Wanjin HONG graduated from Xiamen University (Fujian, China) in 1982 and was one of a few hundred Chinese students chosen for further graduate training in the United States via the CUSBEA program. He received his PhD from the State University of New York (SUNY Buffalo), and was a postdoctoral fellow there before he joined the Institute of Molecular and Cell Biology (IMCB) in Singapore as a principal investigator in 1989. He was also a professor of Institutes of Biomedical Sciences, Xiamen University from 2006 to 2010. He is also a honorable professor of School of Pharmaceutical Sciences, Xiamen University from 2010 to now. At present, he is a Professor and Executive Director of IMCB. He is currently the Editor-in-Chief for Bioscience Reports (BsR) and a member of the editorial board for several other journals, such as the Journal of Biological Chemistry (JBC), Traffic, and Molecular Membrane Biology (MMB).
Our early work identified targeting signals for Golgi-localized integral membrane proteins as well as the Tyr-based targeting signal for TGN38.We also established the molecular and functional conservation of the recycling pathway for the mammalian KDEL receptor to retrieve luminal ER proteins. We have contributed significantly in the identification and functional characterization of numerous proteins participating in membrane trafficking in mammalian cells.For example, half of the 40 or so known mammalian SNAREs, which participate in vesicle fusion events, were independently identified and functionally studied by us. Our recent works using gene knockout mice have established a physiological role for endobrevin/VAMP8 in the regulated secretion by acinar cells of several exocrine organs and also several secretory cells in the circulation and kidney collecting duct cells. Our lab is among the first few to independently discover that the phox (PX) domain represents a new motif for interacting with phosphoinositides, unveiling a novel mechanism for the cell to integrate diverse cellular processes via a spectrum of about 47 PX domain proteins. Our study of SNX27 (a PX-domain sorting nexin) using knockout mice suggests that SNX27 may act as a general regulator in the endosome for membrane proteins (such as GPCRs and ion channels) containing type I PZD-binding motif. We have also contributed to the understanding of the molecular mechanisms governing the action of small GTPases such as Arl1, Rab7 and Rab34. We are among the first few labs to reveal that Arl1 functions to recruit GRIP-domain Golgin-97 and Golgin-245 on the TGN to regulate endosomal traffic back to the Golgi apparatus.The collaborative work with Song Haiwei’s lab has revealed a novel mode of action of small GTPases in that two Arl1 molecules interact with dimerized effectors. Similar mode of action was also revealed for Rab7 and its effector (RILP). We also contributed to the current understanding of COPII in protein export from the ER, COG complex involved in Golgi function and human diseases called congenital disorders of glycosylation (CDG), and Tom1 VHS domain protein family in post-Golgi sorting.
Xiumin Wang , Associate Professor
Ph.D, Shenyang Pharmaceutical University, China
Selected Publications:（last 5 years）
Chan, S.W., Lim, C.J., Huang, C.X., Chong, Y.F., Gunaratne, H.J., Hogue, K.A., Blackstock, W.P., Harvey, K.F., and Hong, W. WW domain-mediated interaction with Wbp2 is important for the oncogenic property of TAZ. Oncogene (2011) 30, 600-610.
(Showed that Wbp2 is a regulator of the Hippo pathway by acting as a positive factor for TAZ and YAP)
Cai, L., Loo, L.S., and Hong, W. Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N-methyl-D-aspartate (NMDA) Receptor 2C (NR2C). Mol. Cell. Biol. (2011) 31, 1734-1747.
(Defined that SNX27 is a general endosomal sorting protein for surface proteins with PDZ-binding motifs)
Chan, S.W., Lim, C.J., Chong, Y.F., Venkatesan Pobbati, A., Huang, C.X., and Hong, W. Hippo pathway-independent regulation of TAZ and YAP by Angiomotin family. J. Biol. Chem. (2011) 286, 7018-7026.
(Identified angiomotin as a novel regulator of TAZ and YAP in the Hippo pathway)
Pobbati, A.V., Chan, S.W., Lee, I., Song, H., Hong, W.Structural and functional similarity between the Vgll1-TEAD and the YAP-TEAD complexes. Structure (2012) 20, 1135-1140.
(revealed structural similarity of Vgll1-TEAD and YAP-TEAD complexes)
Zhu, D., Zhang, Y., Lam, P.P., Dolai, S., Liu, Y., Cai, E.P., Choi, D., Schroer, S.A., Kang, Y., Allister, E.M., Qin, T., Wheeler, M.B., Wang, C.C., Hong, W., Woo, M., Gaisano, H.Y.Dual Role of VAMP8 in Regulating Insulin Exocytosis and Islet β Cell Growth. Cell Metabolism (2012) 16, 238-249.
Wang, X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y., Mu, Y., Loo, L.S., Cai, L., Thompson, R.C., Yang, B., Chen, Y., Johnson, P.F., Wu, C., Bu, G., Mobley, W.C., Zhang, D., Gage, F.H., Ranscht, B., Zhang, Y.W., Lipton, S.A., Hong, W., and Xu, H. Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome. Nature Medicine (2013) 19, 473-480.
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