Xuan Zhu Ph.D.
1998.8-2001.7 College of Pharmacy, Yanbian University, M.S.
2001.8-2005.8 College of Pharmaceutical Scienc,Seoul National University, Ph.D.
2006.4-2012.7 School of Pharmaceutical Science, Xiamen University, Associate Prof.
2012.8-present School of Pharmaceutical Science, Xiamen University, Prof.
Our research interests are in the development of biodegradable polymers for biomedical and pharmaceutical applications; nano-/micro- particles for drug delivery; and adhesive preparation.
Over the past 7 years, We focused on the development of: 1) novel biodegradable and biocompatible polymer drug carriers; 2) the nanotechnology based targeted drug delivery system of antineoplastic; 3).the synthesis and the molecular imaging evaluation of new nano-probe.
Permeability and quantity are the bottleneck problems for the ocular drug delivery system which that transits cornea, conjunctiva and sclera. There are several disadvantages of systemic drug delivery and local drug delivery by ocular route, such as low penetrability, low bioavailability and inconvenient usage. According to the special structure and microenvironment of eyes, our study introduces the design concept which collects the quick dissolution, quick solvation and adhesion, to increase the penetration and transit dose of biodegradable polymer nanoparticles in cornea, conjunctiva and sclera etc, using the quick dissolution and enforced adhesion of nanoparticles in tears, and controlling the nanoparticles’ characters by adjusting all the effective factors. By means of systemic study of the nanoparticles transition in eyes, we hope to provide theoretical and experimental basis in treating the ocular disease safely by ocular drug delivery system.
Hua Song, Ph.D. Associate Professor,
Shanghai University of T.C.M, China
Qing Chen assistant professor
Ph.D. China Pharmaceutical University, China
Selected Publications:（last 5 years）
Bo Sun*, Rui Liu Zhong-Dang Xiao, Xuan Zhu*. c-MET Protects Breast Cancer Cell from Apoptosis Induced by Sodium Butyrate. Plos One. 2012. 7(1):e30143.
Hang Ruan, Zhen Zhang, Xin-fang Liang, Yan Fu, Mei-qin Su, Qi-lin Liu, Xiu-min Wang, and Xuan Zhu*. Metabolism of dl-Praeruptorin A in Rat Liver Microsomes using HPLC-Electrospray Ionization Tandem Mass Spectrometry. Archives of Pharmacal Research. 2011.34(8):1311-1321.
Zhen Zhang, Yingying Liu, Meiqin Su, Xinfang Liang, Wufang Wang, Xuan Zhu*. Pharmacokinetics, tissue distribution and excretion study of dl-praeruptorin A of peucedanum praeruptorum in rats by liquid chromatography tandem mass spectrometry. Phytomedicine. 2011;18:527-532.
Hang Ruan, Zhen Zhang, Xuan Zhu*. Liquid chromatography tandem mass spectrometry pharmacolinetic study of dl-praeruptorin A in rat plasma. Biomedical Chromatography. 2010;24(11):1193-8.
Xuan Zhu*, Meiqin Su, Shaoheng Tang, Lingsong Wang, Xinfang Liang, Feihong Meng, Ying Hong, Zhiran Xu .Synthesis of thiolated chitosan and preparation nanoparticles with sodium alginate for ocular drug delivery. Molecular Vision. Molecular vision.2012;18:1973-1982.