introduction

Qiang Zhou,Ph.D.

  发布时间: 2016-09-08   信息员:    浏览次数: 28



Qiang Zhou , Ph. D

Professor


Experience

Dr. Zhou received his bachelor degree from University of Science  & Technology of China in 1986 and went to University of California at Los  Angeles to pursue graduate study and earned his Ph.D. in Molecular Biology from  UCLA at 1992.Supported by a  postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical  Research, he received postdoctoral training from 1993 to 1996 in Dr. Phillip  Sharp’s laboratory at MIT. In 1997, he joined the Department of Molecular and  Cell Biology at UC Berkeley, where currently he is a full professor, and a  charter member of the NIH AIDS Molecular and Cellular Biology (AMCB) Study  Section, the chair of the Tang Distinguished Scholarship Program at UC Berkeley  and a member on the editorial board of the Bioscience Journal, Scientific  consultant to Novartis Institute for Biomedical Research.In 2006, he was recruited to Xiamen  University , and awarded as “Minjiang Scholar Lecture Professor” , In 2010, he  was elected to the “National Thousand Talents Program”. Dr. Zhou has published  more than 50 papers in prestigious journals such  as Science, Nature ,Genes&Development , Molecular Cell, PNAS, and holds two  U.S. patents.


Research  interests

We interests in control of gene transcription elongation and  diseases, and mainly focus on the mechanism of transcriptional elongation  regulation of eukaryotes and AIDS and drug development.


Team

Yuhua Xue assistant professor

Ph.D. Xiamen University, China


Selected  Publications:last 5 years


Ruichuan Chen, Min Liu, Huan Li, Yuhua Xue,  Wanichaya N. Ramey, N anhai He, Nanping Ai, Haohong Luo, Ying Zhu, Nan Zhou and  Qiang Zhou. PP2B and PP1 alpha cooperatively disrupt 7SK snRNP to release P-TEFb  for transcription in response to Ca2+ signaling. Genes Dev. 2008 May  15;22(10):1356-68.

He, N., Jahchan, N. S., Hong, E., Bayfield, M. A.,  Maraia, R. J., Luo, K., and Zhou, Q. A La-related protein modulates 7SK snRNP  integrity to suppress P-TEFb-dependent transcriptional elongation and  tumorigenesis. Mol. Cell 2008. 29, 588-599

Nanhai He, Min Liu, Joanne Hsu, Yuhua Xue, Seemay  Chou, Alma Burlingame, Nevan J.Krogan, Tom Alber, and Qiang Zhou. HIV-1 Tat and  host cellular AFF4 recruit two distinct transcription elongation factors into a  bifunctional elongation complex for coordinated activation of HIV-1  transcription. Mol Cell. 2010 May 14; 38(3):428-38.

Nanhai HeCaleb K. ChanBijan SobhianSeemay ChouYuhua XueMin LiuTom AlberMonsef Benkiraneand Qiang Zhou. Human Polymerase-Associated Factor complex (PAFc)  connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin.  PNAS. 2011 September , vol. 108 no.36 E636-E645.

Liu, M., Hsu, J., Chan, C., Li, Z., and Zhou, Q. The  E3 ubiquitin ligase Siah1 controls ELL2 stability and Super Elongation Complexes  (SECs) formation to modulate HIV-1 transcription. Mol Cell. 2012 May  11;46(3):325-34.

Zichong Li, Jia Guo, Yuntao Wu and Qiang Zhou. The  BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4  inhibition of Tat-transactivation. Nuleic Acids Res. 2013, Vol. 41, No. 1  277–287 doi:10.1093/nar/gks976


Tel: +86-592-218-9698

Fax: +86-592-218-1879

Email:qzhou947072001 @yahoo.com


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