introduction

Hu Zhou,Ph.D.

  发布时间: 2016-09-08   信息员:    浏览次数: 42



Hu Zhou, Ph.D.

Professor


Experience

Dr. Zhou received his bachelor degree from Anhui University, his  master degree from Xuzhou Medical College and his Ph.D. degree from Tsinghua  University in China. Following postdoctoral training at the Sanford-Burnham  Medical Research Institute in the United States, he joined the School of  Pharmaceutical Science of Xiamen University as an associate professor in 2011.  He was promoted to professor of Chemical Biology in 2012.


Research

Dr. Zhou’s group investigates the regulatory modes of nuclear  receptors and cellular signal transductions, as well as their reciprocal  interactions. His group also delineates the novel mechanisms of tumor initiation  and progression, and reveals druggable targets. Based on the discovered targets,  they carry out high-throughput screening to find new lead compounds. The group  applies multiple approaches, including computer-aided design and organic  synthesis, to improve the lead compounds to preclinical drugs.


Team

Zhiping Zeng, Assistant Professor

Ph.D Xiamen University,China

Dr. Zeng received both his bachelor degree and Ph.D.  degree from Xiamen University in China. He uses computer-aided design and  organic synthesis to optimize lead compounds.


Selected  Publications:last 5 years

Gao W, Liu J, Hu M, Huang M, Cai S, Zeng Z, Lin B,  Cao X, Chen J, Zeng JZ, Zhou H*, Zhang XK*. Regulation of proteolytic cleavage  of retinoid X receptor-α by GSK-3b. Carcinogenesis. 2013 Mar 5. [Epub ahead of print] ( *  co-corresponding authors).

Zhou H,* Liu W,* Su Y, Wei Z, Liu J, Kolluri SK, Wu  H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B,  Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. NSAID sulindac  and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.  Cancer Cell 2010, 17(6):560-573. ( * co-first authors)

Yan TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H,  Li WG, Cao X, Lin YY, He JY, Gao WW, Zhao Y, Xie L, Chen JB, Zhang XK, Zeng JZ.  Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma.  Cancer Res. 2010, 70(6):2285-2295.

Han YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F,  Lu N, Liu J, Zeng JZ, Zhang XK. A unique cytoplasmic localization of retinoic  acid receptor-gamma and its regulations. J Biol Chem, 2009, 284(27):18503-18514.  

Zhang L X,* Zhou H,* Su Y,* Sun Z H, Zhang H W,  Zhang L, Zhang Y, Ning Y H, Chen Y G, Meng A M. Zebrafish Dpr2 inhibits mesoderm  induction by promoting degradation of nodal receptors. Science, 2004, 306(5693):  114-117. ( * co-first authors)


Tel:+86-592-288-2552

Fax:+86-592-215-1579

Emai:huzhou@xmu.edu.cn


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