陈登岳助理教授

发布者:张欧扬发布时间:2017-03-20浏览次数:7396


陈登岳博士、助理教授


简介:

    陈登岳博士主要从事靶向抗肿瘤药物的设计递送定制微流控器件连续控制合成大/小分子药物的研究与开发工作。2008年于天津大学化工学院获得工学学士学位,2010年获得北京交通大学理学硕士学位,同年赴美 New Jersey Institute of Technology开展博士课题研究,与BMS(百事美施贵宝)公司合作开发新型连续性制药器件。2015年获得工学博士学位,同年进入Shire生物制药公司美国总部担任研发科学家。近年来共发表SCI文章27篇,其中以第一作者或通讯作者共发表了24篇文章(13篇为JCR一区,10篇为JCR二区),专利6项,目前主持国家基金1项、省基金1项、教育部专项基金3项,以及多项与企业合作横向课题。

教育与工作经历:

1. 2015/4-2016/4,美国Shire制药公司,研发科学家

2. 2010/92014/12,美国新泽西理工大学,化学与制药工程学院,博士

3. 2008/92010/7, 北京交通大学,理学院,硕士

4. 2004/92008/7, 天津大学,化工学院,学士

荣誉:

2022年获得福建省高层次人才称号

基金项目:

1.  中国国家自然基金青年项目,微纤维管束结晶器内聚合物包覆纳米药物晶体的可控制备(21706221),2018.1-2020.1221万人民币,主持。

2.  福建省自然基金青年项目,新型多孔微膜丝结晶器内纳米载药脂质体的可控制备(2018J05143),2018.4-2021.43万人民币,主持。

3.  中央高校基本科研业务费专项,微流控可控制备自组装无载体纳米药物用于肿瘤光化学联合治疗与多模式成像诊疗一体化研究,2020.8-2021.810万人民币,主持。

4.  中央高校基本科研业务费专项,基于计算流体力学的新冠病毒传播机制与防护措施的机理研究(20720200048),2020.2-2020.1210万人民币,主持。

5.  中央高校基本科研业务费专项,快速冷却微膜丝结晶器内连续可控生产聚合物包覆的纳米药物晶(20720190077),2019.1-2019.1225万人民币,主持。

6.  美国国家自然科学基金项目GOALI: Continuous coating of ultrafine drug particles by heterogeneous polymer nucleation in a hollow fiber membrane module2011/01-2013/1230万美金,已结题,主要参与人。

 

第一或通讯作者发表论文:

1.       He C1, Liu C1, Li M, Li M, Yin J, Han S, Xia J, Chen D*, Cao W*, Lu Q*, Rosei F*.3D hierarchical Cu-MOF nanosheets-based antibacterial mesh. Chemical Engineering Journal. 2022, 446, 137381.(通讯作者, IF= 16.744, JCR一区TOP

2.       Yu J1, Chen D1, Wu J, Wang B*, Field R.Arch-type feed spacer with wide passage node design for spiral-wound membrane filtration with reduced energy cost. Desalination. 2022, 540, 115980.(共同第一作者, IF= 11.2108, JCR一区TOP

3.       Fang Y1, Chen D1, Zhang Y, Field R, Wu J*, Wang B*.Wastewater treatment in large-scale novel corrugated-sheet MBR. Journal of Water Process Engineering. 2022, 50, 103215.(共同第一作者, IF= 7.3398, JCR一区)

4.       Li M1, Liu C1, Yin J, Liu G*, Chen D*. Single-step Synthesis of Highly Tunable Multifunctional Nanoliposomes for Synergistic Cancer Therapy. ACS Applied Materials & Interfaces. 2022, 14 (18), 21301-21309.(通讯作者, IF= 10.383, JCR一区)

5.       Zuo W1, Fan Z, Chen L, Liu J, Wan Z, Xiao Z, Chen W, Wu L, Chen D*, Zhu X*.  Copper-based theranostic nanocatalysts for synergetic photothermal-chemodynamic therapy. Acta Biomaterialia.2022, 147, 258-269.(通讯作者, IF= 10.634, JCR一区TOP

6.       Liu C, Liu Q, Chen L, Li M, Yin J, Zhu X*, Chen D*.A pH-sensitive Self-assembled and Carrier-free Nanoparticle Based on Charge-reversal for Enhanced Synergetic Chemo-phototherapy. Advanced Healthcare Materials.2020, 9, 2000899.(通讯作者, IF= 11.093, JCR一区)

7.       Zuo W1, Chen D1, Fan Z, Chen L, Zhu Z, Zhu Q, Zhu X*.  Design of Light/ROS Cascade-Responsive Tumor-Recognizing Nanotheranostics for Spatiotemporally Controlled Drug Release in Locoregional Photo-Chemotherapy. Acta Biomaterialia.2020, 111, 327-340.  (共同第一作者, IF= 10.634, JCR一区TOP

8.       Gao X, Wang B,Liu Q, Liu C, Li M, Sirkar K K*, Chen D*.Fluid Dynamic and Heat Transfer Simulations of Solid Hollow Fiber Cooling Crystallizer for Continuous Synthesis of Drug Nanoparticles. Crystal Growth & Design. 2020, 20, 6, 4020–4029. (通讯作者, IF=4.010, JCR一区TOP

9.       Ma J1, Chen D1, Li Y, Chen Y, Liu Q, Zhou X, K. Qian, Li Z, Ruan H, Hou Z, Zhu X*. Zinc phthalocyanine-soybean phospholipid complex based drug carrier for switchable photoacoustic/fluorescence image, multiphase photothermal/ photodynamic treatment and synergetic therapy. Journal of Controlled Release, 2018, 284:1-14.(共同第一作者, IF= 11.467, JCR一区TOP

10.   Chen D1, Wang B1, Sirkar K K*. Hydrodynamic modeling of porous hollow fiber anti-solvent crystallizer for continuous production of drug crystals. Journal of Membrane Science, 2018, 556, 185-195.(第一作者, IF=10.530, JCR一区TOP

11.   Zhou X, Zhu X, Wang B, Li J, Liu Q, Gao X, Sirka K K*, Chen D*, Continuous production of drug nanocrystals by porous hollow fiber-based anti-solvent crystallization, Journal of Membrane Science, 2018,564,682-690.(通讯作者, IF=10.530, JCR一区TOP

12.   Liu Q1, Zhu X1, Wang B, Zhou X, Liu C, Gao X, Sirkar K K*, Chen D*, Continuous synthesis of drug nanocrystals by solid hollow fiber cooling crystallization, International Journal of Pharmaceutics, 2020, 576, 118978.(通讯作者, IF= 6.510, JCR一区)

13.   Chen D, Singh D, Sirkar K K*, Pfeffer R. Continuous preparation of polymer coated drug crystals by solid hollow fiber membrane-based cooling crystallization. International Journal of Pharmaceutics, 2016, 499(1), 395-402.(第一作者, IF= 6.510, JCR一区)

14.   Liu Q1, Li M1, Liu C, Yin J, Zhu X *, Chen D*, Continuous Synthesis of Polymer-Coated Drug Nanoparticles by Heterogeneous Nucleation in a Hollow-Fiber Membrane Module, Industrial & Engineering Chemistry Research, 2022, 61, 1, 349-358.(通讯作者, IF= 4.326, JCR二区TOP

15.   Chen Y, Chen Q, Zhu Q, Liu J, Li Y, Gao X, Chen D*, Zhu X*. Small Molecular Theranostic Assemblies Functionalized by Doxorubicin–Hyaluronic Acid–Methotrexate Prodrug for Multiple Tumor Targeting and Imaging-Guided Combined Chemo-Photothermal Therapy, MolecularPharmaceutics, 2019, 16, 2470-2480. (通讯作者, IF= 5.364, JCR二区)

16.   Zhao D, Song H, Zhou X, Chen Y, Liu Q, Gao X, Zhu X*,Chen D*. Novel facile thermosensitive hydrogel as sustained and controllable gene release vehicle for breast cancer treatment. European Journal of Pharmaceutical Sciences, 2019, 134, 145-152. (通讯作者, IF= 5.112, JCR二区)

17.   Jin C1, Chen D1, Pfeffer R, Sirkar K K*. An extended duration operation for solid hollow fiber membrane-based cooling crystallization. Powder Technology, 2020, 365, 106-114.(第一作者, IF= 5.640, JCR二区)

18.   Zhou X, Wang B, Liu Q, Liu C, Gao X,Sirkar K K*, Chen D*. An Extended Duration Operation for Porous Hollow Fiber-Based Antisolvent Crystallization, Industrial & Engineering Chemistry Research, 2019, 58, 1243112437. (第一作者, IF= 4.326, JCR二区TOP

19.   Ma J, Wu H, Li Y, Liu Z, Liu G, Guo Y, Hou Z, Zhao Q, Chen D*, Zhu X*. Novel Core-Interlayer-Shell DOX/ZnPc Co-loaded MSNs@ pH-Sensitive CaP@PEGylated Liposome for Enhanced Synergetic Chemo-Photodynamic Therapy, Pharmaceutical Research, 2018, 35(3):57.(通讯作者, IF= 4.580, JCR二区)

20.   Chen D, Sirkar K K*, Jin C, Dhananjay S, Pfeffer R. Membrane-based Technologies in the Pharmaceutical Industry and Continuous Production of Polymer-coated Crystals/Particles, Current Pharmaceutical Design, 2017, 23(2):242-249. (第一作者, IF= 3.310, JCR三区)

21.   Chen D, Singh D, Sirkar K K*. Continuous synthesis of polymer coated drug particles by a porous hollow fiber membrane-based anti-solvent crystallization method. Langmuir, 2015, 31, 432-441.(第一作者, IF= 4.331, JCR二区TOP

22.   Chen D, Singh D, Sirkar K K*. Porous hollow fiber membrane-based continuous technique of polymer coating on submicron and nanoparticles via anti-solvent crystallization. Industrial & Engineering Chemistry Research, 2015, 54(19), 5237-5245.(第一作者, IF= 4.326, JCR二区TOP

23.   Chen D, Singh D, Sirkar K K*. Continuous polymer nanocoating on silica nanoparticles. Langmuir, 2014, 30, 7804-7810.(第一作者, IF= 4.331, JCR二区TOP

24.   Chen D, Singh D, Sirkar K K*. Continuous polymer coating/encapsulation of submicron particles using a solid hollow fiber cooling crystallization method, Industrial & Engineering Chemistry Research, 2014, 53(15), 6388-6400.(第一作者, IF= 4.326, JCR二区TOP

 

非第一或通讯作者发表论文:

25.   Li Y, Lin J, Ma J, Song L, Lin H, Tang B, Chen D, Su G, Ye S, Zhu X, Luo F*, Hou Z*. Methotrexate-Camptothecin Prodrug Nanoassemblies as a Versatile Nanoplatform for Biomodal Imaging-Guided Self-Active Targeted and Synergistic Chemotherapy, ACS Applied Materials & Interfaces, 2017, 9(40), 34650-34665.(第七作者, IF= 10.383, JCR一区TOP

26.   Li Y, Liu G, Ma J, Lin J, Lin H, Su G, Chen D,Ye S, Chen X, Zhu X, Hou Z. Chemotherapeutic drug-photothermal agent co-self-assembling nanoparticles for near-infrared fluorescence and photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy, Journal of Controlled Release, 2017, 258:95-107.(第七作者, IF= 11.467, JCR一区TOP

27.   Li Q, Chen Y, Zhou X, Chen D, Li Y, Yang J*, Zhu X*. Hyaluronic Acid-Methotrexate Conjugates Coated Magnetic Polydopamine Nanoparticles for Multimodal Imaging-Guided Multistage Targeted Chemo-Photothermal Therapy, Molecular Pharmaceutics, 2018, 15(9), 4049-4062.(第四作者, IF= 5.364, JCR二区)

28.   Ma J, Li Y, Liu G, Li A, Chen Y, Zhou X, Chen D, Hou Z*, Zhu X*. Novel theranostic zinc phthalocyanine–phospholipid complex self-assembled nanoparticles for imaging-guided targeted photodynamic treatment with controllable ROS production and shape-assisted enhanced cellular uptake, Colloids And Surfaces B-Biointerfaces, 2018, 162,76-89.(第七作者, IF= 5.999, JCR二区)

29.   Wang Z, Guo K, Liu H*, Liu C, Geng Y, Lu Z, Jia B, Chen D. Effects of bubble size on the mass transfer of bubble swarms with Sauter mean diameters of 0.38–4.88 mm in a co-current up-flow bubble column, Journal of Chemical Technology and Biotechnology. https://doi.org/10.1002/jctb.6445. (第八作者,IF= 3.709, JCR 三区)

 

专利:

1.申请日2017 02 22日,申请号2017100951528,发明名称:“用实壁纤维管束结晶器制丙烯酸树脂包覆纳米药物的方法”

2.申请日2017 02 22日,申请号2017201595920,实用新型名称:“丙烯酸树脂包覆纳米药物的制备装置”

3.申请日2017 02 22日,申请号2017100951617,发明名称:“聚合物包覆纳米药物制备装置与制备方法”

4.申请日2017 02 22日,申请号2017201586739,实用新型名称:“一种聚合物包覆纳米药物制备装置”

5. Kamalesh K Sirkar(#), Robert Pfeffer, Dhananjay Singh ,Dengyue Chen , System and method for continuous polymer coating of particles.2015.5.7 ,美国, US: 201414532663:A.

6.Kamalesh K Sirkar(#), Robert Pfeffer, Dengyue Chen, Dhananjay Singh, Porous hollow fiber anti-solvent crystallization-based continuous method of polymer coating on submicron and nanoparticles.2016.6.16 ,美国, US: 201514968456:A.

 

团队建设与联系方式:

    本研究组氛围好,科研经费充裕,所涉及的科研项目创新性高实用性强,文章可发表于SCI一区期刊。欢迎本科生、研究生报考!电子邮件:dchen@xmu.edu.cn