Dr. Wolfgang Dubiel
Dr. Dubiel obtained his Ph.D. at the Institute of Biochemistry, Humboldt University Berlin in 1982. After postdoctoral work at the Humboldt University Berlin and at the Department of Biochemistry, University of Utah, Salt Lake City, USA, he returned to the Institute of Biochemistry, Humboldt University Berlin as a lecturer in 1993. In 1999, Dr. Dubielobtained an appointment as a Professor and became the Head of the Division of Molecular Biology, Department of General, Visceral, Vascular and Thoracic Surgery, Charité – Universitätsmedizin Berlin. In 2016, Dr. Dubiel was invited as a Visiting Professor at the School of Pharmaceutical Sciences, Xiamen University, inDr. Dieter A. Wolf’s laboratory.
Dr. Dubiel is a leading expert in the field of intracellular protein degradation by the ubiquitin proteasome system. Among his most important achievements is the discovery of the COP9 signalosome complex (CSN), a regulator of cullin-RING ubiquitin ligases (CRLs).Since 2000, his research is focused on the structural and functional characterization of the CSN in human cells as well as its utility as cancer drug target. A very recent achievement was the identification of the CSN as a master regulator of adipogenesis, the differentiation of fat cells (adipocytes). The CSN is involved in the re-modeling of the CRL network in adipocytes to switch to the differentiation mode. This makes the CSN an attractive target for the treatment of obesity and other metabolic diseases.
At Xiamen University, in Dr. Wolf’s lab, Dr. Dubiel will focus on the role of the CSN and of CSN variants in tumor cells and during adipogenesis. In collaboration with Dr. Wolf, he will screena new library of largely unexplored natural product resources of the South China Sea presently being developed in Dr. Zhang’s group. Using this library, he expects to identify novel modulators of adipogenic pathways that could provide proof-of-concept for targeting the CSN in metabolic disease.
Huang X, Ordemann J, Pratschke J, Dubiel W. (2016) Overexpression of COP9 signalosome subunits, CSN7A and CSN7B, exerts different effects on adipogenic differentiation. FEBS Open Bio. 6, 1102-1112
Gummlich L, Kähne T, Naumann M, Kilic E, Jung K, Dubiel W. (2016) New Insights Into the Mechanism of COP9 Signalosome-Cullin-RING Ubiquitin-Ligase Pathway Deregulation in Urological Cancers.Int Rev Cell Mol Biol. 323, 181-229
Dubiel D, Ordemann J, Pratschke J, Dubiel W, Naumann M. (2015) CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis.Int J Biochem Cell Biol. 66, 95-100
Huang X, Ordemann J, Müller JM, Dubiel W. (2012)The COP9 signalosome, cullin 3 and Keap1 supercomplex regulates CHOP stability and adipogenesis.Biol Open. 1, 705-710
Leppert U, Henke W, Huang X, Müller JM, Dubiel W. (2011) Post-transcriptional fine-tuning of COP9 signalosome subunit biosynthesis is regulated by the c-Myc/Lin28B/let-7 pathway.J Mol Biol. 409, 710-721
Hetfeld BK, Helfrich A, Kapelari B, Scheel H, Hofmann K, Guterman A, Glickman M, Schade R, Kloetzel PM, Dubiel W. (2005)The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1.Curr Biol. 15, 1217-1221
Zhou C, Wee S, Rhee E, Naumann M, Dubiel W, Wolf DA. (2003) Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p.Mol Cell. 11, 927-938
Uhle S, Medalia O, Waldron R, Dumdey R, Henklein P, Bech-Otschir D, Huang X, Berse M, Sperling J, Schade R, Dubiel W. (2003) Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.EMBO J. 22, 1302-1312