Guanghui Wang

Associate Professor

Email:guanghui@xmu.edu.cn

EDUCATION

1997-2002 Shenyang Pharmaceutical University, B.S.

2002-2007 Shenyang Pharmaceutical University, Ph.D.

EXPERIENCE

2007-2014Assistant Professor, Institute of Biomedical Research & School of Pharmaceutical Sciences Xiamen University, China

2014-presentAssociate Professor, School of Pharmaceutical Sciences Xiamen University, China

RESEARCH

Dr. Wang is interested in studying the molecular mechanisms of nuclear receptor (RXR, Nur77, etc) in cancer and other human diseases. She has published more than 20 research papers and holds more than 3 patents. She has been supported by 3 program projects recent years from National Natural Science Foundation of China. She also attend the programs of Fujian major program grant and Fundamental Research Funds for the Central Universities, etc.

Selected  Publications:（last 5 years)

Yuqi Zhou, Wei Zhao, Guobin Xie, Mingfeng Huang,Mengjie Hu, Xin Jiang, Dequan Zeng, Jie Liu, Hu Zhou, Haifeng Chen, Guang-Hui Wang* and Xiao-Kun Zhang*Induction of Nur77-dependent apoptotic pathway by a coumarin derivative through

activation of JNK and p38 MAPK Carcinogenesis. 2014,35:2660–2669

Ting Lin†, Guanghui Wang†, Wenjun Shan, Dequan Zeng, Rong Ding, Xin Jiang, Dan Zhu, Xiaoxuan Liu, Shuiyuan Yang, Haifeng Chen*.Myrotheciumones: Bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens. Bioorganic & Medicinal Chemistry Letters.2014,24:2504–2507

Guang-Hui Wang, Fu-Quan Jiang, Ying-Hui Duan, Zhi-Ping Zeng, Fan Chen, Yi Dai, Jie-Bo Chen, Jinxing Liu, Jie Liu, Hu Zhou1, Hai-Feng Chen, Jin-Zhang Zeng, Ying Su, Xin-Sheng Yao* and Xiao-Kun Zhang*.Targeting Truncated Retinoid X Receptor-a by CF31 Induces TNF-a–Dependent Apoptosis.Cancer Research 2013,73(1):307-318

Guanghui Wang, Xiaoyu Guo, Haifeng Chen, Ting Lin, Yang Xu, Quancheng Chen, Jie Liu,Jinzhang Zeng, Xiao-kun Zhang*, Xinsheng Yao*.A resveratrol analog, phoyunbene B, induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.

Bioorganic & Medicinal Chemistry Letters.2012, 22: 2114–2118

Ting Lin†, Guang Hui Wang†, Xiang Lin, Zhi Yu Hu, Quan Cheng Chen, Yang Xu,

Xiao Kun Zhang and Hai Feng Chen*.Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate.Molecules. 2011,16: 3351-3359