Professor, Deputy Dean
Dr. Wu received his Ph.D. in Medicinal Chemistry from Shenyang Pharmaceutical University in 2004. He is currently Professor of Medicinal Chemistry of School of Pharmaceutical Sciences Xiamen University. He is an expert on the State Food and Drug Administration Center for Qualification of Licensed Pharmacist. He is invited to be an Editorial Board Member of Strait Pharmaceutical Journal in 2012. His lab is currently funded by the National Natural Science Foundation of China, National Science and Technology Major Project, and 863 Project.
Synthetic Medicinal Chemistry, Natural Product Chemistry and Chemical Biology;
Zhen lab’s primary research interests are the discovery and development of novel pharmaceuticals. His lab is also interested in designing chemical probes to study gene regulation. His research program focuses on the design and synthesis of novel RXRα-targeting agents for the future development of an improved clinical agent within this class of cancer chemotherapeutic agents.
Zhen’s lab has been studying the isolation, structural elucidation and the anti-tumor activity of secondary metabolites from deep-sea environmental metagenomic libraries clones. One focus of his research program is to obtain new functional gene clusters and lead compounds through the discovery of new clone secondary metabolic processes by using both the sequenced genomes of cultured clones and the new secondary metabolites. They are currently using this approach for biosynthetic pathways to develop new anti-tumor drugs.
Selected Publications:（last 5 years）
Hong-Ming Cheng, Ying-Kun Qiu, Zhen Wu, Yu-Fen Zhao DNA damage induced by Shikonin in the presence of Cu(II) ions: Potential mechanism of its activity to apoptotic cell death, J Asian Natur product Res 2011，13（1）：12-19
Xiang Gao, Weizhu Chen, Gangtian Zhu, Ruizao Yi, Zhen Wu, Pengxiang Xu,Yufen Zhao Fast separation of antiviral nucleoside phosphoramidate and H-phosphonate diastereoisomers by reversed-phase liquid chromatography, Journal of Chromatography A 2011，1218：1416–1422
Lin Chen, Xi- Xiang Tang, Min zheng, Zhi-Wei Yi, Ying-Kun Qiu, Zhen Wu, A novel indole alkaloid from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth,J Asian Natur product Res 2011，13(5):444-448
MeiXiang Zhu, Yanbing Gao, Zhen Wu, YuFen ZhaoA rapid HPLC/ESI-MS/MS method for quantitative analysis of isovalerylshikonin in rat plasma, Biomedical Chromatography. 2010, 24(4):413-419
Hu-Yi Zhao , Fu-Kai Wu , Ying-Kun Qiu, Zhen Wu , Yong-Tao Jiang , Ji-Yong Chen Studies on cytotoxic constituents from skin of the toad Bufo bufo gargariansJ Asian Natur product Res 2010,12（9）：793-800.
Meixiang Zhu, BaoYing Xie, Guo Tang, Anfu Hu, Meijuan Fang, Zhen Wu, Yufen Zhao. Quantitative determination of five zidovudine pro-drugs of diaryl phosphate triesters in rat plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry, J Pharm Biomed Anal 2008, 48（5）：1417-1424