Lian-Dong Guo, Ph.D.

Associate Professor

Experience

2024-now: Associate Professor, School of Pharmaceutical Sciences, Xiamen University

2020-2023: Post-doctoral Fellow, Department of Chemistry, The Hong Kong University of Science and Technology

2016-2020: Post-doctoral Fellow, Department of Chemistry, Southern University of Science and Technology

Education

2010-2016: Ph. D., Xiamen University, China

2006-2010: B. Sc., Fuzhou University, China

Research

Natural products are an important source for drug discovery, and the scarcity of natural sources represents a significant constraint on the innovation of drugs derived from natural products. Emphasizing the importance of natural products in drug discovery, our group aims to develop innovative synthetic methods and strategies to efficiently synthesize these compounds with significant biological activities.

SelectedPublications:

1、Guo, L.-D.; Wu, Y.; Xu, X.; Lin, Z.; Tong, R.* Bent π-Conjugation within a Macrocycle: Asymmetric Total Syntheses of Spirohexenolides A and B. Angew. Chem. Int. Ed.2024, 63, e202316259.

2、Guo, L.-D.; Xu, Z.; Tong, R.* Asymmetric Total Synthesis of Indole Diterpenes Paspalicine,Paspalinine, and Paspalinine-13-ene. Angew. Chem. Int. Ed.2022, 61, e202115384.

3、Guo, L.-D.^# (co-first author); Chen, Y.^#; Xu, J.* Total Synthesis of Daphniphyllum Alkaloids: From Bicycles to Diversified Caged Structures. Acc. Chem. Res.2020, 53, 2726–2737.

4、Guo, L.-D.; Zhang, Y.; Hu, J.; Ning, C.; Fu, H.; Chen, Y.; Xu, J.* Asymmetric total synthesis of Yuzurimine-type Daphniphyllum Alkaloid (+)-Caldaphnidine J. Nat. Commun. 2020, 11, 3538.

5、Guo, L.-D.; Hu, J.; Zhang, Y.; Tu, W.; Zhang, Y.; Pu, F.; Xu, J.* Enantioselective Total Synthesis of (−)-Caldaphnidine O via a Radical Cyclization Cascade. J. Am. Chem. Soc.2019, 141, 13043−13048.

6、Guo, L.-D.; Hou, J.; Tu, W.; Zhang, Y.; Zhang, Y.; Chen, L.; Xu, J.* Total synthesis of dapholdhamine B and dapholdhamine B lactone. J. Am. Chem. Soc.2019, 141, 11713−11720.

7、Guo, L.-D.; Huang, X.-Z.; Luo, S.-P.; Cao, W.-S.; Ruan, Y.-P.; Ye, J.-L.; Huang, P.-Q.* Organocatalytic, Asymmetric Total Synthesis of (−)‐Haliclonin A. Angew. Chem. Int. Ed.2016, 55, 4064−4068.

Email:  liandongguo@xmu.edu.cn