Professor, “Min-Jiang” Scholar
Dr. Liu received his bachelor degree from the School of Life Sciences at Xiamen University in China in 2001. He then worked as a research technician at the Sanford-Burnham Medical Research Institute from 2002 to 2005 in the United States. Dr. Liu earned his Ph.D. in Biology from the University of California, San Diegoin 2011. He spent two years as a postdoctoral fellow in the School of Medicine at University of California, San Diego prior to his appointment as a full-time professor at the School of Pharmaceutical Sciences in Xiamen University in 2013.He was awarded as “Min-Jiang Scholar Distinguished Professor” and was elected to the “National Thousand Young Talents Program”. Dr. Liu’s research work has beenpublished in prestigious journals such as Cell,Nature, Cancer Cell and Molecular Cell.
The Liu laboratory is interested in studying the molecular mechanisms underlying gene transcription regulation by epigenetic regulators, and its implication in cancer and other human diseases. The epigenetic regulators include but not limited to those histone/DAN/RNA modifying enzymes, “reader” proteins recognizing such modifications, and non-coding RNAs. Based on the molecular mechanisms identified, the Liu laboratory is also interested in the screening, synthesizing and optimizing small molecule inhibitors which can specifically and efficiently target to the epigenetic regulators of interest, aiming to prevent and/or cure cancer and other human diseases. Dr. Liu identified the first histone H4 lysine 20 demethylase named PHF8 and described its role in cell cycle regulation and the underlying molecular mechanisms. Recently, he revealed a novel paradigm in gene transcription regulation, in which histone demethylase JMJD6 in conjunction with its functional partner Brd4 regulates promoter-proximal Pol II pause release through association with distal enhancers, which were defined as “Anti-pause Enhancers”. The pause release function of JMJD6/Brd4 was primarily achieved through JMJD6 dual enzymatic activities targeting both histone and RNA methylation. The aforementioned research findings along with others have been published in several scientific journals with high impact factors, such as Cell, Nature, Cancer Cell and Molecular Cell.
Histone Demethylase Function in Gene Transcription Regulation
Histone Demethylase Function in Cell Cycle Progression
WeiweiGao, Postdoctoral Fellow
Haifeng Shen, PhD Student
Mingfeng Huang, PhD Student
Bingling Peng, MasterStudent
Huanteng Xu, Master Student
Jia Yi, Master Student
Rongquan Xiao, Master Student
Taotao Shi, Master Student
Wenjuan Zhang, Research Technician in Bioinformatics
Selected Publications:（last 5 years）
Liu W ⃰#，Ma Q#, Wong K, Li W, Ohgi K, Zhang J, Aggarwal AK, Rosenfeld MG⃰.Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release.Cell. 2013 Dec 19;155(7):1581-95. ( ⃰ 共同通讯作者，#共同第一作者)
Liu W, Tanasa B, Tyurina O.V., Zhou T.Y., Gassmann R, Liu W.T., Ohgi K.A., Benner C, Garcia-Bassets I, Aggarwal A.K., Desai A, Dorrestein P.C., Glass C.K., Rosenfeld M.G. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature. 2010 Jul 22; 466(7305):508-12（第一作者）
Zhou Hu #, Liu W#, Su Y, Wei Z, Liu J, Kolluri S.K., Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li W.G., Lin B, Zhang H.P., Yu J, Luo S.P., Zeng J.Z., Duester G, Huang P.Q., Zhang X.K. NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling. Cancer Cell. 2010 Jun 15;17(6):560-73 (#共同第一作者).
Yang L #,Lin C #,Liu W, Zhang J, Ohgi K.A., Grinstein J.D, Dorrestein P.C., Rosenfeld M.G. ncRNA- and Pc2 Methylation-dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs. Cell 2011 Nov 11; 147(4):773-88 (#共同第一作者).
Stender J.D., Pascual G, Liu W, Kaikkonen M.U., Do K, Spann N, Boutros M, Perrimon N, Rosenfeld M.G., Glass C.K. Control of Pro-Inflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20. Molecular Cell. 48, 1–11, October 12, 2012.
Zhou Z.H., Qiu, J.S., Liu W, Zhou Y, Plocinik, M.R., Li, H.R., Hu, Q.D., Ghosh, G, Adams, J.A., Rosenfeld, M.G., Fu, X.D. The Akt-SRPK-SR Axis Constitutes a Major Pathway in Transducing EGF Signaling to Regulate Alternative Splicing in the Nucleus. Molecular Cell 2012 Aug 10; 47(1-12).