Jingjing Xie,  Ph.D.

Assistant Professor

Experience

2010.09-2015.06, College of Chemistry, Fuzhou University, PhD

2015.09-update，School of Pharmaceutical Sciences, Xiamen University, Assistant Professor

Research

Nanobiotechnology; nanoparticles-based drug delivery, especially focus on intracellular biomacromolecules such as peptide delivery; Surface functionalization of macroporous silica nanoparticles or PAMAM dendrimers for the diagnosis, therapy and prevention of disease, especially cancer

Selected  Publications (last 5 years):

1. Weixia Xu, Min Zhou, Zhihan Guo1, Sijin Lin1, Mingyu Li, Qi Kang, Yang Xu, Xiaokun Zhang, Jingjing Xie*. Impact of macroporous silica nanoparticles at sub-50nm on bio-behaviors and biosafety in drug-resistant cancer models. Colloids and Surfaces B:Biointerfaces 206 (2021)111912. (Corresponding author)

2. Jingjing Xie^∗, Weixia Xu, Yuehuang Wu, Boning Niu, Xiaokun Zhang∗. Macroporous organosilicon nanocomposites co-deliver Bcl2-converting peptide and chemotherapeutic agent for synergistic treatment against multidrug resistant cancer. Cancer Letters 469 (2020) 340–354. (First and Corresponding author)

3. Pengjin Ge, Boning Niu, Yuehuang Wu, Weixia Xu, Mingyu Li, Huisong Sun, Hu Zhou, Xiaokun Zhang^*, Jingjing Xie^*. Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers

delivery with specificity and biosafety. Chemical Engineering Journal 383 (2020) 123228. (Corresponding author)

4. Yuehuang Wu, Pengjin Ge, Weixia Xu, Mingyu Li, Qi Kang, Xiaokun Zhang, Jingjing Xie^*. Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment. Materials Science & Engineering C108 (2020) 110386. (Corresponding author)

5. Yu Li, Ting Zhang, Jing Huang, Haiyan Dong*, Jingjing Xie*, Lee Jia. Biostable Double-Strand Circular Aptamers Conjugated onto Dendrimers for Specific Capture and Inhibition of Circulating Leukemia Cells. OncoTargets and Therapy 2020:13 13465–13477. (Corresponding author)

6. Haiyan  Dong, Bo Lu, Jie Wang, Jingjing Xie, Kuancan Liu, Lee Jia and Junyang Zhuang*. Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis. Chem. Commun., 2019, 55, 14797-14800.

7. Xu, W.; Gao, X.; Ge, P.; Jiang, F.; Zhang, X.;Xie, J*. Dendrimer-like mesoporous silica nanospheres with suitable surface functionality to combat the multidrug resistance. Int J Pharm2018, 553, 349-362. (Corresponding author)

8.Xu, W.; Ge, P.; Niu, B.; Zhang, X.; Liu, J.; Xie, J*. Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells. J Colloid Interface Sci2018, 527, 141-150. (Corresponding author)

9.Dong, H.; Han, L.; Wang, J.;Xie, J.; Gao, Y.; Xie, F.; Jia, L. In vivo inhibition of circulating tumor cells by two apoptosis-promoting circular aptamers with enhanced specificity. J Control Release2018, 280, 99-112.

10.Dong, H. Y.; Han, L. Y.; Wu, Z. S.; Zhang, T.; Xie, J. J.; Ma, J.; Wang, J.; Li, T.; Gao, Y.; Shan, J. W.; Sinko, P. J.; Jia, L. Biostable Aptamer Rings Conjugated for Targeting Two Biomarkers on Circulating Tumor Cells in Vivo with Great Precision. Chem Mater2017, 29, 10312-10325.

Email:  xiejj@xmu.edu.cn