Wangjin Hong,Ph.D.

  发布时间: 2016-09-08   信息员:    浏览次数: 220

Wanjin HongPh.D




Wanjin HONG graduated from Xiamen University (Fujian, China) in 1982  and was one of a few hundred Chinese students chosen for further graduate  training in the United States via the CUSBEA program. He received his PhD from  the State University of New York (SUNY Buffalo), and was a postdoctoral fellow  there before he joined the Institute of Molecular and Cell Biology (IMCB) in  Singapore as a principal investigator in 1989. He was also a professor of  Institutes of Biomedical Sciences, Xiamen University from 2006 to 2010. He is  also a honorable professor of School of Pharmaceutical Sciences, Xiamen  University from 2010 to now. At present, he is a Professor and Executive  Director of IMCB. He is currently the Editor-in-Chief for Bioscience Reports  (BsR) and a member of the editorial board for several other journals, such as  the Journal of Biological Chemistry (JBC), Traffic, and Molecular Membrane  Biology (MMB).



Our early work identified targeting signals for Golgi-localized  integral membrane proteins as well as the Tyr-based targeting signal for  TGN38.We also established the molecular  and functional conservation of the recycling pathway for the mammalian KDEL  receptor to retrieve luminal ER proteins. We have contributed significantly in  the identification and functional characterization of numerous proteins  participating in membrane trafficking in mammalian cells.For example, half of the 40 or so known  mammalian SNAREs, which participate in vesicle fusion events, were independently  identified and functionally studied by us. Our recent works using gene knockout  mice have established a physiological role for endobrevin/VAMP8 in the regulated  secretion by acinar cells of several exocrine organs and also several secretory  cells in the circulation and kidney collecting duct cells. Our lab is among the  first few to independently discover that the phox (PX) domain represents a new  motif for interacting with phosphoinositides, unveiling a novel mechanism for  the cell to integrate diverse cellular processes via a spectrum of about 47 PX  domain proteins. Our study of SNX27 (a PX-domain sorting nexin) using knockout  mice suggests that SNX27 may act as a general regulator in the endosome for  membrane proteins (such as GPCRs and ion channels) containing type I PZD-binding  motif. We have also contributed to the understanding of the molecular mechanisms  governing the action of small GTPases such as Arl1, Rab7 and Rab34. We are among  the first few labs to reveal that Arl1 functions to recruit GRIP-domain  Golgin-97 and Golgin-245 on the TGN to regulate endosomal traffic back to the  Golgi apparatus.The collaborative work  with Song Haiweis lab has revealed a novel mode of action of small GTPases in  that two Arl1 molecules interact with dimerized effectors. Similar mode of  action was also revealed for Rab7 and its effector (RILP). We also contributed  to the current understanding of COPII in protein export from the ER, COG complex  involved in Golgi function and human diseases called congenital disorders of  glycosylation (CDG), and Tom1 VHS domain protein family in post-Golgi sorting.  



Xiumin Wang , Associate Professor

Ph.D, Shenyang Pharmaceutical University,  China



Selected Publications:last 5 years

Chan, S.W., Lim,  C.J., Huang, C.X., Chong, Y.F., Gunaratne, H.J., Hogue, K.A., Blackstock, W.P.,  Harvey, K.F., and Hong, W. WW domain-mediated interaction with Wbp2 is important  for the oncogenic property of TAZ. Oncogene (2011) 30, 600-610.  

(Showed that Wbp2  is a regulator of the Hippo pathway by acting as a positive factor for TAZ and  YAP)

Cai, L., Loo,  L.S., and Hong, W. Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth  Retardation and Elevated Levels of N-methyl-D-aspartate (NMDA) Receptor 2C  (NR2C). Mol. Cell. Biol. (2011) 31, 1734-1747.

(Defined that  SNX27 is a general endosomal sorting protein for surface proteins with  PDZ-binding motifs)

Chan, S.W., Lim,  C.J., Chong, Y.F., Venkatesan Pobbati, A., Huang, C.X., and Hong, W. Hippo  pathway-independent regulation of TAZ and YAP by Angiomotin family. J. Biol. Chem.  (2011) 286,  7018-7026.

(Identified  angiomotin as a novel regulator of TAZ and YAP in the Hippo pathway)  

Pobbati,  A.V., Chan, S.W., Lee, I., Song, H., Hong, W.Structural  and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes.  Structure (2012) 20, 1135-1140.

(revealed structural similarity of Vgll1-TEAD and  YAP-TEAD complexes)

Zhu,  D., Zhang, Y., Lam, P.P., Dolai, S., Liu, Y., Cai, E.P., Choi, D., Schroer,  S.A., Kang, Y., Allister, E.M., Qin, T., Wheeler, M.B., Wang, C.C., Hong, W.,  Woo, M., Gaisano, H.Y.Dual  Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth. Cell  Metabolism (2012) 16, 238-249.

Wang,  X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y., Mu, Y., Loo, L.S., Cai, L.,  Thompson, R.C., Yang, B., Chen, Y., Johnson, P.F., Wu, C., Bu, G., Mobley, W.C.,  Zhang, D., Gage, F.H., Ranscht, B., Zhang, Y.W., Lipton, S.A., Hong, W., and Xu,  H. Loss of sorting nexin 27 contributes to  excitatory synaptic dysfunction by modulating glutamate receptor recycling in  Down's syndrome. Nature Medicine (2013)  19, 473-480.


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