Qiang Zhou , Ph. D
Dr. Zhou received his bachelor degree from University of Science & Technology of China in 1986 and went to University of California at Los Angeles to pursue graduate study and earned his Ph.D. in Molecular Biology from UCLA at 1992.Supported by a postdoctoral fellowship from the Jane Coffin Childs Memorial Fund for Medical Research, he received postdoctoral training from 1993 to 1996 in Dr. Phillip Sharp’s laboratory at MIT. In 1997, he joined the Department of Molecular and Cell Biology at UC Berkeley, where currently he is a full professor, and a charter member of the NIH AIDS Molecular and Cellular Biology (AMCB) Study Section, the chair of the Tang Distinguished Scholarship Program at UC Berkeley and a member on the editorial board of the Bioscience Journal, Scientific consultant to Novartis Institute for Biomedical Research.In 2006, he was recruited to Xiamen University , and awarded as “Minjiang Scholar Lecture Professor” , In 2010, he was elected to the “National Thousand Talents Program”. Dr. Zhou has published more than 50 papers in prestigious journals such as Science, Nature ,Genes&Development , Molecular Cell, PNAS, and holds two U.S. patents.
We interests in control of gene transcription elongation and diseases, and mainly focus on the mechanism of transcriptional elongation regulation of eukaryotes and AIDS and drug development.
Yuhua Xue assistant professor
Ph.D. Xiamen University, China
Selected Publications:（last 5 years）
Ruichuan Chen, Min Liu, Huan Li, Yuhua Xue, Wanichaya N. Ramey, N anhai He, Nanping Ai, Haohong Luo, Ying Zhu, Nan Zhou and Qiang Zhou. PP2B and PP1 alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. Genes Dev. 2008 May 15;22(10):1356-68.
He, N., Jahchan, N. S., Hong, E., Bayfield, M. A., Maraia, R. J., Luo, K., and Zhou, Q. A La-related protein modulates 7SK snRNP integrity to suppress P-TEFb-dependent transcriptional elongation and tumorigenesis. Mol. Cell 2008. 29, 588-599
Nanhai He, Min Liu, Joanne Hsu, Yuhua Xue, Seemay Chou, Alma Burlingame, Nevan J.Krogan, Tom Alber, and Qiang Zhou. HIV-1 Tat and host cellular AFF4 recruit two distinct transcription elongation factors into a bifunctional elongation complex for coordinated activation of HIV-1 transcription. Mol Cell. 2010 May 14; 38(3):428-38.
Nanhai He，Caleb K. Chan，Bijan Sobhian，Seemay Chou，Yuhua Xue，Min Liu，Tom Alber，Monsef Benkirane，and Qiang Zhou. Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. PNAS. 2011 September , vol. 108 no.36 E636-E645.
Liu, M., Hsu, J., Chan, C., Li, Z., and Zhou, Q. The E3 ubiquitin ligase Siah1 controls ELL2 stability and Super Elongation Complexes (SECs) formation to modulate HIV-1 transcription. Mol Cell. 2012 May 11;46(3):325-34.
Zichong Li, Jia Guo, Yuntao Wu and Qiang Zhou. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation. Nuleic Acids Res. 2013, Vol. 41, No. 1 277–287 doi:10.1093/nar/gks976