Hu Zhou, Ph.D.
Dr. Zhou received his bachelor degree from Anhui University, his master degree from Xuzhou Medical College and his Ph.D. degree from Tsinghua University in China. Following postdoctoral training at the Sanford-Burnham Medical Research Institute in the United States, he joined the School of Pharmaceutical Science of Xiamen University as an associate professor in 2011. He was promoted to professor of Chemical Biology in 2012.
Dr. Zhou’s group investigates the regulatory modes of nuclear receptors and cellular signal transductions, as well as their reciprocal interactions. His group also delineates the novel mechanisms of tumor initiation and progression, and reveals druggable targets. Based on the discovered targets, they carry out high-throughput screening to find new lead compounds. The group applies multiple approaches, including computer-aided design and organic synthesis, to improve the lead compounds to preclinical drugs.
Zhiping Zeng, Assistant Professor
Ph.D Xiamen University,China
Dr. Zeng received both his bachelor degree and Ph.D. degree from Xiamen University in China. He uses computer-aided design and organic synthesis to optimize lead compounds.
Selected Publications:（last 5 years）
Gao W, Liu J, Hu M, Huang M, Cai S, Zeng Z, Lin B, Cao X, Chen J, Zeng JZ, Zhou H*, Zhang XK*. Regulation of proteolytic cleavage of retinoid X receptor-α by GSK-3b. Carcinogenesis. 2013 Mar 5. [Epub ahead of print] ( * co-corresponding authors).
Zhou H,* Liu W,* Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell 2010, 17(6):560-573. ( * co-first authors)
Yan TD, Wu H, Zhang HP, Lu N, Ye P, Yu FH, Zhou H, Li WG, Cao X, Lin YY, He JY, Gao WW, Zhao Y, Xie L, Chen JB, Zhang XK, Zeng JZ. Oncogenic potential of retinoic acid receptor-gamma in hepatocellular carcinoma. Cancer Res. 2010, 70(6):2285-2295.
Han YH, Zhou H, Kim JH, Yan TD, Lee KH, Wu H, Lin F, Lu N, Liu J, Zeng JZ, Zhang XK. A unique cytoplasmic localization of retinoic acid receptor-gamma and its regulations. J Biol Chem, 2009, 284(27):18503-18514.
Zhang L X,* Zhou H,* Su Y,* Sun Z H, Zhang H W, Zhang L, Zhang Y, Ning Y H, Chen Y G, Meng A M. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science, 2004, 306(5693): 114-117. ( * co-first authors)