Xiao-Nan Wu, Ph.D.

Associate Professor

Experience

2014-present, School of Pharmaceutical Science, Xiamen University, Assistant/Associate Professor

2011-2014, College of Chemistry and Chemical Engineering, Xiamen University, Postdoctoral fellow

2004-2011, School of Life Sciences, Xiamen University, Ph.D.

2008, Department of Immunology, University of Western Ontario, Visiting Scholar

2000-2004, School of Life Sciences, Xiamen University, BS

Research

Dr. Xiao-Nan Wu is devoted to the research on the molecular mechanisms of cell signaling transduction and gene transcription regulation in major diseases such as cancer, as well as the development of targeted small molecule drugs. Dr. Wu has discovered the molecular mechanisms of homologous/heterologous dimerization involved in signal transduction in the large amyloid-like fiber complex of RIP3 in cell programmed necrosis signal transduction, elucidating the molecular mechanisms of endogenous programmed necrosis blockade, and participating in the development of drug strategies targeting the PDK1-RSK signaling pathway to intervene in lethal colitis. Dr. Wu's research work has been published in journals such as Molecular Cell, Cell Death and Differentiation, and Cell Discovery. Dr. Wu has hosted two National Natural Science Foundation projects, two provincial-level projects, one Xiamen University President Fund project, and guided one national undergraduate innovation project.

Selected  Publications (last 5 years):

1、Yang, Z.H.#, Wu, X.N.#, He, P.#, Wang, X., Wu, J., Ai, T., Zhong, C.Q., Wu, X., Cong, Y., Zhu, R., et al. (2020). A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade. Mol Cell 80, 296-310 e296.

2、Wu, X.N.#, Shi, T.T.#, He, Y.H.#, Wang, F.F.#, Sang, R., Ding, J.C., Zhang, W.J., Shu, X.Y., Shen, H.F., Yi, J., et al. (2017). Methylation of transcription factor YY2 regulates its transcriptional activity and cell proliferation. Cell Discov 3, 17035.

3、Zhang, W.J.#, Wu, X.N.#, Shi, T.T.#, Xu, H.T.#, Yi, J., Shen, H.F., Huang, M.F., Shu, X.Y., Wang, F.F., Peng, B.L., et al. (2016). Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation. Sci Rep 6, 21718.

4、Gao, W.W., Xiao, R.Q., Peng, B.L., Xu, H.T., Shen, H.F., Huang, M.F., Shi, T.T., Yi, J., Zhang, W.J., Wu, X.N., et al. (2015). Arginine methylation of HSP70 regulates retinoid acid-mediated RARbeta2 gene activation. Proc Natl Acad Sci U S A 112, E3327-3336.

5、Wu, X.N.#, Yang, Z.H.#, Wang, X.K., Zhang, Y., Wan, H., Song, Y., Chen, X., Shao, J., and Han, J. (2014). Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis. Cell Death Differ 21, 1709-1720.

6、Wu, X.N.#, Wang, X.K.#, Wu, S.Q., Lu, J., Zheng, M., Wang, Y.H., Zhou, H., Zhang, H., and Han, J. (2011). Phosphorylation of Raptor by p38beta participates in arsenite-induced mammalian target of rapamycin complex 1 (mTORC1) activation. J Biol Chem 286, 31501-31511.

7、Zheng, M., Wang, Y.H., Wu, X.N., Wu, S.Q., Lu, B.J., Dong, M.Q., Zhang, H., Sun, P., Lin, S.C., Guan, K.L., et al. (2011). Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol 13, 263-272.

Tel: +86-592-2881145

Fax: +86-592-2881145

Email:  xnwu@xmu.edu.cn