiu, Y. Q.; Chen, H. F.; Jin, X. J.; Yao, X. J.; Dai, Y.; Yao, X. S*.Chiral separation and absolute configurations of two pairs of racemicpolyprenylated benzophenones from Hypericum sampsonii. Fitoterapia, 2017, 116, 39–44.

[10] Tian, W. J.#; Qiu, Y. Q.; Jin, X. J.; Chen, H. F.; Yao, X. J.; Dai, Y.; Yao, X. S*. Hypersampsones S–W, new polycyclicpolyprenylated acylphloroglucinols fromHypericum sampsonii. RSC Advances, 2016, 6, 50887–50894.

[11] Tian, W. J.#; Qiu, Y. Q.; Jin, X. J.; Chen, H. F.; Yao, X. J.; Dai, Y.; Yao, X. S*. Novel polycyclic polyprenylated acylphloroglucinols from Hypericum sampsoniiTetrahedron 2014, 70, 7912−7916.

[12] Tian, W. J.#; Qiu, Y. Q.; Yao, X. J.; Chen, H. F.; Dai, Y.; Zhang, X. K.; Yao, X. S*. Dioxasampsones A and B, two polycyclic polyprenylated acylphloroglucinols with unusual epoxy ring fused skeleton from Hypericum sampsoniiOrganic Letters, 2014, 16, 6346–6349.

[13] Tian, W. J.#; Yu, Y.; Yao, X. J.; Chen, H. F.; Dai, Y.; Zhang, X. K.; Yao, X. S*. Norsampsones A−D, four new decarbonyl polycyclic polyprenylatedacylphloroglucinols from Hypericum sampsoniiOrganic Letters, 2014, 16, 3448–3451.

 

联系方式:

Email: tianwj@xmu.edu.cn