Introduction

Mingyu Li

  发布时间: 2016-09-28   信息员:    浏览次数: 702

Mingyu Li, Ph.D.

Associate Professor

Experience:

Dr. Mingyu Li got his bachelor degree and master degree from Ocean University of China in 2003 and 2006. He received his Ph.D from same school in 2010. From 2010 to 2011, he worked as assistant scientist in Third Institute of Oceanography of State Oceanic Administration. In 2011, he moved to Vanderbilt University Medical Center and began his postdoctoral research training until 2016.He joined the School of Pharmaceutical Science of Xiamen University as an associate professor in 2016. He has published high-quality papers in Diabetes, Am J PhysiolEndocrinolMetab, Genome Research, Genetics, and so on. He is also the peer reviewer of several journals, including Scientific Reports, Plos One, General and Comparative Endocrinology.

  

Research Interests:

The pancreatic alpha cells and beta cells secrete glucagon and insulin respectively, which are counter-regulatory hormones to balance the glucose levels and ensure euglycaemia. Abnormal secretion of glucagon and insulin hormones is a hallmark of type 1 and type 2 diabetes, and so both cell types play a significant role in diabetes. In combination with zebrafish and mouse models, our research focus on: 1) the molecular mechanisms of alpha and beta cells compensation or regeneration; 2) modeling diabetes in zebrafish and its application in drugs screening; 3) the role of nuclear receptors in the regulation of alpha and beta cells functions.

  

Selected Publications:(last 5 years):

  1. Mingyu Li#, Liyuan Zhao#, Patrick Page-McCaw, Wenbiao Chen. Zebrafish genome engineering using the CRISPR-Cas9 system. Trends in Genetics (2nd revision).

  2. Mingyu Li, Patrick Page-McCaw,Wenbiao Chen. FGF1 mediates overnutrition-induced compensatory β-Cell differentiation in zebrafish. Diabetes. 2016, 65(1):96-109.

  3. Mingyu Li, Danielle Dean, Liyuan Zhao, Wendell E. Nicholson, Alvin C. Powers, Wenbiao Chen. Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. J Endocrinol, 2015, 227 (2) 93-103.

  4. Mingyu Li, Lisette A Maddison, Patrick Page-McCaw, Wenbiao Chen. Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae. Am J PhysiolEndocrinolMetab. 2014, 306(7): E799-807.

  5. Mingyu Li, Qiuhua Li, Zhijun Yang, Guohai Hu, Ting Li, Xinhua Chen, JingqunAo. Identification of Cathepsin B from large yellow croaker (Pseudosciaenacrocea) and its role in the processing of MHC class II-associated invariant chain. Dev Comp Immunol. 2014, 45(2):313-320.

  6. Mingyu Li, Lisette A. Maddison, Zachary Crees, Wenbiao Chen.Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish. Zebrafish. 2013 Jun;10(2):170-6.

  7. Mingyu Li, Yang Ding, Yinnan Mu, JingqunAo, Xinhua Chen*.Molecular cloning and characterization of caspase-3 in large yellow croaker (Pseudosciaenacrocea). Fish & Shellfish Immun. 2011, 30 (3):910-916.

  8. Yinnan Mu#, Mingyu Li#, Feng Ding#, Yang Ding, JingqunAo, Songnian Hu, Xinhua Chen. De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaenacrocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response.PLoS One. 2014, 9(5):e97471.(# Co-first author).

  9. Xiaoqiang Xiao#, Mingyu Li#, Kunru Wang#, Qiwei Qinand Xinhua Chen*. Characterization of large yellow croaker (Pseudosciaenacrocea) β-actin promoter supports β-actin gene as an internal control for gene expression modulation and its potential application in transgenic studies in fish.Fish & Shellfish Immun. 2011, 30(4-5):1072-1079.(# Co-first author).

  10. Gaurav K Varshney, Wuhong Pei, Matthew C. LaFave, Jennifer Idol, Lisha Xu, Viviana Gallardo, Blake Carrington, Kevin Bishop, Marypat Jones, Mingyu Li, Ursula Harper, Sunny Huang, Wenbiao Chen, Raman Sood, Johan Ledin, and Shawn M. Burgess. High-Throughput Gene targeting and phenotyping in Zebrafish Using CRISPR/Cas9. Genome Res. 2015 Jul; 25(7): 1030-1042.

  11. Linlin Yin, Lisette A Maddison, Mingyu Li, Nergis Kara, Mathew C Lafave, Gaurav K Varshney, Shawn M Burgess, James G Patton and Wenbiao Chen. Multiplex conditional mutagenesis using transgenic expression of cas9 and sgRNAs.Genetics. 2015 Jun;200(2):431-41.

  12. Jingqun Ao, Yinnan Mu, Li-Xin Xiang, DingDing Fan, MingJi Feng, Shicui Zhang, Qiong Shi, Lv-Yun Zhu, TingLi, Yang Ding, Li Nie, Qiuhua Li, Wei-ren Dong, Liang Jiang, Bing Sun, XinHui Zhang, Mingyu Li, Hai-QiZhang, ShangBo Xie, YaBing Zhu, XuanTing Jiang, Xianhui Wang, Pengfei Mu, Wei Chen, Zhen Yue, ZhuoWang, Jun Wang, Jian-Zhong Shao, Xinhua Chen. Genome sequencing of the perciform fish Larimichthyscrocea provides insights into stress adaptation.PLoS Genet, 2015, 11(4): e1005118.

  13. Lisette A. Maddison, Mingyu Li, Wenbiao Chen. Conditional Gene-Trap Mutagenesis in Zebrafish. Methods Mol Biol. 2014;1101:393-411.


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